Sol_75N98026Q00970.pdf

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National Institutes of Health OD - Office of Logistics and Acquisition Operations 6100 Executive Blvd., Room 6B05 Bethesda, MD 20892-7511

75N98026Q00970

JADDUA JOHNSTON

+10

000-000000

08/07/2026

08/24/2026 0800 ED

Multiple

The purpose of this COMPETITIVE COMBINED

SYNOPSIS / SOLICITATION is to acquire

Synthesis of compounds and intermediates

Period of Performance: 09/07/2026 to

01/07/2027

This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the contracting officer will make their full text available. Also, the full text of a clause may be accessed electronically at this address:

HTTPS://ACQUISITION.GOV/FAR

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NSN 7540-01-152-8067

75N98026Q00970

The following FAR clauses and Provisions are applicable to this award.

FAR 52.204-13 System for Award Management

Maintenance (Oct 2018);

FAR 52.204-18 Commercial and Government Entity

Code Maintenance (Aug 2020);

HHSAR 352.222-70, Contractor Cooperation in

Equal Employment Opportunity Investigations

(Dec 2015).

FAR 52.212-4 Contract Terms and Conditions -In addition to all the applicable commercial

Products and Commercial Services (Nov 2023)

FAR 52.212-5 Contract Terms and Conditions

Required to Implement Statutes or Executive

Orders/Commercial Products and Commercial

Services (Jan 2025)

FAR 52.217-8 Option to Extend Services (Nov

1999)

FAR 52.252-2 CLAUSES INCORPORATED BY REFERENCE

Award enclosure:

Quote

Statement of Work

IPP Invoicing and Payment Provisions

To avoid delay in payment, all invoices must be uploaded into the invoicing processing platform

(IPP) (https://www.ipp.gov). The invoice must match the line item description on the purchase order. It must also state that payment is to be made using a three-way match.

You are reminded that only the contracting officer of record can make any changes to this award any changes made at the direction of the program without an executed modification and null and void and are done at the contractor's own risk.

COMBINED SYNOPSIS / SOLICITATION (COMPETITIVE)

Title: Synthesis of compounds and intermediates

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes only solicitation; proposals are being requested, and a separate written solicitation will not be issued.

(ii) The solicitation number is 75N98026Q00970. This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition.

This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold (if applicable).

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a (Firm-Fixed-Price) to the offeror responsible whose proposal represents the best value to the Government.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular effective August 7, 2026

(iv) The associated NAICS code is 541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and the small business size standard is 1000 employees.

This requirement is unrestricted.

(v) Description of Requirement:

To support these research activities, the Contractor shall synthesize and deliver the five compounds listed below under non-GMP conditions, with a target purity of greater than or equal to 95%, together with a Certificate of Analysis (COA) for each compound.

Target Compounds:

1. N-Methyl-N-(3-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)methanesulfonamide ABCL Code: ABCL-0482 Quantity: 5 g

2. N,N-Diethyl-3-(5-phenyl-1,2,4-oxadiazol-3-yl)pyrrolidine-1-carboxamide ABCL Code: A1-133143 Quantity: 5 g

3. N-(3-Acetyl-2-methylbenzofuran-5-yl)-N-((4-methoxyphenyl)sulfonyl)isonicotinamide ABCL Code: A1-133142 Quantity: 5 g

4. 3,4,5-Trimethoxy-N-(4-((9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methoxy)phenyl)benzamide ABCL Code: ABCL-0485 Quantity: 5 g

5. N-Cycloheptyl-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]quinoline-2-carboxamide ABCL Code: A1-133147 Quantity: 5 g

Period of Performance:

The period of performance shall begin upon receipt of the purchase order and continue for up to 12 weeks, in accordance with the compound-specific lead times in the attached quote.

Estimated lead times after receipt of purchase order are as follows:

• ABCL-0482: 8 weeks

• A1-133143: 8–10 weeks

• A1-133142: 8 weeks

• ABCL-0485: 12 weeks

• A1-133147: 10–12 weeks

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all necessary services, qualified personnel, materials, equipment, and facilities, not otherwise provided by the Government, as needed to perform the work described in this Statement of Work.

Specific Requirements:

The Contractor shall:

1. Synthesize 5 grams each of the five target compounds listed above under non-GMP conditions.

2. Purify each compound to a target purity of ≥95%.

3. Confirm compound identity and purity using the Contractor’s standard analytical methods.

4. Provide a Certificate of Analysis (COA) for each delivered compound.

5. Package and ship the compounds to NCATS using appropriate procedures for research chemicals.

6. Provide biweekly progress updates during the period of performance.

7. Participate in teleconferences to discuss project status, risks, timelines, or any technical issues.

8. Notify NIH promptly of any technical challenges, delays, or anticipated scope changes that may affect timelines, yield, purity, or budget.

LEVEL OF EFFORT:

Estimated level of effort: one project manager and qualified synthetic chemistry personnel over the course of the project, for a total performance period of up to 12 weeks, depending on compound complexity and synthesis timelines.

GOVERNMENT RESPONSIBILITIES

NIH/NCATS will:

1. Provide the Contractor with the purchase order and any necessary administrative documentation.

2. Provide compound identifiers, structures, and any available technical information needed to initiate synthesis, if not already included in the quote package.

3. Review progress updates and respond to Contractor questions in a timely manner.

4. Participate in status teleconferences as needed.

5. Provide a shipping account number if NIH elects to use its own shipping account;

otherwise, shipping charges may be invoiced in accordance with the quote.

DELIVERY OR DELIVERABLES

The Contractor shall provide the following deliverables:

1. 5 grams of each of the five target compounds listed in this SOW.

2. Certificate of Analysis (COA) for each compound.

3. Biweekly written progress updates via email.

4. Final shipment notification and supporting documentation upon completion.

Deliverables shall be sent to the NIH/NCATS points of contact identified in the purchase order or task documentation.

REPORTING REQUIREMENTS

1. The Contractor shall provide biweekly progress reports during performance of the work.

2. Reports shall summarize:

o current synthesis status for each compound, o any technical issues encountered, o expected completion dates, o any anticipated deviations from scope, quantity, purity target, or schedule.

3. Final documentation, including COAs, shall accompany or precede shipment of the compounds.

OTHER CONSIDERATIONS

Travel:

N/A

Key Personnel:

Information System Security Plan:

N/A

Data Rights:

All project-related results, reports, analytical information, and deliverables generated under this SOW shall be treated as confidential and shall be the property of the Government, to the extent provided under the applicable agreement.

Section 508—Electronic and Information Technology Standards:

N/A

Publications and Publicity:

No publication, public disclosure, or publicity regarding the work performed under this SOW shall occur without prior written permission from the Government.

Confidentiality of Information:

All information, data, structures, compound details, and results associated with this project shall be kept confidential by the Contractor and shall not be disclosed to third parties without written authorization from the Government.

(vi) Delivery Location:

NIH/NCATS- 9808 Medical Center Drive, Rockville, MD 20850

(viii) FAR 52.204-7, System for Award Management, applies to this acquisition.

(ix) The provision at FAR 52.212-1, Instructions to Offerors—Commercial Items, applies to this acquisition. Add any agency-specific instructions as required.

(x) The provision at FAR 52.212-2, Evaluation—Commercial Items, applies to this acquisition.

(a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation represents the best value to the Government, price and other factors considered.

(b) Evaluation Factors:

• Price

• Technical capability

• Past performance

• Delivery schedule

(c) A written notice of award or acceptance of an offer, issued within the time specified in the offer, shall result in a binding contract without further action by either party. The Government reserves the right to accept any offer before the expiration date.

(xi) FAR 52.212-4, Contract Terms and Conditions—Commercial Items, applies to this acquisition.

(xii) Additional contract requirements or terms and conditions, as determined necessary by the Contracting Officer and consistent with customary commercial practices: None

(xiii) The Defense Priorities and Allocations System (DPAS) is not applicable.

(xiv) Submission Requirements:

Responses must include sufficient information to demonstrate the offeror’s capability to provide the required product or service. Quotes shall include, at a minimum:

• Unit and total price

• Shipping and handling costs

• Delivery timeframe after award

• Delivery terms

• F.O.B. point (destination or origin)

• Product or catalog numbers (if applicable)

• Product/service description

Additional evaluation considerations may include past performance, warranty, lifecycle cost, maintenance availability, and environmental or energy efficiency.

Responses must include the Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification. All offerors must be actively registered in the System for Award Management (SAM) at www.sam.gov.

All responses must be received by August 24, 8:00AM EST and must reference solicitation number 75N98026Q00970. Responses may be submitted electronically to Jaddua.Johnston@nih.gov

(xv) Point of Contact: Jaddua Johnston Contracting Specialist, Phone Number: 240-569-0006

Email: Jaddua.Johnston@nih.gov mailto:Jaddua.Johnston@nih.gov

STATEMENT OF WORK (SERVICES)

(SOW)

GENERAL INFORMATION

Title of Project:

Synthesis of compounds and intermediates for Ewing sarcoma project

Statement of Need and Purpose:

This purchase order supports the synthesis of compounds and intermediates for a project that is developing compounds targeted towards Ewing sarcoma. The custom non-GMP synthesis, purification, analytical characterization, and delivery of 5 grams each of these small-molecule compounds will be prepared for research purposes in support of ongoing NCATS medicinal chemistry and preclinical development activities.

The purpose of this effort is to obtain research-grade material of each target compound at a minimum purity suitable for further scientific evaluation.

Background Information and Objective:

Scientists from NCATS and the University of North Carolina are working together to find a new treatment for Ewing Sarcoma, a rare bone and tissue cancer, by fixing how DNA is packaged inside cancer cells. In healthy cells, DNA is wrapped up like a neatly organized library where only specific genes are "open" and readable, but in Ewing Sarcoma cells, this system breaks down, leaving the wrong parts of the DNA accessible and causing the cells to become cancerous. To map out exactly where these errors are, the researchers use a specialized scanning tool called ATAC-Seq, which identifies which parts of the DNA are open or closed.

The team is seeking to purchase and test this specific list of chemical compounds to see if they can act as a reset button, forcing the chaotic DNA structure of the cancer cells to look and behave like normal, healthy cells again. Ultimately, their goal is to prove that fixing this DNA packaging will stop the cells from being cancerous, either by using these exact compounds or developing new medicines based on them.

To support these research activities, the Contractor shall synthesize and deliver the five compounds listed below under non-GMP conditions, with a target purity of greater than or equal to 95%, together with a Certificate of Analysis (COA) for each compound.

Target Compounds:

1. N-Methyl-N-(3-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)methanesulfonamide ABCL Code: ABCL-0482 Quantity: 5 g

2. N,N-Diethyl-3-(5-phenyl-1,2,4-oxadiazol-3-yl)pyrrolidine-1-carboxamide ABCL Code: A1-133143 Quantity: 5 g

3. N-(3-Acetyl-2-methylbenzofuran-5-yl)-N-((4-methoxyphenyl)sulfonyl)isonicotinamide ABCL Code: A1-133142 Quantity: 5 g

4. 3,4,5-Trimethoxy-N-(4-((9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methoxy)phenyl)benzamide ABCL Code: ABCL-0485 Quantity: 5 g

5. N-Cycloheptyl-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]quinoline-2-carboxamide ABCL Code: A1-133147 Quantity: 5 g

Period of Performance:

The period of performance shall begin upon receipt of the purchase order and continue for up to 12 weeks, in accordance with the compound-specific lead times in the attached quote.

Estimated lead times after receipt of purchase order are as follows:

• ABCL-0482: 8 weeks

• A1-133143: 8–10 weeks

• A1-133142: 8 weeks

• ABCL-0485: 12 weeks

• A1-133147: 10–12 weeks

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all necessary services, qualified personnel, materials, equipment, and facilities, not otherwise provided by the Government, as needed to perform the work described in this Statement of Work.

Specific Requirements:

The Contractor shall:

1. Synthesize 5 grams each of the five target compounds listed above under non-GMP conditions.

2. Purify each compound to a target purity of ≥95%.

3. Confirm compound identity and purity using the Contractor’s standard analytical methods.

4. Provide a Certificate of Analysis (COA) for each delivered compound.

5. Package and ship the compounds to NCATS using appropriate procedures for research chemicals.

6. Provide biweekly progress updates during the period of performance.

7. Participate in teleconferences to discuss project status, risks, timelines, or any technical issues.

8. Notify NIH promptly of any technical challenges, delays, or anticipated scope changes that may affect timelines, yield, purity, or budget.

LEVEL OF EFFORT:

Estimated level of effort: one project manager and qualified synthetic chemistry personnel over the course of the project, for a total performance period of up to 12 weeks, depending on compound complexity and synthesis timelines.

GOVERNMENT RESPONSIBILITIES

NIH/NCATS will:

1. Provide the Contractor with the purchase order and any necessary administrative documentation.

2. Provide compound identifiers, structures, and any available technical information needed to initiate synthesis, if not already included in the quote package.

3. Review progress updates and respond to Contractor questions in a timely manner.

4. Participate in status teleconferences as needed.

5. Provide a shipping account number if NIH elects to use its own shipping account;

otherwise, shipping charges may be invoiced in accordance with the quote.

DELIVERY OR DELIVERABLES

The Contractor shall provide the following deliverables:

1. 5 grams of each of the five target compounds listed in this SOW.

2. Certificate of Analysis (COA) for each compound.

3. Biweekly written progress updates via email.

4. Final shipment notification and supporting documentation upon completion.

Deliverables shall be sent to the NIH/NCATS points of contact identified in the purchase order or task documentation.

REPORTING REQUIREMENTS

1. The Contractor shall provide biweekly progress reports during performance of the work.

2. Reports shall summarize:

o current synthesis status for each compound, o any technical issues encountered, o expected completion dates, o any anticipated deviations from scope, quantity, purity target, or schedule.

3. Final documentation, including COAs, shall accompany or precede shipment of the compounds.

OTHER CONSIDERATIONS

Travel:

N/A

Key Personnel:

Information System Security Plan:

Data Rights:

All project-related results, reports, analytical information, and deliverables generated under this SOW shall be treated as confidential and shall be the property of the Government, to the extent provided under the applicable agreement.

Section 508—Electronic and Information Technology Standards:

N/A

Publications and Publicity:

No publication, public disclosure, or publicity regarding the work performed under this SOW shall occur without prior written permission from the Government.

Confidentiality of Information:

All information, data, structures, compound details, and results associated with this project shall be kept confidential by the Contractor and shall not be disclosed to third parties without written authorization from the Government.

Title