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This is a Funding Opportunity Announcement (FOA) PAR-25-353, reissuing PAR-20-119, for the National Cooperative Drug/Device Discovery/Development Groups (NCDDG) program focusing on treatment of mental disorders through a U19 Cooperative Agreement mechanism. The funding is provided by the Department of Health and Human Services' National Institutes of Health under the Mental Health Research Grants program (CFDA 93.242).

The FOA seeks applications to advance discovery, preclinical development, and proof of concept testing of new therapeutic agents and neurostimulation approaches for mental disorders, substance use disorders, and alcohol use disorders. It emphasizes academia-industry partnerships and supports multiple research projects under a unified program goal requiring multidisciplinary, long-term approaches. Eligible applicants include higher education institutions, nonprofits, tribal organizations, for-profit organizations, government entities, and small businesses. A companion U01 FOA is available for investigators seeking support for more focused, discrete projects.

PAR-25-353 Full Announcement Text

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