PAR-25-154-Full-Announcement.html

This is a Notice of Funding Opportunity (NOFO) announcement for PAR-25-154, "HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed)" issued by the Department of Health and Human Services National Institutes of Health. The funding opportunity supports pilot projects to identify new druggable targets for pain management as part of the NIH Helping to End Addiction Long Term (HEAL) initiative, which aims to accelerate the development of novel medications for opioid addiction treatment.

The grant is available to a wide range of applicants including higher education institutions, small businesses, tribal organizations, nonprofits, and government entities. The initiative falls under multiple CFDA programs, primarily focusing on research in areas such as arthritis and musculoskeletal diseases (93.846), alcohol research (93.273), drug use and addiction (93.279), child health (93.865), oral diseases (93.121), neurosciences (93.853), complementary health (93.213), aging research (93.866), and translational sciences (93.350). The program specifically supports basic biochemical and biological research to characterize understudied proteins for pain management applications.