RFP Att. 14_Business Proposal Budget Template_TO_4.xlsx

XLSX spreadsheet 132 KB Posted Apr 26, 2024

Attached to: Manufacturing and Nonclinical Studies Support for the Development of Therapeutic Biotechnology Products (Biologics) for Neurological related Disorders
Solicitation number: 75N95024R00050
Issued by: Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse

About this file

Written by GovTribe AI · Apr 26, 2024

This document is a Request for Proposals (RFP) for Manufacturing and Nonclinical Studies Support for the Development of Therapeutic Biotechnology Products (Biologics) for Neurological related Disorders. The National Institutes of Neurological Disorders and Stroke (NINDS) has a need for current Good Manufacturing Practices (cGMP) manufacturing and Good Laboratory Practice (GLP) nonclinical (preclinical) support services to support translational development of therapeutic biotechnology products for NIH drug discovery and development programs. The Contractor shall provide support for both Biologics cGMP manufacturing and GLP nonclinical services, including execution of the studies and completing study reports and documentation that will enable regulatory filing and evaluation of biological therapeutics in clinical trials. The RFP is a Ramp-On re-opening and re-soliciting of a previous RFP, with the purpose of adding one or more contractors to the existing Indefinite Delivery / Indefinite Quantity (IDIQ) contract pool supporting this program. The ordering period of the IDIQ contracts expires on September 29, 2030.

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Other files

File	Type	Posted
Pre-Proposal Conference_Transcript.pdf	PDF	Jun 10, 2024
Amendment 3_Questions and Responses_6.10.2024.pdf	PDF	Jun 10, 2024
Pre-Proposal Conference_Slides.pptx	PPTX presentation	Jun 10, 2024
Amendment 2_Questions and Responses_5.31.2024.pdf	PDF	May 31, 2024
Amendment 1_Questions and Responses_5.17.2024.pdf	PDF	May 17, 2024
RFP Att. 17_SF-LLL.pdf	PDF	Apr 26, 2024
RFP No. 75N95024R00050_Cover Letter.pdf	PDF	Apr 26, 2024
RFP Att. 23_STO 3 - ASO Manufacturing Task Order.pdf	PDF	Apr 26, 2024
RFP Att. 9_NIH 2043.pdf	PDF	Apr 26, 2024
RFP Att. 10_HHS Subcontracting Plan Template.docx	DOCX document	Apr 26, 2024
RFP Att. 24_STO 4 - BPN-Biologics PK and Tox Task Order.pdf	PDF	Apr 26, 2024
RFP Att. 8_Additional Technical Proposal Instructions.pdf	PDF	Apr 26, 2024
RFP Att. 22_STO 2 - AAV Manufacturing Task Order.pdf	PDF	Apr 26, 2024
RFP Att. 3_IDIQ Contract SOW.pdf	PDF	Apr 26, 2024
RFP Att. 1_Packaging and Delivery of Proposals.pdf	PDF	Apr 26, 2024
RFP Att. 19_Invoice Instructions NIH(RC)2.pdf	PDF	Apr 26, 2024
RFP Att. 18_Invoice Instructions NIH(RC)1.pdf	PDF	Apr 26, 2024
RFP Att. 7_VAS Worksheet.pdf	PDF	Apr 26, 2024
RFP Att. 5_Technical Proposal Cost Summary.pdf	PDF	Apr 26, 2024
RFP Att. 15_Points-of-contact.pdf	PDF	Apr 26, 2024
RFP Att. 20_DEC Acknowledgment.pdf	PDF	Apr 26, 2024
RFP Att. 2_Proposal Intent Response Form.pdf	PDF	Apr 26, 2024
RFP Att. 11_Business Proposal Budget Template_TO_1.xlsx	XLSX spreadsheet	Apr 26, 2024
RFP Att. 21_STO 1- Kickoff and Project Management Plan.pdf	PDF	Apr 26, 2024
RFP Att. 16_Wage Rate Determination (2023).pdf	PDF	Apr 26, 2024
RFP Att. 4_Section K RepsandCerts.pdf	PDF	Apr 26, 2024
RFP Att. 12_Business Proposal Budget Template_TO_2.xlsx	XLSX spreadsheet	Apr 26, 2024
RFP No. 75N95024R00050.pdf	PDF	Apr 26, 2024
RFP Att. 6_Summary_of_Related_Activities.pdf	PDF	Apr 26, 2024
RFP Att. 13_Business Proposal Budget Template_TO_3.xlsx	XLSX spreadsheet	Apr 26, 2024

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TO4_SUMMARY

	SUMMARY OF PROPOSED COSTS		Attachment #14 - Sample Task Order 4 – Pharmacokinetics and Toxicology Studies
	Contractor's Name**			Base Task -
Single-Dose Rat PK Study		Optional Task 1 (Study 2) -
Single-Dose Mouse PK Study		Optional Task 2 (Study 3) - Multiple-Dose Rat PK Study		Optional Task 3 (Study 4) - Multiple-Dose Mouse PK Study	Optional Task 4 (Study 5) -
PD (Tissue Distribution in Mice)		Optional Task 5

(Study 6) (multi-year) - Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis Optional Task 5 (Study 6) (multi-year) -

Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis		Optional Task 6 (Study 7) -
Dog GLP Single-Dose PK		Optional Task 7 (Study 8) -
GLP NHP Single-Dose PK		Optional Task 8 (Study 9) -
GLP Dog Multi-Dose PK		Optional Task 9 (Study 10) -
GLP NHP Multi-Dose PK		Optional Task 10 (Study 11) -
Single-dose GLP toxicity study in rats		Optional Task 11 (Study 12) -
Single-dose toxicity GLP study in NHPs		TOTAL
	RFP No.**		CONTRACT YEAR 1	CONTRACT YEAR 1	CONTRACT YEAR 1	CONTRACT YEAR 1	CONTRACT YEAR 1	CONTRACT YEAR 2	CONTRACT YEAR 3	CONTRACT YEAR 2	CONTRACT YEAR 2	CONTRACT YEAR 2	CONTRACT YEAR 2	CONTRACT YEAR 3	CONTRACT YEAR 3
		Period ( dates)##	2/1/25	2/1/25	2/1/25	2/1/25	2/1/25	2/1/26	2/1/27	2/1/26	2/1/26	2/1/26	2/1/26	2/1/27	2/1/27
			Through	Through	Through	Through	Through	Through	Through	Through	Through	Through	Through	Through	Through
			1/31/26	1/31/26	1/31/26	1/31/26	1/31/26	1/31/27	1/31/28	1/31/27	1/31/27	1/31/27	1/31/27	1/31/28	1/31/28
	Direct Labor - Percent of Effort		$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0
	Fringe Benefits - Percent of Effort		0	0	0	0	0	0	0	0	0	0	0	0	0	$0
	Direct Labor - Hourly		0	0	0	0	0	0	0	0	0	0	0	0	0	$0
	Fringe Benefits - Hourly		0	0	0	0	0	0	0	0	0	0	0	0	0	$0
	Total Direct Labor & Fringe Benefits		$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0

Overhead (Note 1) 0% $0 0% $0 0% $0 0% $0 0% $0 0% $0 $0 0% $0 $0 $0 $0 $0 $0 $0

Materials and Supplies	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0
Professional Travel	0	0	0	0	0	0	0	0	0	0	0	0	0	$0
Equipment	0	0	0	0	0	0	0	0	0	0	0	0	0	$0
Consultants	0	0	0	0	0	0	0	0	0	0	0	0	0	$0
Other Direct Costs	0	0	0	0	0	0	0	0	0	0	0	0	0	$0
Subcontracts	0	0	0	0	0	0	0	0	0	0	0	0	0	$0
Total Other Direct Costs	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0

Subtotal: Direct Labor, Fringe Benefits, Overhead , & Other Directs		$0		$0		$0		$0		$0		$0		$0		$0		$0		$0		$0		$0		$0	$0
Exclusion(s) From Base For G&A		0		0		0		0		0		0		0		0		0		0		0		0		0	$0
Adjusted Base for G&A		$0		$0		$0		$0		$0		$0		$0		$0		$0		$0		$0		$0		$0	$0
G&A (Note 2)	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	$0
Total Proposed Cost Excluding Fee		0		0		0		0		0		0		0		0		0		0		0		0		0	0
Proposed Fee/Profit	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	0%	0	$0
Total Proposed Cost Plus Fee/Profit		$0		$0		$0		$0		$0		$0		$0		$0		$0		$0		$0		$0		$0	$0

NOTES:
1.	Not all organizations allocate indirect cost in the same way. It is important that you use the indirect rate structure applicable to your organization.
	For example, if you have a two tier indirect rate structure, then you will use a two tier structure when proposing indirect costs.
	Generally, Universities and Non-Profits have fringe benefit and G&A (or sometimes called F&A) rates, while For-Profit Companies can have
	various indirect rates such as fringe benefits, overhead, G&A, etc.

The base for overhead costs includes direct labor and fringe benefits. Please modify if your base is different.

If applicable, insert exclusions to the G&A base in row 26.

2.	If you have questions regarding indirect (F&A) rates see website: http://oamp.od.nih.gov/dfas/indirect-cost-branch/indirect-cost-submission
	This website also contains definitions, examples, and training.

LEGEND:
**	Please insert the Company's name and the RFP #.

## Please insert the Company's name and the RFP #.

TO4_LABOR - Percent of Effort

SUMMARY OF DIRECT LABOR	Sample Task Order 4 – Pharmacokinetics and Toxicology Studies
AND FRINGE BENEFITS
PERCENT OF EFFORT
Contractor's Name**		Base Task

(Study 1) -

Single-Dose Rat PK Study	Optional Task 1 (Study 2) -
Single-Dose Mouse PK Study	Optional Task 2 (Study 3) -
Multiple-Dose Rat PK Study	Optional Task 3 (Study 4) - Multiple-Dose Mouse PK Study	Optional Task 4 (Study 5) -
PD (Tissue Distribution in Mice)	Optional Task 5

(Study 6) (multi-year) - Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis Optional Task 5 (Study 6) (multi-year) -

Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis	Optional Task 6 (Study 7) -
Dog GLP Single-Dose PK	Optional Task 7 (Study 8) -
GLP NHP Single-Dose PK	Optional Task 8 (Study 9) -
GLP Dog Multi-Dose PK	Optional Task 9 (Study 10) -
GLP NHP Multi-Dose PK	Optional Task 10 (Study 11) -
Single-dose GLP toxicity study in rats	Optional Task 11 (Study 12) -

Single-dose toxicity GLP study in NHPs

									Contract Year One					Contract Year One					Contract Year One					Contract Year One					Contract Year One					Contract Year Two					Contract Year Three					Contract Year Two					Contract Year Two
	RFP No.**							2/1/25	Through	1/31/26			2/1/25	Through	1/31/26			2/1/25	Through	1/31/26			2/1/25	Through	1/31/26			2/1/25	Through	1/31/26			2/1/26	Through	1/31/27			2/1/27	Through	1/31/28			2/1/26	Through	1/31/27			2/1/26	Through
				CURRENT	ADJUSTED		PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE		PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE		PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE		PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE		PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE		PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE		PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE	PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE	PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE	PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE	PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE	PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE	PERCENT
OF	NUMBER	SALARY	FRINGE	FRINGE	SALARY	FRINGE
		EMPLOYEE	POSITION	BASE SALARY	BASE SALARY		EFFORT	MONTHS	COST	RATE	COST	EFFORT	MONTHS	COST	RATE	COST	EFFORT	MONTHS	COST	RATE	COST	EFFORT	MONTHS	COST	RATE	COST	EFFORT	MONTHS	COST	RATE	COST	EFFORT	MONTHS	COST	RATE	COST	EFFORT	MONTHS	COST	RATE	COST	EFFORT	MONTHS	COST	RATE	COST	EFFORT	MONTHS	COST
	1			$0	$0		0%	12.00	$0	0%	$0	0%	12.00	$0	0%	$0	0%	12.00	$0	0%	$0	0%	12.00	$0	0%	$0	0%	12.00	$0	0%	$0	0%	12.00	$0	0%	$0	0%	12.00	$0	0%	$0	0%	12.00	$0	0%	$0	0%	12.00	$0
	2			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	3			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	4			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	5			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	6			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	7			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	8			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	9			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	10			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	11			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	12			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	13			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	14			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	15			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	16			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	17			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	18			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	19			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	20			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	21			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	22			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	23			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	24			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	25			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	26			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	27			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	28			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	29			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	30			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
	31			0	0		0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0	0%	0	0%	12.00	0
					SUBTOTALS =		0%		$0		$0	0%		$0		$0	0%		$0		$0	0%		$0		$0	0%		$0		$0	0%		$0		$0	0%		$0		$0	0%		$0		$0	0%		$0

THE FOLLOWING BOXES IN COLUMN "D" BELOW MAY BE USED TO

CALCULATE THE ADJUSTED BASE SALARY, AS INDICATED:

(Use of these cells will affect all of the adjusted base salary column; if individual

anniversary dates differ, the adjusted base salaries must be entered individually

in Column "D" of the spreadsheet and explained in the budget justification)

ANNUAL INCREASE FACTOR:	0.00%	-	Insert annual cost of living % and/or merit increases
			as applicable and explain the % in the budget justification

ANNUAL INCREASE DATE: 00/00/00 - Insert annual increase date.

NUMBER OF MONTHS AT NEXT ANNUAL INCREASE 0 - Insert number of months at the new salary.

*Adjust the number of months per period as recommended in the RFP.

TO4_LABOR - Hourly

SUMMARY OF DIRECT LABOR	Sample Task Order 4 – Pharmacokinetics and Toxicology Studies
AND FRINGE BENEFITS
Hourly Rates
Contractor's Name**		Base Task

(Study 1) -

Single-Dose Rat PK Study	Optional Task 1 (Study 2) -
Single-Dose Mouse PK Study	Optional Task 2 (Study 3) -
Multiple-Dose Rat PK Study	Optional Task 3 (Study 4) -
Multiple-Dose Mouse PK Study	Optional Task 4 (Study 5) -
PD (Tissue Distribution in Mice)	Optional Task 5

(Study 6) (multi-year) - Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis Optional Task 5 (Study 6) (multi-year) -

Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis	Optional Task 6 (Study 7) -
Dog GLP Single-Dose PK	Optional Task 7 (Study 8) -
GLP NHP Single-Dose PK	Optional Task 8 (Study 9) -
GLP Dog Multi-Dose PK	Optional Task 9 (Study 10) -
GLP NHP Multi-Dose PK	Optional Task 10 (Study 11) -
Single-dose GLP toxicity study in rats	Optional Task 11 (Study 12) -

Single-dose toxicity GLP study in NHPs

							Contract Year One					Contract Year One					Contract Year One					Contract Year One					Contract Year One					Contract Year Two					Contract Year Three					Contract Year Two					Contract Year Two
RFP No.**						2/1/25	Through	1/31/26			2/1/25	Through	1/31/26			2/1/25	Through	1/31/26			2/1/25	Through	1/31/26			2/1/25	Through	1/31/26			2/1/26	Through	1/31/27			2/1/27	Through	1/31/28			2/1/26	Through	1/31/27			2/1/26	Through	1/31/27
			CURRENT BASE	ADJUSTED	NUMBER	NUMBER	SALARY	FRINGE	FRINGE	NUMBER	NUMBER	SALARY	FRINGE	FRINGE	NUMBER	NUMBER	SALARY	FRINGE	FRINGE	NUMBER	NUMBER	SALARY	FRINGE	FRINGE	NUMBER	NUMBER	SALARY	FRINGE	FRINGE	NUMBER	NUMBER	SALARY	FRINGE	FRINGE	NUMBER	NUMBER	SALARY	FRINGE	FRINGE	NUMBER	NUMBER	SALARY	FRINGE	FRINGE	NUMBER	NUMBER	SALARY	FRINGE	FRINGE
	EMPLOYEE	POSITION	HOURLY RATE	HOURLY RATE	HOURS	MONTHS	COST	RATE	COST	HOURS	MONTHS	COST	RATE	COST	HOURS	MONTHS	COST	RATE	COST	HOURS	MONTHS	COST	RATE	COST	HOURS	MONTHS	COST	RATE	COST	HOURS	MONTHS	COST	RATE	COST	HOURS	MONTHS	COST	RATE	COST	HOURS	MONTHS	COST	RATE	COST	HOURS	MONTHS	COST	RATE	COST
1			$0.00	$0.00	0.00	12.00	$0	0%	$0	0.00	12.00	$0	0%	$0	0.00	12.00	$0	0%	$0	0.00	12.00	$0	0%	$0	0.00	12.00	$0	0%	$0	0.00	12.00	$0	0%	$0	0.00	12.00	$0	0%	$0	0.00	12.00	$0	0%	$0	0.00	12.00	$0	0%	$0
2			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
3			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
4			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
5			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
6			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
7			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
8			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
9			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
10			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
11			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
12			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
13			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
14			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
15			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
16			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
17			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
18			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
19			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
20			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
21			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
22			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
23			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
24			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
25			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
26			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
27			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
28			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
29			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
30			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
31			0.00	0.00	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0	0.00	12.00	0	0%	0
				SUBTOTALS =	0.00		$0		$0	0.00		$0		$0	0.00		$0		$0	0.00		$0		$0	0.00		$0		$0	0.00		$0		$0	0.00		$0		$0	0.00		$0		$0	0.00		$0		$0

THE FOLLOWING BOXES IN COLUMN "D" BELOW MAY BE USED TO

CALCULATE THE ADJUSTED BASE SALARY, AS INDICATED:

(Use of these cells will affect all of the adjusted base salary column; if individual

anniversary dates differ, the adjusted base salaries must be entered individually in

Column "D" of the spreadsheet and explained in the budget justification)

NUMBER OF HOURS FOR FULL TIME EQUIVALENT: 0 -- Insert your direct work year.

			Insert annual cost of living % and/or merit increases
ANNUAL INCREASE FACTOR:	0.00%	--	as applicable and explain the % in the budget
			justification

ANNUAL INCREASE DATE: 00/00/00 -- Insert annual increase date.

NUMBER OF MONTHS AT NEXT ANNUAL INCREASE 0 -- Insert number of months at the the new hourly rate.

*Adjust the number of months per period as recommended in the RFP.

TO4_Materials

SUMMARY OF MATERIALS AND SUPPLIES		Sample Task Order 4 – Pharmacokinetics and Toxicology Studies
Contractor's Name**
RFP No.**
	Base Task

(Study 1) -

Single-Dose Rat PK Study	Optional Task 1 (Study 2) -
Single-Dose Mouse PK Study	Optional Task 2 (Study 3) -
Multiple-Dose Rat PK Study	Optional Task 3 (Study 4) -
Multiple-Dose Mouse PK Study	Optional Task 4 (Study 5) -
PD (Tissue Distribution in Mice)	Optional Task 5

(Study 6) (multi-year) - Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis Optional Task 5 (Study 6) (multi-year) -

Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis	Optional Task 6 (Study 7) -
Dog GLP Single-Dose PK	Optional Task 7 (Study 8) -
GLP NHP Single-Dose PK	Optional Task 8 (Study 9) -
GLP Dog Multi-Dose PK	Optional Task 9 (Study 10) -
Single-dose GLP toxicity study in rats	Optional Task 9 (Study 11) -
GLP NHP Multi-Dose PK	Optional Task 11 (Study 12) -

Single-dose toxicity GLP study in NHPs

			Contract Year One			Contract Year One			Contract Year One			Contract Year One			Contract Year One			Contract Year Two			Contract Year Three			Contract Year Two			Contract Year Two			Contract Year Two			Contract Year Two			Contract Year Three			Contract Year Three
		2/1/25	Through	1/31/26	2/1/25	Through	1/31/26	2/1/25	Through	1/31/26	2/1/25	Through	1/31/26	2/1/25	Through	1/31/26	2/1/26	Through	1/31/27	2/1/27	Through	1/31/28	2/1/26	Through	1/31/27	2/1/26	Through	1/31/27	2/1/26	Through	1/31/27	2/1/26	Through	1/31/27	2/1/27	Through	1/31/28	2/1/27	Through	1/31/28
		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit
	ITEM	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	TOTAL
1		$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00
2		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
3		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
4		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
5		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
6		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
7		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
8		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
9		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
10		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
11		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
12		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
13		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
14		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
15		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
16		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
17		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
18		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
19		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
20		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
21		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
22		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
23		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
24		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
25		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
26		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
27		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
28		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
29		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
30		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	$0.00
	TOTAL =			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00	$0.00

Please use current catalog, historical documentation, or vendor quotes.

Supporting documentation may be requested at a later date

&24&USUMMARY OF MATERIALS AND SUPPLIES

TO4_Travel

SUMMARY OF TRAVEL COSTS	Sample Task Order 4 – Pharmacokinetics and Toxicology Studies
Contractor's Name**
RFP No.**

Cost Element Base Task (Study 1) -

Single-Dose Rat PK Study	Optional Task 1 (Study 2) -
Single-Dose Mouse PK Study	Optional Task 2 (Study 3) -
Multiple-Dose Rat PK Study	Optional Task 3 (Study 4) -
Multiple-Dose Mouse PK Study	Optional Task 4 (Study 5) -
PD (Tissue Distribution in Mice)	Optional Task 5

(Study 6) (multi-year) - Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis Optional Task 5 (Study 6) (multi-year) -

Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis	Optional Task 6 (Study 7) -
Dog GLP Single-Dose PK	Optional Task 7 (Study 8) -
GLP NHP Single-Dose PK	Optional Task 8 (Study 9) -
GLP Dog Multi-Dose PK	Optional Task 9 (Study 10) -
Single-dose GLP toxicity study in rats	Optional Task 10 (Study 11) -
GLP NHP Multi-Dose PK	Optional Task 11 (Study 12) -
Single-dose toxicity GLP study in NHPs	TOTAL
		Contract Year One	Contract Year One	Contract Year One	Contract Year One	Contract Year One	Contract Year Two	Contract Year Three	Contract Year Two	Contract Year Two	Contract Year Two	Contract Year Two	Contract Year Three	Contract Year Three
		2/1/2025 - 1/31/2026	2/1/2025 - 1/31/2026	2/1/2025 - 1/31/2026	2/1/2025 - 1/31/2026	2/1/2025 - 1/31/2026	2/1/2026 - 1/31/2027	2/1/2027 - 1/31/2028	2/1/2026 - 1/31/2027	2/1/2026 - 1/31/2027	2/1/2026 - 1/31/2027	2/1/2026 - 1/31/2027	2/1/2027 - 1/31/2028	2/1/2027 - 1/31/2028
	Trip #	1	1	1	1	1	1	1	1	1	1	1	1	1
	Site
	Reason
	Airfare	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0
	Lodging	0	0	0	0	0	0	0	0	0	0	0	0	0
	Meals	0	0	0	0	0	0	0	0	0	0	0	0	0
	Incidentals	0	0	0	0	0	0	0	0	0	0	0	0	0
	Ground Transport	0	0	0	0	0	0	0	0	0	0	0	0	0
	Total Per Trip	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0
	No. of persons	0	0	0	0	0	0	0	0	0	0	0	0	0
	SUBTOTAL =	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0

Trip #	2	2	2	2	2	2	2	2	2	2	2	2	2
Site
Reason
Airfare	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0
Lodging	0	0	0	0	0	0	0	0	0	0	0	0	0
Meals	0	0	0	0	0	0	0	0	0	0	0	0	0
Incidentals	0	0	0	0	0	0	0	0	0	0	0	0	0
Ground Transport	0	0	0	0	0	0	0	0	0	0	0	0	0
Total Per Trip	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0
No. of persons	0	0	0	0	0	0	0	0	0	0	0	0	0
SUBTOTAL =	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0

Trip #	3	3	3	3	3	3	3	3	3	3	3	3	3
Site
Reason
Airfare	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0
Lodging	0	0	0	0	0	0	0	0	0	0	0	0	0
Meals	0	0	0	0	0	0	0	0	0	0	0	0	0
Incidentals	0	0	0	0	0	0	0	0	0	0	0	0	0
Ground Transport	0	0	0	0	0	0	0	0	0	0	0	0	0
Total Per Trip	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0
No. of persons	0	0	0	0	0	0	0	0	0	0	0	0	0
SUBTOTAL =	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0
TOTAL COST =	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0

Please review the RFP for the recommended number of trips and destinations if applicable.

Please use the company or institutional travel policy unless current Government Per Diem rates

are utilized. Please use current vendor quotes for airfare and other travel costs. Supporting

documentation may be requested at a later date.

TO4_Equipment

SUMMARY OF EQUIPMENT COSTS		Sample Task Order 4 – Pharmacokinetics and Toxicology Studies
Contractor's Name**
RFP No.**
	Base Task

(Study 1) -

Single-Dose Rat PK Study	Optional Task 1 (Study 2) -
Single-Dose Mouse PK Study	Optional Task 2 (Study 3) -
Multiple-Dose Rat PK Study	Optional Task 3 (Study 4) -
Multiple-Dose Mouse PK Study	Optional Task 4 (Study 5) -
PD (Tissue Distribution in Mice)	Optional Task 5

(Study 6) (multi-year) - Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis Optional Task 5 (Study 6) (multi-year) -

Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis	Optional Task 6 (Study 7) -
Dog GLP Single-Dose PK	Optional Task 7 (Study 8) -
GLP NHP Single-Dose PK	Optional Task 8 (Study 9) -
GLP Dog Multi-Dose PK	Optional Task 9 (Study 10) -
GLP NHP Multi-Dose PK	Optional Task 10 (Study 11) -
Single-dose GLP toxicity study in rats	Optional Task 11 (Study 12) -

Single-dose toxicity GLP study in NHPs

			Contract Year One			Contract Year One			Contract Year One			Contract Year One			Contract Year One			Contract Year Two			Contract Year Three			Contract Year Two			Contract Year Two			Contract Year Two			Contract Year Two			Contract Year Three			Contract Year Three
		2/1/25	Through	1/31/26	2/1/25	Through	1/31/26	2/1/25	Through	1/31/26	2/1/25	Through	1/31/26	2/1/25	Through	1/31/26	2/1/26	Through	1/31/27	2/1/27	Through	1/31/28	2/1/26	Through	1/31/27	2/1/26	Through	1/31/27	2/1/26	Through	1/31/27	2/1/26	Through	1/31/27	2/1/27	Through	1/31/28	2/1/27	Through	1/31/28
		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit
	ITEM	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	TOTAL
1		$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00
2		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
3		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
4		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
5		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
6		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
7		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
8		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
9		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
10		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
11		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
12		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
13		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
14		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
15		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
16		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
17		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
18		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
19		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
20		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
21		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
22		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
23		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
24		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
25		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
26		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
27		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
28		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
29		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
30		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
	TOTAL =			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00	$0.00

All proposed equipment costs should include a justification and be based on current vendor quotes.

Supporting documentation may be requested at a later date.

&24&USUMMARY OF EQUIPMENT COSTS

TO4_Other Direct

	SUMMARY OF OTHER DIRECT COSTS			Sample Task Order 4 – Pharmacokinetics and Toxicology Studies
	Contractor's Name**
	RFP No.**
			Base Task (Study 1) -
Single-Dose Rat PK Study		Optional Task 1 (Study 2) -
Single-Dose Mouse PK Study		Optional Task 2 (Study 3) -
Multiple-Dose Rat PK Study		Optional Task 3 (Study 4) -
Multiple-Dose Mouse PK Study		Optional Task 4 (Study 5) -
PD (Tissue Distribution in Mice)		Optional Task 5

(Study 6) (multi-year) - Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis Optional Task 5 (Study 6) (multi-year) -

Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis	Optional Task 6 (Study 7) -
Dog GLP Single-Dose PK	Optional Task 7 (Study 8) -
GLP NHP Single-Dose PK	Optional Task 8 (Study 9) -
GLP Dog Multi-Dose PK	Optional Task 9 (Study 10) -
GLP NHP Multi-Dose PK	Optional Task 10 (Study 11) -
Single-dose GLP toxicity study in rats	Optional Task 11 (Study 12) -

Single-dose toxicity GLP study in NHPs

			Contract Year One			Contract Year One			Contract Year One			Contract Year One			Contract Year One			Contract Year Two			Contract Year Three			Contract Year Two			Contract Year Two			Contract Year Two			Contract Year Two			Contract Year Three			Contract Year Three
		2/1/25	Through	1/31/26	2/1/25	Through	1/31/26	2/1/25	Through	1/31/26	2/1/25	Through	1/31/26	2/1/25	Through	1/31/26	2/1/26	Through	1/31/27	2/1/27	Through	1/31/28	2/1/26	Through	1/31/27	2/1/26	Through	1/31/27	2/1/26	Through	1/31/27	2/1/26	Through	1/31/27	2/1/27	Through	1/31/28	2/1/27	Through	1/31/28
		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit		Unit	Unit
	ITEM	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	Price	Quantity	Subtotal	TOTAL
1		$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00	0	$0.00	$0.00
2		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
3		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
4		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
5		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
6		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
7		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
8		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
9		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
10		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
11		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
12		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
13		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
14		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
15		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
16		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
17		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
18		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
19		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
20		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
21		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
22		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
23		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
24		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
25		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
26		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
27		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
28		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
29		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
30		0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00	0	0.00	0.00
	TOTAL =			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00			$0.00	$0.00

Please use current catalog prices, or vendor quotes.

Supporting documentation may be requested at a later date.

&24&USUMMARY OF OTHER DIRECT COSTS

TO4_Consultants

	SUMMARY OF CONSULTANT COSTS	Sample Task Order 4 – Pharmacokinetics and Toxicology Studies
	Contractor's Name**
	RFP No.**
		Base Task (Study 1) -
Single-Dose Rat PK Study		Optional Task 1 (Study 2) -
Single-Dose Mouse PK Study		Optional Task 2 (Study 3) -

Multiple-Dose Rat PK Study

				Contract Year One					Contract Year One					Contract Year One
			2/1/25	Through	1/31/26			2/1/25	Through	1/31/26			2/1/25	Through	1/31/26
	CONSULTANT	Rate	# Hours	# Days	Travel	Subtotal	Rate	# Hours	# Days	Travel	Subtotal	Rate	# Hours	# Days	Travel	Subtotal
(1)		$0			$0	$0	$0			$0	$0	$0			$0	$0
(2)		0			0	0	0			0	0	0			0	$0
(3)		0			0	0	0			0	0	0			0	$0
(4)		0			0	0	0			0	0	0			0	$0
(5)		0			0	0	0			0	0	0			0	$0
(6)		0			0	0	0			0	0	0			0	$0
(7)		0			0	0	0			0	0	0			0	$0
(8)		0			0	0	0			0	0	0			0	$0
(9)		0			0	0	0			0	0	0			0	$0
(10)		0			0	0	0			0	0	0			0	$0
	TOTAL =					$0					$0					$0

	Optional Task 3 (Study 4) -
Multiple-Dose Mouse PK Study	Optional Task 4 (Study 5) -
PD (Tissue Distribution in Mice)	Optional Task 5

(Study 6) (multi-year) - Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis

				Contract Year One					Contract Year One					Contract Year Two
			2/1/25	Through	1/31/26			2/1/25	Through	1/31/26			2/1/26	Through	1/31/27
	CONSULTANT	Rate	# Hours	# Days	Travel	Subtotal	Rate	# Hours	# Days	Travel	Subtotal	Rate	# Hours	# Days	Travel	Subtotal
(1)		$0			$0	$0	$0			$0	$0	$0			$0	$0
(2)		0			0	0	0			0	$0	0			0	$0
(3)		0			0	0	0			0	$0	0			0	$0
(4)		0			0	0	0			0	$0	0			0	$0
(5)		0			0	0	0			0	$0	0			0	$0
(6)		0			0	0	0			0	$0	0			0	$0
(7)		0			0	0	0			0	$0	0			0	$0
(8)		0			0	0	0			0	$0	0			0	$0
(9)		0			0	0	0			0	$0	0			0	$0
(10)		0			0	0	0			0	$0	0			0	$0
	TOTAL =					$0					$0					$0

Optional Task 5 (Study 6) (multi-year) -

Assay Development, and/or Qualification, and/or Validation, and/or Plasma and Tissue Sample Analysis	Optional Task 6 (Study 7) -
Dog GLP Single-Dose PK	Optional Task 7 (Study 8) -

GLP NHP Single-Dose PK

				Contract Year Three					Contract Year Two					Contract Year Two
			2/1/27	Through	1/31/28			2/1/26	Through	1/31/27			2/1/26	Through	1/31/27
	CONSULTANT	Rate	# Hours	# Days	Travel	Subtotal	Rate	# Hours	# Days	Travel	Subtotal	Rate	# Hours	# Days	Travel	Subtotal
(1)		$0			$0	0	$0			$0	$0	$0			$0	$0
(2)		0			0	0	0			0	0	0			0	0
(3)		0			0	0	0			0	0	0			0	0
(4)		0			0	0	0			0	0	0			0	0
(5)		0			0	0	0			0	0	0			0	0
(6)		0			0	0	0			0	0	0			0	0
(7)		0			0	0	0			0	0	0			0	0
(8)		0			0	0	0			0	0	0			0	0
(9)		0			0	0	0			0	0	0			0	0
(10)		0			0	0	0			0	0	0			0	0
	TOTAL =					$0					$0					$0

	Optional Task 8 (Study 9) -
GLP Dog Multi-Dose PK	Optional Task 9 (Study 11) -
GLP NHP Multi-Dose PK	Optional Task 10 (Study 10) -

Single-dose GLP toxicity study in rats

				Contract Year Two					Contract Year Two					Contract Year Three
			2/1/26	Through	1/31/27			2/1/26	Through	1/31/27			2/1/27	Through	1/31/28
	CONSULTANT	Rate	# Hours	# Days	Travel	Subtotal	Rate	# Hours	# Days	Travel	Subtotal	Rate	# Hours	# Days	Travel	Subtotal
(1)		$0			$0	$0	$0			$0	$0	$0			$0	$0
(2)		0			0	0	0			0	0	0			0	0
(3)		0			0	0	0			0	0	0			0	0
(4)		0			0	0	0			0	0	0			0	0
(5)		0			0	0	0			0	0	0			0	0
(6)		0			0	0	0			0	0	0			0	0
(7)		0			0	0	0			0	0	0			0	0
(8)		0			0	0	0			0	0	0			0	0
(9)		0			0	0	0			0	0	0			0	0
(10)		0			0	0	0			0	0	0			0	0
	TOTAL =					$0					$0					$0

Optional Task 11 (Study 12) - Single-dose toxicity GLP study in NHPs

				Contract Year Three
			2/1/27	Through	1/31/28
	CONSULTANT	Rate	# Hours	# Days	Travel	Subtotal	TOTAL
(1)		$0			$0	$0	$0
(2)		0			0	0	$0
(3)		0			0	0	$0
(4)		0			0	0	$0
(5)		0			0	0	$0
(6)		0			0	0	$0
(7)		0			0	0	$0
(8)		0			0	0	$0
(9)		0			0	0	$0
(10)		0			0	0	$0
	TOTAL =					$0	$0

TO4_Subcontracts

	SUMMARY OF SUBCONTRACTOR COSTS			Sample Task Order 4 – Pharmacokinetics and Toxicology Studies
	Contractor's Name**
	RFP No.**
		SUBCONTRACT #	Base Task (Study 1) -
Single-Dose Rat PK Study	Optional Task 1 (Study 2) -

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File details come from the government source that posted it. Updated Apr 26, 2024.