Sol_75N98026Q00990.pdf

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National Institutes of Health OD - Office of Logistics and Acquisition Operations 6100 Executive Blvd., Room 6B05 Bethesda, MD 20892-7511

75N98026Q00990

JADDUA JOHNSTON

+10

000-000000

08/07/2026

08/24/2026 0800 ED

Multiple

The purpose of this COMPETITIVE COMBINED

SYNOPSIS / SOLICITATION is to acquire

PRISM study of a Compound NCGC01219867

Period of Performance: 09/04/2026 to

10/03/2026

This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the contracting officer will make their full text available. Also, the full text of a clause may be accessed electronically at this address:

HTTPS://ACQUISITION.GOV/FAR

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OPTIONAL FORM 336 (4-86)

Sponsored by GSA FAR (48 CFR) 53.110

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NSN 7540-01-152-8067

75N98026Q00990

The following FAR clauses and Provisions are applicable to this award.

FAR 52.204-13 System for Award Management

Maintenance (Oct 2018);

FAR 52.204-18 Commercial and Government Entity

Code Maintenance (Aug 2020);

HHSAR 352.222-70, Contractor Cooperation in

Equal Employment Opportunity Investigations

(Dec 2015).

FAR 52.212-4 Contract Terms and Conditions -In addition to all the applicable commercial

Products and Commercial Services (Nov 2023)

FAR 52.212-5 Contract Terms and Conditions

Required to Implement Statutes or Executive

Orders/Commercial Products and Commercial

Services (Jan 2025)

FAR 52.217-8 Option to Extend Services (Nov

1999)

FAR 52.252-2 CLAUSES INCORPORATED BY REFERENCE

Award enclosure:

Quote

Statement of Work

IPP Invoicing and Payment Provisions

To avoid delay in payment, all invoices must be uploaded into the invoicing processing platform

(IPP) (https://www.ipp.gov). The invoice must match the line item description on the purchase order. It must also state that payment is to be made using a three-way match.

You are reminded that only the contracting officer of record can make any changes to this award any changes made at the direction of the program without an executed modification and null and void and are done at the contractor's own risk.

COMBINED SYNOPSIS / SOLICITATION (COMPETITIVE)

Title: PRISM study of a Compound NCGC01219867

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes only solicitation; proposals are being requested, and a separate written solicitation will not be issued.

(ii) The solicitation number is 75N98026Q00990. This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition.

This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold (if applicable).

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a (Firm-Fixed-Price) to the offeror responsible whose proposal represents the best value to the Government.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular effective August 7, 2026

(iv) The associated NAICS code is 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and the small business size standard is 1000 employees.

This requirement is unrestricted.

(v) Description of Requirement:

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Specific Requirements:

The standard, shared screen format is a 5-day assay with 900 cell lines. Screens are run in our Luminex-format, and compounds are screened at 8pt dose, 3-fold dilution and need to be submitted as 1000x stock concentration in 100% DMSO.

LEVEL OF EFFORT:

PRISM Scientists

GOVERNMENT RESPONSIBILITIES

We will provide the analog to be screened.

DELIVERY OR DELIVERABLES

Data detailing the viability of all 900 cell lines, metrics for the quality of the assay, univariate and multivariate feature set correlation analysis, and all the raw data from NCATS test agents.

REPORTING REQUIREMENTS

The vendor shall provide the results of study to NCATS through the PRISM Portal.

OTHER CONSIDERATIONS

Travel:

N/A

Key Personnel:

Information System Security Plan:

Data Rights:

All data and materials produced, used and analyzed is sole property of the government.

The right to all data belongs to NCATS and the contractor must keep all the data and information confidential.

Section 508—Electronic and Information Technology Standards:

Publications and Publicity:

The result of study will not be published at the moment.

Confidentiality of Information:

Any information provided to the contractor by NCATS or collected by the contractor on behalf of NCATS shall be used only for the purpose of carrying out the provisions of this contract and shall not be disclosed or made known in any manner to any persons except as may be necessary in the performance of the contract.

(vi) Delivery Location:

NIH/NCATS- 9808 Medical Center Drive, Rockville, MD 20850

(viii) FAR 52.204-7, System for Award Management, applies to this acquisition.

(ix) The provision at FAR 52.212-1, Instructions to Offerors—Commercial Items, applies to this acquisition. Add any agency-specific instructions as required.

(x) The provision at FAR 52.212-2, Evaluation—Commercial Items, applies to this acquisition.

(a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation represents the best value to the Government, price and other factors considered.

(b) Evaluation Factors:

• Price

• Technical capability

• Past performance

• Delivery schedule

(c) A written notice of award or acceptance of an offer, issued within the time specified in the offer, shall result in a binding contract without further action by either party. The Government reserves the right to accept any offer before the expiration date.

(xi) FAR 52.212-4, Contract Terms and Conditions—Commercial Items, applies to this acquisition.

(xii) Additional contract requirements or terms and conditions, as determined necessary by the Contracting Officer and consistent with customary commercial practices: None

(xiii) The Defense Priorities and Allocations System (DPAS) is not applicable.

(xiv) Submission Requirements:

Responses must include sufficient information to demonstrate the offeror’s capability to provide the required product or service. Quotes shall include, at a minimum:

• Unit and total price

• Shipping and handling costs

• Delivery timeframe after award

• Delivery terms

• F.O.B. point (destination or origin)

• Product or catalog numbers (if applicable)

• Product/service description

Additional evaluation considerations may include past performance, warranty, lifecycle cost, maintenance availability, and environmental or energy efficiency.

Responses must include the Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification. All offerors must be actively registered in the System for Award Management (SAM) at www.sam.gov.

All responses must be received by August 24, 8:00AM EST and must reference solicitation number 75N98026Q00990. Responses may be submitted electronically to Jaddua.Johnston@nih.gov

(xv) Point of Contact: Jaddua Johnston Contracting Specialist, Phone Number: 240-569-0006

Email: Jaddua.Johnston@nih.gov mailto:Jaddua.Johnston@nih.gov

Version 12-23-2025-1 FAR Part 11—Describing Agency Needs

STATEMENT OF WORK (SERVICES)

(SOW)

GENERAL INFORMATION

Title of Project:

PRISM study of a Compound NCGC01219867

Statement of Need and Purpose:

The National Center for Advancing Translational Sciences needs to evaluate a promising drug-like compound, identified as NCGC01219867, to determine whether it should be advanced as a starting point for therapeutic development. The required service is a Broad Institute pooled cancer cell line drug sensitivity study that tests the compound against approximately 900 barcoded cancer cell lines in a shared five-day assay.

Background Information and Objective:

PRISM is Broad’s pooled cancer-cell-line drug-sensitivity platform. In PRISM, hundreds of barcoded cancer cell lines are mixed together, treated with compounds, and then barcode abundance is measured to infer how much each compound inhibited or killed each cell line. It evaluates the efficacy and viability responses of hundreds of barcoded cancer cells. By using molecular barcoding, researchers can test thousands of compounds without losing single-line data, enabling massive scale.

Period of Performance:

Data will be released on the PRISM Portal approximately 4 months after the submission window closes.

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Specific Requirements:

The standard, shared screen format is a 5-day assay with 900 cell lines. Screens are run in our Luminex-format, and compounds are screened at 8pt dose, 3-fold dilution and need to be submitted as 1000x stock concentration in 100% DMSO.

LEVEL OF EFFORT:

PRISM Scientists

GOVERNMENT RESPONSIBILITIES

Version 12-23-2025-1 FAR Part 11—Describing Agency Needs

We will provide the analog to be screened.

DELIVERY OR DELIVERABLES

Data detailing the viability of all 900 cell lines, metrics for the quality of the assay, univariate and multivariate feature set correlation analysis, and all the raw data from NCATS test agents.

REPORTING REQUIREMENTS

The vendor shall provide the results of study to NCATS through the PRISM Portal.

OTHER CONSIDERATIONS

Travel:

Key Personnel:

Information System Security Plan:

Data Rights:

All data and materials produced, used and analyzed is sole property of the government. The right to all data belongs to NCATS and the contractor must keep all the data and information confidential.

Section 508—Electronic and Information Technology Standards:

Publications and Publicity:

The result of study will not be published at the moment.

Confidentiality of Information:

Any information provided to the contractor by NCATS or collected by the contractor on behalf of NCATS shall be used only for the purpose of carrying out the provisions of this contract and shall not be disclosed or made known in any manner to any persons except as may be necessary in the performance of the contract.

Title