Notice of Intent to Sole Source.pdf

NOTICE OF INTENT TO SOLE SOURCE

Title: CRO Services for Single-Cell Multiomics Profiling

RFQ: 75N95025Q00238

Classification Code: Q301- Laboratory Services.

NAICS Code: 541714 - Research and Development in Biotechnology (except Nanobiotechnology) Size Standard: 1,000 employees

INTRODUCTION

THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO

AWARD A CONTRACT WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION

(INCLUDING BRAND-NAME).

The National Center for Advancing Translational Sciences (NCATS) intends to negotiate on a sole source bases with Proteintech Group, Inc. to provide a single-cell multi-nomics platform that allows combined single-cell RNA sequencing with DNA barcoded antibodies that target up to 325 distinct proteins for 33 sample hPSC-SNs under different inflammatory conditions.

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE and SET ASIDE

STATUS

The intended procurement is classified under NAICS code 541714 - Research and Development in Biotechnology (except Nanobiotechnology). This requirement is not being set-aside for small businesses.

REGULATORY AUTHORITY

This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures. Contracts awarded using FAR Part 13—Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6—Competition Requirements. FAR Subpart 13.106-1 (b) Soliciting from a single source provides that: For purchases not exceeding the simplified acquisition threshold, Contracting officers may solicit from one source IF the contracting officer determines that the circumstances of the contract action deem only one source reasonably available (e.g., urgency, exclusive licensing agreements, brand-name OR industrial mobilization).

The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2025-05 dated August 07, 2025.

DESCRIPTION OF REQUIREMENT

NCATS requires a contract research organization (CRO) to perform Human Discovery Panel (HDP) analysis to obtain single-cell multiomic data that shall inform NCATS on transcriptomic and proteomic alterations during inflammatory sensitization in human pluripotent stem cell-derived sensory neurons (hPSC-SNs). Capable vendors must prepare and sequence a total of 33 samples (provided by NCATS), and will provide NCATS the data upon completion.

The Contractor shall provide a single-cell multi-nomics platform that allows combined single-cell RNA sequencing with DNA barcoded antibodies that target up to 325 distinct proteins for 33 sample hPSC-SNs under different inflammatory conditions. Activities shall include the following:

MultiPro Human Discovery Panel; - Quantity 2.

MultiPro Human Enhanced Blocking Reagent; Quantity 8 Genomics Analysis Service; Quantity 1

CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING

BRAND-NAME) DETERMINATION

The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. For reasons of compatibility and continuity of research experiments, The Proteintech HDP is the only a single-cell multi-omics platform that allows combined single-cell RNA sequencing with DNA barcoded antibodies that target up to 325 distinct proteins specific to the 33 samples of hPSC-SNs under different inflammatory conditions.

The intended source is:

Proteintech Group 5500 Pearl Street Suite 400 Rosemont, IL 60018

USA

CLOSING STATEMENT

THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice.

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. All responsible sources may submit a capability statement, proposal, or quotation which shall be considered by the agency. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Unique Entity Identifier ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.

All responses must be received by the closing date and time of this announcement and must reference the solicitation number, 75N95025Q00238. Responses must be submitted electronically to Andrew Varley, Contract Specialist, at Andrew.varley@@nih.gov and Josh Lazarus, Contracting Officer, at josh.lazarus@nih.gov. U.S. Mail and fax responses will not be accepted.