Sol_75N98026Q00986.pdf

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National Institutes of Health OD - Office of Logistics and Acquisition Operations 6100 Executive Blvd., Room 6B05 Bethesda, MD 20892-7511

75N98026Q00986

JADDUA JOHNSTON

+10

000-000000

08/07/2026

08/24/2026 0800 ED

Multiple

The purpose of this NCOMPETITIVE

COMBINED SYNOPSIS / SOLICITATION is to acquire developing selective small-molecule inhibitors of NNMT for chronic kidney disease

Period of Performance: 09/04/2026 to

03/03/2027

This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the contracting officer will make their full text available. Also, the full text of a clause may be accessed electronically at this address:

Continued...

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NSN 7540-01-152-8067

75N98026Q00986

HTTPS://ACQUISITION.GOV/FAR

The following FAR clauses and Provisions are applicable to this award.

FAR 52.204-13 System for Award Management

Maintenance (Oct 2018);

FAR 52.204-18 Commercial and Government Entity

Code Maintenance (Aug 2020);

HHSAR 352.222-70, Contractor Cooperation in

Equal Employment Opportunity Investigations

(Dec 2015).

FAR 52.212-4 Contract Terms and Conditions -In addition to all the applicable commercial

Products and Commercial Services (Nov 2023)

FAR 52.212-5 Contract Terms and Conditions

Required to Implement Statutes or Executive

Orders/Commercial Products and Commercial

Services (Jan 2025)

FAR 52.252-2 CLAUSES INCORPORATED BY REFERENCE

Award enclosure:

Quote

IPP Invoicing and Payment Provisions

To avoid delay in payment, all invoices must be uploaded into the invoicing processing platform

(IPP) (https://www.ipp.gov). The invoice must match the line item description on the purchase order. It must also state that payment is to be made using a three-way match.

You are reminded that only the contracting officer of record can make any changes to this award any changes made at the direction of the program without an executed modification and null and void and are done at the contractor's own risk.

COMBINED SYNOPSIS / SOLICITATION (COMPETITIVE)

Title: Developing selective small-molecule inhibitors of NNMT for chronic kidney disease

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes only solicitation; proposals are being requested, and a separate written solicitation will not be issued.

(ii) The solicitation number is 75N98026Q00986. This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition.

This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold (if applicable).

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a (Firm-Fixed-Price) to the offeror responsible whose proposal represents the best value to the Government.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular effective August 7, 2026

(iv) The associated NAICS code is 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and the small business size standard is 1000 employees.

This requirement is unrestricted.

(v) Description of Requirement:

Period of Performance:

Documentation of results and presentation of these results to NCATS via email with the next three months after receipt of PO.

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Specific Requirements:

The contractor will conduct a pharmacokinetic (PK/PD) study in mice after, IV and PO, single dose of a lead NNMT inhibitor, n=3/group. They will monitor plasma PK of parent and 1-MNA at 0, 5, 15 30 min, 1, 2, 4, 8, 12, 24 hr post dose, and provide a conc vs time curves and PK parameters in an excel report Test article: 3 compounds

LEVEL OF EFFORT:

Estimated level of effort: 1 PhD level Manager, 1 PhD level scientist, 3 months total.

GOVERNMENT RESPONSIBILITIES

NCATS will provide the NNMT inhibitors from its medicinal chemistry campaign for this study.

DELIVERY OR DELIVERABLES

Contractor is responsible for providing the following deliverables:

1. Blood work results.

2. PK results 3.Results will be sent to Samarjit Patnaik (samarjit.patnaik@nih.gov) and Vinoth Chenniappan (vinothkumar.chenniappan@nih.gov) at NCATS via email.

REPORTING REQUIREMENTS

After completion of work; each study within 3 weeks of receipt of compound.

OTHER CONSIDERATIONS

Travel:

N/A

Key Personnel:

Information System Security Plan:

Data Rights:

All data will be considered confidential and the property of the government

Section 508—Electronic and Information Technology Standards:

Publications and Publicity:

Data will not be published without permission of the government

Confidentiality of Information:

Data will be kept confidential

(vi) Delivery Location:

NIH/NCATS- 9808 Medical Center Drive, Rockville, MD 20850

(viii) FAR 52.204-7, System for Award Management, applies to this acquisition.

(ix) The provision at FAR 52.212-1, Instructions to Offerors—Commercial Items, applies to this acquisition. Add any agency-specific instructions as required.

(x) The provision at FAR 52.212-2, Evaluation—Commercial Items, applies to this acquisition.

(a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation represents the best value to the Government, price and other factors considered.

(b) Evaluation Factors:

• Price

• Technical capability

• Past performance

• Delivery schedule

(c) A written notice of award or acceptance of an offer, issued within the time specified in the offer, shall result in a binding contract without further action by either party. The Government reserves the right to accept any offer before the expiration date.

(xi) FAR 52.212-4, Contract Terms and Conditions—Commercial Items, applies to this acquisition.

(xii) Additional contract requirements or terms and conditions, as determined necessary by the Contracting Officer and consistent with customary commercial practices: None

(xiii) The Defense Priorities and Allocations System (DPAS) is not applicable.

(xiv) Submission Requirements:

Responses must include sufficient information to demonstrate the offeror’s capability to provide the required product or service. Quotes shall include, at a minimum:

• Unit and total price

• Shipping and handling costs

• Delivery timeframe after award

• Delivery terms

• F.O.B. point (destination or origin)

• Product or catalog numbers (if applicable)

• Product/service description

Additional evaluation considerations may include past performance, warranty, lifecycle cost, maintenance availability, and environmental or energy efficiency.

Responses must include the Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification. All offerors must be actively registered in the System for Award Management (SAM) at www.sam.gov.

All responses must be received by August 24, 8:00AM EST and must reference solicitation number 75N98026Q00986. Responses may be submitted electronically to Jaddua.Johnston@nih.gov

(xv) Point of Contact: Jaddua Johnston Contracting Specialist, Phone Number: 240-569-0006

Email: Jaddua.Johnston@nih.gov mailto:Jaddua.Johnston@nih.gov

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

STATEMENT OF WORK (SERVICES)

(SOW)

GENERAL INFORMATION

Title of Project:

Developing selective small-molecule inhibitors of NNMT for chronic kidney disease

Statement of Need and Purpose:

This purchase order supports pharmacokinetic (PK) and pharmacodynamic (PD) studies of three NNMT inhibitors in mice following oral (PO) and IV (intravenous) administration at predecided single dose.

Samples will be collected from plasma at the following time points: 0 min, 5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 8 h, 12 h, and 24 h (n=3 mice per time point). Drug and 1-MNA (1-methyl nicotinamide) concentrations will be measured in plasma evaluate systemic exposure 1-MNA suppression, and facilitate advancement of compounds into preclinical development.

Background Information and Objective:

The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people’s health and save lives.

The National Center for Advancing Translational Sciences (NCATS, Early Translation Branch) is a part of the National Institutes of Health (NIH), whose mission it is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions.

NNMT is a methyl transferase implicated in multiple metabolic diseases with a lead inhibitor from Astra Zeneca in Phase 1 clinical trials for chronic kidney disease (CKD) in diabetes patients. NCATS in collaboration with U Chicago has developed orally bioavalble NNMT inhibitors for cancer therapy and is engaged in a camaoign to develop NNNMT inbhitors with longer half life than the current lead 960. These PK/PD studies will evaluate lead compounds and compare them with the current lead 960.

Period of Performance:

Documentation of results and presentation of these results to NCATS via email with the next three months after receipt of PO.

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Specific Requirements:

The contractor will conduct a pharmacokinetic (PK/PD) study in mice after, IV and PO, single dose of a lead NNMT inhibitor, n=3/group. They will monitor plasma PK of parent and 1-MNA at 0, 5, 15 30 min, 1, 2, 4, 8, 12, 24 hr post dose, and provide a conc vs time curves and PK parameters in an excel report Test article: 3 compounds

LEVEL OF EFFORT:

Estimated level of effort: 1 PhD level Manager, 1 PhD level scientist, 3 months total.

GOVERNMENT RESPONSIBILITIES

NCATS will provide the NNMT inhibitors from its medicinal chemistry campaign for this study.

DELIVERY OR DELIVERABLES

Contractor is responsible for providing the following deliverables:

1. Blood work results.

2. PK results 3.Results will be sent to Samarjit Patnaik (samarjit.patnaik@nih.gov) and Vinoth Chenniappan (vinothkumar.chenniappan@nih.gov) at NCATS via email.

REPORTING REQUIREMENTS

After completion of work; each study within 3 weeks of receipt of compound.

OTHER CONSIDERATIONS

Travel:

Key Personnel:

Information System Security Plan:

Data Rights:

All data will be considered confidential and the property of the government

Section 508—Electronic and Information Technology Standards:

Publications and Publicity:

Data will not be published without permission of the government

Confidentiality of Information:

Data will be kept confidential

ATTACHMENTS

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