Sol_75N94026R00002_Chemistry_Research_for_the_DTT_7_28_26.pdf

1.Requisition or other Purchase Authority: 42 U.S.C. 285l

2. Request for Proposal (RFP) Number:

75N94026R00002

3. Issue Date:

July 28, 2026

4. Set Aside:

[X ] No [ ] Yes See Part IV Section L

5. Title : Chemistry Research for the Division of Translational Toxicology (DTT)

6. ISSUED BY:

Office of Acquisitions and Logistics Management (OALM), Office of the Director (OD), Research and Development and Professional Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development (on behalf of the National Institute of Environmental Health Sciences), NIAAA & NIEHS Team

6701 Rockledge Drive (RKL II) Bethesda, MD 20817

7. SUBMIT OFFERS

TO:

See Part IV, Section L.3

8. Proposals for furnishing the supplies and/or services in THE SCHEDULE will be received as specified in Part IV, Section L.1., "Packaging and Delivery of Proposals”, until 4:30 PM Eastern Standard Time on September 11, 2025. Offers will be valid for 300 days unless a different period is specified by the offeror on the Attachment entitled, "Proposal Summary and Data Record, NIH 2043”.

9. This solicitation requires delivery of proposals as stated in Part IV, Section L.1, "Packaging and Delivery of Proposals”. Proposal is to be delivered electronically via the NIH electronic Contract Proposal Submission (eCPS) website, https://www.ecps.nih.gov

IF YOUR PROPOSAL IS NOT RECEIVED BY THE CONTRACTING OFFICER OR

HIS DESIGNEE AT THE PLACE AND TIME SPECIFIED IN SECTION L.3 OF THE

RFP, THEN IT WILL BE CONSIDERED LATE AND HANDLED IN ACCORDANCE

WITH subparagraph (c)(3) of FAR Provision 52.215-1, Instructions to Offerors-- Competitive Acquisition,"/HHSAR Provision 352.215-70, "Late Proposals and Revisions"

LOCATED IN SECTION L OF THIS SOLICITATION.

10. Offeror must be registered in the System for Award Management (SAM) prior to award of a contract. Offerors must access the CCR through The System for Award Management (SAM) at https://www.sam.gov/SAM/ .

11. FOR INFORMATION CONTACT: Sarah Bank, Contracting Officer e-MAIL: sarah.bank@nih.gov

COLLECT CALLS WILL NOT BE ACCEPTED.

Questions must be submitted in writing via e-mail to sarah.bank@nih.gov and lisa.schaupp@nih.gov in accordance with Article L.2., by August 10, 2026.

Secondary Contact:

Lisa Schaupp, Section Chief, OALM,OD, R&D and Professional Services, NIAAA and NIEHS Team, lisa.schaupp@nih.gov

SECTION B - Supplies or Services/Prices

1. BRIEF DESCRIPTION OF SUPPLIES OR SERVICES

2. ESTIMATED COST PLUS FIXED FEE - OPTION

3. ESTIMATED COST - INCREMENTALLY FUNDED CONTRACT, HHSAR 352.232-70 (DEC 2015)

4. PROVISIONS APPLICABLE TO DIRECT COSTS

5. ADVANCE UNDERSTANDINGS

6. Non-Personal Services and Inherently Government Functions

SECTION C - Description/Specifications

C.1 STATEMENT OF WORK

C.2. REPORTING REQUIREMENTS

C.3. INVENTION REPORTING REQUIREMENT

SECTION D - Packaging and Marking and Shipping SECTION E - Inspection and Acceptance SECTION F - Deliveries or Performance

1. PERIOD OF PERFORMANCE

2. DELIVERIES

3. LEVEL OF EFFORT

4. RFO 52.252-2 Clauses Incorporated by Reference. (FEB 1998)

SECTION G - Contract Administration Data

1. CONTRACTING OFFICER REPRESENTATIVE (COR)

2. INVOICE SUBMISSION/CONTRACT FINANCING REQUEST AND CONTRACT FINANCIAL REPORT

3. INDIRECT COST RATES

4. POST AWARD EVALUATION OF CONTRACTOR PERFORMANCE

5. GOVERNMENT PROPERTY

7. HHSAR 352.237-75 Key Personnel. (DEC 2015)

8. RFO 52.232-40 Providing Accelerated Payments to Small Business Subcontractors. (MAR 2023) .. 21

1. HUMAN SUBJECTS

2. NIH POLICY ON ENHANCING REPRODUCIBILITY THROUGH RIGOR AND TRANSPARENCY

3. NIH POLICY ON ENHANCING PUBLIC ACCESS TO ARCHIVED PUBLICATIONS RESULTING FROM NIH-

FUNDED RESEARCH

4. ACKNOWLEDGEMENT OF FEDERAL FUNDING

5. DISSEMINATION OF FALSE OR DELIBERATELY MISLEADING INFORMATION

RFP Number: 75N94026R00002

6. ANIMAL WELFARE

7. INTRODUCTION OF RODENTS AND RODENT PRODUCTS - NIEHS

8. RESTRICTION ON PORNOGRAPHY ON COMPUTER NETWORKS

9. GUN CONTROL

10. OPTION PROVISION

11. SUBCONTRACTING PROVISIONS

12. HHSAR 352.204-74 Supply Chain Risk Assessment (OCT 2024) (DEVIATION) See Attachment 6 - Supply Chain Risk Management Certification

15. RECORDS MANAGEMENT, HHSAR 352.204-72 (FEB 2024) (DEVIATION)

16. CONFIDENTIALITY OF INFORMATION

17. RESPONSIBILITIES OF INSTITUTIONS REGARDING INVESTIGATOR FINANCIAL CONFLICTS OF

INTEREST

18. PUBLICATION AND PUBLICITY

19. REPORTING MATTERS INVOLVING FRAUD, WASTE AND ABUSE

20. OBTAINING AND DISSEMINATING BIOMEDICAL RESEARCH RESOURCES

21. USE OF FUNDS FOR CONFERENCES, MEETINGS AND FOOD

22. HHSAR 352.239-73 Electronic Information and Technology Accessibility Notice. (DEC 2015)

23. HHSAR 352.270-5 b Care of Live Vertebrate Animals. (DEC 2015)

SECTION I - Contract Clauses

1. GENERAL CLAUSES

2. AUTHORIZED SUBSTITUTION OF CLAUSES

3. ADDITIONAL CONTRACT CLAUSES IN FULL TEXT

5. SERVICE CONTRACT LABOR STANDARDS

SECTION J - List of Documents, Exhibits and Other Attachments SECTION K - Representations, Certifications, and Other Statements of Bidders SECTION L - Instructions, Conditions, and Notices to Bidders SECTION M - Evaluation Factors for Award See Attachment 24 for Additional Evaluation Specifications and Requirements SUBCONTRACTING PROGRAM EVALUATION FACTORS- Not Peer Reviewed

SECTION B - Supplies or Services/Prices

1. BRIEF DESCRIPTION OF SUPPLIES OR SERVICES

This acquisition is to conduct Chemistry Research for the National Institute of Environmental Health Sciences (NIEHS), Division of Translational Toxicology (DTT) and National Toxicology Program (NTP).

The type and extent of chemistry research support provided will be specific to DTT and NTP research needs. Program management procedures and chemistry technical activities will be provided under eight (8) Functional Areas: Logistics and Handling, Characterization, Formulation, Biosample Analysis, Special Studies, Animal Studies, Omics and In Vitro Assays.

Specifications for the Conduct of Chemistry Activities for Toxicology Research Performed by the Division of Translational Toxicology at the National Institute of Environmental Health Sciences (DTT Chemistry Specifications) https://ntp.niehs.nih.gov/data/research/chemistry/rfp

2. ESTIMATED COST PLUS FIXED FEE - OPTION

a. The estimated cost of the Base Period of this contract is $To Be Negotiated.

b. The fixed fee for the Base Period of this contract is $To Be Determined. The fixed fee shall be paid in direct ratio to the level of effort expended; that is, the percent of fee paid shall be equal to the percent of total effort expended. Payment shall be subject to the withholding provisions of the clauses ALLOWABLE COST AND PAYMENT and FIXED FEE referenced in the General Clause Listing in Part II, ARTICLE I.1. of this contract.

c. The total estimated amount of the contract, represented by the sum of the estimated cost plus the fixed fee for the Base Period is $To Be Negotiated.

d. If the Government exercises its option pursuant to the OPTION PROVISION Article in SECTION H of this contract, the Government's total estimated contract amount represented by the sum of the estimated cost plus the fixed fee will be increased as follows:

Period of Performance Period Estimated

Cost ($) Fixed Fee ($) Estimated

Cost Plus Fixed Fee ($)

Level of Effort (LOE)

Hours January 18, 2027 – January 17, 2028

Base Period: Base Effort Base Period: Optional Studies

Total Base Period (Base Plus Optional Studies)

January 18, 2028 – January 17, 2029

Option Period 1: Base Effort

Option Period 1: Optional Studies

Total Option Period 1(Option Period 1 Plus Optional Studies)

January 18, 2029 – January 17, 2030

Option Period 2: Base Effort

Option Period 2: Optional Studies

Total Option Period 2(Option Period 2 Plus

January 18, 2030 – January 17, 2031

Option Period 3: Base Effort

Option Period 3: Optional Studies

Total Option Period 3 (Option Period 3 Plus

January 18, 2031 – January 17, 2032

Option Period 4: Base Effort

Option Period 4: Optional Studies

Total Option Period 4(Option Period 4 Plus

January 18, 2032 – January 17, 2033

Option Period 5: Base Effort

Option Period 5: Optional Studies

Total Option Period 5(Option Period 5 Plus

January 18, 2033 – January 17, 2034

Option Period 6: Base Effort

Option Period 6: Optional Studies

Total Option Period 6 (Option Period 6 Plus

January 18, 2034 – January 17, 2035

Option Period 7: Base Effort

Option Period 7: Optional Studies

Total Option Period 7 (Option Period 7 Plus

January 18, 2035 – January 17, 2036

Option Period 8: Base Effort

Option Period 8: Optional Studies

Total Option Period 8 (Option Period 8 Plus

January 18, 2036 – January 17, 2037

Option Period 9: Base Effort

Option Period 9: Optional Studies

Total Option Period 9 (Option Period 9 Plus

January 18, 2037 – July 17, 2038 (Option to Extend Services FAR 52.217-8 – transition effort)

Option Period 10: Base Effort

Option Period 10: Optional Studies

Total Option Period 10 (Option Period 10 Plus

Total [Base Period and Option(s)]

Note: The period of performance of an option for increased level of effort will not exceed the term of the period in which the option is exercised.

Each item listed above may be incrementally funded (see Incremental Funding clause in Section I in full text, HHSAR 352.232-70). If incremental funding is utilized for one or more of the above items, a separate line item for each incremental funding action will be created and this Article will be modified accordingly.

3. ESTIMATED COST - INCREMENTALLY FUNDED CONTRACT, HHSAR 352.232-70 (DEC

2015)

a. The total estimated cost to the Government for full performance of this contract, including all allowable direct and indirect costs, is To Be Negotiated.

b. The following represents the schedule* by which the Government expects to allot funds to this contract:

CLIN, Task, Number, or Description

Start Date of Funding

End Date of Funding

Estimated Cost ($)

Fee ($) (as appropriate)

Estimated Cost Plus Fee ($)

Base Option 1 Option 2 Option 3 Option 4 Option 5 Option 6 Option 7 Option 8 Option 9

Option 10 - Transition Total Base and Options [Total] [Total] [Total]

*To be inserted after negotiation

c. Total funds currently obligated and available for payment under this contract are To Be Negotiated.

d. The Contracting Officer may issue unilateral modifications to obligate additional funds to the contract and make related changes to paragraphs b. and/or c., above.

e. Until this contract is fully funded, the requirements of the clause at FAR 52.232-22, Limitation of Funds, shall govern. Once the contract is fully funded, the requirements of the clause at FAR 52.232-20, Limitation of Cost, shall govern.

4. PROVISIONS APPLICABLE TO DIRECT COSTS

Items Unallowable Unless Otherwise Provided

Notwithstanding the clauses, ALLOWABLE COST AND PAYMENT, and FIXED FEE, incorporated in this contract, unless authorized in writing by the Contracting Officer, the costs of the following items or activities shall be unallowable as direct costs:

1) Conferences & Meetings, 2)Food for Meals, Light Refreshments & Beverages,

3) Promotional Items,

4) Acquisition, by purchase or lease, of any interest in real property;

5) Special rearrangement or alteration of facilities;

6) Purchase or lease of any item of general purpose office furniture or office equipment regardless of dollar value;

7) Travel Costs including Foreign Travel;

8)Consultant Costs;

9) Subcontract Costs;

10) Patient Care Costs;

11) Accountable Government Property;

12) Printing costs; and

13) Research Funding.

5. ADVANCE UNDERSTANDINGS

Specific elements of cost, which normally require prior written approval of the Contracting Officer before incurrence of the cost (e.g., foreign travel, consultant fees, subcontracts) will be included in this Article if the Contracting Officer has granted his/her approval prior to contract award.

6. Non-Personal Services and Inherently Government Functions

1. Pursuant to FAR 37.1, no personal services shall be performed under this contract. All work requirements shall flow only from the Contracting Officer's Representative (COR) to the Contractor's Project Manager. No Contractor employee will be directly supervised by the Government. All individual employee assignments, and daily work direction, shall be given by the applicable employee supervisor.

If the Contractor believes any Government action or communication has been given that would create a personal services relationship between the Government and any Contractor employee, the Contractor shall promptly notify the Contracting Officer of this communication or action.

2. Pursuant to FAR 7.5, the Contractor shall not perform any inherently Governmental actions under this contract. No Contractor employee shall hold him or herself out to be a Government employee, agent, or representative. No Contractor employee shall state orally or in writing at any time that he or she is acting on behalf of the Government. In all communications with third parties in connection with this contract, Contractor employees shall identify themselves as Contractor employees and specify the name of the company for which they work. In all communications with other Government contractors in connection with this contract, the Contractor employee shall state that they have no authority to in any way change the contract and that if the other contractor believes this communication to be a direction to change their contract, they should notify the Contracting Officer for that contract and not carry out the direction until a clarification has been issued by the Contracting Officer.

3. The Contractor shall insure that all of its employees working on this contract are informed of the substance of this article. Nothing in this article shall limit the Government's rights in any way under the other provisions of the contract, including those related to the Government's right to inspect and accept the services to be performed under this contract. The substance of this article shall be included in all subcontracts at any tier.

SECTION C - Description/Specifications

C.1 STATEMENT OF WORK

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work, dated July 13, 2026, set forth in SECTION J- List of Attachments, attached hereto and made a part of this contract.

Specifications for the Conduct of Chemistry Activities for Toxicology Research Performed by the Division of Translational Toxicology at the National Institute of Environmental Health Sciences (DTT Chemistry Specifications) https://ntp.niehs.nih.gov/data/research/chemistry/rfp

C.2. REPORTING REQUIREMENTS

All reports shall be submitted electronically.

These reports shall be compliant with Section 508 of the Rehabilitation Act of 1973. Additional information about testing documents for Section 508 compliance, including guidance and specific checklists, by application, can be found at: https://www.hhs.gov/web/section-508/index.html and at:

https://www.section508.gov/create/documents, "Create Accessible Documents."

a. Technical Progress Reports

In addition to the required reports set forth elsewhere in this Schedule, the preparation and submission of regularly recurring Technical Progress Reports will be required in any contract resulting from this solicitation. These reports will require descriptive information about the activities undertaken during the reporting period and will require information about planned activities for future reporting periods. The frequency and specific content of these reports will be determined prior to contract award. [Note: Beginning May 25, 2008, the Contractor shall include the applicable PubMed Central or NIH Manuscript Submission reference number when citing publications that arise from its NIH funded research.]

For proposal preparation purposes, please see the Statement of Work (ATTACHMENT 2 to this RFP), Section 1.6 “Reports and Deliverables”.

Summary of Salient Results

The Contractor will be required to prepare and submit, with the final report, a summary (not to exceed 200 words) of salient results achieved during the performance of the contract. This report will be required on or before the expiration date of the contract.

b. Other Reports/Deliverables

1. 1. Reporting of Financial Conflict of Interest (FCOI)

All reports and documentation required by 45 CFR Part 94, Responsible Prospective Contractors including, but not limited to, the New FCOI Report, Annual FCOI Report, Revised FCOI Report, and the Mitigation Report, shall be submitted to the Contracting Officer in Electronic format. Thereafter, reports shall be due in accordance with the regulatory compliance requirements in 45 CFR Part 94. 45 CFR Part 94 is available at:

https://www.ecfr.gov/current/title-45/part-94.

See Part 94.5, Responsibilities of Institutions regarding Investigator financial conflicts of interest for complete information on reporting requirements.

(Reference the INSTITUTIONAL RESPONSIBILITY REGARDING INVESTIGATOR FINANCIAL CONFLICTS OF INTEREST Article in SECTION H of this contract.)

2. Source Code and Object Code

Unless otherwise specified herein, the Contractor shall deliver to the Government, upon the expiration date of the contract, all source code and object code developed, modified, and/or enhanced under this contract.

3. HHS Security And Privacy Language For Information And It Procurements

Reporting requirements for HHS Security and Privacy Language for Information and Information Technology Procurements are applicable to this solicitation. Please see the Statement of Work Appendix A “HHS SECURITY AND PRIVACY LANGUAGE FOR INFORMATION AND IT PROCUREMENTS” (ATTACHMENT 2 to this RFP) for a list of applicable deliverables reporting requirements.

4. Section 508 Annual Report

The Contractor must submit an annual Section 508 report in accordance with the schedule set forth by the Contracting Officer (CO)/Contracting Officer Representative (COR). The Section 508 Report Template and Instructions for completing the report are available at: https://www.hhs.gov/sites/default/files/web/508/contracting/technology/section_508 _annual_report.doc.

5. Service Contract Annual Report

The Contractor shall submit an Annual Service Contract Report to hƩps://www.SAM.gov on or before November 15 each year (covering a reporƟng period of the applicable recently complete Federal Government Fiscal Year, October 1 through September 30), in accordance with FAR 52.204- 14, Service Contract ReporƟng Requirements. The full text of this FAR clause is contained in SecƟon I. This report is separate from the Service Contract Act, which does not apply to this requirement.

The intent of this high-level reporƟng is for the Federal Government to assess the balance of in-house versus contracted-out work.

C.3. INVENTION REPORTING REQUIREMENT

All reports and documentation required by FAR Clause 52.227-11, Patent Rights-Ownership by the Contractor including, but not limited to, the invention disclosure report, the confirmatory license, and the Government support certification, shall be directed to the Division of Extramural Inventions and Technology Resources (DEITR), OPERA, OER, NIH, 6705 Rockledge Drive, Suite 310, MSC 7980, Bethesda, Maryland 20892-7980 (Telephone: 301-435-1986). In addition, one copy of an annual utilization report, and a copy of the final invention statement, shall be submitted to the Contracting Officer. The final invention statement (see FAR 27.303(b)(2)(ii)) shall be submitted to the Contracting Officer on the expiration date of the contract.

The first annual utilization report shall be submitted in accordance with the DELIVERIES Article in Section F of this contract. The final invention statement (see FAR 27.303(b)(2)(ii)) shall be submitted on the expiration date of the contract. All reports shall be sent to the following address:

Contracting Officer’s Representative (COR): ________________________ (to be completed upon award)

Contracting Officer (CO): _________________________ (to be completed upon award)

Contract Specialist (CS): _________________________ (to be completed upon award)

If no invention is disclosed or no activity has occurred on a previously disclosed invention during the applicable reporting period, a negative report shall be submitted to the Contracting Officer at the address listed above.

To assist contractors in complying with invention reporting requirements of the clause, the NIH has developed "Interagency Edison," an electronic invention reporting system. Use of Interagency Edison is required as it streamlines the reporting process and greatly reduces paperwork. Access to the system is through a secure interactive Web site to ensure that all information submitted is protected.

Interagency Edison and information relating to the capabilities of the system can be obtained from the Web (http://www.iedison.gov), or by contacting the Extramural Inventions and Technology Resources Branch, OPERA, NIH.

SECTION D - Packaging and Marking and Shipping

All deliverables required under this contract shall be packaged, marked and shipped in accordance with Government specifications. At a minimum, all deliverables shall be marked with the contract number and Contractor name. The Contractor shall guarantee that all required materials shall be delivered in immediate usable and acceptable condition.

SECTION E - Inspection and Acceptance

a. The Contracting Officer or the duly authorized representative will perform inspection and acceptance of materials and services to be provided.

b. For the purpose of this SECTION, the Contracting Officer’s Representative (TBD) is the authorized representative of the Contracting Officer.

c. Inspection and acceptance will be performed at:

National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS) Research Triangle Park, NC 27709

Acceptance may be presumed unless otherwise indicated in writing by the Contracting Officer or the duly authorized representative within 30 days of receipt.

d. This contract incorporates the following clause by reference, with the same force and effect as if it were given in full text. Upon request, the Contracting Officer will make its full text available.

RFO 52.246-9 Inspection of Research and Development (Short Form). (APR 1984)

RFO 52.246-5 Inspection of Services—Cost-Reimbursement APR 1984

SECTION F - Deliveries or Performance

1. PERIOD OF PERFORMANCE

a. The period of performance of the Base Period of this contract shall be from January 18, 2027 through January 17, 2028.

b. If the Government exercises its option(s) pursuant to the OPTION PROVISION Article in Section H of this contract, the period of performance will be increased as listed below:

Option Option Period Option Period 1 January 18, 2028 – January 17, 2029 Option Period 2 January 18, 2029 – January 17, 2030 Option Period 3 January 18, 2030 – January 17, 2031 Option Period 4 January 18, 2031 – January 17, 2032 Option Period 5 January 18, 2032 – January 17, 2033 Option Period 6 January 18, 2033 – January 17, 2034 Option Period 7 January 18, 2034 – January 17, 2035 Option Period 8 January 18, 2035 – January 17, 2036 Option Period 9 January 18, 2036 – January 17, 2037 Option Period 10 – Option to Extend Services January 18, 2037 – July 17, 2038

2. DELIVERIES

Satisfactory performance of the final contract shall be deemed to occur upon performance of the work described in the Statement of Work Article in SECTION C of this contract and upon delivery and acceptance by the Contracting Officer, or the duly authorized representative, of the following items in accordance with the stated delivery schedule.

A brief description of Reporting Requirements and Deliverables is in the Statement of Work (SOW) and additional details are in Chapter 7 of the specifications, https://ntp.niehs.nih.gov/data/research/chemistry/rfp.

See Section J- Attachment 4 for Reporting Requirements and Delivery Schedule.

3. LEVEL OF EFFORT

a. During the period of performance of this contract, the Contractor shall provide TBD direct labor hours. The labor hours exclude vacation, holiday, and sick leave. These labor hours include subcontractor labor hours. It is estimated that the labor hours are constituted as specified below and will be expended approximately as follows:

Labor Hours

Labor Category Year 1 Year 2 Year 3 Year 4 Year 5 Year 6 Year 7 Year 8 Year 9 Year 10 Senior Research Professional

Research Professional

Technical Staff Support Staff Totals

Option Studies Labor Category Year 1 Year 2 Year 3 Year 4 Year 5 Year 6 Year 7 Year 8 Year 9 Year 10

Senior Research Professional

Research Professional

Technical Staff Support Staff Totals NOTE: To be completed upon award. See Section L, Proposal Instructions, for further information on estimating hours. Sub Attachment E. provides the Government’s estimated effort; Attachment 24.

and SUB ATTACHMENT B – Sample Research Outlines provide further detailed information as to anticipated types/quantities of work.

b. The Contractor shall have satisfied the requirement herein if not less than 90% nor more than 110% of the total direct labor hours specified herein are furnished. These terms and conditions do not supersede the requirements of either the "Limitation of Cost" or "Limitation of Funds" clause.

c. In the event fewer hours than the minimum specified number of direct labor hours in the total categories are used by the Contractor in accomplishing the prescribed work and the Government has not invoked its rights under FAR Clause 52.249-6, TERMINATION (Cost- Reimbursement) incorporated in this contract, these parties agree that the fee will be adjusted based solely upon the quantity of hours by which the number of direct labor hours furnished is less than the number of direct labor hours specified in this ARTICLE. The resulting adjustment shall be evidenced by a contract modification.

4. RFO 52.252-2 Clauses Incorporated by Reference. (FEB 1998)

This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at this/these address(es): This contract incorporates the following clause(s) by reference, with the same force and effect as if it were given in full text. Upon request, the Contracting Officer will make its full text available. Also, the full text of a clause may be accessed electronically at this address: https://www.acquisition.gov/browse/index/far.

FEDERAL ACQUISITION REGULATION (48 CFR CHAPTER 1) CLAUSE:

52.242-15, Stop Work Order (August 1989) - Alternate I (April 1984) is applicable to this contract.

(End of clause)

SECTION G - Contract Administration Data

1. CONTRACTING OFFICER REPRESENTATIVE (COR)

The following Contracting Officer Representative (COR) will represent the Government for the purpose of this contract:

[To be specified at award]

The COR is responsible for: (1) monitoring the Contractor's technical progress, including the surveillance and assessment of performance and recommending to the Contracting Officer changes in requirements; (2) interpreting the statement of work and any other technical performance requirements; (3) performing technical evaluation as required; (4) performing technical inspections and acceptances required by this contract; and (5) assisting in the resolution of technical problems encountered during performance.

The following Alternate COR is responsible for carrying out the duties of the COR only in the event that the COR can no longer perform his/her duties as assigned.

[To be specified at award]

The Contracting Officer is the only person with authority to act as agent of the Government under this contract. Only the Contracting Officer has authority to: (1) direct or negotiate any changes in the statement of work; (2) modify or extend the period of performance; (3) change the delivery schedule;

(4) authorize reimbursement to the Contractor for any costs incurred during the performance of this contract; (5) otherwise change any terms and conditions of this contract; or (6) sign written licensing agreements. Any signed agreement shall be incorporated by reference in Section K of the contract

The Government may unilaterally change its COR and/or ACOR designation.

2. INVOICE SUBMISSION/CONTRACT FINANCING REQUEST AND CONTRACT FINANCIAL

REPORT

1. Invoice Submission/Contract Financing Request, NIH(RC)-1 for NIH Cost-Reimbursement Type Contracts are attached and made part of this contract. The Contractor shall follow the attached instructions and submission procedures specified below to meet the requirements of a "proper invoice" pursuant to FAR Subpart 32.9, Prompt Payment.

a. The Contractor must submit invoices to the Department of Treasury's Invoice Processing Platform (IPP) at https://www.ipp.gov with a copy of the invoice to the approving official, as directed below.

The Contractor shall submit a copy of the electronic invoice to the following Approving Official (Contracting Officer) and Contracting Officer Representative:

Official: Contracting Officer

Name- [To Be Specified Prior to Award] Email Address- [To Be Specified Prior to Award]

Contracting Officer's Representative

Name- [To Be Specified Prior to Award] Email Address- [To Be Specified Prior to Award]

For inquiries regarding the status of invoices, contact OFM Customer Service via email at ofm_customer_service@mail-cmp.niceincontact.com or via phone at 301-496-6088. To send your inquiries via other available communication methods refer to the OFM Customer Service website at https://ofm.od.nih.gov/Pages/Customer-Service.aspx.

Note: The OFM Customer Service is open Eastern Standard Time Monday - Friday from 8:30 a.m. to 5:00 p.m. and is closed between 12:00 p.m. to 1:00 p.m.

c. In addition to the requirements specified in FAR 32.905 for a proper invoice, the Contractor shall include the following information on the face page of all payment requests:

a. Name of the Office of Acquisitions. The Office of Acquisitions for this contract is OALM, OD, R&D and Professional Services- Division B.

b. Federal Taxpayer Identification Number (TIN). If the Contractor does not have a valid TIN, it shall identify the Vendor Identification Number (VIN) on the payment request. The VIN is the number that appears after the Contractor's name on the face page of the contract. [Note: A VIN is assigned to new contracts awarded on or after June 4, 2007, and any existing contract modified to include the VIN number.] If the Contractor has neither a TIN, Unique Entity Identifier (UEI), or VIN, contact the Contracting Officer. Note: The Contractor shall not include TIN if it is a Social Security Number.

c. Unique Entity Identifier (UEI). The UEI is located in the System for Award Management (SAM) and replaces the Dun & Bradstreet Data Universal Numbering System (DUNS) number. The UEI number must identify the Contractor's name and address exactly as stated in the contract and as registered in the Central Contractor Registration (CCR) database. If the Contractor does not have a valid UEI number, it shall identify the Vendor Identification Number (VIN) on the payment request. The VIN is the number that appears after the Contractor's name on the face page of the contract. [Note: A VIN is assigned to new contracts awarded on or after June 4, 2007, and any existing contract modified to include the VIN number.] If the Contractor has neither a TIN, UEI, or VIN, contact the Contracting Officer.

d. Invoice Matching Option. This contract requires a two-way match.

e. Unique Invoice Number. Each payment request must be identified by a unique invoice number, which can only be used one time regardless of the number of contracts or orders held by an organization.

f. The Contract Title is:

Chemistry Research for the Division of Translational Toxicology (DTT)

g. Contract Line Items as follows:

Line Item # Line Item Description PRISM Line 1 Base Period PRISM Line 2 Option Period 1 PRISM Line 3 Option Period 2 PRISM Line 4 Option Period 3 PRISM Line 5 Option Period 4 PRISM Line 6 Option Period 5 PRISM Line 7 Option Period 6 PRISM Line 8 Option Period 7 PRISM Line 9 Option Period 8 PRISM Line 10 Option Period 9 PRISM Line 11 Option Period 10

2. Inquiries regarding payment of invoices shall be directed to the designated billing office,

(301) 496-6452.

3. The Contractor shall include the following certification on every invoice for reimbursable costs incurred with Fiscal Year funds subject to HHSAR Clause 352.231-70, Salary Rate

Limitation in SECTION I of this contract. For billing purposes, certified invoices are required for the billing period during which the applicable Fiscal Year funds were initially charged through the final billing period utilizing the applicable Fiscal Year funds:

'I hereby certify that the salaries charged in this invoice are in compliance with HHSAR Clause 352.231-70, Salary Rate Limitation in SECTION I of the above referenced contract.'

1. CONTRACT FINANCIAL REPORT

a. Financial reports on the attached Form NIH 2706, Financial Report of Individual Project/Contract, shall be submitted by the Contractor in accordance with the Instructions for Completing Form NIH 2706, which accompany the form, in an original and two copies, not later than the 30th working day after the close of the reporting period. The line entries for subdivisions of work and elements of cost (expenditure categories) which shall be reported within the total contract are listed in paragraph e., below. Subsequent changes and/or additions in the line entries shall be made in writing.

b. Unless otherwise stated in that part of the Instructions for Completing Form NIH 2706, entitled " PREPARATION INSTRUCTIONS ," all columns A through J, shall be completed for each report submitted.

c. The first financial report shall cover the period consisting of the first full [Calendar Month/Three Calendar Months] following the date of the contract, in addition to any fractional part of the initial month. Thereafter, reports will be on a [Monthly/Quarterly] basis.

d. The Contracting Officer may require the Contractor to submit detailed support for costs contained in one or more interim financial reports. This clause does not supersede the record retention requirements in FAR Part 4.7.

e. The following is a listing of expenditure categories to be reported:

f. The Government may unilaterally revise the NIH 2706 to reflect the allotment of additional funds.

3. INDIRECT COST RATES

In accordance with Federal Acquisition Regulation (FAR) (48 CFR Chapter 1) Clause 52.216-7 (d)(2), Allowable Cost and Payment incorporated by reference in this contract in PART II, SECTION I, the cognizant Contracting Officer Representative responsible for negotiating provisional and/or final indirect cost rates is identified as follows:

Director, Division of Financial Advisory Services Office of Acquisition Management and Policy National Institutes of Health

6011 EXECUTIVE BLVD, ROOM 549C, MSC-7663

BETHESDA MD 20892-7663

These rates are hereby incorporated without further action of the Contracting Officer. Go to the Indirect Cost Submission web page: https://oamp.od.nih.gov/division-of-financial-advisory-services/indirect-cost-branch/indirect-cost-submission for electronic copies of the Branch's information package documents.

4. POST AWARD EVALUATION OF CONTRACTOR PERFORMANCE

a. Contractor Performance Evaluations

Interim and Final evaluations of Contractor performance will be prepared on this contract in accordance with FAR Subpart 42.15. The Final performance evaluation will be prepared at the time of completion of work. In addition to the Final evaluation, Interim evaluation(s) will be prepared Annually on the anniversary of the award date.

Interim and Final evaluations will be provided to the Contractor as soon as practicable after completion of the evaluation. The Contractor will be permitted sixty days to review the document and to submit additional information or a rebutting statement. If agreement cannot be reached between the parties, the matter will be referred to an individual one level above the Contracting Officer, whose decision will be final.

Copies of the evaluations, Contractor responses, and review comments, if any, will be retained as part of the contract file, and may be used to support future award decisions.

a. Electronic Access to Contractor Performance Evaluations

Contractors may access evaluations through a secure Web site for review and comment at the following address:

https://www.cpars.gov

5. GOVERNMENT PROPERTY

If this RFP will result in the acquisition or use of Government Property provided by the contracting agency or if the Contracting Officer authorizes in the preaward negotiation process, the acquisition of property (other than real property), this ARTICLE will include applicable provisions and incorporate the HHS Publication, entitled, 'HHS Contracting Guide for Contract of Government Property,' Appendix Q, which can be found at:

https://oamp.od.nih.gov/sites/default/files/DGS/HHS%20Contracting%20Guide%20for%20Contract%2 0of%20Government%20Property-Appendix%20Q.pdf

7. HHSAR 352.237-75 Key Personnel. (DEC 2015)

The key personnel specified in this contract are considered to be essential to work performance. At least 30 days prior to the contractor voluntarily diverting any of the specified individuals to other programs or contracts the Contractor shall notify the Contracting Officer and shall submit a justification for the diversion or replacement and a request to replace the individual. The request must identify the proposed replacement and provide an explanation of how the replacement's skills, experience, and credentials meet or exceed the requirements of the contract (including, when applicable, Human Subjects Testing requirements). If the employee of the contractor is terminated for cause or separates from the contractor voluntarily with less than thirty days notice, the Contractor shall provide the maximum notice practicable under the circumstances. The Contractor shall not divert, replace, or announce any such change to key personnel without the written consent of the Contracting Officer.

The contract will be modified to add or delete key personnel as necessary to reflect the agreement of the parties.

(End of clause)

The following positions are considered to be essential to the work being performed hereunder:

Name Title

Principal Investigator (PI)

Deputy Principal Investigator (PI)

8. RFO 52.232-40 Providing Accelerated Payments to Small Business Subcontractors.

(MAR 2023)

(a)(1) In accordance with 31 U.S.C. 3903 and 10 U.S.C. 3801, within 15 days after receipt of accelerated payments from the Government, the Contractor shall make accelerated payments to its small business subcontractors under this contract, to the maximum extent practicable and prior to when such payment is otherwise required under the applicable contract or subcontract, after receipt of a proper invoice and all other required documentation from the small business subcontractor.

(2) The Contractor agrees to make such payments to its small business subcontractors without any further consideration from or fees charged to the subcontractor.

(b) The acceleration of payments under this clause does not provide any new rights under the Prompt Payment Act.

(c) Include the substance of this clause, including this paragraph (c), in all subcontracts with small business concerns, including subcontracts with small business concerns for the acquisition of commercial products or commercial services.

(End of clause)

SECTION H - Special Contract Requirements

1. HUMAN SUBJECTS

It is hereby understood and agreed that research involving human subjects shall not be conducted under this contract, and that no material developed, modified, or delivered by or to the Government under this contract, or any subsequent modification of such material, will be used by the Contractor or made available by the Contractor for use by anyone other than the Government, for experimental or therapeutic use involving humans without the prior written approval of the Contracting Officer.

2. NIH POLICY ON ENHANCING REPRODUCIBILITY THROUGH RIGOR AND

TRANSPARENCY

Contractors shall adhere to the NIH policy of enhancing reproducibility through rigor and transparency by addressing each of the four areas of the policy in performance of the Statement of Work and in publications, as applicable: 1) Scientific Premise; 2) Scientific Rigor; 3) Consideration of Relevant Biological Variables, including Sex; and 4) Authentication of Key Biological and/or Chemical Resources.

This policy applies to all NIH funded research and development, from basic through advanced clinical studies. See NIH Guide Notice, NOT-OD-15-103 , "Enhancing Reproducibility through Rigor and Transparency" and NOT-OD-15-102 , "Consideration of Sex as a Biological Variable in NIH-funded Research" for more information. In addition, publications are expected to follow the guidance at https://www.nih.gov/research-training/rigor-reproducibility/principles-guidelines-reporting-preclinical-research, whether preclinical or otherwise, as appropriate. More information is available at https://grants.nih.gov/policy/reproducibility/index.htm, including FAQs and a General Policy Overview.

3. NIH POLICY ON ENHANCING PUBLIC ACCESS TO ARCHIVED PUBLICATIONS

RESULTING FROM NIH-FUNDED RESEARCH

NIH-funded investigators shall submit to the NIH National Library of Medicine's (NLM) PubMed Central (PMC) electronic versions of all Author Accepted Manuscripts arising from this contract in whole or in part, upon acceptance for publication. NIH defines the Author Accepted Manuscripts as the author's final version that has been accepted for journal publication and includes all revisions resulting from the peer review process, including all associated tables, graphics, and supplemental material. NIH-funded investigators shall notify their Contracting Officers and Contracting Officer Representatives upon the acceptance of an Author Accepted Manuscript resulting from the contract, even if co-authored with those not using contract funds. Through execution of this contract, contractor, and through implementation of this provision by contractor to each of contractor's investigators and subcontractor, and through implementation of this provision to each of subcontractor's investigators, conducting work under this contract or a subcontract, respectively, hereby grants to NIH a royalty-free, nonexclusive, and irrevocable right to reproduce, publish, or otherwise use for federal purposes and to authorize others to do so, all Author Accepted Manuscripts that result from this contract, which includes making Author Accepted Manuscripts publicly available in PubMed Central upon the Official Date of Publication, in accordance with the 2024 NIH Public Access Policy. Upon receipt of a PMCID, investigators should report the PMCID to their Contracting Officers and Contracting Officer Representatives to demonstrate compliance with this term of the contract. The PMC archive will permanently preserve and retain these manuscripts for use by the public, health care providers, educators, scientists, and NIH. NIH Policy directs electronic submissions to the NIH/NLM/PMC:

https://www.ncbi.nlm.nih.gov/pmc/.

Additional information is available at: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25- 047.html and https://grants.nih.gov/policy-and-compliance/policy-topics/public-access

4. ACKNOWLEDGEMENT OF FEDERAL FUNDING

The Contractor shall clearly state, when issuing statements, press releases, requests for proposals, bid solicitations and other documents describing projects or programs funded in whole or in part with Federal money: (1) the percentage of the total costs of the program or project which will be financed with Federal money; (2) the dollar amount of Federal funds for the project or program; and (3) the percentage and dollar amount of the total costs of the project or program that will be financed by nongovernmental sources.

5. DISSEMINATION OF FALSE OR DELIBERATELY MISLEADING INFORMATION

The Contractor shall not use contract funds to disseminate information that is deliberately false or misleading.

6. ANIMAL WELFARE

All research involving live, vertebrate animals shall be conducted in accordance with the Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS Policy). The PHS Policy can be accessed at: https://olaw.nih.gov/policies-laws/phs-policy.htm.

In addition, the research involving live vertebrate animals shall be conducted in accordance with the description set forth in the Vertebrate Animal Section (VAS) of the contractor's technical proposal, as modified in the Final Proposal Revision (FPR), which is incorporated by reference.

7. INTRODUCTION OF RODENTS AND RODENT PRODUCTS - NIEHS

No rodent or rodent product shall be delivered to NIEHS directly or through collaborative research or holding facilities under contract to NIEHS except by prior approval by the Comparative Medicine Branch, NIEHS. The approval form, Application to Introduce Rodents and Rodent Products into NIEHS, is available by contacting the Comparative Medicine Branch, Quality Assurance Laboratory at 984-287- 3912. Approval must be obtained by the Contractor prior to shipment to NIEHS of the rodents and/or rodent products. The Contractor must be sure that this approval exists and is current before transferring rodents or rodent products into the NIEHS. Refusal or negligence to do so will be considered a material breach of contract and may be treated as any other such material breach.

Requests for approval should be submitted within 30 days of the shipping date to: NIEHS, Comparative

Medicine Branch, Quality Assurance Laboratory, PO Box 12233, MD C1-06, Building 101, Room C128, Research Triangle Park, NC, 27709. United States Department of Agriculture permits are required for the importation of monoclonal antibodies, hybridoma cell lines, cell cultures, and other biologic materials that have been in contact with material of animal origin. USDA permit forms and information are available online (https://www.aphis.usda.gov/aphis/resources/permits). A copy of the completed permit form should be submitted to the Comparative Medicine Branch.

8. RESTRICTION ON PORNOGRAPHY ON COMPUTER NETWORKS

The Contractor shall not use contract funds to maintain or establish a computer network unless such network blocks the viewing, downloading, and exchanging of pornography.

9. GUN CONTROL

The Contractor shall not use contract funds in whole or in part, to advocate or promote gun control.

10. OPTION PROVISION

Unless the Government exercises its option pursuant to the Option Clause set forth in SECTION I., the contract will consist only of the Base Period of the Statement of Work as defined in Sections C and F of the contract. Pursuant to FAR Clause 52.217-7, Option for Increased Quantity-Separately Priced Line Item and FAR Clause 52.217-9, Option to Extend the Term of the Contract set forth in SECTION I. of this contract, the Government may, by unilateral contract modification, require the Contractor to perform additional options set forth in the Statement of Work and also defined in Sections C and F of the contract. If the Government exercises this option, notice must be given at least 60 days prior to the expiration date of this contract, and the estimated cost (plus fixed fee) of the contract will be increased as set forth in the ESTIMATED COST PLUS FIXED FEE Article in SECTION B of this contract.

11. SUBCONTRACTING PROVISIONS

a. Small Business Subcontracting Plan

1.The Small Business Subcontracting Plan, dated TBD, is attached hereto and made a part of this contract.

2. The failure of any Contractor or subcontractor to comply in good faith with FAR Clause 52.219-8, entitled " Utilization of Small Business Concerns" incorporated in this contract and the attached Subcontracting Plan, will be a material breach of such contract or subcontract and subject to the remedies reserved to the Government under FAR Clause 52.219-16 entitled, "Liquidated Damages- Subcontracting Plan."

b. Subcontracting Reports

1. An offeror is to submit their respective subcontracting plan electronically using the U.S. Department of Health and Human Services (HHS) Small Business Customer

Experience (SBCX) system at https://osdbu.hhs.gov. The offeror shall follow the instructions outlined in the SBCX Industry Guide at: https://oamp.od.nih.gov/nih-document-generation-system/dgs-workform-information/attachment-files-section-j to successfully submit their subcontracting plan by the proposal submission deadline.

2. The official point of receipt for determining timely submission of an offeror's subcontracting plan is the SBCX system and/or email notification. Once the subcontracting plan is successfully submitted in the SBCX system the offeror should receive an email notification and confirmation message of completion upon submission.

3. If an offeror's subcontracting plan is not confirmed as received within the SBCX system by the proposal submission date specified in the solicitation, it will be considered late in accordance with subparagraph (c)(3) of FAR Clause 52.215-1, Instructions to Offeror-Competition Acquisition. Disposition of late submittals of a subcontracting plan by an offeror via the SBCX system is at the discretion of the Contracting Officer.

4. Any technical questions regarding the use of the SBCX system may be submitted via email message to the SBCX help desk at client.support@apexlogic.com. The client support hours of operation are Monday - Friday, 6:00 a.m. - 8:00 p.m. Eastern Standard Time (EST). Note: help desk tickets can be submitted 24 hours a day / 7 days a week and a representative will respond within the presented client support hours of operation for assistance.

5. Individual Subcontract Reports ( ISR)

The Contractor must submit the following Subcontracting reports electronically via https://www.sam.gov.

Regardless of the effective date of this contract, the Report shall be due on the following dates for the entire life of this contract:

April 30th

October 30th

Expiration Date of Contract

6. Summary…