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This document is a Notice of Funding Opportunity (NOFO) for the Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed) federal grant opportunity.

The National Cancer Institute (NCI) is seeking applications for projects that aim to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research. The goal is to demonstrate that mammalian models are robust representations of human biology, appropriate for testing questions of clinical importance, and provide reliable information to benefit patients. Eligible applicant types include independent school districts, nonprofits, for-profit organizations, higher education institutions, and state/local governments. The funding will support projects focused on overcoming translational deficiencies of mammalian oncology models, defining new uses of mammalian models for translational challenges, advancing standard practices, validating and credentialing models, or challenging current translational model usage. This grant opportunity is part of the NCI's Cancer Detection and Diagnosis Research, Cancer Treatment Research, Cancer Cause and Prevention Research, and Cancer Biology Research federal grant programs.