Sol_75N98026Q00995.pdf

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National Institutes of Health OD - Office of Logistics and Acquisition Operations 6100 Executive Blvd., Room 6B05 Bethesda, MD 20892-7511

75N98026Q00995

JOHN JOHNSON

+10

000-000000

08/10/2026

08/15/2026 1400 ED

Multiple

1 8

NON-COMPETITIVE

COMBINED SYNOPSIS / SOLICITATION

Title: Iconeus-One Xcel

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested, and a separate written solicitation will not be issued.

(ii) The solicitation number is 75N98026Q00995/PCA-NIDA-07449. This solicitation is issued as a Notice of Intent (NOI) for a non-competitive combined synopsis/solicitation to award a contract or purchase order without providing for full and open competition (including brand-name, if applicable).

This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold. Additional authority includes 41 U.S.C. 1901 and FAR 6.302-3(a)(2)(ii).

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, intends to negotiate and award a firm fix-price award on a non-competitive basis to Iconeus 25 boulevard Romain Rolland 75014 Paris, France to lease and then procure an Iconeus One Xcel System with 4D a volumetric imaging probe to conduct whole brain imaging in awake, freely moving rodents in various behavioral conditions.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular March 2026.

(iv) The associated NAICS code is 541715, and the small business size standard is Other Small Business.

This requirement is NOT set aside for small business.

(v) Description of Requirement:

Iconeus

Has the worldwide exclusive license for patents that allow for: MPW™(Multi Plane Wave)™:

The multi plane wave technology provides ultrafast and ultra-sensitive imaging with an SNR increased by a factor of ten as compared to the other plane waves technologies. It makes Iconeus One the best platform for studying the whole brain, especially in deep brain structures.

· BPS™ (Brain Positioning System): This technology delivers a reliable and automatic functional atlas registration during the acquisition. This feature turns Iconeus One into a productive tool that helps to generate more data in less time. Furthermore, the data are more reproducible across experiments and scientists.

· ULM: Ultrasound Localization Microscopy: This unique and patented super-resolution technology allows the user to achieve dynamic blood imaging and brain vessel imaging with an unprecedented resolution down to 5μm.

· 4D-MultiArray Probes: Using simultaneous multi-slice acquisitions, these unique and patented transducers allow whole-brain coverage without compromising on sensitivity or framerate.

ICONEUS-ONE XCEL

· Portable imaging station with four-axis motorized scanning platform

· Interactive live imaging with reference atlas

· Allows for simultaneous acquisition of large amounts of data and efficient removal of non-vascular signals from surrounding tissues IcoPrime-4D MultiArray probe

· Fast and detailed 3D imaging of rodent brains

· Simultaenous MultiSlicing functional ultrasound imaging with high-sensitivity for head-fixed rodents

· Optimized for whole-brain neuroimaging in fixed-head configurations to mobile setups that ensure maximum contrast and eliminating electrical noise

Software Suite

· Maps intrinsic brain connectivity (resting-state functional connectivity; connectivity matrices)

· Task-based functional neuroimaging (functional activation mapping)

· Vasculature imaging analysis

· Adaptive brain atlas

Salient characteristics

· Ultra-high sensitivity doppler imaging allowing whole brain studies from mice (transcranial) to non-human primate

· Unparalleled spatiotemporal functional resolution (100μm, ≈ 10ms)

· Real-time neurofunctional monitoring during experiments

· Breakthrough resolution of blood flow imaging down to 5μm in the whole brain even in deep structures

· 4D HD angiography

· Functional connectivity mapping

· Anesthetized or awake and mobile animals

· Automatic probe positioning and automatic functional area registration

· Built in Allen Institute mice brain functional atlas and possibility to integrate any functional atlas

· “Plug & scan” easy and ready to use platform for increased productivity

· Mobile device so it is easy to take it anywhere it is needed

Quantity: One of each of the below (rental for 12 months with a purchase option)

Iconeus One Xcel System

4D MultiArray probe

Delivery Date:

12-16 weeks ARO

(vi) Delivery Location:

NIH/NIDA

251 Bayview Blvd STE 200

BRC Bldg. RM 08A723

Baltimore MD 21224

(viii) FAR 52.204-7, System for Award Management, applies to this acquisition.

(ix) The provision at FAR 52.212-1, Instructions to Offerors—Commercial Items, applies to this acquisition. Add any additional instructions as required.

(x) The provision at FAR 52.212-2, Evaluation—Commercial Items, applies to this acquisition.

(a) A written notice of award or acceptance of an offer, issued to the successful offeror within the time specified in the offer, shall result in a binding contract without further action by either party.

The Government reserves the right to accept any offer (or part of an offer) before the expiration date, whether or not discussions are conducted, unless a written notice of withdrawal is received prior to award. Add additional evaluation criteria as required.

(xi) FAR 52.212-4, Contract Terms and Conditions—Commercial Items, applies to this acquisition.

(xii) Additional contract requirements or terms and conditions, as determined necessary by the Contracting Officer and consistent with customary commercial practices: None.

(xiii) The Defense Priorities and Allocations System (DPAS) is not applicable to this requirement.

(xiv) Submission Requirements:

Responses must include sufficient information to demonstrate the respondent’s capability to provide the required product or service. Price quotations shall include, at a minimum: unit price, list price, shipping and handling costs, delivery timeframe after award, delivery terms, prompt payment discount terms, F.O.B. point (destination or origin), product or catalog numbers, product descriptions, and any other relevant information.

Evaluation factors may include, but are not limited to: past performance, technical capability, special features, trade-in considerations, expected lifecycle, warranty, maintenance availability, and environmental or energy efficiency considerations.

Respondents claiming to be manufacturers or authorized resellers of a specified brand-name product must provide:

(a) Product, catalog, model, and/or part number(s);

(b) Product description;

(c) Documentation demonstrating that the offered item meets all required salient characteristics;

(d) Quantity;

(e) Estimated price or cost;

(f) Shipping, handling, and/or installation charges; and

(g) Delivery timeframe after receipt of order.

Responses must also include the Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification. All offerors must be actively registered in the System for Award Management (SAM) at www.sam.gov.

All responses must be received by (August 15th, 2026, 2PM, EST) and must reference solicitation number 75N98026Q00995/PCA-NIDA-07449. Responses may be submitted electronically to johnsonjr@mail.nih.gov.

(xv) Point of Contact:

John Johnson, Program Specialist, 667-312-5580, and johnsonjr@mail.nih.gov mailto:johnsonjr@mail.nih.gov

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

The Stress and Addiction Neuroscience Unit is looking to “rent-to-purchase” a functional ultrasound system that allows for whole brain imaging in awake, freely moving rodents in various behavioral conditions.

Background Information and Objective:

The NIDA IRP Mission is to conduct state-of-the-art basic, preclinical and clinical research on mechanisms that underlie substance use disorder, addiction and relapse.

Ultimately, we hope to translate these efforts into new methods for the prevention and treatment of substance use disorder highlighting the following: enhancing our research by taking advantage of our unique and outstanding strengths; increasing translational research and fortifying our clinical portfolio; strengthening our basic science with investment in technology and prioritizing Trans-NIH initiatives and growing strong ties with other institutes.

We conduct state-of-the-art neuropsychopharmacology research using preclinical models of drug addiction with translational relevance. We have conducted brain imaging in anesthetized rodents with functional magnetic resonance imaging. We are aiming now to image the whole brain of awake, freely moving rodents. This approach will provide an unprecedented way of investigating whole-brain circuitries while rodents are engaging in drug-related behaviors. We plan to test the effects of compounds that reduce drug seeking and taking while examining brain-wide activity. This system is compatible with our recently procured Phenosys JetBall and Neurotar Mobile Home Cage.

2. Generic Name of Product:

Iconeus-One Xcel

Purchase Description:

Iconeus Has the worldwide exclusive license for patents that allow for:

• MPW™(Multi Plane Wave)™: The multi plane wave technology provides ultrafast and ultra-sensitive imaging with an SNR increased by a factor of ten as compared to the other plane waves technologies. It makes Iconeus One the best platform for studying the whole brain, especially in deep brain structures.

• BPS™ (Brain Positioning System): This technology delivers a reliable and automatic functional atlas registration during the acquisition. This feature turns Iconeus One into a productive tool that helps to generate more data in less time.

Furthermore, the data are more reproducible across experiments and scientists.

• ULM: Ultrasound Localization Microscopy: This unique and patented super-resolution technology allows the user to achieve dynamic blood imaging and brain vessel imaging with an unprecedented resolution down to 5μm.

• 4D-MultiArray Probes: Using simultaneous multi-slice acquisitions, these unique and patented transducers allow whole-brain coverage without compromising on sensitivity or framerate.

ICONEUS-ONE XCEL

• Portable imaging station with four-axis motorized scanning platform

• Interactive live imaging with reference atlas

• Allows for simultaneous acquisition of large amounts of data and efficient removal of non-vascular signals from surrounding tissues

IcoPrime-4D MultiArray probe

• Fast and detailed 3D imaging of rodent brains

• Simultaenous MultiSlicing functional ultrasound imaging with high-sensitivity for head-fixed rodents

• Optimized for whole-brain neuroimaging in fixed-head configurations to mobile setups that ensure maximum contrast and eliminating electrical noise

Software Suite

• Maps intrinsic brain connectivity (resting-state functional connectivity;

connectivity matrices)

• Task-based functional neuroimaging (functional activation mapping)

• Vasculature imaging analysis

• Adaptive brain atlas

3. Salient characteristics

• Ultra-high sensitivity doppler imaging allowing whole brain studies from mice (transcranial) to non-human primate

• Unparalleled spatiotemporal functional resolution (100μm, ≈ 10ms)

• Real-time neurofunctional monitoring during experiments

• Breakthrough resolution of blood flow imaging down to 5μm in the whole brain even in deep structures

• 4D HD angiography

• Functional connectivity mapping

• Anesthetized or awake and mobile animals

• Automatic probe positioning and automatic functional area registration

• Built in Allen Institute mice brain functional atlas and possibility to integrate any functional atlas

• “Plug & scan” easy and ready to use platform for increased productivity

• Mobile device so it is easy to take it anywhere it is needed

4. Quantity: One of each of the below (rental with purchase option)

Iconeus One Xcel System 4D MultiArray probe

5. Delivery Date: Desired delivery date is 12-16 weeks ARO

Period of Performance:

One year (with option for extension or purchase)

6. Option(s):

Rental can be extended to up to 36 months. To purchase after a 1-year lease, the difference between the full price and the amount already paid off the year would be required plus a final purchase option fee.

Title