Sources Sought Notice.pdf

SOURCES SOUGHT NOTICE

1. Solicitation Number: 75N95025Q00238

2. Title of Product: Human Discovery Panel (HDP) analysis to obtain single cell multiomic data

3. Classification Code: Q301- Laboratory Services.

4. NAICS Code: 541380 - Testing Laboratories and Services

5. Size Standard: $34,000,000 in revenue or less

6. Description:

The National Institute on Drug Abuse (NIDA) on behalf of the National Center for Advancing Translational Sciences (NCATS) is seeking Capability Statements from Business organizations under the North American Industry Classification System (NAICS) code 334519, that can complete Human Discovery Panel (HDP) analysis to obtain single cell multiomic data.

This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition; Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. The established NAICS code is 541380 - Testing Laboratories and Services

Background and Objectives:

NCATS requires a contract research organization (CRO) to perform Human Discovery Panel (HDP) analysis to obtain single-cell multiomic data that shall inform NCATS on transcriptomic and proteomic alterations during inflammatory sensitization in human pluripotent stem cell-derived sensory neurons (hPSC-SNs). Capable vendors must prepare and sequence a total of 33 samples (provided by NCATS), and will provide NCATS the data upon completion.

Interested Vendors must demonstrate their capability to provide a single-cell multi-nomics platform that allows combined single-cell RNA sequencing with DNA barcoded antibodies that target up to 325 distinct proteins for 33 sample hPSC-SNs under different inflammatory conditions.

Requirements: Capable Vendors must demonstrate their ability to provide the brand name or equal services:

MultiPro Human Discovery Panel; - Quantity 2.

MultiPro Human Enhanced Blocking Reagent; Quantity 8 Genomics Analysis Service; Quantity 1

Capability statement /information sought. Companies that believe they possess the capabilities to provide the required products should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately.

Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Capability statements must also include the Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of Contact Information. The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.

For equipment/supply requirements, responses must include the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture). For equipment/supply requirements, small businesses must also address the size status of the manufacturer under the applicable NAICS code (i.e. address Non- Manufacturer Rule).

Interested companies are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice.

However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number.

The information submitted may be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required.

All responses to this notice must be submitted electronically to the Contract Specialist.

Facsimile responses are NOT accepted. The response must be submitted to Andrew Varley, Contract Specialist, at e-mail address Andrew.Varley@nih.gov.

The response must be received on or before August 12, 2025, at 11:00 AM, Eastern Time.

“Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in www.sam.gov. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).”