PA-25-307-Full-Announcement.html

This is a Federal Grant Opportunity announcement (PA-25-307) from the National Institutes of Health (NIH) for the Exploratory/Developmental Research Project Grant (Parent R21) specifically for basic experimental studies with humans. The grant supports early-stage and conceptual research projects that may involve considerable risk but could lead to breakthroughs in biomedical, behavioral, or clinical research through novel techniques, methodologies, or models.

The opportunity is open to a wide range of applicants including government entities, nonprofits, higher education institutions, for-profit organizations, tribal governments, and small businesses. The research must fall within NIH's definition of both a clinical trial and basic research, specifically focusing on studies that experimentally manipulate variables with human participants to understand fundamental phenomena without specific applications in mind. The grant is supported through multiple NIH programs including Lung Diseases Research (93.838), Cardiovascular Diseases Research (93.837), Mental Health Research (93.242), Drug Use and Addiction Research (93.279), and several other research programs spanning areas such as aging, vision, blood diseases, and sleep disorders.