PAR-27-068-Full-Announcement.html

Department of Health and Human Services

Part 1. Overview Information

Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES (NIGMS)

Funding Opportunity Title

Limited Competition: NIGMS Mature Synchrotron Resources (MSR) for Structural Biology (P30 - Clinical Trial Not Allowed)

Activity Code

P30 Center Core Grants

Announcement Type

Reissue of

PAR-22-166

Related Notices

Funding Opportunity Number (FON)

PAR-27-068

Companion Notice of Funding Opportunity

None

Number of Applications

See Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s)

93.859

Notice of Funding Opportunity Purpose

This Notice of Funding Opportunity (NOFO) supports "mature" resources at synchrotron facilities that provide user access to X-ray beamlines for static and dynamic imaging of biological systems ranging from molecules to organs. "Mature" refers to the techniques made available at the resource beamlines, which must be well established and provide utility to the communities they serve without requiring significant novel technology development. Applications may only request support for existing synchrotron resources that are currently supported by NIGMS funding. The facility is expected to be maintained or upgraded to current best practices, make its capabilities and availability known to the biomedical research community through outreach activities, and provide user training and support.

This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.

Funding Opportunity Goal(s)

The National Institute of General Medical Sciences (NIGMS) supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. NIGMS also supports research in specific clinical areas that affect multiple organ systems: anesthesiology and peri-operative pain; clinical pharmacology common to multiple drugs and treatments; and injury, critical illness, sepsis, and wound healing. NIGMS-funded scientists investigate how living systems work at a range of levels – from molecules and cells to tissues and organs – in research organisms, humans, and populations. Additionally, to ensure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in supporting the training of future scientists and developing research capacity throughout the country.

Key Dates

Posted Date

August 31, 2026

Open Date (Earliest Submission Date)

September 02, 2026

October 02, 2026

October 02, 2026

Not Applicable

July 2027

October 01, 2027

October 01, 2027

Not Applicable

July 2028

October 02, 2028

October 02, 2028

Not Applicable

July 2029

All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Expiration Date

October 03, 2028

Due Dates for E.O. 12372

Not Applicable

Required Application Instructions

It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide, except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Table of Contents

Part 1. Overview Information Key Dates Part 2. Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII. Other Information

Part 2. Full Text of Announcement

Section I. Notice of Funding Opportunity Description

Purpose This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered.

This NOFO will continue support of NIGMS-funded mature synchrotron resources that provide synchrotron-based techniques for static and dynamic imaging of biological systems ranging from molecules to organs. Awards under this NOFO will support synchrotron-based resources with technologies that are at an advanced, stable level, and require minimal development to maintain that state. Mature synchrotron resources must:

Supported Activities Funding through this NOFO will support:

Early-stage technology development research is not supported through this NOFO. However, the NIGMS Technology Development program supports this type of research through the R01 activity code and interested synchrotron resource investigators are encouraged to contact NIGMS staff to discuss projects that may be appropriate for this program.

NIGMS Mature Synchrotron Resources must consist of:

Expectations of Mature Synchrotron Resources NIGMS expects that each mature synchrotron resource supports a broad user base, including but not limited to:

Applications Not Responsive to this NOFO The following types of applications are not responsive to this NOFO and will not be reviewed:

See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information

Funding Instrument

Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed

New

Renewal

Revision

The OER Glossary and the How to Apply - Application Guide provides details on these application types. Only those application types listed here are allowed for this NOFO.

Clinical Trial?

Not Allowed: Only accepting applications that do not propose clinical trials.

Need help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards

The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Award Budget

Application budgets are not limited, but need to reflect the actual needs of the proposed project.

Award Project Period

Support for up to five years may be requested.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III. Eligibility Information

1. Eligible Applicants

Eligible Organizations

Nonprofits Other Than Institutions of Higher Education

For-Profit Organizations

Local Governments

Federal Governments

Eligible Agencies of the Federal Government

U.S. Territory or Possession

Other

Independent School Districts

Public Housing Authorities/Indian Housing Authorities

Native American Tribal Organizations (other than Federally recognized tribal governments)

Faith-based or Community-based Organizations

Regional Organizations

Requirement for Current NIGMS Support: This NOFO is limited to applicants requesting support for existing synchrotron resources that are currently supported by NIGMS funding. Applications cannot support resources whose funding ended more than 36 months prior to the application due date.

Foreign Organizations/International Collaborations

Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Required Registrations

Applicant organizations Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications for additional information.

System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. Foreign organizations must obtain a NATO Commercial and Government Entity (NCAGE) Code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI)- A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.

Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. Obtaining an eRA Commons account can take up to 2 weeks.

All PD(s)/PI(s) must be registered with ORCID. The personal profile associated with the PD(s)/PI(s) eRA Commons account must be linked to a valid ORCID ID. For more information on linking an ORCID ID to an eRA Commons personal profile see the ORCID topic in our eRA Commons online help.

Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide.

PD/PI(s) should possess the skills, knowledge and resources required to provide leadership to all key components of the resource, not only to individual select activities.

At least one of the PDs/PIs must devote at least 2.4 person-months. At least one senior scientist, an individual distinct from the PD(s)/PI(s), must devote at least 6 person-months to the synchrotron resource.

2. Cost Sharing This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement, Section 1.2- Definitions of Terms.

3. Additional Information on Eligibility Number of Applications

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

The NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application. This means that the NIH will not accept:

A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.

A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2.3.9.4 Similar, Essentially Identical, or Identical Applications).

Section IV. Application and Submission Information

1. Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST or an institutional system-to-system solution. A button to apply using ASSIST is available in Part 1 of this NOFO. See the administrative office for instructions if planning to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide, except where instructed in this notice of funding opportunity to do otherwise (in this NOFO, in a policy notice, or other notice from NIH Guide for Grants and Contracts) and where instructions in the How to Apply - Application Guide are directly related to the Grants.gov downloadable forms currently used with most NIH opportunities. Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Page Limitations All page limitations described in the How to Apply- Application Guide and the Table of Page Limits must be followed.

Required

Required

Required

NA

Required

Instructions for the Submission of Multi-Component Applications

The following section supplements the instructions found in How to Apply- Application Guide and should be used for preparing a multi-component application.

Revision applications must include an Overall component and the components that are affected by the revision. Therefore, the component requirements listed below may not apply to the revision application.

Overall Component When preparing the application, use Component Type 'Overall'.

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions, as noted.

SF424(R&R) Cover (Overall) Complete entire form.

PHS 398 Cover Page Supplement (Overall) Follow standard instructions.

Research & Related Other Project Information (Overall) Follow standard instructions.

Project Narrative: Provide the Project Narrative for the entire application.

Other Attachments: The following attachments are required.

Publications Enabled by the Resource:

Provide an attachment titled "Publications Enabled by the Resource" listing publications that demonstrate the Resource's impact on the biomedical user community. Organize publications under subheadings by the primary technique that aligns with each Technology Operations Core.

Project/Performance Site Locations (Overall) Enter primary site only.

A summary of Project/Performance Sites in the Overall section of the assembled application image in eRA Commons compiled from data collected in the other components will be generated upon submission.

Research and Related Senior/Key Person Profile (Overall) Include only the Project Director/Principal Investigator (PD/PI) and any multi-PDs/PIs (if applicable to this NOFO) for the entire application.

A summary of Senior/Key Persons followed by their Biographical Sketches in the Overall section of the assembled application image in eRA Commons will be generated upon submission.

Budget (Overall) The only budget information included in the Overall component is the Estimated Project Funding section of the SF424 (R&R) Cover.

A budget summary in the Overall section of the assembled application image in eRA Commons compiled from detailed budget data collected in the other components will be generated upon submission.

PHS 398 Research Plan (Overall) Introduction to Application: For Resubmission and Revision applications, an Introduction to Application is required in the Overall component.

Specific Aims: Describe the overall aims of the Resource.

Provide evidence that the Resource provides needed training and expertise to users.

Letters of Support: Include letters of support following instructions in the How To Apply - Application Guide. Do not include letters from people who do not have an assigned role in the Resource. For example, do not include past users or potential users.

Resource Sharing Plan:

Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide.

In the context of the Resource Sharing Plan, resources include software, materials, protocols, instrument components or interfaces, data pipelines, workshop video archives, training tutorials, etc. that Resource staff develop and disseminate to the greater research community. Dissemination can occur in many forms, including free distribution, fee-for-service, or commercialization.

Provide the Resource Sharing Plan for the entire project here.

Other Plan(s):

All instructions in the How to Apply- Application Guide must be followed, with the following additional instructions:

A Data Management and Sharing Plan is not applicable for this NOFO.

Appendix:

Only limited items are allowed in the Appendix. Follow all instructions for the Appendix as described in How to Apply- Application Guide; any instructions provided here are in addition to the How to Apply - Application Guide instructions.

PHS Human Subjects and Clinical Trials Information (Overall) When involving human subjects research, clinical research, and/or NIH-defined clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply - Application Guide, with the following additional instructions:

If you answered "Yes" to the question "Are Human Subjects Involved?" on the R&R Other Project Information form, there must be at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record within the application. The study record(s) must be included in the component(s) where the work is being done, unless the same study spans multiple components. To avoid the creation of duplicate study records, a single study record with sufficient information for all involved components must be included in the Overall component when the same study spans multiple components.

Study Record: PHS Human Subjects and Clinical Trials Information All instructions in the How to Apply - Application Guide must be followed.

Delayed Onset Study

Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply- Application Guide must be followed.

PHS Assignment Request Form (Overall) All instructions in the How to Apply- Application Guide must be followed.

Administration Core When preparing your application, use Component Type 'Admin Core.' All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions, as noted.

SF424 (R&R) Cover (Administration) Complete only the following fields:

PHS 398 Cover Page Supplement (Administration) Follow application instructions.

Research & Related Other Project Information (Administration) Human Subjects: Answer only the 'Are Human Subjects Involved?' and 'Is the Project Exempt from Federal regulations?' questions.

Vertebrate Animals: Answer only the 'Are Vertebrate Animals Used?' question.

Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

Other Attachments: Provide the following attachments:

User Forms (Required): Provide samples of all forms to be filled out by Resource users including those for:

Provide all forms, with accompanying instructions, in one PDF file named "UserForms".

External Advisory Committee report (for standing EACs): Provide the latest report from the Resource External Advisory Committee. Name the file "EACReport".

Project /Performance Site Location(s) (Administration) List all performance sites that apply to the specific component.

Note: The Project Performance Site form allows up to 300 sites, prior to using additional attachment for additional entries.

Research & Related Senior/Key Person Profile (Administration)

Budget (Administration) Budget forms appropriate for the specific component will be included in the application package.

Applicants are strongly encouraged to contact NIGMS Scientific/Research staff early in the process of developing an application to discuss the budget for the proposed Resource.

Budget Restrictions: Funds may not be requested for alteration and renovation or direct support for Resource users' research projects.

Personnel:

Supplies: Supplies related to the administration activities of the Resource are permitted and may include consumable laboratory research materials, office materials, and small equipment costing less than $10,000 (unless the institution has a lower limit).

Equipment and Service Contracts: Do not include equipment or service contracts here. Include requests in the appropriate Technology Operations Core(s).

Travel: Domestic and foreign travel support for Resource personnel are permitted, provided the travel is directly related to Resource activities.

Funds to support travel by the appropriate personnel of the Resource for up to three program meetings in the course of the project period should be requested in the budget. The purpose of the meetings is to share information with other Mature Synchrotron Resource directors including but not limited to user support, ideas for standardization across Resources, ideas to improve service and descriptions of new facility features. Request funds for travel to an annual PD(s)/PI(s) meeting.

Note: If an annual meeting of an External Advisory Committee (EAC) is planned, funds for support of any EAC member travel should be requested in the Consultant Services category rather than the travel category.

Consultants: Consultants (including External Advisory Committee members) and any associated costs are permitted.

Budget Justification:, Provide detailed information about support received or anticipated from other entities. Examples include co-funding by another government agency, user fees, or institutional support.

Note: The R&R Budget form included in many of the component types allows for up to 100 Senior/Key Persons in section A and 100 Equipment Items in section C prior to using attachments for additional entries. All other SF424 (R&R) instructions apply.

PHS 398 Research Plan (Administration) Specific Aims: Concisely state the goals of the proposed Administration component.

Research Strategy: Describe, in separate sections, the:

Organizational Structure and Staff Responsibilities

Resource Operating Procedures The Resource should be operated safely and effectively to provide the best quality user facility possible. It must be accessible to all biomedical researchers whose projects are vetted through a peer review process. Plans must ensure that all users have fair access to the Resource.

Long Dark Period Planning: Provide dates and durations of any anticipated extended periods when the synchrotron will not be available to users because of planned upgrades. Provide detailed plans of any necessary staff activities in support of the planned upgrades.

Contingency Planning: Unexpected extended facility outages can occur due to fire, flood, earthquakes, accidents, theft, catastrophic equipment breakdowns and other causes. Include plans for contingencies in which the facility is unable to perform its functions for an extended period (months or longer). Include provisions for support (for example, alternative employment) of personnel if they are unable to perform resource support functions for an extended period. Institutional support in terms of backup and/or special insurance is an option, as are reciprocal arrangements with other Resources.

To sustain efficient management of the Resource, include a contingency plan in the event the PD(s)/PI(s) can no longer fulfill the obligation due to health, retirement, or other circumstances.

External Advisory Committee Each Resource must have an External Advisory Committee (EAC). The PD(s)/PI(s) appoint the members of the EAC, whose roles include but are not limited to advising the PD(s)/PI(s) on operations and future Resource directions, particularly in planning additional grant applications, maintaining state-of-the-art capabilities through new technology implementation, and in setting priorities for allocation of Resource facilities.

If the Resource has a standing EAC, list the current members and briefly describe their qualifications and roles.

If the Resource does not currently have an EAC, refrain from assembling one prior to or during application review, or approaching or identifying potential candidates. Instead, describe the expected roles of the EAC and plans for selecting members with regard to areas of expertise relevant to the Resource.

If any other local executive committees or other local committees for the Resource are proposed or already exist, describe their composition, function and meeting schedules.

Mature Synchrotron Resources PD/PI Meeting PD(s)/PI(s) in this Program should plan to organize and rotate hosting an annual meeting of PDs/PIs and appropriate staff from the Mature Synchrotron Resources to discuss best practices and possible standardization, share technical information, and assess the current needs of the greater biomedical research user community. Other investigators who operate and staff resources that may be eligible for the Mature Synchrotron Resource program should be encouraged to participate. The meeting host should include a virtual attendance option.

Plans for Collecting and Reporting Metrics Tracking the demand for and utilization of the Resource is important for ongoing improvements in the short term and for gauging long-term Resource impact. A reporting plan should be tailored to the Resource to best evaluate its productivity, availability, efficiency, and impact. Provide a plan for annual data collection and reporting that is tailored to best evaluate the Resource's productivity, availability, efficiency, and impact.

In this section provide only the plan proposing the information to be collected in the future and reported in the Resource's Research Performance Progress Report. Do not provide data for categories listed here in the application. Data demonstrating impact of the Resource on the research community should be included in the Overall section.

Anticipated data types include:

Applications and Review: Data relating to applications received and accepted from all PIs and new PIs, review evaluations and outcomes for Resource use requests, including average wait time between application approval & beam time access.

Letters of Support: Include letters of support following instructions in the How to Apply - Application Guide. Do not include letters from persons who do not have an assigned role in the Resource. For example, do not include past users or potential users.

Resource Sharing Plan: While individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide, this information should be included in the Overall component.

Other Plan(s):

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions:

Do not include a Data Management and Sharing (DMS) Plan within this Component. If a DMS Plan is required for this NOFO, it must be included within the Overall Component.

Appendix: Only limited items are allowed in the Appendix. Follow all instructions for the Appendix as described in the How to Apply - Application Guide.

PHS Human Subjects and Clinical Trials Information (Administration) When involving human subjects research, clinical research, and/or NIH-defined clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply - Application Guide, with the following additional instructions:

If you answered "Yes" to the question "Are Human Subjects Involved?" on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record.

Study Record: PHS Human Subjects and Clinical Trials Information All instructions in the How to Apply - Application Guide must be followed.

Delayed Onset Study Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply - Application Guide must be followed.

Technology Operations Core When preparing your application, use Component Type 'Core'.

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions, as noted.

SF424 (R&R) Cover (Technology Operations Core) Complete only the following fields:

PHS 398 Cover Page Supplement (Technology Operations Core) Follow application instructions.

Research & Related Other Project Information (Technology Operations Core) Human Subjects: Answer only the "Are Human Subjects Involved?" and "Is the Project Exempt from Federal regulations?" questions.

Vertebrate Animals: Answer only the "Are Vertebrate Animals Used?" question.

Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

Other Attachments:

Section Titled "User Research Projects" followed by the name of the Technology Operations Core describing five representative user projects formatted as follows:

Any references

Project /Performance Site Location(s) (Technology Operations Core) List all performance sites that apply to the specific component.

Note: The Project Performance Site form allows up to 300 sites, prior to using additional attachment for additional entries.

Research & Related Senior/Key Person Profile (Technology Operations Core)

Budget (Technology Operations Core) Budget forms appropriate for the specific component will be included in the application package.

Applicants are strongly encouraged to contact program staff early in the process of developing an application to discuss the budget for the proposed Resource.

Funds may not be requested for alteration and renovation or direct support for Resource users' research projects.

Personnel:

Equipment:

Travel: Domestic and foreign travel support for Resource personnel are permitted, provided the travel is directly related to Resource activities.

Supplies: Supplies related to Resource operations are permitted and may include consumable laboratory research materials and small equipment costing less than $10,000 (unless the institution has a lower limit).

Consultants: Consultants fees and any associated costs are permitted.

Note: The R&R Budget form included in many of the component types allows for up to 100 Senior/Key Persons in section A and 100 Equipment Items in section C prior to using attachments for additional entries. All other SF424 (R&R) instructions apply.

PHS 398 Research Plan (Technology Operations Core) Specific Aims: Describe the goals of the proposed Technology Operations Core. Include explicit sub-aims for each planned improvement intended to maintain the facility at the state of the art.

Research Strategy: Technology Operations Cores should provide advanced technologies and services that are stable with regard to major developments and are appropriate for the anticipated research needs of the biomedical research user community they serve. The research strategy should describe plans to:

Each Resource must include at least one Technology Operations Core supporting a specific synchrotron-based method that requires dedicated instrumentation, software, methods, and expertise. Each Technology Core should provide an important resource for biomedical researchers. The Resource is expected to actively recruit user research projects and provide broad access to Resource capabilities, as described in detail in the User Training and Outreach and Administration components. Discuss the role and contributions of the leader(s) of the Technology Operations Core. Do not repeat information that is included in the biosketches.

User Support and Providing Access to the Resource

Maintenance Activities

Planned Improvements While technology development is not a primary goal of the Resource, implementation of technologies that enhance the impact on the user community and improve the utility of the Technology Operations Core is an important activity of the Resource. Whenever possible, plans should be made to utilize open-source software and/or equipment that either can be obtained commercially or has been previously developed.

Any technology development or updates (e.g., software, algorithm development, or hardware engineering) proposed should be:

Planned improvements should be discussed with NIGMS Scientific/Research staff prior to submission to ensure they conform to the NOFO requirements.

Technology updates may be necessary to maintain the Resource at the state of the art or to advance service objectives. Discuss the role and contribution of Resource staff in implementing improvements to this Technology Operations Core.