PAR-26-106-Revised-Full-Announcement.html

Department of Health and Human Services

Part 1. Overview Information

Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

NATIONAL INSTITUTES OF HEALTH (NIH)

Office of AIDS Research (OAR)

Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)

Funding Opportunity Title

Development of Collaborative Research Facilities or Research-Resource Facilities (C06 Clinical Trial Not Allowed)

Activity Code

C06 Research Facilities Construction Grant

Announcement Type

Reissue of

PAR-25-061

Related Notices

Funding Opportunity Number (FON)

PAR-26-106

Companion Funding Opportunity

None

Number of Applications

See Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s)

93.352, 93.310

Funding Opportunity Purpose

This Notice of Funding Opportunity (NOFO) solicits applications to develop shared-use research facilities or research-supporting facilities that enable collaborative research and benefit broad research communities at large. The NOFO supports two existing construction programs: the Biomedical Research Facilities (BRF) program and the HIV/AIDS Research Facilities (HRF) program.

The BRF program supports the construction or modernization of biomedical research facilities that advance basic, translational, clinical, or behavioral science research in all areas. Intended facilities include shared research spaces, core facilities, biorepositories, or other shared-use resource facilities that serve a broad scientific community with a significant, long-term impact on biomedical research.

The HRF program funds the development of HIV/AIDS research or research-supporting resources that the empowered research activities must align with the NIH Office of AIDS Research (OAR) priorities, as outlined at OAR HIV/AIDS Research Priorities, including research focusing on the long-term health consequences of HIV infection.

NIH encourages applications from institutions across all geographic regions of the country, including Institutions of Emerging Excellence (IEE) in biomedical research, to strengthen the nation's research capacity.

Funding Opportunity Announcement Goal(s)

The Office of Research Infrastructure Programs (ORIP) is a program office in the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) dedicated to supporting research infrastructure and related research resource programs. ORIP consists of the Division of Comparative Medicine (DCM) and the Division of Construction and Instruments (DCI).

Key Dates

Posted Date

March 6, 2026

Open Date (Earliest Submission Date)

March 06, 2026

April 06, 2026

Not Applicable

Not Applicable

December 2026

January 25, 2027

Not Applicable

Not Applicable

December 2027

January 25, 2028

Not Applicable

Not Applicable

December 2028

All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Expiration Date

January 26, 2028

Due Dates for E.O. 12372

As described in the NIH Grants Policy Statement, an applicant must provide a copy of the application to the State Single Point of Contact (SPOC) no later than the time the application is submitted to NIH. SPOC comments must be submitted to NIH with the application, or the application must indicate the date on which the application was provided to the SPOC for review.

Required Application Instructions

It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide, except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts).

Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

Applications that do not comply with these instructions may be delayed or not accepted for review.

Table of Contents

Part 1. Overview Information Key Dates Part 2. Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII. Other Information

Part 2. Full Text of Announcement

Section I. Notice of Funding Opportunity Description

The NIH Office of Research Infrastructure Programs (ORIP) administers two extramural construction programs: the Biomedical Research Facilities (BRF) program and the HIV/AIDS Research Facilities (HRF) program. These programs support the construction and modernization of biomedical research facilities that advance basic, translational, clinical, or behavioral science research, including those dedicated to the HIV/AIDS research. The primary goal of this NOFO is to support the development of modern, shared-use facilities that enhance collaborative biomedical research with broad and high impact, create research training opportunities, cultivate the future generations of the biomedical research workforce, and sustain critical biomedical research resources for broad and long-lasting impact.

The BRF program solicits applications from eligible higher education and research institutions to construct new or modernize existing shared-use research facilities. BRF facilities support biomedical and behavioral research in all scientific areas, especially research in emerging scientific areas with strong potential for impact. Supported facilities must serve a wide research community, locally (within the applicant institution), regionally (across several institutions), or nationally, demonstrating value beyond a single research group or department. Appropriate facilities include but are not limited to: institution-wide multidisciplinary collaborative research spaces, core laboratories, state-of-the-art facilities to house advanced technologies such as imaging centers, biorepositories, and other shared-use facilities that support emerging new approach methodologies or human-based research technologies. Additionally, these facilities can play a crucial role in advancing implementation science by providing the physical infrastructure necessary to develop, test, refine, and scale evidence-based interventions, ensuring their effective integration into real-world applications. Facilities that solely or primarily focus on supporting animal research or animal care activities are not among the priorities of this NOFO.

The HRF program supports the development or modernization of shared-use research facilities that the supported research must align with the HIV/AIDS research priorities established by the NIH Office of AIDS Research (OAR). These facilities are expected to strengthen a sustainable infrastructure that enables cutting-edge, collaborative biomedical and behavioral HIV/AIDS research, enhances preservation and advancement of critical HIV/AIDS research resources, and offers robust training opportunities to foster the next generation of HIV/AIDS researchers.

This NOFO encourages applications from eligible institutions across all geographic regions of the country, including Institutions of Emerging Excellence (IEEs) in biomedical research, as defined in 42 USC 283k(c)(2)(D), to contribute to strengthening our nation's biomedical research capability. All proposed projects must align with an institution's current infrastructure and long-term strategic vision and demonstrate lasting benefit for the broader research community. Successful projects are expected to provide shared, collaborative environments that advance a broad range of research teams and promote institutional excellence. Laboratory spaces dedicated solely to individual investigators or single research groups are not supported under this NOFO.

NIH intends to allocate at least 25% of the funds appropriated to the BRF program to support IEE projects. IEEs are expected to have demonstrated emerging excellence in a biomedical or behavioral research field and are located in a geographic area facing significant public health challenges, such as limited access to healthcare services or inadequate research infrastructure. Per 42 USC 283k(c)(2)(D), eligible IEEs must be actively engaged in addressing the health deficit of the populations they serve. While many IEEs reside in regions that traditionally receive fewer NIH or other federal research grants, such as Institutional Development Award (IDeA)-eligible states, geographic location alone does not determine IEE eligibility. For example, an institution in a non-IDeA state may qualify if it lacks essential research infrastructure and demonstrates a focused, mission-driven effort to advance research in areas aligned with the unmet health needs of its local population.

For the BRF program, to be considered as an IEE under this NOFO, an applicant institution must explicitly identify itself as such and justify its status in the Project Narrative section. IEE applicants must clearly articulate the biomedical or behavioral research focus they are striving to establish or expand and describe how the proposed facility project will significantly advance that goal. Applications should also demonstrate how the institution is building research capacity and training the next generation of scientists to address regional health deficit. While IEE faculty is expected to dedicate significant time to teaching, this NOFO does not support projects with purely instructional or didactic activities.

NIH recognizes that cutting-edge physical infrastructures are essential for the conduct of novel, advanced research and the support of specialized research-enabling operations. Dedicated collaborative research facilities and shared-use resource spaces, such as clean rooms for barrier housing or GLP-compliant spaces for compound synthesis, as well as biosafety-level laboratories for research involving human participants, are critical to support specialized equipment and technologies, emerging experimental protocols, and enhance institutional research capacity. Modern physical infrastructure necessitates the implementation of advanced engineering designs that comply with required engineering standards to sustain the intended operation over many years.

Therefore, all construction design must conform to the latest edition of the NIH Design Requirements Manual (DRM) and its referenced policies, codes, standards, and technical criteria. For applications submitted to this NOFO, it is expected that each project will implement the best engineering solutions and modern technologies. In situations where animal facilities are proposed, the proposed animal facilities must be compliant with the Required Codes and Standards as specified in Section 1.2.1, including the Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals (Policy) and Guide for the Care and Use of Laboratory Animals (Guide).

Note: There is no maximum for the total cost of a construction project under this NOFO. Each of the two programs, however, allows a different range of the Total Federal Funds Requested. Specifically, the Total Federal Funds Requested allows the range of $2,000,000 to $8,000,000 for applications under the BRF program and $2,000,000 to $4,000,000 for the HRF applications.

Moreover, the HRF program supports HIV/AIDS-related research that aligned with the NIH OAR priorities, including implementation science for preventing HIV infection, facilities for manufacturing safe HIV interventions/treatments with more effective viral eradication or sustained viral suppression for viruses in their latent reservoirs, or vaccines more potent to suppress viruses with high mutational potential or multiple genetic variants.

While this NOFO permits a nominal level of supports for fixed equipment listed in Section IV, it is not intended for applications requesting research instruments, replacement of aging or failing equipment, or funding for routine operational needs. Requests for these purposes are not appropriate and will not be supported. Applications for billable medical care, office space, or classrooms are not appropriate in response to this NOFO.

Applicants may request funds to cover design and implementation costs of the project. Specifically, the allowable costs include the architectural and engineering design fees, contingency fees, construction and fixed equipment expenses, and fees for commissioning of the facility. See the Funding Restrictions section for further details on allowable and non-allowable costs. Applicants are encouraged to follow sustainable design principles and to use green technologies.

To appropriately conceive, develop, construct, and successfully complete the project, a Program Director/Principal Investigator (PD/PI) should possess knowledge of the relevant scientific field(s) to be served by the proposed facility, demonstrate leadership skills, and assemble a team with technical expertise related to all aspects of the project. The PD/PI does not need to be a currently NIH-funded investigator but is expected to have an appropriate standing in the institutional administration and the research community to lead and oversee the project.

The project should meet the following criteria and documentation requirements:

Applicants are strongly encouraged to contact the Scientific/Research Contact listed in Section VII. Agency Contacts to discuss their planned projects before submitting applications. For additional guidance, visit the C06 Frequently Asked Questions web page.

See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information

Funding Instrument

Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed

New

The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.

Funds Available and Anticipated Number of Awards

The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Award Budget

Application budgets are not limited but need to reflect the actual needs of the proposed project.

The allowed direct cost (Total Federal Funds Requested) is $2,000,000 to $8,000,000 for BRF facilities and $2,000,000 to $4,000,000 for HRF facilities. Applications with a budget less than $2,000,000 will not be considered.

Award Project Period

The total project period shall not exceed five years. Funds will be provided in a single award with up to a 60-month budget and project period.

Architectural and engineering design fees are immediately available to applicants at the time of the Notice of Award (NoA); all other award funds are restricted until the Office of Research Infrastructure Programs (ORIP) approves the design documents; upon approval, the NIH will issue a revised NoA to release the restricted award funds.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III. Eligibility Information

1. Eligible Applicants

Eligible Organizations

Added for due dates on or after January 25, 2027, see Notice NOT-OD-26-089.

For-Profit Organizations

Local Governments

Federal Governments

Other

Foreign Organizations/International Collaborations

Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Required Registrations

Applicant organizations Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for late submission, please reference NIH Grants Policy Statement 2.3.9.2 Electronically Submitted Applications for additional information.

Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. Obtaining an eRA Commons account can take up to 2 weeks.

All PD(s)/PI(s) must be registered with ORCID. The personal profile associated with the PD(s)/PI(s) eRA Commons account must be linked to a valid ORCID ID. For more information on linking an ORCID ID to an eRA Commons personal profile see the ORCID topic in our eRA Commons online help.

Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed construction as the Program Director/Principal Investigator (PD/PI) is invited to work with their organization to develop an application for support. Multiple PDs/PIs are not allowed.

The PD/PI should hold appropriate stature within the institutional administration structure and research community to be able to oversee various facets of the entire project. The PD/PI should also have a demonstrated record of leadership skills to recruit and guide expert Key Personnel with complementary technical and scientific skills to successfully accomplish the construction project.

For the description of roles of Key Personnel, see Senior/Key Person Profile Expanded.

2. Cost Sharing This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1.2 Definition of Terms

3. Additional Information on Eligibility Number of Applications

Only one application per institution (identified by NIH IPF number) is allowed.

NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application. This means that the NIH will not accept:

A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.

A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2.3.9.4 Similar, Essentially Identical, or Identical Applications).

Section IV. Application and Submission Information

1. Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution. See the administrative office for instructions for plans to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide, except where instructed in this notice of funding opportunity to do otherwise (in this NOFO, in a policy notice, or other notice from NIH Guide for Grants and Contracts). Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Page Limitations

All page limitations described in the How to Apply - Application Guide and the Table of Page Limits must be followed.

The Project Information attachment of the SF424 (R&R) Other Project Information form is limited to:

Instructions for Application Submission

The following section supplements the instructions found in the How to Apply - Application Guide and should be used for preparing an application to this NOFO.

SF424(R&R) Cover

All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:

Estimated Project Funding: Applicants must provide the 'Total Federal Funds Requested', 'Total Federal and Non-Federal Funds', and 'Estimated Program Income'.

Is Application Subject to Review by State Executive Order 12372 Process: Applicants should indicate "yes" and provide the date the application was submitted to the State.

SF424(R&R) Project/Performance Site Locations

All instructions in the SF424 (R&R) Application Guide must be followed.

SF424(R&R) Other Project Information

All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:

Title: The title must start with either "BRF:" or "HIV:" to ensure applications are properly grouped for review, funding consideration and reporting.

Project Summary/Abstract: The Project Summary/Abstract should contain a succinct and accurate description of the proposed construction project emphasizing the critical need for the facility and its expected long-term impact. The application's broad, long-term objectives should be stated, concisely describing how the facility will enhance the infrastructure and biomedical research at the applicant institution. For example, it should describe how a proposed collaborative research facility will advance HIV/AIDS, human health, or chronic disease research in adults or explain how a well-structured core facility will provide integrated research and services to meet the needs of regional researchers.

NOTE: The Project Summary/Abstract must be no longer than 30 lines of text.

Project Narrative: In this section, using no more than two or three sentences, describe the project and the relevance of this project to public health. Be succinct and use plain language that can be understood by a general, lay audience. In addition, if an IEE Status is claimed, use this section to declare the IEE status of the applicant institution and briefly explain the justification, such as indicating the specific populations with health status deficit that will benefit from the biomedical research supported by the proposed project.

Bibliography & References Cited: List only publications that are applicable to the construction proposal.

Facilities & Other Resources: Not Applicable. Do not include an attachment here.

Equipment: Not Applicable. Do not include an attachment here.

Other Attachments:

For this NOFO, the following 12 components are expected in the Other Attachments.

1) Overview (required) (File Name: Overview).

The Overview cannot exceed 1 page and must summarize the project, stating its goals, and outlining the proposed approaches to achieve them. Specifically, this section should include a description of the space affected by the project and any equipment which is requested in this application – Tables 1 and 2 may be referenced to simplify the presentation. A short statement should also be included to summarize how the project will enhance institutional-wide research programs and benefit research groups. As a part of this statement, if applicable, an IEE applicant must identify and briefly justify its status. In this section, as part of the justification, an applicant should state the long-term goals of improving a particular research or research training capacity or enhancing a research or research training area and how the proposed investments in the physical infrastructure will advance the institution to excellence in that domain.

2) Scientific Justification and Facility Development (required) (File Name: Scientific Justification and Facility Development) This space is used for Scientific Justification and Development of the Facility. It is up to the PD/PI to allocate the 12 pages allowed for the project description to the sections: Scientific Justification and Development of the Facility. A successful application does not need to reach the page limitation; however, it must justify the request from a scientific perspective and describe technical design approaches with enough details to make clear the merits of the overall project. These merits include plans for long-term use of the space by many researchers.

The Scientific Justification section should focus on how the proposed project will expand the institution's biomedical research capabilities or enhance its research-support infrastructure. The request must be driven by clearly defined scientific needs, such as spaces to accommodate specific instrumentation specialized laboratory and research settings. Applicants should describe how the new or modernized facility will directly support research activities–for example, by enabling high-throughput computational models to interpret biological systems, or developing advanced data analysis software. The PD/PI must: describe the current institutional infrastructure and its limitations; explain how those limitations hinder ongoing or planned biomedical research; and detail how the proposed upgrades will meet the evolving needs of the research community. Applications should also connect the infrastructure improvements to the research community that will benefit–whether institution-wide, regional, or national. For instance, a core facility modernization aimed at supporting chronic disease research should outline infrastructure gaps specific to studies involving targeted populations and how the proposed improvements will address those needs. Finally, applicants are strongly encouraged to provide 10-year projections of the research services and/or resources the new facility will deliver once operational, emphasizing long-term impact and sustainability.

In the case of an IEE application under the BRF program, the PD/PI should outline ongoing efforts at the institution for the advancement of biomedical research and relate these efforts to the long-term growth plans at the institution. As part of the justification for this project, the PD/PI should specify in what area they are striving to achieve excellence and explain how this project helps advance the research capacity or research training capacity, and how the infrastructure will help the institution to reach the goal. Plans to solve deficits in the available research infrastructure and funding should be a part of the justification of needs for the new infrastructure. This justification should be specific about the research area to be supported and address the relevant expertise and other available resources on which plans for the research expansion are built. Current NIH research funding is not an eligibility requirement but if available should be included in this project's justification, along with research funding from other sources, such as other Federal agencies, private foundations, and the institution (e.g., endowments). Table 3 may be included, as applicable. IEE applicants should be striving to establish research or research training capacity that serves the needs described above.

For facilities that support NIH funded research projects, explaining how the new or improved infrastructure will advance the conduct of the selected active NIH-funded research projects. Centers and other resources that support a regional or nation-wide community of researchers should describe their role in enabling specific research activities and justify how the NIH-funded research projects will be directly enhanced by the proposed infrastructure improvements. Long-term plans for support of infrastructure and research programs should be outlined to illustrate the institutional commitment for the scientific program. Table 3 should be used to reference these projects, active at the time of the application submission.

For all applications, this section should be made clear that there will be a strong research community at the institution to rely on the new infrastructure, even when the listed grants expire. It should also provide a bridge between the long-term institutional vision for biomedical research and the proposed infrastructure development. The narrative of this section should describe how the facility will be used by or provide services to many researchers. This section should conclude with a paragraph about how the PD/PI will work with the project Key Personnel on overseeing the planning process and its execution. The team members' individual roles and their responsibilities at different stages of the project should establish their expected contribution towards the overall goal. It is also important for the PD/PI to describe how the team will be organized and demonstrate how its members will work together at different stages of the project. The PD/PI should document that the team as a group has expertise and skills necessary to design and construct the facility so that the scientific objectives are met.

The Development of the Facility section should present technical specifications, details of the architectural and engineering design, and the proposed construction processes. The PD/PI should provide enough details about implementation of the project, including technical challenges that will need to be overcome. This narrative should start with the location of the building in which the facility is to be housed (if a new structure is to be erected) or the location of the existing building (if a present facility is to be modernized) in relation to other buildings in the immediate area. In either case the narrative should also describe the location of the project in the building. The level of detail of the application's Line Drawings, data in Tables 1 and 2 and the narrative of this section must provide sufficient information for reviewers to determine the functionality of the overall design plans, and the safety and reliability of the proposed facility. The design specifications must adhere to the federal and industry standards and meet the requirements set by standard operating procedures described in the section Scientific Justification, as applicable. Professionally made schematic drawings are encouraged in order to clarify the specifications and avoid potential design related questions.

In the narrative, all requested fixed equipment should be justified as being relevant to the function of the facility. Fixed equipment may include infrastructure equipment, such as HVAC units serving the facility and other large, fixed equipment that is built into the building structure such as mechanical, electrical, and plumbing (MEP) systems. In addition to these very essential items for building operations, requests can be made for casework, fixed laboratory equipment or other equipment required to achieve full functionality of the facility as proposed. Also, the installation needs of all fixed equipment in the context of the engineering aspects of the project, such as MEP specifications for their installation, should be presented - see data in Table 2, below.

The PD/PI should provide engineering and architectural criteria as relevant to the project, including:

All these criteria should be justified in the context of the specific function(s) of the requested facility, and a description of how they will be met should be provided. Construction design for the NIH-funded facilities shall conform to the latest edition of the NIH Design Requirements Manual (DRM).

In summary, all requests must be justified in terms of both the scientific needs and the corresponding technical requirements for the facility. In particular, to address the rationale for the technical design, plans for the use of the facility must be clearly outlined. Attention must be paid to federal and industry biosafety standards and codes, so upon the completion of this project, the occupancy permit can be secured, and the facility can serve its research purpose.

Whenever practicable, the applicant should employ sustainable design practices and green technologies. Sustainability is the outcome of an integrated process of facility development and operation, incorporating a balance of life-cycle cost, environmental impact, and occupant health, safety, security, and productivity. The sustainable design should consider the following primary elements of energy use efficiency; water use efficiency, indoor environmental quality, and material and resources selection, as applicable:

If an award is made, for all improvements and repair projects that impact 40% or more of the overall floor area of a building, the applicant must obtain certification, during the design phase, from the U.S. Green Building Council's Leadership in Energy and Environmental Design (LEED) or the Green Building Initiative's Green Globes System Certification rating system.

3) Annotated satellite and/or map views of the envisioned construction site (required): illustrate the location of the construction and relationship with respect to adjacent buildings, areas, and roads (name the attachment: Annotated map views).

4) Line Drawings (required, name the attachment: Line drawings): Each line drawing must be formatted to fit on an 8.5" x 11" sheet of paper. (Do not submit "blueprints".) All floor plans must be legible, with the scale clearly indicated on each page. The floor plans must indicate the location of equipment and illustrate safety clearances and workspace. If applicable, submit drawings of the existing and proposed space. The drawings must indicate:

Note, construction designs for NIH-funded facilities shall conform to the latest edition of the NIH Design Requirements Manual (DRM). Although the line drawings do not count toward the page limits, do not include additional text.

5) Table 1 (required): list the size (dimensions) and square footage of each component (e.g., clean room, laboratory, closet etc.) that will be directly affected by the project. (name the attachment: Dimension Table)

6) Table 2 (required): list of requested fixed equipment. Table 2 should include information such as the manufacturer, model number, size, capacity, total cost, and location in the facility. Total cost of each item must be supported by vendor quotes in the Budget Justification and Vendor Quotes attachment (see below). (name the attachment: Equipment Table)

7) Table 3 (optional): list of active research grants which are directly related to the project. This table must have the following columns: (1) Funding Agency; (2) Grant Number; (3) PD/PI Name; (4) Annual Direct Costs for the current fiscal year; (5) Start and End Dates. Do not list more than 12 relevant grants. (name the attachment: Active grants)

8) Project timeline (required): To demonstrate how the project will be completed within the five-year budget and award period. Please include the major steps in the project. (name the attachment: Project timeline).

9) Budget Justification and Vendor Quotes (required, name the attachment: Budget Justification and Quotes): Justify and describe the application budget for the project. All vendor quotes should be attached here. In addition to supplying vendor quotes as applicable, the budget justification should include detailed breakdowns of the costs that comprise each of the budget categories:

10) Institutional Support Letter (required, name the attachment: Institutional Support Letter(s)). A letter from a high-ranking institutional official (e.g., Dean, Provost, President) indicating institutional support for the research activities to be conducted in the new facility and to document that it will be used as proposed. The letter must be co-signed by an institutional Signing Official. This letter should include plans to support such expenses as future operating and maintenance costs, staff salaries, and user training (if needed). Additionally, institutional commitment to cover unforeseen expenses during the construction phase is strongly encouraged.

11) Certification of Title to Site (required, name the attachment: Certification of Title to Site): Applicants must include a legal opinion describing the interest the applicant institution has in the performance site. The legal opinion should describe any mortgages or other foreclosable liens on the property, including the principal amount of the mortgage (and rate of interest); the dates of the mortgage; the terms and conditions of repayment; the appraised value of the property; and any provisions designed to protect the Federal interest in the property. The facility must be utilized for biomedical research purposes for which it was approved for at least 10 years beginning on the date of beneficial occupancy of the space. Any lease agreement must cover a length of time sufficient for the usage requirement and be a minimum of 10 years in length from the completion of the facility.

12) Support Letters (optional): A maximum of seven optional support letters may be attached. Attach all the support letters in a single file (name the attachment: Support Letters).

SF424(R&R) Senior/Key Person Profile Expanded

All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:

The Key Personnel must have complementary scientific and technical skills. The PD/PI is expected to be a senior PhD-level scientist who has a significant role at the applicant institution to ensure the success of the construction/modernization project, for example, a College Dean who oversees research space, Director of an Institute or Center, or a Scientific Director of a Core Facility. Also, an individual with technical proficiency in engineering or architectural matters who will serve as a Construction Project Manager must be identified. This person's responsibility will include oversight of the design, implementation of the project, and communication between the scientific and technical staff at every step of the development of the application and subsequent execution of the project. A project role for this person should be specified as "Other" or "Other Professional" and a bio-sketch with relevant information about professional qualifications and expertise should be attached. This person will closely work with the PD/PI and an outside consulting firm on all technical aspects of the project, including planning, designing, constructing, completing, and commissioning of the facility. A project role for this person should be specified as "Other" or "Other Professional" and a biographical sketch with relevant information about their professional qualifications and expertise must be attached.

Depending on the scope of the project, other Key Personnel, such as a Facility Manager in an ABSL3 facility or Imaging center, may be identified. The Facility Manager should provide appropriate expertise to assist with setting scientific requirements for the technical design and to make possible the immediate use of the completed facility. Often, this person would be a PhD-level scientist, for example, a scientist/core director if a specialized-used facility is planned.

SF424C Budget Information for Construction Programs

All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:

The Budget Information for Construction Programs (SF424C) must be used to attach an overall application budget page for the total requested funds.

Applicants must provide the "Total Federal Funds Requested", "Total Federal and Non-Federal Funds", and "Estimated Program Income' on the SF424 (R&R) Cover form.

PHS 398 Cover Page Supplement

All instructions in the SF424 (R&R) Application Guide must be followed.

PHS Assignment Request Form

All instructions in the SF424 (R&R) Application Guide must be followed.

3. Unique Entity Identifier and System for Award Management (SAM) See Part 2. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov.

4. Submission Dates and Times Part I. contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.

Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH's electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications.

Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.

Information on the submission process and a definition of on-time submission are provided in the How to Apply - Application Guide.

5. Intergovernmental Review (E.O. 12372) This initiative is subject to intergovernmental review.

6. Funding Restrictions All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Pre-award costs are allowable only as described in the NIH Grants Policy Statement 7.9.1 Selected Items of Cost.