RFA-HL-26-009-Full-Announcement.html

This is a Request for Application (RFA) announcement for a limited competition to fund Clinical Research Sites (CRS) for the MACS/WIHS Combined Cohort Study (MWCCS) under cooperative agreement U01. The funding opportunity aims to renew an epidemiological cohort study of HIV in US adults for 2026-2032, following over 5,600 participants including both people living with HIV (PLWH) and without HIV (PLWOH). The study will use a populomics approach examining health determinants across multiple scales from molecular to sociopolitical levels.

The opportunity is limited to institutions previously funded under RFA-HL-19-008 and will support up to 13 Clinical Research Sites. It is administered by the NIH Department of Health and Human Services and runs parallel to two companion U01 opportunities: RFA-HL-26-010 for a Data Analysis and Sharing Center and RFA-HL-26-011 for a Leadership and Coordination Center. The grant spans multiple NIH research programs including women's health, lung diseases, cardiovascular diseases, cancer prevention, mental health, alcohol research, drug addiction, infectious diseases, minority health, aging research, and sleep disorders research.