Sol_75N98027Q00035.pdf

REQUEST FOR QUOTATION

(THIS IS NOT AN ORDER)

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9000 Rockville Pike Building 10 Room 6S257

National Institutes of Health OD - Office of Logistics and Acquisition Operations 6100 Executive Blvd., Room 6B05 Bethesda, MD 20892-7511

75N98027Q00035

NICHOLAS CAPOBIANCO

+10

000-000000

NIH/NHLBI

20892

10/27/2026

11/10/2026 0900 ES

Multiple

Bethesda

MD

The purpose of this NON-COMPETITIVE

COMBINED SYNOPSIS / SOLICITATION is to provide NHLBI with Bioruptor Pico

Sonication Device.

The following FAR clauses and Provisions are applicable to this award.

FAR 52.204-13 System for Award

Management Maintenance (Oct 2018);

FAR 52.204-18 Commercial and Government

Entity Code Maintenance (Aug 2020);

HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity

Investigations (Dec 2015).

FAR 52.212-4 Contract Terms and

Continued...

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NSN 7540-01-152-8067

75N98027Q00035

Conditions -In addition to all the applicable commercial Products and Commercial Services

(Nov 2023)

FAR 52.252-2 CLAUSES INCORPORATED BY REFERENCE

NON-COMPETITIVE COMBINED SYNOPSIS / SOLICITATION

Title: Request for a Bioruptor® Pico Sonication Device

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested, and a separate written solicitation will not be issued.

(ii) The solicitation number is 75N98027Q00035. This solicitation is issued as a Notice of Intent (NOI) for a non-competitive combined synopsis/solicitation to award a contract or purchase order without providing for full and open competition (including brand-name, if applicable). This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold. Additional authority includes 41 U.S.C. 1901 and FAR 6.302-3(a)(2)(ii).

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, intends to negotiate and award a firm-fixed-price purchase order on a non-competitive basis to Hologic Sales and Services, LLC (Hologic Diagenode), 400 Morris Ave, Suite 101, Denville, NJ 07834 for one (1) Bioruptor® Pico Sonication System and associated starter maintenance/consumable accessories.

Justification for the Award: The National Heart, Lung, and Blood Institute (NHLBI) Systems Biology Center requires the Bioruptor® Pico Sonication System to maintain strict continuity and experimental consistency across ongoing chromatin immunoprecipitation coupled with next-generation sequencing (ChIP-seq) and related epigenomic assays. The laboratory previously established its foundational ChIP-seq protocols and baseline datasets using the Bioruptor® Pico platform. Prior testing with single-probe sonicators and single-sample focused acoustic systems failed to maintain consistent chromatin fragment sizes due to single-sample processing limitations and probe decay. The Bioruptor® Pico uniquely combines cooled water-bath indirect sonication with simultaneous multi-sample processing in Pico-specific 0.65 mL (up to 12 samples) and 1.5 mL (up to 6 samples) microtubes. Transitioning to a different acoustic platform or sample vessel would alter shearing kinetics, fragment-size distributions, chromatin recovery, and ChIP enrichment, invalidating comparison with prior datasets and imposing an unacceptable burden in staff time, reagent costs, and loss of scarce primary and rare cell biological material. Hologic Sales and Services, LLC (Hologic Diagenode) is the original equipment manufacturer and exclusive distributor of the Bioruptor® Pico system, with no authorized third-party resellers.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2026-01, effective 03/13/2026.

(iv) The associated NAICS code is 334516 (Analytical Laboratory Instrument Manufacturing), and the small business size standard is 1,000 employees. This requirement is not set aside for small business.

(v) Description of Requirement:

The NHLBI Systems Biology Center requires one (1) Bioruptor® Pico Sonication System and associated starter maintenance and consumable accessories to prepare chromatin for ChIP-seq and related epigenomic studies of transcriptional regulation, chromatin looping, enhancer activity, and epigenetic control of gene expression in primary cells and rare cell populations. Consistent chromatin fragmentation into uniform DNA–protein complexes directly impacts data quality, resolution, reproducibility, and the ability to accurately identify regulatory elements and protein–DNA interactions across the genome.

Minimum Functional and Performance Requirements (Salient Characteristics):

• Chromatin Shearing: Must reproducibly fragment chromatin from primary cells and rare cell populations into uniform DNA–protein complexes suitable for ChIP-seq while preserving epitopes required for immunoprecipitation.

• Control and Reproducibility: Must provide adjustable sonication ON/OFF durations and cycle counts so that sample-specific shearing conditions can be optimized and repeated across experiments.

• Sample Protection: Must provide indirect sonication in closed tubes and an integrated cooling system to control sample heating during processing and reduce the risk of cross-contamination and sample damage.

• Low-Input Processing and Tube Compatibility: Must process low-input samples in compatible 0.65 mL and 1.5 mL microtubes, with holders that support consistent tube positioning and parallel simultaneous processing of multiple samples (12 samples in 0.65 mL tubes or 6 samples in 1.5 mL tubes per run).

• Maintenance, Installation, and Support: Must include the Essential Maintenance Starter Pack providing one (1) year of comprehensive support covering manufacturing repairs and firmware updates, a quality control kit including a high-quality tube holder, a bonus pack of shearing consumables, and no-charge installation and training.

Required Line Items and Quantities:

Line Item

Part / Catalog Number

Description Quantity

0001 B01080011 Bioruptor® Pico including Essential Maintenance Starter Pack

1 Unit

0002 B01201140 Tube holder and dock for 1.5 mL tubes – Pico 1 Unit

0003 C30010011 0.65 mL microtubes for Bioruptor® Pico 1 Pack (50 tubes)

0004 C30010016 1.5 mL Bioruptor® Microtubes with Caps 1 Pack (50 tubes)

0005 G10010017 Shipping and Handling – Bioruptor® Pico 1 Lot

(vi) Delivery Location:

National Institutes of Health (NIH) / NHLBI Building 10, Room 6S257 9000 Rockville Pike Bethesda, MD 20892 Required Delivery Timeframe: Within 60 calendar days after receipt of order (ARO).

Deliveries shall be made Monday through Friday during normal business hours and coordinated in advance with the technical point of contact.

(vii) [Reserved]

(viii) FAR 52.204-7, System for Award Management, applies to this acquisition.

(ix) The provision at FAR 52.212-1, Instructions to Offerors—Commercial Items, applies to this acquisition.

(x) The provision at FAR 52.212-2, Evaluation—Commercial Items, applies to this acquisition.

(a) A written notice of award or acceptance of an offer, issued to the successful offeror within the time specified in the offer, shall result in a binding contract without further action by either party. The Government reserves the right to accept any offer (or part of an offer) before the expiration date, whether or not discussions are conducted, unless a written notice of withdrawal is received prior to award.

(xi) FAR 52.212-4, Contract Terms and Conditions—Commercial Items, applies to this acquisition.

(xii) Additional contract requirements or terms and conditions, as determined necessary by the Contracting Officer and consistent with customary commercial practices: None.

(xiii) The Defense Priorities and Allocations System (DPAS) is not applicable to this requirement.

(xiv) Submission Requirements:

Responses must include sufficient information to demonstrate the respondent’s capability to provide the required product or service.

Price quotations shall include, at a minimum: unit price, list price, shipping and handling costs, delivery timeframe after award, delivery terms, prompt payment discount terms, F.O.B. point (destination or origin), product or catalog numbers, product descriptions, and any other relevant information.

Evaluation factors may include, but are not limited to: past performance, technical capability, special features, trade-in considerations, expected lifecycle, warranty, maintenance availability, and environmental or energy efficiency considerations.

Respondents claiming to be manufacturers or authorized resellers of a specified brand-name product must provide:

(a) Product, catalog, model, and/or part number(s);

(b) Product description;

(c) Documentation demonstrating that the offered item meets all required salient characteristics;

(d) Quantity;

(e) Estimated price or cost;

(f) Shipping, handling, and/or installation charges; and

(g) Delivery timeframe after receipt of order.

Responses must also include the Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification.

All offerors must be actively registered in the System for Award Management (SAM) at www.sam.gov.

All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency.

All responses must be received by November 10, 2026 at 9:00 AM EST and must reference solicitation number 75N98027Q00035. Responses may be submitted electronically to nicholas.capobianco@nih.gov.

https://www.google.com/url?q=http%3A%2F%2Fwww.sam.gov mailto:nicholas.capobianco@nih.gov

(xv) Point of Contact:

Nicholas Capobianco Contracting Specialist National Institutes of Health Email: nicholas.capobianco@nih.gov mailto:nicholas.capobianco@nih.gov

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