PAR-25-446-Full-Announcement.html

This document is a Notice of Funding Opportunity (NOFO) from the National Institute on Drug Abuse (NIDA), part of the Department of Health and Human Services National Institutes of Health, focusing on research for discovering and developing interventions to prevent and treat substance use disorders (SUDs) and overdose. The grant opportunity is assigned to the Drug Use and Addiction Research Programs (CFDA 93.279) and will utilize the UG3/UH3 activity code, supporting both preclinical and clinical research studies aimed at advancing candidate interventions toward regulatory approval or clinical adoption.

The funding opportunity encourages collaborative investigations that combine expertise across multiple disciplines, including pharmacology, toxicology, medicinal chemistry, neuromodulation, digital interventions, clinical trials, and regulatory science. While specific award amounts are not detailed, the program typically supports project periods of up to 5 years, with grants awarded directly to applicant institutions after scientific merit review. Potential applicants are currently being notified to develop meaningful collaborations and responsive projects, with a focus on high-impact research that can quickly yield results to address substance use disorders and overdose prevention.