Statement of Need SON_Microtome.pdf
PDF 172 KB Posted
- Solicitation number
- 75N98026Q01029
About this file
This is a Statement of Need (SON) from the National Heart, Lung, and Blood Institute at the NIH Clinical Center for the procurement of a Compresstome Vibrating Microtome system VF-800-0Z.
The National Heart, Lung, and Blood Institute seeks to establish a translational research platform focused on elucidating the pathobiology of pulmonary fibrosis and identifying critical early intervention time-points before irreversible fibrosis occurs. The requested equipment will support molecular assessment, drug testing, biomarker discovery, and cellular profiling across fibrosing lung diseases. The Compresstome Vibrating Microtome VF-800-0Z is a precision instrument designed to cut live or fixed lung tissue into slices ranging from 40–2000 μm with 1 μm resolution. The system includes Auto Zero-Z™ technology that eliminates Z-axis deflection and ensures consistently smooth tissue surfaces without manual calibration, enabling the generation of viable, structurally intact precision-cut lung slices (PCLS) from fibrotic explants for up to 10 days of pharmacologic testing. The required procurement includes the following items: one Compresstome VF-800-0Z Vibrating Microtome (Product Number VF-800-0ZVM-NC), one Starter Kit VF-800 Domestic (VF-800-0ZSK-USA), one Gooseneck LED Sample Visualization Lamp (VF-G-LAMP), and virtual training and demonstration support (VF-TD-PP). Delivery is required to Room 8S205, 10 Center Drive, Bethesda, MD 20892. The point of contact and contact information will be provided upon award.
View the file
Other files
| File | Type | Posted |
|---|---|---|
| Notice of Intent-75N98026Q01029.pdf |
On GovTribe
Work with this file
- Download the original file
- Contacts named in this file
- Similar government files
- Ask GovTribe AI about this file
Text version
Statement of Need (SON)
1. Project Title Compresstome Vibrating Microtome system VF-800-0Z to Support Lung Transplant and Tissue Biology Research
2. Statement of Need and Objectives
The program is to bring patients to the NIH Clinical Center, elucidate the pathobiology of pulmonary fibrosis and pinpoint critical early intervention time-points before irreversible fibrosis occurs. This innovative platform addresses a significant gap in translational research, providing the means for molecular assessment, drug testing, and biomarker discovery within actual human fibrotic tissue. The equipment will serve as a vital resource in collaborative projects aimed at unraveling fibrosis mechanisms, advancing therapeutic development, and conducting cellular profiling across a wide range of fibrosing lung diseases. The system will improve efficiency, reduce variability, and allow integration of multiplexed data critical for understanding complex biological systems.
3. Product Specifications/Features/Salient Characteristics
The Compresstome Vibrating Microtome (Tissue Slicer; Vibrating microtome) VF-800-0Z is a precision vibrating microtome designed to cut live or fixed lungtissue into slices ranging from 40–2000 μm with 1 μm resolution. It includes Auto Zero-Z™ technology, which eliminates Z-axis deflection and ensures consistently smooth tissue surfaces without requiring manual calibration. This model is essential for generating viable, structurally intact PCLS from fibrotic explants, enabling up to 10 days of pharmacologic testing. Compared to manual slicing, the Compresstome offers superior reproducibility, tissue preservation, and sectioning accuracy critical for downstream molecular and functional assays. The quote includes a full starter kit, LED sample visualization lamp, and virtual training and demo support.
Quantity Product Number Description
1 VF-800-0ZVM-
NC
Compresstome® Vibrating Microtome:Compresstome Models:Compresstome® VF- 800-0Z Vibrating Microtome (Tissue Slicer)
1 VF-800-0ZSK-
USA
Compresstome® Vibrating Microtome:Compresstome Consumables:Compresstome® Starter Kit VF-800 (Domestic)
1 VF-G-LAMP Compresstome® Vibrating Microtome:Compresstome Parts:Gooseneck Lamp
1 VF-TD-PP Training and Demo
4. Delivery Information and Location 10 Center Drive, Room 8S205
Bethesda, MD 20892
5. Point of Contact and Contact Information To be provided upon award.
| Statement of Need (SON) |
| 1. Project Title |
| 2. Statement of Need and Objectives |
| 3. Product Specifications/Features/Salient Characteristics |
| 4. Delivery Information and Location |
| 5. Point of Contact and Contact Information |
File details come from the government source that posted it. Updated .