Sample_Task_Order__2_REV_12-21-15.pdf

SAMPLE TASK ORDER REQUEST FOR PROPOSAL #2

NOTE: THIS IS ONLY A SAMPLE - NO TASK ORDER AWARD WILL BE MADE IN RESPONSE TO THIS

REQUEST

Contractor: _________TBD_____________

Contract No: ________TBD _____________

TORP No: _ 2__ Modification No: _____

Order Title: Pharmacokinetic-Pharmacodynamic-Efficacy Evaluations with Selected Compounds in Human Tumor Xenografts in Nude Mice

Order Originator: ____ _______ Date Prepared: _ ________

Task Order Type: Cost Reimbursement (CR)

Part I. INITIATOR’S REQUEST

A. Period of Performance: TO BE DETERMINED

B. Statement of Work/Protocol/Project Description:

The purpose of this Task Order is to perform pharmacokinetic-pharmacodynamic-efficacy evaluation(s) with an investigational anticancer agent(s) in a mouse tumor model.

For the base period:

The contractor shall provide all necessary labor and materials to carry out the appended protocol entitled, “Pharmacokinetic-Pharmacodynamic-Efficacy Evaluation of [NSC XXX] in [cell line TBD] Tumor Xenografts in Nude Mice.” All collected samples are to be shipped to an NCI-designated laboratory for analysis.

For Options 1 - 5:

For each Option, the contractor shall carry out a protocol similar to that provided for the base period. The test articles and tumor cell lines may be different for each option, but overall designs (number of animals, dosing events, sample collections) will be similar. Options are considered additional quantities and may be exercised anytime during the Task Order Period of Performance.

C. Deliverables:

A fully signed protocol shall be provided to the COR prior to initiation of the evaluation, along with evidence of IACUC approval.

Data collected (animal weights, clinical observations, etc.) to be provided in Excel (or other agreed upon format) within 5 working days after the end of the in-life phase.

Collected samples will be shipped to the protocol-designated laboratory. Sample collection information and inventory to be provided with shipment and copied to the COR electronically.

Separate reports for the base and all options exercised. Each report shall include methods, in-life observations, and any problems or deviations encountered. Draft reports will be due 14 working days after the last sample is collected. The final report will be due 14 working days after return of the draft report for revision.

hudakad Typewritten Text RFP Number: N02CM67000-11 hudakad Typewritten Text Attachment 19-2

D. Additional Instructions:

As Task Orders may be competed among the contractors if multiple awards are made pursuant to this RFP, please consider and provide information in your response to address Items E and F.

E. Evaluation Factors:

Proposals will be evaluated on the following factors, in order of importance:

1) Technical (Weight 40%): Demonstrated experience in conducting experiments with human tumor xenograft models in mice. Evidence of technical ability to implant, stage, treat, monitor, and obtain samples from such experiments. Experience in packaging and shipping frozen samples to designated recipients.

2) Schedule (Weight 30%): Documented ability and capacity to rapidly initiate xenograft evaluations in mice. Timely delivery of results and dispatch of shipped samples within 5 working days (or earlier) after the end of the in-life phase. Evidence of previous achievement of similar timeline goals.

3) Cost (Weight 30%): Reasonableness of labor mix, proposed hours, animal costs, and total costs.

F. Order Response:

The Technical Proposal shall be 3-4 pages in length and consist of an outline of your approach to appended protocol. Specific procedural recommendations and/or alternative methods may be recommended. Include a proposed timeline for the work from protocol approval to submission of the final report.

The Business Response shall at least include a Coversheet and a Budget (provided substantially as indicated in Part II of this form). The Coversheet shall at least consist of:

• RFP Number

• Task Order RFP Number

• Name, address, email and telephone number of point of contact

• Name, address, email and telephone number of contract Administration Office (if applicable)

• Date of submission

• Name, title, address, email, telephone and signature of authorized Business Representative

(person authorized to sign contracts on behalf of the organization).

Budgets for the base period and each Option should be provided separately. Note: this Order will initially be awarded for the base period and associated costs to conduct the appended protocol. The Government may decide to unilaterally exercise and fund one or more Options for additional work as listed above. A notice of intent to exercise each option would be sent seven days prior to unilateral exercise.

G. Order Response Due Date: Responses to this Task Order should be included in your technical and business proposals for this RFP.

TASK ORDER REQUEST FOR PROPOSAL (TORP)

Contractor: _____________[fill in]____________________ Contract No: ___ __________________

TORFP No: __ 2 ___ Modification No: __ 0____ Date Prepared: ______________________

Part II. CONTRACTOR’s RESPONSE TO ORDER REQUEST* (*The Contractor shall attach a detailed budget to this form to identify all proposed costs.)

A. Estimated Cost and Effort:

1. Labor hours – list order leader, specific individuals to be assigned, labor category, and estimated hours for each.

2. Labor costs – list by labor category and total.

3. Employee benefits.

4. Direct materials.

5. Travel.

6. Subcontracts.

7. Other direct costs.

8. Indirect costs.

9. Total estimated costs for this Order: ______________

B. Detailed description of the approach to be used and of the deliverable(s). (Be specific):

APPROVAL TO PROCEED: The Contractor shall not exceed the estimated labor hours, estimated Order amount, or change the Order leader without the prior written approval of the Contracting Officer’s Representative and the Contracting Officer.

1. For the Contractor: _____________________________ Date: __________________

(Signature)

Typed Name: __________________________________

2. For the Government: ____________________________ Date: __________________ Contracting Officer’s Representative (COR)

____________________________ Date: __________________ Contracting Officer