NOTICE OF INTENT to Sole Source.pdf

NOTICE OF INTENT to Sole Source

SOLICITATION NUMBER:

75N95025Q00077

TITLE:

Preventative Maintenance 10x Genomics Chromium iX/X

CLASSIFICATION CODE:

J065 Medical, Dental and Veterinary Equipment

NAICS CODE:

811210 – Laboratory instrument repair and maintenance services

RESPONSE DATE:

January 17, 2025

PRIMARY POINT OF CONTACT:

Frederick Weddington, Contract Specialist NINDS Contracts Management Branch, NIDA Frederick.Weddington@nih.gov

DESCRIPTION:

THIS IS A PRE-SOLICITATION NOTICE OF INTENT TO AWARD ON A SOLE

SOURCE BASIS. THIS IS NOT A REQUEST FOR QUOTE/PROPOSALS.

On behalf of the National Institute of Neurological Disorders and Stroke (NINDS), the Office of Acquisitions Contracts Management Branch Red, NINDS Section of the National Institute on Drug Abuse (NIDA), intends to solicit on a sole-source basis by a request for quotation to 10x Genomics, Inc. to provide maintenance support service on the 10x Genomics Chromium X single cell capture system for Molecular Neurobiology Section on or around January 20, 2025, with an award issued on or around January 26, 2025. The purpose of this acquisition is to acquire maintenance support services, for 2 (two) IWT Rack Washers, 3 (three) IWT Tunnel Washers and 1 (one) IWT Multi-Magic 2 Semi-Automatic Bottle Processor (a total of six (6) cage and bottle processing machines). These services shall be provided by an Original Equipment Manufacturer (OEM)-Authorized Service Provider of the six (6) cage and bottle processing machines, and all maintenance services shall be performed by OEM certified factory-trained technicians using OEM certified parts.

mailto:Frederick.Weddington@nih.gov

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE and SET

ASIDE STATUS

The intended procurement is classified under NAICS code 811210 with a Size Standard of $34M.

This acquisition is NOT set aside for small businesses, but rather is a sole-source acquisition to Genomics, Inc.

REGULATORY AUTHORITY

This acquisition is conducted under the authority of the Federal Acquisition Regulations (FAR) Subpart 13.106-1 (b) Soliciting from a single source.

BACKGROUND, PURPOSE AND OBJECTIVES OF REQUIREMENT

The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people’s health and save lives.

The mission of the Molecular Neurobiology Section is to identify the signaling pathways important for neural regeneration after injury. The lab currently uses mouse olfactory epithelium, which has robust regenerative capacity, as a model for neural regeneration.

A primary approach to understanding mechanisms of neural regeneration is to sequence the regions of open chromatin, which correlate gene regulatory elements, in individual nuclei and the genes that are expressed in individual cells. The Chromium X device partitions cells or nuclei into individual “gel emersions” that allow for the generation and sequencing of their gene expression profiles (transcriptomes) and accessible chromatin profiles (epigenomes). The Chromium X has the capability of partitioning thousands of individual cells or nuclei from a single sample, which are then used to construct a single cell sequencing library.

The Chromium X single cell capture system is required to partition cells/nuclei for single cell sequencing libraries that are compatible with libraries generated in the Molecular Neurobiology Section over the past 3.5 years. The Chromium X requires routine preventative maintenance and an assurance plan that covers lost reagents due to a failed run. This contract will ensure minimal downtime due to hardware and/or software malfunction. Additionally, the contract is required to maintain this research equipment in operable condition for single cell/single nuclei partitioning (“captures’), provide for the replacement of lost replacement during failed captures, and prevent costly repairs.

CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION

(INCLUDING BRAND-NAME) DETERMINATION

Genomics, Inc., as the authorized provider of the 10x Genomics Chromium X single cell capture system, is the only contractor that is OEM-authorized and capable of providing the necessary maintenance support service because the equipment is proprietary.

Genomics, Inc. is the only source for factory trained and certified technicians to provide these services and to maintain and service the equipment.

Only Genomics, Inc. is capable of providing the necessary maintenance support service because the equipment requiring maintenance is proprietary to this company, the original equipment manufacturer. Genomics, Inc. does not authorize any other contractors to perform this work. Use of any other contractor would jeopardize the machines functionality by risking mechanical design and software control standards.

Only an OEM-authorized service provider has access to the latest services and support information. Replacement parts or accessories must be compatible with the existing equipment, and only Genomics, Inc. can certify compatibility. An OEM-authorized service provider is the only source with direct access to these parts and labor.

Genomics, Inc. is the only source authorized by the OEM to provide the support and maintenance services for this equipment. Because of the significant investment by NINDS in the purchase of this equipment, using an OEM-Authorized Service Provider is essential for maintaining the integrity of the system.

In accordance with FAR part 10, extensive market research was conducted to reach this determination. Specifically, contact with knowledgeable individuals both in industry and Government, as well as reviews of available product literature, revealed no other sources. A review of the GSA Advantage, Dynamic Small Business Search, and previous Government acquisitions returned no results that meet all requirements.

Therefore, only Genomics, Inc. is found to be capable of meeting the needs of this requirement.

The intended source is:

10x Genomics, Inc.

6230 Stoneridge Mall Road Pleasanton, CA 94588-3260

Estimated Period of Performance:

Base year: January 27, 2025 – January 26, 2026 Option year 1: January 27, 2026 – January 26, 2027 Option year 2: January 27, 2027 – January 26, 2028 Option year 3: January 27, 2028 – January 26, 2029 Option year 4: January 27, 2029 – January 26, 2030

Place of Performance:

National Institute of Neurological Disorders and Stroke Building 35; Room 2B203 35 Convent Drive Bethesda, Maryland 20892

Contract Type:

A firm-fixed price type contract with option periods is planned for this acquisition, consistent with commercial practices.

CLOSING STATEMENT

THIS NOTICE OF INTENT TO AWARD ON A SOLE-SOURCE BASIS IS NOT A

REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice.

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. All responsible sources may submit a capability statement, proposal, or quotation which shall be considered by the agency. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All responses must provide evidence that they can provide equipment that meets all of the requirements in this announcement.

All responses must be received by the closing date and time of this announcement and must reference the solicitation number, 75N95025Q00077 Responses must be submitted electronically to Frederick Weddington, Contract Specialist, Contracts Management Branch – Red, NINDS Section, NIDA, at Frederick.Weddington@nih.gov.

U.S. Mail and Fax responses will not be accepted.

http://www.sam.gov/ mailto:Frederick.Weddington@nih.gov