Sol_75N98026Q01212.pdf

NON-COMPETITIVE

COMBINED SYNOPSIS / SOLICITATION

Title: Plasma metabolon assay for Baltimore Longitudinal Study of Aging (BLSA)

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested, and a separate written solicitation will not be issued.

(ii) The solicitation number is 75N98026Q01212/PCA-NIA-08124. This solicitation is issued as a Notice of Intent (NOI) for a non-competitive combined synopsis/solicitation to award a contract or purchase order without providing for full and open competition (including brand-name, if applicable).

This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold. Additional authority includes 41 U.S.C. 1901 and FAR 6.302-3(a)(2)(ii).

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, intends to negotiate and award a firm fix-price award on a non-competitive basis to Metabolon Inc. 617 Davis Drive, Suite 100, Morrisville, NC 27560 to assay global metabolomics data and short chain fatty acids (SCFA) via the Metabolon platform from 369 blood samples in the BLSA.

These metabolomics data will be used to identify metabolomic signatures of anthropometric aging quantified via a 3D body scanner.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular March 2026.

(iv) The associated NAICS code is 541715, and the small business size standard is Other Small Business.

This requirement is NOT set aside for small business.

(v) Description of Requirement:

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Specific Requirements:

The Contractor shall –

Provide everything necessary to perform plasma metabolomic profiling including tools and reagents to run the global metabolomic and targeted SCFA panels. The contractor will provide the data report that include rationale and objective, methods used to generate the data and any technical information that will be needed to perform downstream analyses. The contractor will provide raw data as well as any processed data on the abundance of the metabolites including data on over 1000 metabolites as well as SCFA.

LEVEL OF EFFORT:

A team of researchers required to complete the metabolomic profiling and quality control.

GOVERNMENT RESPONSIBILITIES:

The government shall provide adequate quantities of archived plasma samples (total of 369 samples plus 12 reference samples to merge this new acquired data with previously acquired data via the Metabolon platform in the BLSA) to the contractor to enable the performance of plasma metabolite profiling detailed above.

DELIVERY OR DELIVERABLES:

The contractor shall provide an electronic copy of spreadsheet or database files including the abundance of metabolites assessed. The contractor shall also provide written documentation to describe any quality control and process of the data generated along with the codes that were used to conduct each of the QC and processing procedure.

REPORTING REQUIREMENTS:

The contractor shall provide data reports and results from the metabolomic assessments for the 369 samples sent to the contractor. During the contracting period, the contractor will provide reports should there should be any problems that arose and state the resolution or provide an explanation if a solution was not identified.

(vi) Delivery Location:

NIH/NIA

251 Bayview Blvd STE 100

Baltimore MD 21224

(viii) FAR 52.204-7, System for Award Management, applies to this acquisition.

(ix) The provision at FAR 52.212-1, Instructions to Offerors—Commercial Items, applies to this acquisition. Add any additional instructions as required.

(x) The provision at FAR 52.212-2, Evaluation—Commercial Items, applies to this acquisition.

(a) A written notice of award or acceptance of an offer, issued to the successful offeror within the time specified in the offer, shall result in a binding contract without further action by either party.

The Government reserves the right to accept any offer (or part of an offer) before the expiration date, whether or not discussions are conducted, unless a written notice of withdrawal is received prior to award. Add additional evaluation criteria as required.

(xi) FAR 52.212-4, Contract Terms and Conditions—Commercial Items, applies to this acquisition.

(xii) Additional contract requirements or terms and conditions, as determined necessary by the Contracting Officer and consistent with customary commercial practices: None.

(xiii) The Defense Priorities and Allocations System (DPAS) is not applicable to this requirement.

(xiv) Submission Requirements:

Responses must include sufficient information to demonstrate the respondent’s capability to provide the required product or service. Price quotations shall include, at a minimum: unit price, list price, shipping and handling costs, delivery timeframe after award, delivery terms, prompt payment discount terms, F.O.B. point (destination or origin), product or catalog numbers, product descriptions, and any other relevant information.

Evaluation factors may include, but are not limited to: past performance, technical capability, special features, trade-in considerations, expected lifecycle, warranty, maintenance availability, and environmental or energy efficiency considerations.

Respondents claiming to be manufacturers or authorized resellers of a specified brand-name product must provide:

(a) Product, catalog, model, and/or part number(s);

(b) Product description;

(c) Documentation demonstrating that the offered item meets all required salient characteristics;

(d) Quantity;

(e) Estimated price or cost;

(f) Shipping, handling, and/or installation charges; and

(g) Delivery timeframe after receipt of order.

Responses must also include the Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification. All offerors must be actively registered in the System for Award Management (SAM) at www.sam.gov.

All responses must be received by (September 23rd, 2026, 2PM, EST) and must reference solicitation number 75N98026Q01212/PCA-NIA-08124. Responses may be submitted electronically to johnsonjr@mail.nih.gov.

(xv) Point of Contact:

John Johnson, Program Specialist, 667-312-5580, and johnsonjr@mail.nih.gov mailto:johnsonjr@mail.nih.gov

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

STATEMENT OF WORK (SERVICES)

(SOW)

GENERAL INFORMATION

Title of Project:

Plasma metabolon assay for Baltimore Longitudinal Study of Aging (BLSA) Statement of Need and Purpose:

This purchase is to assay global metabolomics data and short chain fatty acids (SCFA) via the Metabolon platform from 369 blood samples in the BLSA. These metabolomics data will be used to identify metabolomic signatures of anthropometric aging quantified via a 3D body scanner.

Background Information and Objective:

The objective of the study is to identify metabolomics profiles, including longitudinal alterations, and related pathways related to anthropometric aging. Aging is associated with anthropometric changes that are linked to disease risk and functional limitations, but the biological underpinnings of anthropometric aging are less clear. Preliminary data show that anthropometric aging is associated with loss of sensorimotor function, lower extremity mass, and lower levels of leucine in the plasma, suggesting muscle weakness. Identification of metabolomics profiles of anthropometric aging may reveal biological processes underlying the connection between anthropometric aging and functional deficit and diseases. These metabolomic profiles may be used clinically to identify the pace of anthropometric aging and estimate functional decline and disease risk. In order to have compatible plasma metabolomics data in the BLSA, Metabolon assay - the same platform used to analyze plasma metabolites and SCFA previously in the BLSA - will be used in this study.

Period of Performance:

One year from date of the award

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Specific Requirements:

The Contractor shall –

Provide everything necessary to perform plasma metabolomic profiling including tools and reagents to run the global metabolomic and targeted SCFA panels. The contractor will provide the data report that include rationale and objective, methods used to generate the data and any technical information that will be needed to perform downstream analyses. The contractor will provide raw data as well as any processed data on the abundance of the metabolites including data on over 1000 metabolites as well as SCFA.

LEVEL OF EFFORT:

A team of researchers required to complete the metabolomic profiling and quality control.

GOVERNMENT RESPONSIBILITIES

The government shall provide adequate quantities of archived plasma samples (total of 369 samples plus 12 reference samples to merge this new acquired data with previously acquired data via the Metabolon platform in the BLSA) to the contractor to enable the performance of plasma metabolite profiling detailed above.

DELIVERY OR DELIVERABLES

The contractor shall provide an electronic copy of spreadsheet or database files including the abundance of metabolites assessed. The contractor shall also provide written documentation to describe any quality control and process of the data generated along with the codes that were used to conduct each of the QC and processing procedure.

REPORTING REQUIREMENTS

The contractor shall provide data reports and results from the metabolomic assessments for the 369 samples sent to the contractor. During the contracting period, the contractor will provide reports should there should be any problems that arose and state the resolution or provide an explanation if a solution was not identified.

OTHER CONSIDERATIONS

Travel:

N/A

Key Personnel:

The key personnel requirements for the senior researcher are as follows:

• A Masters or PhD in a laboratory science field

• Extensive experience in high throughput lab methods.

Information System Security Plan:

N/A

Data Rights:

The National Institute on Aging shall have unlimited rights to and ownership of all deliverables provided under this contract including reports, recommendations, briefings, work plans and all other deliverables. This includes the deliverables provided under the basic contract and any optional task deliverables exercised by the contracting officer. In addition, it includes any additional deliverables required by contract change. The definition of “unlimited rights” is contained in Federal Acquisition Regulation (FAR) 27.401, “Definitions.” FAR clause 52.227-14, “Rights in Data-General, ” is hereby incorporated by reference and made a part of this contract/order.

Section 508—Electronic and Information Technology Standards:

The contractor is not required to develop, procure, maintain, or use Electronic and Information Technology (EIT) in the performance of the SOW.

Publications and Publicity:

The government will perform data analysis. The contractor will not write or publish articles from the of data produced as a result of the requirements of the SOW.

Confidentiality of Information:

The government will not provide to the contractor any information or data of a personal nature about individual(s) or proprietary information or data pertaining to an institution or organization which is confidential.

ATTACHMENTS

1. Independent Government’s Cost Estimate