RFQ_Attachment_2_BrandNameJustificaiton_NanoString.pdf

3. Description of the supplies or services required to meet the agency’s needs (including the estimated value).

a. Project title:

NanoString CosMx Spatial Gene Expression Library Preparation Kits (6K)

b. Project description:

NanoString’s CosMx is a commercially available high-plex in situ analysis platform that can provide spatial multiomics with formalin-fixed paraffin-embedded (FFPE) and fresh frozen (FF) tissue samples at cellular and subcellular resolution. CosMx SMI enables rapid quantification and visualization of up to 1,000 RNA and 64 validated protein analytes. It is the flexible, spatial single-cell imaging platform that will drive deeper insights for cell aliasing, tissue phenotyping, cell-cell interactions, cellular processes, and biomarker discovery. In order to continue their research, the CDSL requires four (4) CMx RNA, four (4) Inst Buffer Kit, Med, two

(2) CMx RNAse Inhib, 2 sl Kits, two (2) CMx Slide Prep Kits, FFPE RNA, two (2) CMx Hs Univ Cell Seg Kits, RNA, two (2) CMx Hs CD68 Marker Kits, RNA, two (2) CMx Hs 6K Discovery RNA Panels, two (2) CosMx SMI Flow Cells, 4 sld, four (4) CMx Cleaning Tray Kits, three (3) CMx RNA 6Kplx 2sl Img Tray Kits, and one (1) S&H 1 - 8 Kits / Slides.

Requirement type.

Research & development (R&D) R & D support services Support services (non-R&D)

X Supplies/equipment Information technology (IT) Construction Architect-engineer (A & E) services Design-build Other (specify): ____________________

Type of action

New requirement X Follow-on: 75N91023P00558 and 75N91023P00502

Other (specify):

Proposed contract/order type.

X Firm-fixed-price Other fixed-price (specify, e.g., fixed-price award-fee, fixed-price incentive-fee): __________ Cost-plus-fixed-fee Other cost reimbursement (specify, e.g., cost-plus-award-fee, cost-plus-incentive-fee): ___________ Time and materials Indefinite delivery (specify whether indefinite quantity, definite quantity, or requirements): ___________ Other (specify): ___________ Completion Form Term form

Acquisition identification number:

c. Total estimated dollar value and performance/delivery period.

The total estimated value for this requirement based on the Independent Government Estimate (IGE) is

The anticipated delivery period for the items is thirty (30) days after receipt of order.

4. Identification of the statutory authority permitting other than full and open competition.

X This acquisition is conducted under FAR 13.106-1 (b)(1)(i)

(b) Soliciting from a single source.

(1) For purchases not exceeding the simplified acquisition threshold.

(i) Contracting officers may solicit from one source if the Contracting Officer determines that the circumstances of the contract action deem only one source reasonably available (e.g., urgency, exclusive licensing agreements, brand-name or industrial mobilization).

5. Demonstration that the proposed contractor(s) unique qualifications or the nature of the acquisition requires use of the authority cited.

a. Name and address of the Brand Name contractor(s).

NanoString 530 Fairview Ave N, Suite 200 Seattle, WA 98109

b. Nature of the acquisition and proposed unique qualifications of the contractor(s).

The NCI, CCR’s, Cancer Data Science Laboratory (CDSL) has been conducting scientific research utilizing NanoString’s CosMx Spatial gene expression library preparation reagent kits (6K) in order to try and better understand tumor heterogeneity and tumor evolution. As such these kits are required to conduct further research, and to ensure scientifically comparable data to previous efforts are obtained. Utilization of a different brand or method by the CDSL for their ongoing research would result in scientifically incomparable data. A change from this platform to another at this time would require research efforts to be duplicated and additional cost to the Government. As such, no other brand of reagents is able meet the Government’s requirement at this time.

6. Description of the efforts made to ensure that offers are solicited from as many potential sources as practicable. Indicate whether a SAM.gov notice was or will be publicized as required by FAR Subpart 5.2 and, if not, which exception under FAR 5.202 applies.

As required by FAR Subpart 5.2, a SAM.gov combined synopsis solicitation will be publicized and cited as a commercial item purchase (as stated FAR Part 12) with the authority to use simplified procedures of commercial items as authorized in FAR 13.106-1 (b)(1)(ii). In accordance with FAR 5.102(a)(6), this brand name justification is being published with the solicitation.

7. Determination by the Contracting Officer that the anticipated cost/price to the Government will be fair and reasonable.

Prior to award the Contracting Officer (CO) will make a determination that the price is fair and reasonable. It is anticipated that determination will be made utilizing the IGE and historical data; however, the CO reserves the right to utilize any other means deemed appropriate in accordance with FAR 13.106-3 (a)(2).

8. Description of the market research conducted (see FAR Part 10) and the results, or a statement of the reasons market research was not conducted.

Market research for this effort included a review of historical data for similar past procurements conducted by the NCI’s CDSL and other Government entities for the purchase of the required materials. Additionally, a Source Sought Notice (SSN) #75N91024Q00139 was posted to SAM.gov on 06/26/2024 thru 06/28/2024, which upon closing received no responses.

9. Any other facts supporting the use of other than full and open competition.

All relevant information supporting the procurement of the brand name product are captured above.

10. Listing of sources, if any, that expressed, in writing, an interest in the acquisition.

At this time, no sources expressed interest in writing for the proposed acquisition.

All sources who respond to the combined synopsis solicitation will be considered.

11. Statement of the actions, if any, the agency may take to remove or overcome any barriers to competition before any subsequent acquisition for the required supplies or services.

NCI anticipates their needs will successfully be met as a result of an open market combined synopsis solicitation. If upon completion of the anticipated Purchase Order, it is identified that similar items are needed, the NCI will conduct market research to reevaluate if there are other manufacturers and products that can meet the requiring program’s needs, or better suit their research needs.

12. Program office certification.

This is to certify that the portions of this justification that have been developed by the undersigned program office personnel, including supporting information and/or data verifying the Government’s minimum needs, schedule requirements and other rationale for other than full and open competition, are accurate and complete.

Official Name & Title Signature Date

Project Officer

Project Officer’s

Immediate Supervisor

13. Contracting Officer certification.

This is to certify that the justification for the proposed acquisition has been reviewed and that to the best of my knowledge and belief the information and/or data provided to support the rationale and recommendation for approval is accurate and complete.

Official Name & Title Signature Date

Contracting Officer