PCA-NIA-01448- SOW_POTS_REVISED-1.pdf
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- Attached to
- Notice of Intent to Sole Source- service to perform the Mass Spec in control, analyze, and compare the data
- Solicitation number
- PCA-NIA-01448
About this file
Statement of Work Summary
This is a Statement of Work (SOW) for services issued by the National Institute on Aging (NIA), Laboratory of Cardiovascular Science (LCS) under FAR Part 11. The project, titled "Detection of the 14-3-3 protein binding partners in the heart targeted AdCy8 overexpression mouse strain," requires mass spectrometry analysis services to identify protein binding partners and compare results between wild-type and transgenic mouse tissue models. The contract period of performance runs from April 13, 2026 to May 4, 2026, with typical project duration of approximately 5 weeks. The contractor must provide a Senior Researcher labor category to perform mass spectrometry analysis on 28 samples, analyze raw data, and deliver comparative analysis between control and AC8TG tissues.
The contractor is responsible for furnishing all necessary personnel, materials, equipment, technology, and facilities. Specific deliverables include raw data, detailed analysis, a results spreadsheet, software for data analysis and configuration, and a comprehensive report explaining findings. The government will deliver the 28 samples to the contractor at the National Institute on Aging/IRP facility in Baltimore, Maryland (BRC Building/Room 9B135). Inspection and acceptance will be conducted by the end user. Key personnel include Senior Researcher Maria Grazia Perino (NIA) and Richard Jones, Ph.D. from MS Bioworks, LLC (Ann Arbor, MI). All data produced becomes the sole property of the NIH under FAR 52.227-14 Rights in Data-General. The contractor must submit monthly invoices to the Department of Treasury's Invoice Processing Platform (IPP) within 10 business days after each billing cycle, charged at rates specified in the Schedule of Items by Contract Line Item Number (CLIN). Travel is not required, and the laboratory will publish raw data, analysis, and conclusions in a scientific journal upon completion.
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| PCA-NIA-01448- Notice of Intent to Sole Source.pdf |
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Text version
Version 11-30-2016-1 FAR Part 11—Describing Agency Needs
STATEMENT OF WORK (SOW)
(SERVICES)
GENERAL INFORMATION
Title of Project:
Detection of the 14-3-3 protein binding partners in the heart targeted AdCy8 overexpression mouse strain.
Statement of Need and Purpose:
The purpose of this acquisition is to receive service to perform Mass Spectrometry in control, analyze, and compare the data.
Background Information and Objective:
The National Institute on Aging (NIA) Laboratory of Cardiovascular Science (LCS) is studying the detection of the 14-3-3 protein binding partners in the overexpression of adenylyl cyclase in the heart-targeted AdCy8 overexpression mouse strain. The mouse heart produces a strong beating heart with the upregulation of many pathways. The 14-3-3 protein is one of these proteins that emerge as central for the heart survival and regulation of the cell cycle and mitosis check points. The purpose of this project is to study the role of the 14-3-3 protein partners in order to elucidate their pathways and their mechanisms in heart cell survival, cell renewal and cell mitosis, and their regulation.
The plan is to analyze the role of the 14-3-3 protein by detecting its binding partners in the AdCy8 overexpression model. This analysis will be done through the use of mass spectrometry (MS) and comparison of the results with the wild type mouse model.
Period of Performance:
April 13, 2026 to May 4, 2026
SCOPE OF WORK
General Requirements: qualified personnel, material, equipment, technology and facilities.
Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:
Specific Requirements:
The contractor shall provide the following:
• Labor category: Senior researcher.
• The contractor will perform the Mass Spectrometry in control and AC8TG tissues on 28 samples.
• The contractor will analyze and compare the data.
• This type of project typically requires 5 weeks
LEVEL OF EFFORT:
GOVERNMENT RESPONSIBILITIES:
The government will deliver 28 samples to the contractor for analysis.
DELIVERY OR DELIVERABLES: Samples will be delivered to the contractor as described in The requirements above.
The contractor will perform Mass Spectrometry, get the raw data, analyze it and make comparisons between groups (wild type and transgenic tissues).
The contractor should provide the raw data, the analysis and a report explaining the results.
Inspection and Acceptance:
To be done by end user
REPORTING REQUIREMENTS:
The contractor will report on each step of the analysis and send a spreadsheet of results.
The contractor will provide software for analyzing and configuring the data and the results.
Delivery or Performance Location
National Institute on Aging/IRP National Institutes of Health BRC Building/ Room 9B135 Baltimore, MD 21224
OTHER CONSIDERATIONS
Travel:
Not required.
Key Personnel:
Senior Researcher: Maria Grazia Perino (NIA)
AND
Richard Jones, Ph.D.
MS Bioworks, LLC
3970 Varsity Drive
Ann Arbor, MI 48108
P: 734-546-3811
Information System Security Plan:
Not required.
Data Rights: All Data produced will be sole property of NIH
The Government requires ownership of data/information delivered under this award as prescribed in FAR 52.227-14 Rights in Data-General (May 2014).
All data and benefits acquired by this work are the property of the US government and the contractor is aware of this requirement.
Section 508—Electronic and Information Technology Standards:
Not required.
Publications and Publicity:
Upon analysis of this work, the laboratory will publish the raw data, the analysis and the conclusions in a scientific journal.
Confidentiality of Information:
Not required.
Invoices
• Two-Way Invoices: The Contractor shall submit invoices to the Department of Treasury’s Invoice Processing Platform (IPP) at: https://www.ipp.gov
• Three-Way Invoices: The Contractor shall submit invoices to the Department of Treasury’s Invoice Processing Platform (IPP) at https://www.ipp.gov
• Invoices shall be submitted on a monthly basis no later than 10 business days after the billing cycle of the previous month.
• Invoices shall include only those services rendered during the billing period.
• Invoices shall be billed at the rates, and in accordance with the Contract Line Item Number (CLIN), as listed in the Schedule of Items.
• The Contractor shall submit invoices to the Department of Treasury’s Invoice Processing Platform (IPP) at https://www.ipp.gov https://www.ipp.gov/ https://www.ipp.gov/ https://www.ipp.gov/
| SCOPE OF WORK |
| DELIVERY OR DELIVERABLES: Samples will be delivered to the contractor as described in The requirements above. |
| Not required. |
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