RFA-DA-25-078-Full-Announcement.html

This is a Request for Application (RFA) announcement for the HEAL Initiative focused on translational research to address the overdose crisis. The opportunity (RFA-DA-25-078) is administered by the Department of Health and Human Services National Institutes of Health and uses an R61/R33 phased innovation award mechanism with clinical trials being optional.

The RFA serves as a parent announcement for the HEAL Initiative Translation to Practice Team, specifically targeting research on overdose deaths and the intersection of pain and Opioid Use Disorder (OUD). It works in conjunction with several Notice of Special Interest (NOSI) announcements covering workforce development, exposure to violence, and leveraging inpatient hospitalizations. The grant opportunity is open to a wide range of applicants including small businesses, government entities, nonprofits, educational institutions, and tribal organizations. It falls under multiple CFDA programs including Mental Health Research (93.242), Drug Use and Addiction Research (93.279), Alcohol Research (93.273), Child Health and Development (93.865), Complementary Health (93.213), and Aging Research (93.866).