SQC009939_1_NIH_NIAAA_JEOL_JNM-ECZL400S_20220511-112256.pdf

Quotation No. SQC009939_1

Date: 5/11/2022 Quotation is valid for 150 days

Instrument: Prepared for:

JNM-ECZL400S Dr. Malliga Iyer 400 MHz, 9.4 T NMR Spectrometer NIH NIAAA

5625 Fishers Lane

Rockville, MD 20852

Bid No.: ECZL400S NMR

JEOL Contact: Robert DiPasquale Division Manager, Analytical Inst.

dipas@jeol.com 617-470-3646 Sales Administration Support:

SalesAdmin@jeol.com 978-535-5900

JEOL USA, Inc.

11 Dearborn Road, Peabody, MA 01960 T 978-535-5900 • F 978-536-2221 • www.jeolusa.com

JNM-ECZL400S

Quotation

11 Dearborn Road Peabody, MA 01960 Phone: 978-535-5900 Fax: 978-536-2221

Dr. Malliga Iyer malliga.iyer@nih.gov

NIH NIAAA

5625 Fishers Lane

Rockville, MD 20852

Quotation No.: SQC009939_1

Quotation Date: 5/11/2022

Quoted Price Valid for 150 Days

Line Qty Description Ext. Price 1 1 JNM-ECZL400S: 400 MHz, 9.4 T NMR Spectrometer $250,400.00

2 1 NM-04890SCMYWSD: NMR Magnet, 9.4T, Shielded, 54mm, Year Hold $0.00

3 1 NM-04620SB-K5-4S: Vibration Damping Table for 400 MHz Magnet, Pneumatic

$12,700.00

4 1 NMR-WS-PC: Dell Precision Workstation / Windows 10 64-Bit, I5-11500, 16GB mem, 2TB Disk, 2GB graphics

$1,350.00

5 1 NM-80008HFXS-4S: 400MHZ 5MM FG/RO HFX DIGITAL AUTO TUNE PROBE $69,200.00

6 1 NM-04920HOU4JY: SPINNER HOUSING 400JJYH $2,570.00

7 1 NM-71190AT-4S: AUTO TUNING UNIT $14,500.00

8 1 NM-51740DW10-4S: 10L N2 Dewar $3,730.00

9 1 NM-02591ASC24-4S: Auto Sample Changer for 24 Samples $20,500.00

10 1 NMR-Cryogens-400: Startup Cryogens for 400NB/YH $12,000.00

Sub Total Amount: $386,950.00

Discount: ($73,875.00) Freight: $3,500.00 Total Amount: $316,575.00

All Prices are in US Dollars.

Please send your Purchase Order to salesadmin@jeol.com Freight Terms: FCA: DESTINATION, INSIDE DELIVERY Estimated Delivery: 6-8 Months After Receipt of Order Payment Terms: 100% Net 30 days after Delivery Acceptable forms of Payment: Check, Wire or ACH

Comments / Special Conditions:

Shipping and installation included with quotation (cryogens are the responsibility of the customer).

JEOL will also remove the existing Bruker 500 NMR at no additional charge if needed.

Basic Terms & Conditions:

Prices quoted do not include any applicable sales and/or use taxes.

mailto:salesadmin@jeol.com?subject=Purchase%20Order%20to%20JEOL

Quotation No.: SQC009939_1 Page 2 of 6 Quotation Date: 5/11/2022

JEOL manufactured equipment is guaranteed against defects in workmanship and component failure for a period of one year from the date of customer's first use of the instrument. In the event that installation and/or acceptance is delayed by the Customer but not by JEOL, the warranty period will begin 60 days after the agreed upon delivery date. Under this warranty policy the labor necessary to repair the instrument and all parts (except consumables) are provided by JEOL at no cost to the Customer. JEOL reserves the right to repair or replace components at their sole discretion. The warranty does not cover components which have been damaged through misuse or accident on the part of the buyer nor does it include components which have been modified by the customer.

Third Party electrical/safety inspection, if required, would add to the promised delivery schedule, and the cost of inspections and any required physical modifications to the instrument would be borne by the buyer.

JEOL USA will hold the instrument for up to 30 days past the agreed delivery date. In the event that the customer’s intended room is not ready, JEOL will deliver the instrument to an appropriate storage or temporary facility provided by the customer.

Mr. Timothy P.R. Turner Sales Administration Supervisor salesadmin@jeol.com tturner@jeol.com

Quotation No.: SQC009939_1 Page 3 of 6

Line Qty Detailed Description Ext. Price

1 1 JNM-ECZL400S: 400 MHz, 9.4 T NMR Spectrometer Basic, Fixed Configuration, Broadband Pulsed Field Gradient NMR System Includes:

NMR Pulse Programmer Pulse programming language with support for eight-dimensional data collection Automatic high-speed pulse sequence decomposition to identify and exploit parallelism within a pulse sequence Master timing sequencer unit with 5 ns timing resolution Minimum event time 20 ns depending on event 2 GB pulse sequence / waveform memory for shaped rf control

Spectrometer RF Generation System Modular RF backplane with sequencer bus controlling 8 frequency sources Two full-band transmitter modules covering 5 to 1,300 MHz with up to 159 dB attenuation, the final output frequencies are filtered appropriately to match the NMR spectrometer operational frequencies.

With direct digital synthesis (DDS) units of the intermediate frequency (IF) with:

0.001 Hz offset frequency resolution

0° to 360° phase shift with 0.005° phase resolution 0 to 100% RF shape amplitude with 0.01% resolution

0 dB to 79 dB Step Attenuator with 1 dB step User-defined pulse shapes (phase, frequency, amplitude) including pre-defined pulse shapes (sinc, gauss, seduce, eburp, iburp, uburp, shifted laminar) User-defined decoupler modulations including pre-defined modulations (Waltz, Waugh, Garp, MPF, Wurst) Homonuclear and heteronuclear decoupling modes

NMR RF Power and Field Gradient Amplifiers Linear, class AB 50-watt RF power amplifier for high-band (365 to 430 MHz) Linear, class AB 150-watt RF power amplifier for low-band (10 to 170 MHz)

Z-axis pulsed field gradient amplifier delivering 10-ampere current.

Magnet Console and Preamplifiers Low noise GaAs high sensitivity preamplifier for high-band and low noise wideband SiGe preamplifier low-band frequencies Active transmit/receive duplexer Liquid cryogenic level monitoring system for helium and nitrogen Includes relay switching for automatic 2H gradient shimming

Digital Receiver Wide-band high sensitivity Digital Quadrature Detection receiver with 16 bit 100 MHz ADC digital IF with 64 bit signal averaging and phase and

$250,400.00

Quotation No.: SQC009939_1 Page 4 of 6

Line Qty Detailed Description Ext. Price frequency offset control providing sweep widths from 50 Hz to 10 MHz

Lock and Shim System Deuterium internal digital lock system with computer-controlled auto-lock functions Gradient shimming capability using shim set Z1 gradient or PFG Z gradient Room temperature matrix shim system (25 shims) and power supply.

Matrix shim design minimizes orthogonal shim interactions

AIR/VT System Computer controlled air controller for sample loading and spinning Variable temperature controller, range -170° C to +250° C in 0.1° C steps.

(The operational VT range varies with the probe.)

The NMR system includes a heater for operation above ambient temperature.

An optional 10-liter LN2 Dewar kit is required for operation below ambient temperature.

Spectrometer power supply, chassis, and table Single phase 100 to 240 V AC, 50/60 Hz, 15A Includes worktable for computer and printer

Software Comprehensive Delta FT-NMR Software including 1, 2, 3-D data acquisition, processing, display, and plotting for Microsoft Windows™ or Apple macOS™ operating systems Customer site-wide license for Delta NMR software JEOL "Flex Automation" automated 'point and click' NMR operation software with automatic gradient shimming, user-defined automation and data presentation Macro programming language DOSY data analysis and presentation.

Training Initial customer training performed by JEOL installation personnel.

Three days of on-site training with a JEOL NMR applications chemist after instrument acceptance.

Tuition for two people to attend a 5-day NMR training course at JEOL's Training Institute (travel, meals and accommodations are not included)

Installation In-place delivery, setup, installation, and performance of specifications done in the customer's laboratory Set of NMR reference standards for NMR tests and calibration One year all parts and labor warranty.

A workstation table and printer are Optionally available and are not included with the JEOL NMR system unless explicitly listed on the

Quotation No.: SQC009939_1 Page 5 of 6

Line Qty Detailed Description Ext. Price quotation.

All specifications subject to change All trademarks are the property of the respective owners.

2 1 NM-04890SCMYWSD: NMR Magnet, 9.4T, Shielded, 54mm, Year Hold Shielded superconducting magnet solenoid, cryostat and cryo-shims with room temperature bore diameter of 54 mm operating at 9.39T providing NMR observation of 1H at 400MHz.

400/54/JJ/YH Performance Specifications:

Field Drift: ≤ 4 Hz/hr Radial 5 Gauss Line: 0.5 m (19.7 in) Minimum Ceiling Height: ≥ 2.84 m (112 in) Helium Hold Time: ≥ 365 days Nitrogen Hold Time: ≥ 14 days

Includes: Liquid cryogenic level sensors for helium and nitrogen, liquid nitrogen braided stainless steel fill hose, and liquid helium transfer tube Anti-Vibration Platforms are optionally available

3 1 NM-04620SB-K5-4S: Vibration Damping Table for 400 MHz Magnet, Pneumatic Pneumatic Anti-Vibration Table for 400 MHz Magnet Effective for:

Vertical Vibration greater than 2 Hz Horizontal Vibration greater than 2.2 Hz Note Resonance Conditions:

Vertical 1.3 Hz Horizontal 1.5 Hz

$12,700.00

4 1 NMR-WS-PC: Dell Precision Workstation / Windows 10 64-Bit, I5-11500, 16GB mem, 2TB Disk, 2GB graphics Complete spectrometer control and data processing through a personal computer that equals or exceeds the following specifications:

3.0 GHz (4.4 GHz Turbo) 6 Core CPU, 16 Gbyte RAM, 2 Tbyte disk drive, 2 Gbyte color graphics card, 24" color flat screen display, DVD+/-RW drive, alphanumeric keyboard, optical mouse, and Microsoft Windows 10 Pro 64-bit operating system.

$1,350.00

5 1 NM-80008HFXS-4S: 400MHZ 5MM FG/RO HFX DIGITAL AUTO TUNE PROBE

5 mm high sensitivity ROYAL HFX NMR probe Provides 1H{19F}, 19F{1H}, 13C{1H,19F}, and X{1H,19F} experiments with switchable magnet idler coil tuning and no performance loss in standard 1H or 19F mode.

Coils optimized for proton, fluorine, and multinuclear observation and decoupling Digital auto-tune and match ready, Z-axis pulsed field gradient coil, 2H lock

$69,200.00

Quotation No.: SQC009939_1 Page 6 of 6

Line Qty Detailed Description Ext. Price

Nuclei include: 1H, 19F, 31P to 15N, 39K, and 109Ag Variable Temperature operation from -100° C to +150°C Requires a separate Auto-Tune Unit

6 1 NM-04920HOU4JY: SPINNER HOUSING 400JJYH

$2,570.00

7 1 NM-71190AT-4S: AUTO TUNING UNIT

Provides for automatic tuning and matching of compatible NMR probes with optimal sensitivity and pulse widths.

$14,500.00

8 1 NM-51740DW10-4S: 10L N2 Dewar For low temperature NMR operation (Ambient to -150° C) Actual temperature range may be limited by the NMR probe.

Includes: Non-Magnetic 10 liter liquid nitrogen Dewar, Dewar Adapter with heater and LN2 Dewar filling tool.

$3,730.00

9 1 NM-02591ASC24-4S: Auto Sample Changer for 24 Samples 24-position Auto-Sample changer for NMR systems Includes 24 each 5mm variable temperature compatible sample spinners Mounts on top of magnet bore

$20,500.00

10 1 NMR-Cryogens-400: Startup Cryogens for 400NB/YH JEOL supplied startup Cryogens for normal magnet installation, includes:

Liquid Helium Liquid Nitrogen Compressed Helium Gas

Does not include Compressed Nitrogen Gas

Please see the JEOL Installation guide for more information.

$12,000.00

(REV: April 2019)

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The products (each, a “Product”) are offered for sale on the terms and conditions offered herein. Notwithstanding any terms or conditions on customer purchase orders, JEOL's acceptance of an order is expressly made conditional on Customer's agreement to these Terms and Conditions, unless otherwise specifically agreed to in writing. In the absence of such an agreement, commencement of performance and/or delivery shall be for Customer's convenience only and shall not be deemed or construed to be acceptance of Customer's terms and conditions, or any one of them.

Acceptance of the Products ordered hereunder by Customer shall constitute Customer’s agreement to JEOL's Terms and Conditions provided herein. Any additional or inconsistent terms issued by Customer shall not be binding upon JEOL.

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a. Except as set forth in 4.d., or if specified otherwise within the body of JEOL’s final quotation to customer, payment of the purchase price for the Product(s) shall be as follows: thirty percent (30%) shall be due on Customer’s placement of the order for the Product(s);

sixty percent (60%) shall be due on the date of delivery of the Product(s); and ten percent (10%) shall be due upon acceptance of the Product(s), which shall be no later than thirty (30) days after the delivery of each such Product or component thereof, as set forth in Section 8.

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c. Delivery dates for the Product(s) are estimated on the basis of the prompt receipt by JEOL of all necessary information from Customer.

If Customer delays in furnishing complete information, JEOL may extend the date of delivery. Should delivery or installation of Product(s) be delayed, in whole or in part, for any reason for which JEOL is not responsible, installation and demonstration of said Product(s) shall be deemed satisfactorily completed thirty (30) days from the date of delivery or tender of delivery of the Product(s) to Customer. JEOL shall not be liable for delays in the manufacture, delivery or installation of the Product(s), or for failure to manufacture, deliver or install the Product(s), resulting from any cause or causes whatsoever beyond JEOL's reasonable control, including, but not limited to, acts of God, fire, labor disturbance, flood, acts of the Customer, war, civil unrest, terrorism, priorities, transportation delays, or from any other cause or causes beyond JEOL's reasonable control, and in no event shall JEOL be liable for special or consequential damages. Customer shall accept and permit delayed delivery and installation of Product(s) when due to any cause beyond JEOL's reasonable control.

(REV: April 2019)

7. WARRANTY

a. Product(s) manufactured by JEOL are warranted for a period of one (1) year, from the date of Customers first use of the Product(s), against defects in workmanship and component failure. In the event that installation and/or acceptance of the Product(s) is delayed by the Customer, the warranty period will begin sixty (60) days after the originally scheduled delivery date. During the warranty period, all labor and parts necessary to repair the Product(s) shall be provided by JEOL at no cost to the Customer. JEOL reserves the right to repair or replace components at its sole discretion. This warranty does not cover components that (i) have been damaged through misuse or accident, (ii) have been modified by the Customer or by any third party, or (iii) are considered consumable.

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