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STATEMENT OF WORK

Rotations for Medical Genetics and Genomic Medicine Residency and Fellowship Training Programs.

Background:

The National Human Genome Research Institute (NHGRI), Division of Intramural Research (DIR) was established to serve as a hub where development of technology for the rapid isolation and analysis of disease genes will be carried out. The DIR’s basic research laboratories and clinical branches develop and use the most advanced techniques to conduct research in medical genetics. Research includes identifying and understanding the molecular basis of human genetic disease and planning and carrying out clinical trials to test methods for the treatment.

The mission of the DIR includes the training of physicians and doctoral degree fellows in Medical Genetics through the Medical Genetics and Genomic Medicine Training Programs. These programs are administered by the Office of the Clinical Director (OCD) and are accredited by the Accreditation Council for Graduate Medical Education (ACGME).

Requirements for board certification of competency of our trainees include broad exposure to and experience with pediatric and adult genetic disorders, including metabolic and mitochondrial disorders, complex traits, skeletal dysplasia’s, clefting, phacomatoses, and chromosomal disorders. The training must include information on the diagnosis and management of these disorders, including the opportunity to rotate in CLIA approved diagnostic genetic laboratories run by American Board of Medical Genetics (ABMG) certified staff. Another component must be the follow up of abnormal newborn screening results. Residents spend two of the 5 years training in Pediatrics at Children’s National Hospital, a world-renowned institution in metropolitan Washington, D.C. The pediatrics training is based in a diverse, urban setting and includes training experiences in the surrounding capital region. The curriculum includes rotations in subspecialty pediatrics, PICU, NICU, emergency medicine, well baby nursery, as well as inpatient and outpatient general pediatrics. Graduates are eligible to sit for the ABP board examination and well equipped to work in primary care and pediatric subspecialties.

To meet these requirements the Medical Genetics Branch and OCD seek nearby institutions to provide these components of training for board certification in Clinical Genetics, Clinical Biochemical Genetics, Medical Biochemical Genetics, Clinical Molecular Genetics and Clinical Cytogenetics. The staff, which must include both ACGME board certified geneticist(s) and a genetic counselor, will be required to train fellows in the approach, and management of various genetic disorders. In addition, trainees need to have training in applicable laboratory techniques and the clinical interpretation and implications of the test results. The staff must also participate in the comprehensive teaching of residents, including participation in lecture series, journal clubs, and case conferences. A genetic counselor will assist in the training of fellows in the interpretation and genetic implication of tests they are learning to perform in these diagnostic laboratories. Residents spend two of the 5 years training in Pediatrics at Children’s National Hospital, a world-renowned institution in metropolitan Washington, D.C. The pediatrics training is based in a diverse, urban setting and includes training experiences in the surrounding capital region. The curriculum includes rotations in subspecialty pediatrics, PICU, NICU, emergency medicine, well baby nursery, as well as inpatient and outpatient general pediatrics. Residents also spend 2 years completing requirements of a Medical Genetics residency at NHGRI/NIH which includes 18 months of clinical/laboratory rotations and 6 months of genetics-focused research. Clinical genetics rotations expose residents to inpatient and outpatient general genetics (adult and pediatric), cancer genetics, prenatal genetics, metabolism, and specialty genetics, and laboratory genetics rotations focus on molecular genetics, cytogenetics, and biochemical genetics. Rotations occur within NIH as well as at numerous institutions across the DMV region and offer exposure to common genetic conditions as well as unique rare diagnoses seen at NIH. The fifth and final year of training can either be used for research or subspecialty genetics training. Graduates are eligible to sit for board examinations by both ABP and ABMGG.

Related Efforts:

This project is necessary for NHGRI/DIR because it will help provide the DIR with access to CLIA/CAO and American Board of Medical Genetics and Genomics approved settings to train fellows in the laboratory techniques related to pediatric genetics, including diagnostic testing laboratories.

Children’s National Hospital has established an expansive clinical genetics program. In addition, they have a biochemical and molecular genetics laboratory that offers extensive testing, including several assays not available at other testing laboratories. Thus, our fellows need to rotate at this site in order to become proficient in the diagnosis and management of pediatric genetic disorders and in the running and interpretation of the biochemical and molecular genetic assays. The National Human Genome Research Institute (NHGRI), in conjunction with Children's National Hospital, offers a unique opportunity for medical school graduates to complete a combined, four-year residency program in pediatrics and medical genetics. There is one resident per year in this track.

Purpose and Objectives:

The purpose of this requirement is to maintain formal training program sites for the instruction of fellows as part of the requirements for board certification in Laboratory Genetics and Genomics. Division of Intramural Research (DIR) was established to serve as a hub where development of technology for the rapid isolation and analysis of disease genes will be carried out. The DIR’s basic research laboratories and clinical branches develop and use the most advanced techniques to conduct research in medical genetics. Research includes identifying and understanding the molecular basis of human genetic disease and planning and carrying out clinical trials to test methods for the treatment.

The mission of the DIR includes the training of physicians and doctoral degree fellows in medical genetics through the Medical Genetics and Genomic Medicine Training Programs. These programs are administered by the Office of the Clinical Director (OCD) and is accredited by the Accreditation Council for Graduate Medical Education (ACGME).

Requirements for board certification of competency of our trainees include broad exposure to and experience with pediatric and adult genetic disorders, including metabolic and mitochondrial disorders, complex traits, skeletal dysplasia’s, clefting, phacomatoses, and chromosomal disorders. The training must include information on the diagnosis and management of these disorders, including the opportunity to rotate in CLIA approved diagnostic genetic laboratories run by American Board of Medical Genetics (ABMG) certified staff. Another component must be the follow up of abnormal newborn screening results. Residents spend two of the 5 years training in Pediatrics at Children’s National Hospital, a world-renowned institution in metropolitan Washington, D.C. The pediatrics training is based in a diverse, urban setting and includes training experiences in the surrounding capital region. The curriculum includes rotations in subspecialty pediatrics, PICU, NICU, emergency medicine, well baby nursery, as well as inpatient and outpatient general pediatrics. Graduates are eligible to sit for the ABP board examination and well equipped to work in primary care and pediatric subspecialties.

To meet these requirements the Medical Genetics Branch and OCD seek nearby institutions to provide these components of training for board certification in Clinical Genetics, Clinical Biochemical Genetics, Medical Biochemical Genetics, Clinical Molecular Genetics and Clinical Cytogenetics. The staff, which must include both ACGME board certified geneticist(s) and a genetic counselor, will be required to train fellows in the approach, diagnosis, and management of various genetic disorders. In addition, trainees need to have training in applicable laboratory techniques and the clinical interpretation and implications of the test results. The staff must also participate in the comprehensive teaching of residents, including participation in lecture series, journal clubs, and case conferences. A genetic counselor will assist in the training of fellows in the interpretation and genetic implication of tests they are learning to perform in these diagnostic laboratories. Residents spend two of the 5 years training in Pediatrics at Children’s National Hospital, a world-renowned institution in metropolitan Washington, D.C. The pediatrics training is based in a diverse, urban setting and includes training experiences in the surrounding capital region. The curriculum includes rotations in subspecialty pediatrics, PICU, NICU, emergency medicine, well baby nursery, as well as inpatient and outpatient general pediatrics. Residents also spend 2 years completing requirements of a Medical Genetics residency at NHGRI/NIH which includes 18 months of clinical/laboratory rotations and 6 months of genetics-focused research. Clinical genetics rotations expose residents to inpatient and outpatient general genetics (adult and pediatric), cancer genetics, prenatal genetics, metabolism, and specialty genetics, and laboratory genetics rotations focus on molecular genetics, cytogenetics, and biochemical genetics. Rotations occur within NIH as well as at numerous institutions across the DMV region and offer exposure to common genetic conditions as well as unique rare diagnoses seen at NIH. The fifth and final year of training can either be used for research or subspecialty genetics training. Graduates are eligible to sit for board examinations by both ABP and ABMGG.

The goal of the program is to:

1. Provide a training facility that will conduct two-week virtual rotations in pharmacogenomic testing and interpretation and in cancer cytogenetics for our Ph.D. Medical Genetics trainees seeking certification in Laboratory Genetics and Genomics, To provide a genetic counselor to assist in the training of the fellows in the genetic counseling implications of the diagnoses that have been made.

To participate in the comprehensive training of all trainees in genetics as part of the Medical Genetics and Genomic Medicine Residency and Fellowship Training Programs.

Project title:

Training in Pediatrics through the combined Pediatrics/Genetics residency co-sponsored by CNH and NHGRI.

Project description:

This project is necessary for NHGRI/DIR because it will help provide the DIR with access to CLIA/ CAP and American Board of Medical Genetics approved settings to train fellows in the laboratory techniques related to pediatric genetics, including diagnostic testing laboratories.

Children’s National Hospital has established an expansive clinical genetics program. In addition, they have a biochemical and molecular genetics laboratory that offers extensive testing, including several assays not available at other testing laboratories. Thus, our fellows need to rotate at this site in order to become proficient in the diagnosis and management of pediatric genetic disorders and in the running and interpretation of the biochemical and molecular genetic assays. The National Human Genome Research Institute (NHGRI), in conjunction with Children's National Hospital, offers a unique opportunity for medical school graduates to complete a combined, four-year residency program in pediatrics and medical genetics. There is one resident per year in this track.

Contractor Requirements:

1. Each year the training program will enroll one trainee.

2. Each trainee is expected to complete postgraduate year 1 and 2 (PGY1 and 2) at which point they will transition to become FTEs at NHGRI to complete the remaining part of the training (PGY3-5)

3. Track the progress of each resident to ensure that they will have had necessary experiences for American Board of Pediatrics (ABP) certification.

Specific tasks to be performed are:

1. The Contractor must enroll each year in the training program up to six (6) laboratory genetics and genomics fellows. Each fellow will spend two (2) weeks in the rotation.

2. The Contractor must track the progress of each fellow, to ensure the fellows will have gained necessary experiences for ABMGG certification.

Capability of Contractor Evaluation:

The Contractor shall describe procedures needed to successfully train the residents in Pediatrics and the genetic implications of the biochemical genetic tests.

Facilities:

The Contractor shall arrange to have suitable facilities, which include dedicated space for performance of administrative duties associated with tracking the progress of the pediatric residents throughout the training.

Quality Control:

The Contractor shall establish and adhere to timelines for:

The Contractor shall provide all the experiences required to achieve Accreditation Council for Graduate Medical Education (ACGME) competencies and readiness to sit for the ABP board certification.

The Contractor shall evaluate each fellow to insure they have a full understanding of all the techniques taught during training experiences.

The Contractor shall provide personnel qualifications are to be provided by the Contractor to the Project Officer for review and approval prior to the award of the contract.

Required Reports/Deliverables: Description of Reports:

The Contractor shall prepare and deliver semiannual progress reports (6-month Clinical Competency Committee reports) in the specified to the recipients designate to have two semiannual Clinical Competency Committee reports in January and June of each year.

Description of Reports:

Semiannual Progress Reports – Project Officer within 30 calendar days after each reporting period. This report shall include the following information:

1. Number of fellows instructed.

2. Number of fellows recommended to repeat all or parts of the training sessions and why.

3. A narrative explaining educational progress or any problems that happened during the 6-month period, when they occurred and how they were resolved.

Period of Performance: September 30, 2026 – September 29, 2027

Contract Type:

The contract will be awarded as a firm-fixed price, single award purchase order under FAR 13 Simplified Acquisition Threshold (SAT). A firm-fixed priced contract is being used for this acquisition because the requirement can be fully defined, described, and risk involved is minimal or can be predicted with an acceptable degree of certainty.

Government Property:

No Government furnished property will be required for this requirement.