PAR-25-442-Full-Announcement.html

This document is a Notice of Funding Opportunity (NOFO) from the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH), focusing on "Expanding the Target Landscape by Drugging the Undruggable" through an R21 grant mechanism. The funding opportunity seeks research proposals targeting traditionally undruggable molecular targets within intractable human diseases, with a goal of developing innovative methods or agents that can selectively engage targets that cannot be addressed through conventional therapeutic approaches.

The grant opportunity specifically encourages collaborative investigations combining expertise in translational science, drug discovery, and drug development. Applicants must identify a human disease-relevant undruggable target class and develop preclinical proof-of-concept studies demonstrating modulation of such targets. While applications are not currently being solicited, potential applicants are advised to begin developing collaborative projects and research strategies. The NOFO is designed to jumpstart research that demonstrates innovative strategies for modulating targets traditionally considered inaccessible, with projects serving as use cases that could potentially be applied to broader undruggable target classes. The funding is associated with the National Center for Advancing Translational Sciences federal grant program (CFDA 93.350) and aims to accelerate the translation of scientific discoveries into potential medical treatments.