PD_PD_Purchase-Description.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

NCATS ETB is looking to expand its covalent screening library of small molecules.

Adding diversity to chemical libraries is imperative to our operation, as we screen a variety of targets against these in-house collections.

2. Background Information and Objective:

The current DPI compound collection notably lacks a collection of custom covalent libraries. Covalent inhibitors offer several advantages, including the ability to target proteins considered undruggable in live cells, the development of novel affinity-based probes, enhanced potency, and prolonged duration of action. This approach is particularly appealing in both medicinal chemistry and chemical biology research.

Acquiring these compounds from Enamine is imperative to development of a focused, custom covalent library that spans a broader and more diverse chemical space.

Screening compounds with reactive warheads has emerged as a promising strategy to both discover and validate new targets, and to identify hits for targets that are otherwise considered undruggable. Acquiring such a library will provide complete access to resources for DPI groups, thereby advancing their programs and enhancing or complementing their quantitative high-throughput screening (qHTS) campaigns.

3. Generic Name of Product: Custom Covalent Library

4. Purchase Description:

Provided in separate excel file

5. Salient characteristics:

1. Small molecules must have validated biological and pharmacological activities.

2. Must be available for high-throughput screening (HTS) and high-content screening

(HCS).

3. Must come with detailed biological and chemical information with LC/MS and/or NMR reports to ensure high quality.

4. Guaranteed to have a purity of >90% (accuracy +/-5%) that is to be confirmed by

NMR and/or LCMS spectra.

6. Quantity:

Please see section 4 (purchase description)

7. Delivery Date:

One-time delivery to be made within six (6) weeks after receipt of order

8. Period of Performance: N/A

9. Option(s): N/A

ID Catalog ID Amount, umol Price, USD Comment Lead time Collection SMILES Set s275550____18175226____18168390____17777574 Z5080548655 1.6 138.3 4-6 weeks mRDB CN1CC=2C=CC(CN(CC3=CC=4C(Br)=CC=CC4S3)S(=O)(=O)F)=CC2C1=O Sulfamoyl fluorides s275550____18177890____18166464____17777574 Z5080761640 1.6 138.3 4-6 weeks mRDB COC=1C=CC=2SC(CN(CC=3C=CC=4C(=O)N(C)CC4C3)S(=O)(=O)F)=CC2C1 Sulfamoyl fluorides s275550____18177890____16729700____17777574 Z5080807960 1.6 138.3 4-6 weeks mRDB CN1CC=2C=C(CN(CC3=CN(N=C3C)C=4C=CC=CC4)S(=O)(=O)F)C=CC2C1=O Sulfamoyl fluorides s275550____18167164____18687340____17777574 Z9354372511 1.6 138.3 4-6 weeks mRDB C[C@H](F)CCN(CC1=NOC=C1C(C)(C)C)S(=O)(=O)F Sulfamoyl fluorides s275550____18176158____18162392____17777574 Z9354372514 1.6 138.3 4-6 weeks mRDB CCC(CN(CC=1C=CC(SC)=C(OC)C1)S(=O)(=O)F)OC Sulfamoyl fluorides s275550____18176184____17777468____17777574 Z9354372527 1.6 138.3 4-6 weeks mRDB CC(C)C(C)CN(CC=1C=CC(=O)N(C)C1)S(=O)(=O)F Sulfamoyl fluorides s275550____18170716____16731316____17777574 Z9354372539 1.6 138.3 4-6 weeks mRDB CCS(=O)CCN(CC=1C=C(Cl)C=C2CCOC21)S(=O)(=O)F Sulfamoyl fluorides s275550____18180510____17777334____17777574 Z9354372543 1.6 138.3 4-6 weeks mRDB CNC(=O)OCCCN(CC=1C=CC=CC1C2CC2)S(=O)(=O)F Sulfamoyl fluorides s275550____19116650____18163406____17777574 Z9354372548 1.6 138.3 4-6 weeks mRDB CC(C)CC(C)CN(CC1=CN(C)N=C1C2CCC2)S(=O)(=O)F Sulfamoyl fluorides s275550____18180574____16731498____17777574 Z9354372551 1.6 138.3 4-6 weeks mRDB CCC(C)(COC)CN(CC=1C=CC=C(OC2CC2)C1F)S(=O)(=O)F Sulfamoyl fluorides s275550____18167224____16729616____17777574 Z9354372555 1.6 138.3 4-6 weeks mRDB CCOC[C@@H](C)N(CC=1C(OC)=CC=C2C=CC=CC12)S(=O)(=O)F Sulfamoyl fluorides s275550____18168164____16731844____17777574 Z9354372558 1.6 138.3 4-6 weeks mRDB CCC(CC)CN(CC=1C=CC=2N(C)C(=O)SC2C1)S(=O)(=O)F Sulfamoyl fluorides s275550____18163714____16732062____17777574 Z9354372561 1.6 138.3 4-6 weeks mRDB CC(C)(O)C(C)(C)CN(CC1=CC=NN1CC2CCC2)S(=O)(=O)F Sulfamoyl fluorides s275550____21533616____18162936____17777574 Z9354372564 1.6 138.3 4-6 weeks mRDB CC(O)(CN(CC1=NC=2CCCCCC2S1)S(=O)(=O)F)C(F)F Sulfamoyl fluorides s275550____17775208____16731662____17777574 Z9354372566 1.6 138.3 4-6 weeks mRDB CNC(=O)CCN(CC1=CN=C(S1)C=2C=CC(Cl)=CC2)S(=O)(=O)F Sulfamoyl fluorides s275550____20029298____16731638____17777574 Z9354372569 1.6 138.3 4-6 weeks mRDB CC(C)CC(C#C)N(CC=1C=CC=2N(C)C(=O)CCC2C1)S(=O)(=O)F Sulfamoyl fluorides s275550____18160114____18160902____17777574 Z9354372572 1.6 138.3 4-6 weeks mRDB COC[C@H](C)N(CC=1C=CC=C(CC2CCC2)C1)S(=O)(=O)F Sulfamoyl fluorides s275550____18180710____18169580____17777574 Z9354372581 1.6 138.3 4-6 weeks mRDB CCOC(CN(CC=1C=CSC1S(=O)(=O)C)S(=O)(=O)F)C2CCC2 Sulfamoyl fluorides s275550____18168008____18160694____17777574 Z9354372583 1.6 138.3 4-6 weeks mRDB CC(O)C(C)N(CC=1C=CC=C(CC=2C=CC=CC2)C1)S(=O)(=O)F Sulfamoyl fluorides s275550____18167480____16731078____17777574 Z9354372595 1.6 138.3 4-6 weeks mRDB CCC(O)CN(CC=1C=CC=2OC=3C=CC=CC3C2C1)S(=O)(=O)F Sulfamoyl fluorides s275550____18176178____18168842____17777574 Z9354372601 1.6 138.3 4-6 weeks mRDB CN1N=C(Br)C=C1CN(C2CC32CCC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18166934____18160478____17777574 Z9354372608 1.6 138.3 4-6 weeks mRDB CC(C)N1CC(C)(CN(CC2=CC=C(S2)C(C)(C)C)S(=O)(=O)F)C1=O Sulfamoyl fluorides s275550____18714736____18176160____17777574 Z9354372613 1.6 138.3 4-6 weeks mRDB CC(C)C=1C=C(CN(CC(C)N2N=C(C)C=C2C)S(=O)(=O)F)ON1 Sulfamoyl fluorides s275550____18172128____17776924____17777574 Z9354372619 1.6 138.3 4-6 weeks mRDB COC(C)(C)CCN(CC1=CC=C(O1)C2=NC=3C=CC=CC3S2)S(=O)(=O)F Sulfamoyl fluorides s275550____18160146____16730172____17777574 Z9354372621 1.6 138.3 4-6 weeks mRDB CC(C)CC=1C=CC(CN(CCCC2CC2)S(=O)(=O)F)=CC1 Sulfamoyl fluorides s275550____18169406____16731320____17777574 Z9354372623 1.6 138.3 4-6 weeks mRDB CC1=CN(C)N=C1CN(CC2CCC3CC32)S(=O)(=O)F Sulfamoyl fluorides s275550____18179698____16729810____17777574 Z9354372626 1.6 138.3 4-6 weeks mRDB FC=1C=CC(CN(CCC2CCC2)S(=O)(=O)F)=CC1Br Sulfamoyl fluorides s275550____18163414____16730430____17777574 Z9354372629 1.6 138.3 4-6 weeks mRDB CC=1C=CC=C(CN(CC2CC(=C)C2)S(=O)(=O)F)C1F Sulfamoyl fluorides s275550____18168832____16731522____17777574 Z9354372631 1.6 138.3 4-6 weeks mRDB CC(C)(C)OC1CC(N(CC2=CC(C#N)=CS2)S(=O)(=O)F)C31CCC3 Sulfamoyl fluorides s275550____17775556____16730996____17777574 Z9354372633 1.6 138.3 4-6 weeks mRDB CC(C)(O)CN(CC1=CSC(=N1)C=2C=CC=3OCOC3C2)S(=O)(=O)F Sulfamoyl fluorides s275550____18160126____18160478____17777574 Z9354372638 1.6 138.3 4-6 weeks mRDB CC(C)(C)C1=CC=C(CN(CCOC2CCC2)S(=O)(=O)F)S1 Sulfamoyl fluorides s275550____18169492____18169780____17777574 Z9354372643 1.6 138.3 4-6 weeks mRDB CC(C)N1C=CC(CN(CC2C(F)(F)C32CCC3)S(=O)(=O)F)=N1 Sulfamoyl fluorides s275550____18171270____16732036____17777574 Z9354372649 1.6 138.3 4-6 weeks mRDB FC(F)(F)C1=CSC=C1CN(C2CC3(CCC3)C2)S(=O)(=O)F Sulfamoyl fluorides s275550____18178492____16730164____17777574 Z9354372654 1.6 138.3 4-6 weeks mRDB CC(C)N1CC(CCC1=O)N(CC=2SC=CC2Br)S(=O)(=O)F Sulfamoyl fluorides s275550____18176158____18168910____17777574 Z9354372660 1.6 138.3 4-6 weeks mRDB CCC(CN(CC=1C=CC(=CC1)C(=O)N2CCCCC2)S(=O)(=O)F)OC Sulfamoyl fluorides s275550____18177038____21215356____17777574 Z9354372662 1.6 138.3 4-6 weeks mRDB CC=1C=CC(=CC1CN(C[C@@H]2CCC(=O)N2)S(=O)(=O)F)C(F)(F)F Sulfamoyl fluorides s275550____18166052____18161500____17777574 Z9354372671 1.6 138.3 4-6 weeks mRDB CC(CCC=1C=CC=CC1)CN(CC2(C)CC2(Cl)Cl)S(=O)(=O)F Sulfamoyl fluorides s275550____18169598____16729628____17777574 Z9354372678 1.6 138.3 4-6 weeks mRDB CSC=1C=CC(CN(C2CS(=O)(=O)N(C)C2(C)C)S(=O)(=O)F)=CC1 Sulfamoyl fluorides s275550____21848250____16729738____17777574 Z9354372683 1.6 138.3 4-6 weeks mRDB CCCOC=1C=CC(CN([C@@H]2C[C@@H]3CC[C@H]2C3)S(=O)(=O)F)=CC1 |&1:10,12,15,r| Sulfamoyl fluorides s275550____18171590____17777296____17777574 Z9354372687 1.6 138.3 4-6 weeks mRDB CC(CC1CC1)N(CC2=CC(=NN2C)C3CC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18169802____16729836____17777574 Z9354372690 1.6 138.3 4-6 weeks mRDB CCOC=1C=C(CN(CC23CCCC3C2(F)F)S(=O)(=O)F)C=C(Cl)C1OC Sulfamoyl fluorides s275550____18179776____16732010____17777574 Z9354372699 1.6 138.3 4-6 weeks mRDB CN1N=NC(Br)=C1CN(CC2CC3(C2)CC(F)(F)C3)S(=O)(=O)F Sulfamoyl fluorides s275550____18172662____18176832____17777574 Z9354372701 1.6 138.3 4-6 weeks mRDB CCC(C)N1N=CC=C1CN(CC2(CCC3CC2)C3)S(=O)(=O)F Sulfamoyl fluorides s275550____18174454____18164668____17777574 Z9354372705 1.6 138.3 4-6 weeks mRDB CC1(CCN(CC=2C=NN(CC(F)(F)F)C2C3CC3)S(=O)(=O)F)CC1(F)F Sulfamoyl fluorides s275550____18174568____16730722____17777574 Z9354372709 1.6 138.3 4-6 weeks mRDB CCC1=NC(CN(C2CC3(C2)COC(C)(C)C3)S(=O)(=O)F)=CS1 Sulfamoyl fluorides s275550____18163522____18179280____17777574 Z9354372711 1.6 138.3 4-6 weeks mRDB CC(C)(C)N1N=CC=C1CN(CC(O)(C2CC2)C3CC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18168832____18168992____17777574 Z9354372714 1.6 138.3 4-6 weeks mRDB CC=1C=CC=C(F)C1CN(C2CC(OC(C)(C)C)C32CCC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18166694____17777214____17777574 Z9354372716 1.6 138.3 4-6 weeks mRDB CC1=CC(CN(C2CC3CCC(C2)O3)S(=O)(=O)F)=CS1 Sulfamoyl fluorides s275550____18164242____16730164____17777574 Z9354372720 1.6 138.3 4-6 weeks mRDB CC1(C)C(CN(CC=2SC=CC2Br)S(=O)(=O)F)CCS1(=O)=O Sulfamoyl fluorides s275550____18160512____17777332____17777574 Z9354372724 1.6 138.3 4-6 weeks mRDB COCC=1C=CC=CC1CN(C[C@H](O)C=2C=CC(Cl)=CC2)S(=O)(=O)F Sulfamoyl fluorides s275550____18163522____18169172____17777574 Z9354372727 1.6 138.3 4-6 weeks mRDB CC(F)(F)C=1C=CC=C(CN(CC(O)(C2CC2)C3CC3)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____18180286____18161026____17777574 Z9354372730 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CSC1Br)C2CC3(C2)CCOCC3 Sulfamoyl fluorides s275550____18176054____18179772____17777574 Z9354372735 1.6 138.3 4-6 weeks mRDB CCCN1N=CC(CN(CCN2CCCOC2=O)S(=O)(=O)F)=C1C Sulfamoyl fluorides s275550____16730304____19116856____17777574 Z9354372738 1.6 138.3 4-6 weeks mRDB CCN1N=NC(CN(CC2=CC=C(O2)C3CC3C)S(=O)(=O)F)=N1 Sulfamoyl fluorides s275550____17775138____16731980____17777574 Z9354372741 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CCC(=O)N1CCCC1)CC2=CC(Br)=C(Cl)S2 Sulfamoyl fluorides s275550____18166794____16729670____17777574 Z9354372743 1.6 138.3 4-6 weeks mRDB CC=1C=CC(CN(C2CCCCC32CC3)S(=O)(=O)F)=C(C)C1 Sulfamoyl fluorides s275550____18177516____17777148____17777574 Z9354372745 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1=NC(Br)=CS1)C2CN(C2)C(=O)C3CC3 Sulfamoyl fluorides s275550____17775758____18167366____17777574 Z9354372747 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CC=C(OCC=C)C1)C2CCCS(=O)(=O)C2 Sulfamoyl fluorides s275550____18175200____16732048____17777574 Z9354372749 1.6 138.3 4-6 weeks mRDB CCN1N=CC(CN(C[C@@H]2[C@H](C3CCC2CC3)C(F)(F)F)S(=O)(=O)F)=N1 |&1:9,10,r| Sulfamoyl fluorides s275550____18180416____16731454____17777574 Z9354372752 1.6 138.3 4-6 weeks mRDB COCCN1C=C(CN([C@@H]2C[C@@H]3CCCCC[C@H]23)S(=O)(=O)F)C=N1 |&1:9,11,17,r| Sulfamoyl fluorides s275550____18175342____18179064____17777574 Z9354372755 1.6 138.3 4-6 weeks mRDB CC(C)(C)C1=CSC(CN(C2CCC3(C2)OCCO3)S(=O)(=O)F)=N1 Sulfamoyl fluorides s275550____18161558____16730916____17777574 Z9354372757 1.6 138.3 4-6 weeks mRDB CCN1C=C(CN(C[C@@]23CCC[C@H]3CCO2)S(=O)(=O)F)C=N1 |&1:8,12,r| Sulfamoyl fluorides s275550____18177478____20056936____17777574 Z9354372759 1.6 138.3 4-6 weeks mRDB CCC(C1CCC1)N(CC2(CC2)C=3C=CC=CC3Cl)S(=O)(=O)F Sulfamoyl fluorides s275550____18170062____16731000____17777574 Z9354372762 1.6 138.3 4-6 weeks mRDB COC(C)(CN(CC=1C=CC=2OC(C)(C)CC2C1)S(=O)(=O)F)C3CC3 Sulfamoyl fluorides s275550____18161284____17777468____17777574 Z9354372766 1.6 138.3 4-6 weeks mRDB CC(C)OC=1C=CC=CC1[C@@H](C)N(CC=2C=CC(=O)N(C)C2)S(=O)(=O)F Sulfamoyl fluorides s275550____18168780____17777512____17777574 Z9354372769 1.6 138.3 4-6 weeks mRDB CC[C@@H]1OCC[C@H]1N(C[C@@H]2C[C@H]2C=3C=CC=CC3)S(=O)(=O)F |&1:2,6,&2:9,11,r| Sulfamoyl fluorides s275550____18169352____18168842____17777574 Z9354372774 1.6 138.3 4-6 weeks mRDB CN1N=C(Br)C=C1CN(C[C@@H]2C[C@H]2C3=CC=CO3)S(=O)(=O)F |&1:10,12,r| Sulfamoyl fluorides s275550____18180710____18164668____17777574 Z9354372776 1.6 138.3 4-6 weeks mRDB CCOC(CN(CC=1C=NN(CC(F)(F)F)C1C2CC2)S(=O)(=O)F)C3CCC3 Sulfamoyl fluorides s275550____17776064____17777296____17777574 Z9354372778 1.6 138.3 4-6 weeks mRDB CN1N=C(C=C1CN(C2CCCC(F)(F)C2)S(=O)(=O)F)C3CC3 Sulfamoyl fluorides s275550____18179938____18172412____17777574 Z9354372781 1.6 138.3 4-6 weeks mRDB CCN1C=C(CN(CCOC2CC2)S(=O)(=O)F)C(=N1)C3CC3 Sulfamoyl fluorides s275550____18167234____16731346____17777574 Z9354372784 1.6 138.3 4-6 weeks mRDB CC1CC(CO)(CN(CC=2C=CC(=CC2)C3CC3)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____18176118____16730400____17777574 Z9354372788 1.6 138.3 4-6 weeks mRDB COC(=O)C1=CC(CN(CC=2C=CC=3OC(F)(F)OC3C2)S(=O)(=O)F)=CN1C Sulfamoyl fluorides s275550____21686252____16731556____17777574 Z9354372791 1.6 138.3 4-6 weeks mRDB COCC=1C=CC=C(CN(C2CC=3C=CC=C(OC)C3C2)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____18168414____18174240____17777574 Z9354372799 1.6 138.3 4-6 weeks mRDB CC(F)(F)C=1C=CC(CN(CCOCC2CCCC2)S(=O)(=O)F)=CC1 Sulfamoyl fluorides s275550____18172306____16731920____17777574 Z9354372802 1.6 138.3 4-6 weeks mRDB CCN1C=C(Br)C(CN(CC2=NN(CC)C=3C=CC=CC23)S(=O)(=O)F)=N1 Sulfamoyl fluorides s275550____17775558____18169336____17777574 Z9354372808 1.6 138.3 4-6 weeks mRDB CC=1N=C2CCC(CN2N1)N(CC=3C=C(F)C=CC3C(F)(F)F)S(=O)(=O)F Sulfamoyl fluorides s275550____18161902____16731346____17777574 Z9354372817 1.6 138.3 4-6 weeks mRDB COC1(CN(CC=2C=CC(=CC2)C3CC3)S(=O)(=O)F)CCSC1 Sulfamoyl fluorides s275550____18173486____17777322____17777574 Z9354372819 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CCC=1C=CSC1)CC=2C=C3CCCN3N2 Sulfamoyl fluorides s275550____18164540____18163018____17777574 Z9354372823 1.6 138.3 4-6 weeks mRDB CC(C)C1=NN(C=C1CN([C@H]2C[C@@H](C2)C=3C=CC=CC3)S(=O)(=O)F)C(C)(C)C Sulfamoyl fluorides s275550____18177976____17777380____17777574 Z9354372826 1.6 138.3 4-6 weeks mRDB FC(F)(F)CN1C=C(CN(CC=2C=CC=C(C2)C3CC3)S(=O)(=O)F)C=N1 Sulfamoyl fluorides s275550____18166056____17777528____17777574 Z9354372828 1.6 138.3 4-6 weeks mRDB CCO[C@@H]1CCCC[C@H]1N(CC2=CC=NN2C3CCC3)S(=O)(=O)F |&1:3,8,r| Sulfamoyl fluorides s275550____18180710____18159364____17777574 Z9354372832 1.6 138.3 4-6 weeks mRDB CCOC(CN(CC1=CSC=2C=CC(Br)=CC12)S(=O)(=O)F)C3CCC3 Sulfamoyl fluorides s275550____18174602____13398242____17777574 Z9354372837 1.6 138.3 4-6 weeks mRDB CC=1C=CSC1CN(C[C@@]23C[C@H]3COC42CCC4)S(=O)(=O)F |&1:9,11,r| Sulfamoyl fluorides s275550____17775974____18173466____17777574 Z9354372843 1.6 138.3 4-6 weeks mRDB CC1CC=2C=C(CN(C3CN(CC(F)(F)F)C(=O)C3)S(=O)(=O)F)C=CC2O1 Sulfamoyl fluorides s275550____17775058____18171742____17777574 Z9354372845 1.6 138.3 4-6 weeks mRDB CC(C)(C)C1=CC(CN(C2CCC3(CC2)OCCO3)S(=O)(=O)F)=NO1 Sulfamoyl fluorides s275550____18173846____16730200____17777574 Z9354372847 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1SC=CC1Cl)C(C2CCC2)C3CCOC3 Sulfamoyl fluorides s275550____16729988____16731980____17777574 Z9354372848 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CCCOCC1CCCO1)CC2=CC(Br)=C(Cl)S2 Sulfamoyl fluorides s275550____18169390____16729856____17777574 Z9354372851 1.6 138.3 4-6 weeks mRDB CC1=NOC(C)=C1CN(CC2CCC3(CCC3)CO2)S(=O)(=O)F Sulfamoyl fluorides s275550____18717854____18160478____17777574 Z9354372854 1.6 138.3 4-6 weeks mRDB CC(C)(C)C1=CC=C(CN(C2CCOC3(CCCC3)C2)S(=O)(=O)F)S1 Sulfamoyl fluorides s275550____18175490____16731812____17777574 Z9354372857 1.6 138.3 4-6 weeks mRDB CC1=CC=C(CN(CC2=CN=C(S2)C3CCC3)S(=O)(=O)F)O1 Sulfamoyl fluorides s275550____18162370____16730710____17777574 Z9354372862 1.6 138.3 4-6 weeks mRDB CC(CN1N=C(C)C=C1C)N(CC2=CSC(=N2)C3CC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18166506____16730234____17777574 Z9354372865 1.6 138.3 4-6 weeks mRDB COC=1C=CC(CN(CCC2CC2)S(=O)(=O)F)=C3C=CC=CC13 Sulfamoyl fluorides s275550____18163306____18176902____17777574 Z9354372880 1.6 138.3 4-6 weeks mRDB CO[C@@H]1CCC[C@H]1N(CC=2C=NN(CC3CCC3)C2)S(=O)(=O)F |&1:2,6,r| Sulfamoyl fluorides s275550____18169012____18176408____17777574 Z9354372883 1.6 138.3 4-6 weeks mRDB C[C@H](C1CC1)N(CC=2C=CC(=CC2)N3C=CC(C)=N3)S(=O)(=O)F Sulfamoyl fluorides s275550____17776550____16729542____17777574 Z9354372885 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1CCCCS1(=O)=O)CC=2C=CC(Cl)=CC2Cl Sulfamoyl fluorides s275550____17775208____18170118____17777574 Z9354372889 1.6 138.3 4-6 weeks mRDB CNC(=O)CCN(CC1=CN(N=C1C=2C=CC=C(Cl)C2)C=3C=CC=CC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18168836____16730754____17777574 Z9354372896 1.6 138.3 4-6 weeks mRDB FC1(CN(CC2=CSC(=N2)C=3C=CSC3)S(=O)(=O)F)CCC1 Sulfamoyl fluorides s275550____18171300____18160478____17777574 Z9354372904 1.6 138.3 4-6 weeks mRDB CC(C)(C)C1=CC=C(CN(CC2=NN=NN2CC3CC3)S(=O)(=O)F)S1 Sulfamoyl fluorides s275550____18176178____18165984____17777574 Z9354372909 1.6 138.3 4-6 weeks mRDB CC1(C)CCC=2C=C(CN(C3CC43CCC4)S(=O)(=O)F)C=CC21 Sulfamoyl fluorides s275550____18164436____20056936____17777574 Z9354372910 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1(CC1)C=2C=CC=CC2Cl)C3CCOCC3 Sulfamoyl fluorides s275550____18166934____16730396____17777574 Z9354372912 1.6 138.3 4-6 weeks mRDB CC(C)N1CC(C)(CN(CC=2C=CC=C3OC(F)(F)OC32)S(=O)(=O)F)C1=O Sulfamoyl fluorides s275550____21533790____16730396____17777574 Z9354372914 1.6 138.3 4-6 weeks mRDB OC(CC1CC1)CN(CC=2C=CC=C3OC(F)(F)OC32)S(=O)(=O)F Sulfamoyl fluorides s275550____18177996____17777378____17777574 Z9354372916 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CC(OCC2CC2)=CC1)CC3(Br)CC3 Sulfamoyl fluorides s275550____18178294____17777434____17777574 Z9354372919 1.6 138.3 4-6 weeks mRDB CC1CCCC(C1)N(CC2=CN(CC3CC3)N=N2)S(=O)(=O)F Sulfamoyl fluorides s275550____17775734____16731316____17777574 Z9354372922 1.6 138.3 4-6 weeks mRDB CCN1CC(CC1=O)N(CC=2C=C(Cl)C=C3CCOC32)S(=O)(=O)F Sulfamoyl fluorides s275550____18164280____16730754____17777574 Z9354372925 1.6 138.3 4-6 weeks mRDB CC1COCC1N(CC2=CSC(=N2)C=3C=CSC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18166934____16731294____17777574 Z9354372926 1.6 138.3 4-6 weeks mRDB CC(C)N1CC(C)(CN(CC2=CN=C3C=CC(C)=CN23)S(=O)(=O)F)C1=O Sulfamoyl fluorides s275550____18173272____16730166____17777574 Z9354372930 1.6 138.3 4-6 weeks mRDB CSC1=CC=C(CN(CCNC(=O)C2CCCC2)S(=O)(=O)F)S1 Sulfamoyl fluorides s275550____18176178____16731104____17777574 Z9354372933 1.6 138.3 4-6 weeks mRDB CC1(C)CC=2C=CC=C(CN(C3CC43CCC4)S(=O)(=O)F)C2O1 Sulfamoyl fluorides s275550____18177318____18178918____17777574 Z9354372937 1.6 138.3 4-6 weeks mRDB COC=1C(CN(CC(F)(F)C2CC2)S(=O)(=O)F)=CC=C3C=CC=CC13 Sulfamoyl fluorides s275550____18165970____17777468____17777574 Z9354372942 1.6 138.3 4-6 weeks mRDB CN1C=C(CN(CCC2CCCCC2(F)F)S(=O)(=O)F)C=CC1=O Sulfamoyl fluorides s275550____18174454____18162936____17777574 Z9354372945 1.6 138.3 4-6 weeks mRDB CC1(CCN(CC2=NC=3CCCCCC3S2)S(=O)(=O)F)CC1(F)F Sulfamoyl fluorides s275550____18168834____16732062____17777574 Z9354372948 1.6 138.3 4-6 weeks mRDB CCO[C@@H]1COC[C@H]1N(CC2=CC=NN2CC3CCC3)S(=O)(=O)F |&1:3,7,r| Sulfamoyl fluorides s275550____18166934____16731544____17777574 Z9354372950 1.6 138.3 4-6 weeks mRDB CC(C)N1CC(C)(CN(CC2=CC=3C=C(F)C=CC3O2)S(=O)(=O)F)C1=O Sulfamoyl fluorides s275550____18333082____18178918____17777574 Z9354372953 1.6 138.3 4-6 weeks mRDB COC=1C(CN(C[C@@H]2COC(C)(C)O2)S(=O)(=O)F)=CC=C3C=CC=CC13 Sulfamoyl fluorides s275550____17776758____20317426____17777574 Z9354372961 1.6 138.3 4-6 weeks mRDB FC=1C=C(Cl)C=C(F)C1CN(C2CCC3=NN=NN3CC2)S(=O)(=O)F Sulfamoyl fluorides s275550____18168154____18162936____17777574 Z9354372964 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1=NC=2CCCCCC2S1)C3CCCC=C3 Sulfamoyl fluorides s275550____18163836____16731812____17777574 Z9354372967 1.6 138.3 4-6 weeks mRDB CC(N(CC1=CN=C(S1)C2CCC2)S(=O)(=O)F)C=3C=C(Cl)C=C(Cl)C3F Sulfamoyl fluorides s275550____18165730____16731428____17777574 Z9354372971 1.6 138.3 4-6 weeks mRDB CC1=C(CN(CC2(CCC2)C=3C=CC(C)=C(C)C3)S(=O)(=O)F)C=NN1C Sulfamoyl fluorides s275550____13179770____18163406____17777574 Z9354372978 1.6 138.3 4-6 weeks mRDB CN1C=C(CN(CC=2C=CC=CC2)S(=O)(=O)F)C(=N1)C3CCC3 Sulfamoyl fluorides s275550____17775476____18160478____17777574 Z9354372985 1.6 138.3 4-6 weeks mRDB CC(C)(C)C1=CC=C(CN(C2CCCOC=3C=CC=CC23)S(=O)(=O)F)S1 Sulfamoyl fluorides s275550____16729988____18167980____17777574 Z9354372988 1.6 138.3 4-6 weeks mRDB FC=1C=CC(CN(CCCOCC2CCCO2)S(=O)(=O)F)=C(F)C1Cl Sulfamoyl fluorides s275550____18169406____16731296____17777574 Z9354372990 1.6 138.3 4-6 weeks mRDB CC=1C=CN2C(CN(CC3CCC4CC43)S(=O)(=O)F)=CN=C2C1 Sulfamoyl fluorides s275550____18166832____17777286____17777574 Z9354372993 1.6 138.3 4-6 weeks mRDB CN1C=C(CN(CC=2C=CC(=CC2)C3CCC3)S(=O)(=O)F)C(=N1)C(F)F Sulfamoyl fluorides s275550____18169788____18160408____17777574 Z9354372997 1.6 138.3 4-6 weeks mRDB CS(=O)(=O)C[C@H]1C[C@@H](C1)N(CC=2C=C(Cl)C=CC2OC3CCCC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18173486____17777512____17777574 Z9354372999 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CCC=1C=CSC1)C[C@@H]2C[C@H]2C=3C=CC=CC3 |&1:13,15,r| Sulfamoyl fluorides s275550____18166798____16729780____17777574 Z9354373002 1.6 138.3 4-6 weeks mRDB COC=1C=CC=2C=C(CN(CC3CC43CC4)S(=O)(=O)F)C=CC2C1 Sulfamoyl fluorides s275550____18168832____17777116____17777574 Z9354373005 1.6 138.3 4-6 weeks mRDB CC(C)(C)OC1CC(N(CC=2SC=C3OCCOC23)S(=O)(=O)F)C41CCC4 Sulfamoyl fluorides s275550____18171692____18176514____17777574 Z9354373009 1.6 138.3 4-6 weeks mRDB COCC(N(CC1=CN(C)N=C1C2=CC=C(C)O2)S(=O)(=O)F)C3=CC=CO3 Sulfamoyl fluorides s275550____18169802____18166534____17777574 Z9354373012 1.6 138.3 4-6 weeks mRDB FC1(F)C2CCCC21CN(CC=3C=CC=4OC(F)(F)OC4C3)S(=O)(=O)F Sulfamoyl fluorides s275550____18162048____17777434____17777574 Z9354373015 1.6 138.3 4-6 weeks mRDB CCC(N(CC1=CN(CC2CC2)N=N1)S(=O)(=O)F)C=3C=CC=CC3 Sulfamoyl fluorides s275550____18163568____16731346____17777574 Z9354373017 1.6 138.3 4-6 weeks mRDB CCC1=CSC(CCN(CC=2C=CC(=CC2)C3CC3)S(=O)(=O)F)=N1 Sulfamoyl fluorides s275550____18172632____17777182____17777574 Z9354373021 1.6 138.3 4-6 weeks mRDB CC(C)CCO[C@H]1CC[C@@H](CC1)N(CC=2C=CC=3N(C)C(=O)OC3C2)S(=O)(=O)F Sulfamoyl fluorides s275550____20069734____18163436____17777574 Z9354373024 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CCN1C=C(C#N)C=N1)CC2=CC=C(CC3CC3)S2 Sulfamoyl fluorides s275550____18169518____16732062____17777574 Z9354373032 1.6 138.3 4-6 weeks mRDB CN1N=C(C(Cl)=C1CN(CC2=CC=NN2CC3CCC3)S(=O)(=O)F)C(F)(F)F Sulfamoyl fluorides s275550____18176340____18163226____17777574 Z9354373034 1.6 138.3 4-6 weeks mRDB COC=1C=CC=2CCCC(CC2C1)N(CC=3C=NN(C3)C(F)(F)F)S(=O)(=O)F Sulfamoyl fluorides s275550____18165250____18169962____17777574 Z9354373037 1.6 138.3 4-6 weeks mRDB COC=1C=CC(=CC1CN(C2CCCC2C#N)S(=O)(=O)F)N3C=CC=N3 Sulfamoyl fluorides s275550____21072974____16730394____17777574 Z9354373041 1.6 138.3 4-6 weeks mRDB CC=1C=C(CN(CC2=CC=3CCCCCC3S2)S(=O)(=O)F)N(C)N1 Sulfamoyl fluorides s275550____18172686____18163406____17777574 Z9354373045 1.6 138.3 4-6 weeks mRDB CC=1C=CSC1CCN(CC2=CN(C)N=C2C3CCC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18179960____18159364____17777574 Z9354373046 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1=CSC=2C=CC(Br)=CC12)C3CCCC43CC4 Sulfamoyl fluorides s275550____18174688____17777468____17777574 Z9354373049 1.6 138.3 4-6 weeks mRDB CN1C=C(CN(CC(C)(C)CC=2C=CC=CC2)S(=O)(=O)F)C=CC1=O Sulfamoyl fluorides s275550____20069432____17777142____17777574 Z9354373053 1.6 138.3 4-6 weeks mRDB FC(F)C1(CC2(CN(CC=3C=CC=C4CCOC43)S(=O)(=O)F)C1)CO2 Sulfamoyl fluorides s275550____18161330____16729784____17777574 Z9354373055 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1CCCC2(CCOC2)O1)CC3=CC(Br)=CS3 Sulfamoyl fluorides s275550____18176924____16731918____17777574 Z9354373060 1.6 138.3 4-6 weeks mRDB CCOC1(CN(CC=2C=CC(C)=CC2C3=CC=NN3C)S(=O)(=O)F)CCC1 Sulfamoyl fluorides s275550____18168154____18168250____17777574 Z9354373063 1.6 138.3 4-6 weeks mRDB CC=1C=C(CN(C2CCCC=C2)S(=O)(=O)F)N(N1)C3CCCC3 Sulfamoyl fluorides s275550____18176178____18178918____17777574 Z9354373068 1.6 138.3 4-6 weeks mRDB COC=1C(CN(C2CC32CCC3)S(=O)(=O)F)=CC=C4C=CC=CC14 Sulfamoyl fluorides s275550____18166934____18178918____17777574 Z9354373073 1.6 138.3 4-6 weeks mRDB COC=1C(CN(CC2(C)CN(C(C)C)C2=O)S(=O)(=O)F)=CC=C3C=CC=CC13 Sulfamoyl fluorides s275550____18169802____18159364____17777574 Z9354373074 1.6 138.3 4-6 weeks mRDB FC1(F)C2CCCC21CN(CC3=CSC=4C=CC(Br)=CC34)S(=O)(=O)F Sulfamoyl fluorides s275550____20350404____16731918____17777574 Z9354373078 1.6 138.3 4-6 weeks mRDB CO[C@@H]1CCC[C@@H]1N(CC=2C=CC(C)=CC2C3=CC=NN3C)S(=O)(=O)F |&1:2,6,r| Sulfamoyl fluorides s275550____18177150____16731212____17777574 Z9354373083 1.6 138.3 4-6 weeks mRDB CC1CCNC(=O)C1N(CC2=CC=3C=C(C)C=CC3O2)S(=O)(=O)F Sulfamoyl fluorides s275550____18160126____20869242____17777574 Z9354373086 1.6 138.3 4-6 weeks mRDB CN1N=C(CN(CCOC2CCC2)S(=O)(=O)F)C=3CCCCC31 Sulfamoyl fluorides s275550____19497300____18165304____17777574 Z9354373092 1.6 138.3 4-6 weeks mRDB COC=1C=CC(CN([C@@H]2CCN(C2)C(=O)C)S(=O)(=O)F)=CC1OCC3CC3 Sulfamoyl fluorides s275550____17775734____18168570____17777574 Z9354373095 1.6 138.3 4-6 weeks mRDB CCN1CC(CC1=O)N(CC=2C=CN(N2)C3CCCC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18177150____16730396____17777574 Z9354373096 1.6 138.3 4-6 weeks mRDB CC1CCNC(=O)C1N(CC=2C=CC=C3OC(F)(F)OC32)S(=O)(=O)F Sulfamoyl fluorides s275550____18171270____18165388____17777574 Z9354373098 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CC=C2C=CSC12)C3CC4(CCC4)C3 Sulfamoyl fluorides s275550____18172618____16729612____17777574 Z9354373102 1.6 138.3 4-6 weeks mRDB CSC[C@H]1C[C@@H](C1)N(CC=2C=CC(=CC2)C=3C=CC=CC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18169492____16731294____17777574 Z9354373105 1.6 138.3 4-6 weeks mRDB CC=1C=CC2=NC=C(CN(CC3C(F)(F)C43CCC4)S(=O)(=O)F)N2C1 Sulfamoyl fluorides s275550____21686462____17777468____17777574 Z9354373108 1.6 138.3 4-6 weeks mRDB CN1C=C(CN(C2CC=3C=CC=CC3C2(C)C)S(=O)(=O)F)C=CC1=O Sulfamoyl fluorides s275550____16731334____16731296____17777574 Z9354373110 1.6 138.3 4-6 weeks mRDB CCCN1CC(CN(CC2=CN=C3C=C(C)C=CN23)S(=O)(=O)F)CC1=O Sulfamoyl fluorides s275550____18179946____18167202____17777574 Z9354373122 1.6 138.3 4-6 weeks mRDB CCC1=NN(C)C(CN(CC2CC3(CO2)CCOCC3)S(=O)(=O)F)=C1Br Sulfamoyl fluorides s275550____18179960____16730390____17777574 Z9354373126 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CC=2OC=CC2C1)C3CCCC43CC4 Sulfamoyl fluorides s275550____18169406____17776982____17777574 Z9354373128 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1CCC2CC21)CC3=CC=4C=CC=CC4S3 Sulfamoyl fluorides s275550____18178492____18169584____17777574 Z9354373132 1.6 138.3 4-6 weeks mRDB CC(C)N1CC(CCC1=O)N(CC=2C=CC3=C(OCC3(C)C)C2)S(=O)(=O)F Sulfamoyl fluorides s275550____18166252____18172282____17777574 Z9354373135 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CC(C2CC2)=C(C1)C3CC3)CC4(CC4)C#N Sulfamoyl fluorides s275550____18176776____18168390____17777574 Z9354373138 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1=CC=2C(Br)=CC=CC2S1)[C@@H]3C[C@H]3C4CCC4 |&1:16,18,r| Sulfamoyl fluorides s275550____18169598____18172646____17777574 Z9354373141 1.6 138.3 4-6 weeks mRDB CN1C(C)(C)C(CS1(=O)=O)N(CC=2C=C3OCOC3=CC2OC(F)F)S(=O)(=O)F Sulfamoyl fluorides s275550____21848250____18175006____17777574 Z9354373147 1.6 138.3 4-6 weeks mRDB CN1N=C2CCSCC2=C1CN([C@@H]3C[C@@H]4CC[C@H]3C4)S(=O)(=O)F |&1:12,14,17,r| Sulfamoyl fluorides s275550____18163414____16729930____17777574 Z9354373149 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1CC(=C)C1)CC=2C=C(Cl)C=3OCCOC3C2 Sulfamoyl fluorides s275550____18169406____16731890____17777574 Z9354373151 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1CCC2CC21)CC=3C=CC=4CCCC4N3 Sulfamoyl fluorides s275550____20069432____17776982____17777574 Z9354373153 1.6 138.3 4-6 weeks mRDB FC(F)C1(CC2(CN(CC3=CC=4C=CC=CC4S3)S(=O)(=O)F)C1)CO2 Sulfamoyl fluorides s275550____18171286____16729930____17777574 Z9354373155 1.6 138.3 4-6 weeks mRDB CC1CC(CN(CC=2C=C(Cl)C=3OCCOC3C2)S(=O)(=O)F)CC(C)O1 Sulfamoyl fluorides s275550____18163588____16731132____17777574 Z9354373160 1.6 138.3 4-6 weeks mRDB CC(C)N1C=C(CN(CCC2OCCC=3C=CC=CC23)S(=O)(=O)F)C=N1 Sulfamoyl fluorides s275550____18171970____17777214____17777574 Z9354373165 1.6 138.3 4-6 weeks mRDB CC1=CC(CN(CC2CCC3(CCOCC3)CO2)S(=O)(=O)F)=CS1 Sulfamoyl fluorides s275550____18168960____16731500____17777574 Z9354373169 1.6 138.3 4-6 weeks mRDB FC(F)(F)C1=CC(CN(CC2CS(=O)(=O)C=3C=CC=CC23)S(=O)(=O)F)=CS1 Sulfamoyl fluorides s275550____21221392____17777394____17777574 Z9354373176 1.6 138.3 4-6 weeks mRDB CN1C=C(C=N1)C=2C=CC(CN(CC=3C=CN(N3)C(F)F)S(=O)(=O)F)=CC2 Sulfamoyl fluorides s275550____18171928____18172414____17777574 Z9354373179 1.6 138.3 4-6 weeks mRDB CC=1C=CC(CN(C[C@@H]2CC=3C=CC=CC3CO2)S(=O)(=O)F)=CC1Br Sulfamoyl fluorides s275550____17774754____16731526____17777574 Z9354373186 1.6 138.3 4-6 weeks mRDB CC1CCCCC1N(CC2=CC=NN2C=3C=CC=CC3C)S(=O)(=O)F Sulfamoyl fluorides s275550____18168514____16731836____17777574 Z9354373193 1.6 138.3 4-6 weeks mRDB CC(C)N1C=C(CN(C2CCCC(C2)C=3C=CC(Cl)=CC3)S(=O)(=O)F)N=N1 Sulfamoyl fluorides s275550____18162704____18160902____17777574 Z9354373201 1.6 138.3 4-6 weeks mRDB O[C@H]1CCCC[C@H]1N(CC=2C=CC=C(CC3CCC3)C2)S(=O)(=O)F Sulfamoyl fluorides s275550____21533790____16731786____17777574 Z9354373205 1.6 138.3 4-6 weeks mRDB CN1C=C(CN(CC(O)CC2CC2)S(=O)(=O)F)C(=N1)C3CCCCC3 Sulfamoyl fluorides s275550____16731334____16731520____17777574 Z9354373209 1.6 138.3 4-6 weeks mRDB CCCN1CC(CN(CC=2C=CC=C3COCCC23)S(=O)(=O)F)CC1=O Sulfamoyl fluorides s275550____17775314____16730936____17777574 Z9354373212 1.6 138.3 4-6 weeks mRDB CC1=NN(C)C(OC=2C=CC=CC2)=C1CN(CC3(O)CCC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18164056____18161026____17777574 Z9354373216 1.6 138.3 4-6 weeks mRDB FC=1C=CC(=CC1)S(=O)(=O)CCCN(CC=2C=CSC2Br)S(=O)(=O)F Sulfamoyl fluorides s275550____17775734____17776928____17777574 Z9354373217 1.6 138.3 4-6 weeks mRDB CCN1CC(CC1=O)N(CC=2C=NN(N2)C=3C=CC=CC3)S(=O)(=O)F Sulfamoyl fluorides s275550____21531266____18179418____17777574 Z9354373220 1.6 138.3 4-6 weeks mRDB OC(CN(CC=1C=CC(F)=CC1C2CC2)S(=O)(=O)F)C=3C=CC=C(F)C3Br Sulfamoyl fluorides s275550____18171236____16729780____17777574 Z9354373223 1.6 138.3 4-6 weeks mRDB COC=1C=CC=2C=C(CN(CC3(CC3)C4CC4)S(=O)(=O)F)C=CC2C1 Sulfamoyl fluorides s275550____20013086____16731890____17777574 Z9354373226 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CC=2CCCC2N1)[C@@H]3CC[C@H]4C[C@@H]3CO4 |&1:15,18,20,r| Sulfamoyl fluorides s275550____18169856____20921154____17777574 Z9354373231 1.6 138.3 4-6 weeks mRDB FC=1C=C2CCOC2=C(CN(C3CC4=CSC=C4C3)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____17775974____16731900____17777574 Z9354373232 1.6 138.3 4-6 weeks mRDB FC=1C=CC(=CC1)N2N=CC=C2CN(C3CN(CC(F)(F)F)C(=O)C3)S(=O)(=O)F Sulfamoyl fluorides s275550____18160206____20056936____17777574 Z9354373248 1.6 138.3 4-6 weeks mRDB CN(C)C(=O)C=1C=CC=C(CCN(CC2(CC2)C=3C=CC=CC3Cl)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____18179592____21432088____17777574 Z9354373253 1.6 138.3 4-6 weeks mRDB OCCOC=1C=CC=C(CN([C@H]2C[C@H](C2)OC=3C=CC=CC3)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____18168506____18171694____17777574 Z9354373256 1.6 138.3 4-6 weeks mRDB OC1(CCN(CC2=CN=C(O2)C=3C=CC=CC3)S(=O)(=O)F)CCC1 Sulfamoyl fluorides s275550____18173422____16731354____17777574 Z9354373259 1.6 138.3 4-6 weeks mRDB CC(C)N1C=CC(CCN(CC2=CC=NN2C3CCCC3)S(=O)(=O)F)=N1 Sulfamoyl fluorides s275550____18176684____18179064____17777574 Z9354373262 1.6 138.3 4-6 weeks mRDB CN1N=C(CN(CC2=NC(=CS2)C(C)(C)C)S(=O)(=O)F)C=3C=CC=CC3C1=O Sulfamoyl fluorides s275550____18176776____16729780____17777574 Z9354373264 1.6 138.3 4-6 weeks mRDB COC=1C=CC=2C=C(CN([C@@H]3C[C@H]3C4CCC4)S(=O)(=O)F)C=CC2C1 |&1:10,12,r| Sulfamoyl fluorides s275550____18163522____16731920____17777574 Z9354373270 1.6 138.3 4-6 weeks mRDB CCN1N=C(CN(CC(O)(C2CC2)C3CC3)S(=O)(=O)F)C=4C=CC=CC14 Sulfamoyl fluorides s275550____18166934____18173792____17777574 Z9354373273 1.6 138.3 4-6 weeks mRDB CC(C)N1CC(C)(CN(CC2=CN(N=C2C)C=3C=CC=CC3F)S(=O)(=O)F)C1=O Sulfamoyl fluorides s275550____18178866____17777234____17777574 Z9354373276 1.6 138.3 4-6 weeks mRDB FC(F)(F)C=1C=CN(CCCN(CC2=NOC=3CCCCC23)S(=O)(=O)F)N1 Sulfamoyl fluorides s275550____18180616____18171784____17777574 Z9354373280 1.6 138.3 4-6 weeks mRDB FC1(CN(CC2=NC=3CCCCC3S2)S(=O)(=O)F)COCCOC1 Sulfamoyl fluorides s275550____18166264____17777188____17777574 Z9354373282 1.6 138.3 4-6 weeks mRDB CCN1CC(CN(CC=2C=CC=3CCCCC3C2)S(=O)(=O)F)CC1=O Sulfamoyl fluorides s275550____18173236____16731346____17777574 Z9354373284 1.6 138.3 4-6 weeks mRDB CC=1C=NN(CCCN(CC=2C=CC(=CC2)C3CC3)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____18177702____16730120____17777574 Z9354373286 1.6 138.3 4-6 weeks mRDB FC=1C=CC=CC1C2=CC=C(CN(C3CC4C(C3)C4(F)F)S(=O)(=O)F)S2 Sulfamoyl fluorides s275550____18163194____16731000____17777574 Z9354373287 1.6 138.3 4-6 weeks mRDB CC1(C)CC=2C=C(CN(C3COC4(CCC4)C3)S(=O)(=O)F)C=CC2O1 Sulfamoyl fluorides s275550____18169484____18165718____17777574 Z9354373290 1.6 138.3 4-6 weeks mRDB CSC=1C=C(Br)C=CC1CN(CC=2C=NN3CCN(C)C(=O)C23)S(=O)(=O)F Sulfamoyl fluorides s275550____18177700____16731638____17777574 Z9354373293 1.6 138.3 4-6 weeks mRDB CN1C(=O)CCC=2C=C(CN(C3CC(C)(C)OC(C)(C)C3)S(=O)(=O)F)C=CC12 Sulfamoyl fluorides s275550____18178344____16731140____17777574 Z9354373297 1.6 138.3 4-6 weeks mRDB COC=1C=C(F)C=C(CN(CCNC(=O)C=2C=CC(Br)=CC2)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____18160206____16731346____17777574 Z9354373298 1.6 138.3 4-6 weeks mRDB CN(C)C(=O)C=1C=CC=C(CCN(CC=2C=CC(=CC2)C3CC3)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____18172286____16731000____17777574 Z9354373302 1.6 138.3 4-6 weeks mRDB CC1(C)CC=2C=C(CN(C3C[C@@H]4OCCC[C@H]34)S(=O)(=O)F)C=CC2O1 |&1:11,16,r| Sulfamoyl fluorides s275550____18179448____18177722____17777574 Z9354373305 1.6 138.3 4-6 weeks mRDB OC(CN(CC=1C=CC=C(C1)C2CCCC2)S(=O)(=O)F)C3CCC3 Sulfamoyl fluorides s275550____18176802____18904494____17777574 Z9354373307 1.6 138.3 4-6 weeks mRDB CN1C(CN(CC=2C=CC3=C(COC3(C)C)C2)S(=O)(=O)F)CCS1(=O)=O Sulfamoyl fluorides s275550____18176988____17776932____17777574 Z9354373310 1.6 138.3 4-6 weeks mRDB CCO[C@H]1C[C@@H](C1)N(CC=2C=CC(OCC=3C(C)=NOC3C)=CC2)S(=O)(=O)F Sulfamoyl fluorides s275550____17774728____18163436____17777574 Z9354373313 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CCC=1C=CC(Cl)=CC1)CC2=CC=C(CC3CC3)S2 Sulfamoyl fluorides s275550____21047418____18161500____17777574 Z9354373316 1.6 138.3 4-6 weeks mRDB CC(CCC=1C=CC=CC1)CN(CCCN2C=CC=C2)S(=O)(=O)F Sulfamoyl fluorides s275550____18172286____17776986____17777574 Z9354373317 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CC=C2C=CNC12)C3C[C@@H]4OCCC[C@H]34 |&1:17,22,r| Sulfamoyl fluorides s275550____18176244____17777322____17777574 Z9354373320 1.6 138.3 4-6 weeks mRDB CC(O)(CCN(CC=1C=C2CCCN2N1)S(=O)(=O)F)C=3C=CC=CC3 Sulfamoyl fluorides s275550____18166336____16731078____17777574 Z9354373322 1.6 138.3 4-6 weeks mRDB C[C@]1(O)C[C@H](C1)N(CC=2C=CC=3OC=4C=CC=CC4C3C2)S(=O)(=O)F Sulfamoyl fluorides s275550____17775974____16732076____17777574 Z9354373325 1.6 138.3 4-6 weeks mRDB CC=1N=CSC1C=2C=CC(CN(C3CN(CC(F)(F)F)C(=O)C3)S(=O)(=O)F)=CC2 Sulfamoyl fluorides s275550____18174568____16730252____17777574 Z9354373327 1.6 138.3 4-6 weeks mRDB CC1(C)CC2(CC(C2)N(CC=3C=CC=4OCCC4C3)S(=O)(=O)F)CO1 Sulfamoyl fluorides s275550____18169906____18177758____17777574 Z9354373332 1.6 138.3 4-6 weeks mRDB F[C@@H]1COC[C@H]1N(CC=2C=CC(OC3CCOC3)=CC2)S(=O)(=O)F |&1:1,5,r| Sulfamoyl fluorides s275550____17775234____17777512____17777574 Z9354373342 1.6 138.3 4-6 weeks mRDB CC(CN(C[C@@H]1C[C@H]1C=2C=CC=CC2)S(=O)(=O)F)CN3C=CC=N3 |&1:5,7,r| Sulfamoyl fluorides s275550____18173236____20056936____17777574 Z9354373345 1.6 138.3 4-6 weeks mRDB CC=1C=NN(CCCN(CC2(CC2)C=3C=CC=CC3Cl)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____18172118____18172412____17777574 Z9354373348 1.6 138.3 4-6 weeks mRDB CCN1C=C(CN(CC2CC3(CCC3)CO2)S(=O)(=O)F)C(=N1)C4CC4 Sulfamoyl fluorides s275550____18166696____17777334____17777574 Z9354373351 1.6 138.3 4-6 weeks mRDB OC1CC2(C1)CC(CN(CC=3C=CC=CC3C4CC4)S(=O)(=O)F)C2 Sulfamoyl fluorides s275550____18163522____16731800____17777574 Z9354373353 1.6 138.3 4-6 weeks mRDB CC=1C=C2C=C(CN(CC(O)(C3CC3)C4CC4)S(=O)(=O)F)OC2=CC1C Sulfamoyl fluorides s275550____18169856____18159364____17777574 Z9354373358 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1=CSC=2C=CC(Br)=CC12)C3CC4=CSC=C4C3 Sulfamoyl fluorides s275550____18169856____17776982____17777574 Z9354373365 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1=CC=2C=CC=CC2S1)C3CC4=CSC=C4C3 Sulfamoyl fluorides s275550____18172662____18172646____17777574 Z9354373369 1.6 138.3 4-6 weeks mRDB FC(F)OC=1C=C2OCOC2=CC1CN(CC3(CCC4CC3)C4)S(=O)(=O)F Sulfamoyl fluorides s275550____20013086____18165388____17777574 Z9354373382 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CC=C2C=CSC12)[C@@H]3CC[C@H]4C[C@@H]3CO4 |&1:15,18,20,r| Sulfamoyl fluorides s275550____18177608____18164668____17777574 Z9354373390 1.6 138.3 4-6 weeks mRDB FC(F)(F)CN1N=CC(CN(CC2CCC3(CC3(F)F)CC2)S(=O)(=O)F)=C1C4CC4 Sulfamoyl fluorides s275550____16730748____13398242____17777574 Z9354373394 1.6 138.3 4-6 weeks mRDB CC=1C=CSC1CN(CC2(CCOCC2)C=3C=CC=C(F)C3)S(=O)(=O)F Sulfamoyl fluorides s275550____16731908____18160694____17777574 Z9354373398 1.6 138.3 4-6 weeks mRDB CCNC(=O)C1(CN(CC=2C=CC=C(CC=3C=CC=CC3)C2)S(=O)(=O)F)CCC1 Sulfamoyl fluorides s275550____18177308____18166144____17777574 Z9354373403 1.6 138.3 4-6 weeks mRDB CC(C)OC=1C=CC(CN(CC=2C=CC(=CC2)C3=NOC(C)=N3)S(=O)(=O)F)=CC1F Sulfamoyl fluorides s275550____18162438____16731498____17777574 Z9354373422 1.6 138.3 4-6 weeks mRDB CC(C)(CN(CC=1C=CC=C(OC2CC2)C1F)S(=O)(=O)F)C=3C=CC=CC3F Sulfamoyl fluorides s275550____18165542____16731996____17777574 Z9354373426 1.6 138.3 4-6 weeks mRDB CC1CC=2C=C(CN(CC=3SC=NC3C4CC4)S(=O)(=O)F)C=CC2O1 Sulfamoyl fluorides s275550____18160882____16730754____17777574 Z9354373428 1.6 138.3 4-6 weeks mRDB CC1(CN(CC2=CSC(=N2)C=3C=CSC3)S(=O)(=O)F)CCCCCC1 Sulfamoyl fluorides s275550____18164390____18163406____17777574 Z9354373431 1.6 138.3 4-6 weeks mRDB CN1C=C(CN(C2CCC=3C2=CC(F)=CC3F)S(=O)(=O)F)C(=N1)C4CCC4 Sulfamoyl fluorides s275550____17776438____16731844____17777574 Z9354373433 1.6 138.3 4-6 weeks mRDB CC(CC(O)C1=CC=CO1)N(CC=2C=CC=3N(C)C(=O)SC3C2)S(=O)(=O)F Sulfamoyl fluorides s275550____17775330____16731296____17777574 Z9354373439 1.6 138.3 4-6 weeks mRDB CC=1C=CN2C(CN([C@@H]3[C@H](O)CC=4C=CC=CC34)S(=O)(=O)F)=CN=C2C1 Sulfamoyl fluorides s275550____18167174____20318688____17777574 Z9354373442 1.6 138.3 4-6 weeks mRDB CC=1C=CC(Br)=C(CN(C2CCCN(C2)C(=O)C3CCC3)S(=O)(=O)F)C1F Sulfamoyl fluorides s275550____18174544____16731638____17777574 Z9354373445 1.6 138.3 4-6 weeks mRDB CN1C(=O)CCC=2C=C(CN(CCC3CCC(O3)C(F)(F)F)S(=O)(=O)F)C=CC12 Sulfamoyl fluorides s275550____20031174____16730390____17777574 Z9354373448 1.6 138.3 4-6 weeks mRDB CC1(C)OC2(CN(CC=3C=CC=4OC=CC4C3)S(=O)(=O)F)CCC1CC2 Sulfamoyl fluorides s275550____18163950____16730230____17777574 Z9354373451 1.6 138.3 4-6 weeks mRDB CC(N(CC=1OC=2C=CC=CC2C1Cl)S(=O)(=O)F)C3=NN=NN3C4CC4 Sulfamoyl fluorides s275550____19992592____16731212____17777574 Z9354373454 1.6 138.3 4-6 weeks mRDB CC=1C=CC=2OC(CN(C3CC4(C3)COCCO4)S(=O)(=O)F)=CC2C1 Sulfamoyl fluorides s275550____18164982____20921154____17777574 Z9354373456 1.6 138.3 4-6 weeks mRDB FC=1C=C2CCOC2=C(CN(C3CCC=4C=CC=CC34)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____20031174____16731976____17777574 Z9354373458 1.6 138.3 4-6 weeks mRDB CN1N=C2CCCCC2=C1CN(CC3(CCC4CC3)OC4(C)C)S(=O)(=O)F Sulfamoyl fluorides s275550____18161150____16729738____17777574 Z9354373462 1.6 138.3 4-6 weeks mRDB CCCOC=1C=CC(CN([C@@H]2CCCO[C@H]2C=3C=CC(Cl)=CC3)S(=O)(=O)F)=CC1 |&1:10,15,r| Sulfamoyl fluorides s275550____18179232____16730684____17777574 Z9354373467 1.6 138.3 4-6 weeks mRDB CC1(C)CC(CCO1)N(CC=2C=CC=C(OC3CCCC3)C2)S(=O)(=O)F Sulfamoyl fluorides s275550____18176560____18176514____17777574 Z9354373472 1.6 138.3 4-6 weeks mRDB CC1=CC=C(O1)C2=NN(C)C=C2CN(CC3CCCCC(O)C3)S(=O)(=O)F Sulfamoyl fluorides s275550____18174998____16731212____17777574 Z9354373475 1.6 138.3 4-6 weeks mRDB CC=1C=CC=2OC(CN(CC3(CC3)N4N=CC=N4)S(=O)(=O)F)=CC2C1 Sulfamoyl fluorides s275550____18177324____16729768____17777574 Z9354373481 1.6 138.3 4-6 weeks mRDB COC=1C=CC=C2C=C(CN(C3COC4(CCCC4)C3)S(=O)(=O)F)OC12 Sulfamoyl fluorides s275550____18180416____16731976____17777574 Z9354373488 1.6 138.3 4-6 weeks mRDB CN1N=C2CCCCC2=C1CN([C@@H]3C[C@@H]4CCCCC[C@H]34)S(=O)(=O)F |&1:12,14,20,r| Sulfamoyl fluorides s275550____18168414____16731278____17777574 Z9354373492 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CCOCC1CCCC1)CC=2C=C3OCCCN3N2 Sulfamoyl fluorides s275550____18164982____17777434____17777574 Z9354373497 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1=CN(CC2CC2)N=N1)C3CCC=4C=CC=CC34 Sulfamoyl fluorides s275550____18176178____18165800____17777574 Z9354373499 1.6 138.3 4-6 weeks mRDB CC1=NN(CC=2C=CC=CC2)C=C1CN(C3CC43CCC4)S(=O)(=O)F Sulfamoyl fluorides s275550____18178734____18162692____17777574 Z9354373503 1.6 138.3 4-6 weeks mRDB CC(N(CC1=CC=NN1CC=2C=CC=CC2)S(=O)(=O)F)C=3C(C)=NOC3C Sulfamoyl fluorides s275550____18167256____18904494____17777574 Z9354373508 1.6 138.3 4-6 weeks mRDB CC1(C)OCC=2C=C(CN(CC3CCC4(CC4)CC3)S(=O)(=O)F)C=CC21 Sulfamoyl fluorides s275550____18169598____16731716____17777574 Z9354373509 1.6 138.3 4-6 weeks mRDB CN1C(C)(C)C(CS1(=O)=O)N(CC2=CN(N=C2C)C=3C=CC=C(F)C3)S(=O)(=O)F Sulfamoyl fluorides s275550____18168832____17777514____17777574 Z9354373513 1.6 138.3 4-6 weeks mRDB CC1=NN(C=C1CN(C2CC(OC(C)(C)C)C32CCC3)S(=O)(=O)F)C=4C=CC=C(C)C4 Sulfamoyl fluorides s275550____18176336____16732070____17777574 Z9354373515 1.6 138.3 4-6 weeks mRDB C[C@H](COCC=1C=CC=CC1)N(CC2=C(C=NN2C)C3CC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18177516____18169584____17777574 Z9354373518 1.6 138.3 4-6 weeks mRDB CC1(C)COC=2C=C(CN(C3CN(C3)C(=O)C4CC4)S(=O)(=O)F)C=CC21 Sulfamoyl fluorides s275550____18175200____17777234____17777574 Z9354373521 1.6 138.3 4-6 weeks mRDB FC(F)(F)[C@@H]1[C@@H](CN(CC2=NOC=3CCCCC23)S(=O)(=O)F)C4CCC1CC4 |&1:4,5,r| Sulfamoyl fluorides s275550____18179960____19177850____17777574 Z9354373524 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1=CN(N=N1)C2CCCCC2)C3CCCC43CC4 Sulfamoyl fluorides s275550____18177516____16731212____17777574 Z9354373528 1.6 138.3 4-6 weeks mRDB CC=1C=CC=2OC(CN(C3CN(C3)C(=O)C4CC4)S(=O)(=O)F)=CC2C1 Sulfamoyl fluorides s275550____18173422____16729940____17777574 Z9354373531 1.6 138.3 4-6 weeks mRDB CC(C)N1C=CC(CCN(CC=2C=C(Cl)C=3OCCCOC3C2)S(=O)(=O)F)=N1 Sulfamoyl fluorides s275550____21686252____18179418____17777574 Z9354373534 1.6 138.3 4-6 weeks mRDB COC=1C=CC=C2CC(CC21)N(CC=3C=CC(F)=CC3C4CC4)S(=O)(=O)F Sulfamoyl fluorides s275550____18172340____18176516____17777574 Z9354373537 1.6 138.3 4-6 weeks mRDB CN1C=C(CN(CC2CC3C(C2)C3(F)F)S(=O)(=O)F)C(=N1)C=4C=CC=C(F)C4 Sulfamoyl fluorides s275550____18168414____18168256____17777574 Z9354373540 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CCOCC1CCCC1)CC=2C=CC=3SC=NC3C2 Sulfamoyl fluorides s275550____17775614____16730936____17777574 Z9354373545 1.6 138.3 4-6 weeks mRDB CC1=NN(C)C(OC=2C=CC=CC2)=C1CN([C@H]3CC[C@H](O)CC3)S(=O)(=O)F Sulfamoyl fluorides s275550____21732646____17777074____17777574 Z9354373548 1.6 138.3 4-6 weeks mRDB CN(C)C(=O)COC=1C=CC=CC1CN([C@@H]2C[C@@H]3CCC(C)(C)C=4C=CC=C2C34)S(=O)(=O)F |&1:15,17,r| Sulfamoyl fluorides s275550____18161718____16730710____17777574 Z9354373552 1.6 138.3 4-6 weeks mRDB CSC=1C=CC=2OCCC(N(CC3=CSC(=N3)C4CC4)S(=O)(=O)F)C2C1 Sulfamoyl fluorides s275550____18177940____17777110____17777574 Z9354373553 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CC=2CCCC2C1)[C@H]3CCC=4C3=CC=CC4Cl Sulfamoyl fluorides s275550____18177608____18168568____17777574 Z9354373562 1.6 138.3 4-6 weeks mRDB FC1(F)CC21CCC(CN(CC=3C=4OCOC4C=CC3Cl)S(=O)(=O)F)CC2 Sulfamoyl fluorides s275550____20011482____20056936____17777574 Z9354373565 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1=CSC(=N1)C2CC2)CC3(CC3)C=4C=CC=CC4Cl Sulfamoyl fluorides s275550____16730824____17777182____17777574 Z9354373567 1.6 138.3 4-6 weeks mRDB CN1C(=O)OC=2C=C(CN(CCC=3C=CC(OCC#C)=CC3)S(=O)(=O)F)C=CC12 Sulfamoyl fluorides s275550____17775184____18169584____17777574 Z9354373571 1.6 138.3 4-6 weeks mRDB CN1N=CC=2C(CCCC21)N(CC=3C=CC4=C(OCC4(C)C)C3)S(=O)(=O)F Sulfamoyl fluorides s275550____18176244____17777570____17777574 Z9354373575 1.6 138.3 4-6 weeks mRDB CC1=C(CN(CCC(C)(O)C=2C=CC=CC2)S(=O)(=O)F)C=NN1C3CCC3 Sulfamoyl fluorides s275550____18164112____18172412____17777574 Z9354373586 1.6 138.3 4-6 weeks mRDB CCN1C=C(CN([C@H]2CCOC=3C=CC(=CC23)C(C)C)S(=O)(=O)F)C(=N1)C4CC4 Sulfamoyl fluorides s275550____18164982____18180386____17777574 Z9354373592 1.6 138.3 4-6 weeks mRDB FC=1C(CN(C2CCC=3C=CC=CC23)S(=O)(=O)F)=CC=CC1C4CC4 Sulfamoyl fluorides s275550____16730246____18162936____17777574 Z9354373596 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CCCN1C=CC=N1)CC2=NC=3CCCCCC3S2 Sulfamoyl fluorides s275550____18176008____16731104____17777574 Z9354373609 1.6 138.3 4-6 weeks mRDB CC1(C)CC=2C=CC=C(CN(CCOCC3CCOC3)S(=O)(=O)F)C2O1 Sulfamoyl fluorides s275550____20011482____18160650____17777574 Z9354373612 1.6 138.3 4-6 weeks mRDB COC=1C=CC(C2CC2)=C(CN(CC3=CSC(=N3)C4CC4)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____17775558____18161254____17777574 Z9354373614 1.6 138.3 4-6 weeks mRDB CC=1N=C2CCC(CN2N1)N(CC=3C=CC(C)=C(C3)C4CC4)S(=O)(=O)F Sulfamoyl fluorides s275550____18178492____16730080____17777574 Z9354373616 1.6 138.3 4-6 weeks mRDB CC(C)N1CC(CCC1=O)N(CC=2C=CC(=CC2)N3C=CC=N3)S(=O)(=O)F Sulfamoyl fluorides s275550____18180308____17777142____17777574 Z9354373619 1.6 138.3 4-6 weeks mRDB CC1(COC2(CN(CC=3C=CC=C4CCOC43)S(=O)(=O)F)C1)CCC2 Sulfamoyl fluorides s275550____17774724____17777322____17777574 Z9354373623 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=C2CCCN2N1)C3CCCC=4C=CC=CC34 Sulfamoyl fluorides s275550____18160392____17777110____17777574 Z9354373631 1.6 138.3 4-6 weeks mRDB CC(C)(CN(CC=1C=CC=2CCCC2C1)S(=O)(=O)F)C(=O)N3CCCC3 Sulfamoyl fluorides s275550____16730304____16729990____17777574 Z9354373634 1.6 138.3 4-6 weeks mRDB CCC=1OC=2C=CC=CC2C1CN(CC3=CC=C(O3)C4CC4C)S(=O)(=O)F Sulfamoyl fluorides s275550____18164340____20871864____17777574 Z9354373636 1.6 138.3 4-6 weeks mRDB CN1N=C(CN(CC=2C=CC=C3CCOC32)S(=O)(=O)F)C=4CCCC41 Sulfamoyl fluorides s275550____18180462____18165388____17777574 Z9354373640 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CC=C2C=CSC12)C3CCCOC43CCC4 Sulfamoyl fluorides s275550____17775232____18172412____17777574 Z9354373644 1.6 138.3 4-6 weeks mRDB CCN1C=C(CN(C2COC=3C=CC=CC3C2)S(=O)(=O)F)C(=N1)C4CC4 Sulfamoyl fluorides s275550____18178492____16731786____17777574 Z9354373654 1.6 138.3 4-6 weeks mRDB CC(C)N1CC(CCC1=O)N(CC2=CN(C)N=C2C3CCCCC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18180290____18176902____17777574 Z9354373656 1.6 138.3 4-6 weeks mRDB CC(CN(CC=1C=NN(CC2CCC2)C1)S(=O)(=O)F)CN3C=CC(=N3)C(F)(F)F Sulfamoyl fluorides s275550____18165098____16730710____17777574 Z9354373660 1.6 138.3 4-6 weeks mRDB OC(COC=1C=CC=C(C1)C(F)(F)F)CN(CC2=CSC(=N2)C3CC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18180462____16731800____17777574 Z9354373664 1.6 138.3 4-6 weeks mRDB CC=1C=C2C=C(CN(C3CCCOC43CCC4)S(=O)(=O)F)OC2=CC1C Sulfamoyl fluorides s275550____19507806____18164668____17777574 Z9354373670 1.6 138.3 4-6 weeks mRDB FC=1C=CC=2SC=C(CN(CC=3C=NN(CC(F)(F)F)C3C4CC4)S(=O)(=O)F)C2C1 Sulfamoyl fluorides s275550____18180308____18168256____17777574 Z9354373674 1.6 138.3 4-6 weeks mRDB CC1(COC2(CN(CC=3C=CC=4SC=NC4C3)S(=O)(=O)F)C1)CCC2 Sulfamoyl fluorides s275550____18177318____16730838____17777574 Z9354373677 1.6 138.3 4-6 weeks mRDB FC=1C=C(F)C=C(OC=2C=CC(CN(CC(F)(F)C3CC3)S(=O)(=O)F)=CC2)C1 Sulfamoyl fluorides s275550____18169352____20869252____17777574 Z9354373679 1.6 138.3 4-6 weeks mRDB CN1N=C(CN(C[C@@H]2C[C@H]2C3=CC=CO3)S(=O)(=O)F)C=4CC(C)(C)CCC41 |&1:7,9,r| Sulfamoyl fluorides s275550____18164614____16729876____17777574 Z9354373681 1.6 138.3 4-6 weeks mRDB COC=1C=C(CN([C@@H]2C[C@H]3OC(C)(C)O[C@H]3C2)S(=O)(=O)F)C=C4OCCOC14 Sulfamoyl fluorides s275550____18177194____17777262____17777574 Z9354373685 1.6 138.3 4-6 weeks mRDB COC=1C=C2C=CC=CC2=CC1CN(CC3CCCC43CC4)S(=O)(=O)F Sulfamoyl fluorides s275550____18169352____18165388____17777574 Z9354373686 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(C[C@@H]1C[C@H]1C2=CC=CO2)CC=3C=CC=C4C=CSC34 |&1:6,8,r| Sulfamoyl fluorides s275550____18177516____17777142____17777574 Z9354373689 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CC=C2CCOC21)C3CN(C3)C(=O)C4CC4 Sulfamoyl fluorides s275550____18169290____18169584____17777574 Z9354373693 1.6 138.3 4-6 weeks mRDB CC1(C)COC=2C=C(CN(C3CC(O)C43CCOCC4)S(=O)(=O)F)C=CC21 Sulfamoyl fluorides s275550____18174882____17776986____17777574 Z9354373695 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1CCCC21CCC2)CC=3C=CC=C4C=CNC34 Sulfamoyl fluorides s275550____19470452____16730880____17777574 Z9354373699 1.6 138.3 4-6 weeks mRDB CCOC=1C=C2CC(C)OC2=C(CN(C(C3CC3)C=4C=CC=CC4OC)S(=O)(=O)F)C1 Sulfamoyl fluorides s275550____18168332____20866260____17777574 Z9354373705 1.6 138.3 4-6 weeks mRDB FC=1C=2CCCC2C=CC1CN(C[C@@H]3C[C@H]3C=4C=CC=CC4)S(=O)(=O)F |&1:13,15,r| Sulfamoyl fluorides s275550____18177128____18171694____17777574 Z9354373708 1.6 138.3 4-6 weeks mRDB COC1(CN(CC2=CN=C(O2)C=3C=CC=CC3)S(=O)(=O)F)CCCCCC1 Sulfamoyl fluorides s275550____18172286____16729978____17777574 Z9354373712 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=NN(C1)C=2C=CC=CC2)C3C[C@@H]4OCCC[C@H]34 |&1:19,24,r| Sulfamoyl fluorides s275550____18173846____16730252____17777574 Z9354373714 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC=1C=CC=2OCCC2C1)C(C3CCC3)C4CCOC4 Sulfamoyl fluorides s275550____18179304____18171784____17777574 Z9354373717 1.6 138.3 4-6 weeks mRDB FS(=O)(=O)N(CC1=NC=2CCCCC2S1)CC=3C=C(Br)C=C4CCOC43 Sulfamoyl fluorides s275550____18170054____13398248____17777574 Z9354373721 1.6 138.3 4-6 weeks mRDB CC1OCCC1N(CC=2C=CC=CC2OCC=3C=CC=CC3)S(=O)(=O)F Sulfamoyl fluorides s275550____18176276____18179628____17777574 Z9354373726 1.6 138.3 4-6 weeks mRDB CN1C=C2C=CC(CN(CC=3C=CC=C4CCCC43)S(=O)(=O)F)=CC2=N1 Sulfamoyl fluorides…