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This document is a Notice of Funding Opportunity (NOFO) for the High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed) from the Department of Health and Human Services National Institutes of Health.

The HEI Grant Program provides funding for groups of NIH-supported investigators to purchase or upgrade high-end, specialized, commercially available scientific instruments or integrated systems. The minimum award is $750,001, with a maximum of $2,000,000. Eligible applicants include non-501(c)(3) nonprofits, public and private higher education institutions, and other organizations. The program supports the acquisition of equipment such as nuclear magnetic resonance spectrometers, X-ray diffractometers, mass spectrometers, and other advanced biomedical research instruments. This funding opportunity is assigned to the Research Infrastructure Programs (CFDA 93.351), Biomedical Research and Research Training (CFDA 93.859), and Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) federal grant programs.