NOI Creative Biolabs 75N98026Q00867.docx
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- Solicitation number
- 75N98026Q00867
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This is a Notice of Intent (NOI) from the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI), for a Small Business Innovation Research (SBIR) Phase II contract opportunity. The solicitation number is 75N98026Q00867, and the topic focuses on humanized single domain antibodies for therapeutic brain delivery. This is a pre-solicitation notice announcing the government's intent to issue a formal solicitation.
The NOI indicates that Creative Biolabs is the identified offeror for this opportunity. The project aims to develop humanized single domain antibodies capable of crossing the blood-brain barrier for therapeutic applications in treating neurological conditions. While specific response deadlines, award dates, and pricing terms are not detailed in the NOI itself, this is a Phase II SBIR contract, which typically involves small businesses (500 employees or fewer) competing for federal research and development funding. The contracting office is the Department of Health and Human Services, NIH Office of Logistics and Acquisition Operations. Interested parties should monitor official NIH solicitation channels for the formal RFP release and any associated technical requirements, evaluation criteria, and submission deadlines.
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NOTICE OF INTENT: Humanized single domain antibodies for therapeutic brain delivery
(75N98026Q00867)
Sole Source Justification and Notice Authority: FAR 6.302-1 — Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements
Contracting Activity: National Human Genome Research Institute, Division of Intramural Research (NHGRI)
Proposed Contractor: Creative Biolabs
Description of Requirement: Humanized single domain antibodies for therapeutic brain delivery
Justification for Sole Source:
Only One Source: Creative Biolabs is the only known responsible source capable of providing the required services that meet NIDDK compatibility, and continuity requirements in accordance with FAR 6.302-1.
Creative Biolabs is the only known source capable Creative Biolabs is the only known source, capable of meeting the requirement because the requested work relies on its proprietary HuVHHL-S2 humanized semi-synthetic single domain antibody library and related proprietary antibody discovery platform.
The HuVHHL-S2 library is identified as a humanized semi-synthetic single domain antibody library with a reported size greater than 1.0 × 10¹⁰ and is specifically designed for discovery of humanized antibody binders appropriate for translational research applications. In addition, antibodies derived from Creative Biolabs discovery libraries have advanced into Phase I and Phase II clinical trials, demonstrating the translational relevance of the platform.
The requirement also includes delivery of resulting antibody sequence data, complementary deoxyribonucleic acid clone information, and transfer of project-generated intellectual property and materials to the Government for continued National Institutes of Health research use. Based on the proprietary nature of the HuVHHL-S2 library, the associated antibody discovery platform, and the required transfer of resulting intellectual property and materials, Creative Biolabs is the only known contractor capable of meeting the Government’s requirement as written.
Small Business Notification: This notice is not a request for competitive quotes. However, any interested small businesses (including 8(a), service-disabled veteran-owned, HUBZone, small disadvantaged, veteran-owned, and women-owned small businesses) may submit a written capability statement demonstrating their ability to perform the requirement. Submission of capability statements does not constitute a commitment by the Government to compete the proposed award; any decision to compete will be made at the Government’s sole discretion.
Anticipated Award Date: An award is anticipated approximately five (5) days after the date of this notice closes unless the Government determines another vendor can meet the requirement.
Please email responses to danielt@mail.nih.gov no later than 09:00 a.m. EDT on July 31, 2026.
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