HR001124S0032-Amendment-01.pdf
PDF 115 KB Posted
- Attached to
- Broad-Spectrum Antagonists For Editors (B-SAFE)
- Opportunity number
- HR001124S0032
About this file
This document is an amendment to the Broad-Spectrum Antagonists For Editors (B-SAFE) Broad Agency Announcement (BAA) solicitation HR001124S0032, issued by the Defense Advanced Research Projects Agency (DARPA).
The amendment clarifies the content of technical and financial reporting requirements, as well as the proposal abstract submission process. It also adds a new Risk Register attachment. Key details include the deliverables required at the end of each program phase, such as technical reports, financial reports, a transition plan, and a technology transfer package. The technical metrics to be achieved by the end of each phase are also specified, related to the potency, broad-spectrum coverage, and number of inhibitors. The overarching goal of the B-SAFE program is to discover and optimize novel molecules that can inhibit CRISPR-based gene editing processes, in order to promote the safe and controlled use of these technologies.
HR001124S0032-Amendment-01.pdf
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Other files
| File | Type | Posted |
|---|---|---|
| B-SAFE_QA_v2.docx | DOCX document | |
| HR001124S0032_Attachment_B_Abstract_Template_V2.docx | DOCX document | |
| HR001124S0032_Attachment_G_Risk_Register.xlsx | XLSX spreadsheet | |
| Attachment_F_DARPAStandardCostProposalSpreadSheet_TwoTAs.xlsx | XLSX spreadsheet | |
| Attachment_E_Proposal_Instructions_and_Volume_II_Template__Cost_revised20240614_1350.docx | DOCX document | |
| HR001124S0032_Attachment_C_Proposal_Summary_Slide_Template.pptx | PPTX presentation | |
| Attachment_D_Proposal_Instructions_and_Volume_I_Template__Technical_and_Management_revised20240614_1350.docx | DOCX document | |
| HR001124S0032_Attachment_B_Abstract_Template.docx | DOCX document | |
| HR001124S0032_Attachment_A_Abstract_Summary_Slide_Template.pptx | PPTX presentation | |
| HR001124S0032.pdf |
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Text version
The purpose of Amendment 1 to HR001124S032, the Broad-Spectrum Antagonists For Editors (B-SAFE) Broad Agency Announcement, is to clarify the content of Tables 1 and 4 and the proposal abstract submission requirements, and add a Risk Register attachment.
Changes bolded/highlighted/underlined below.
Phase Deliverable Frequency I, II, and III Technical Report Monthly I, II, and III Financial Report Monthly I CD 1 Report End of Phase 1 II CD 2 Report End of Phase 2 II Transition Plan End of Phase 2 III CD 3 Report End of Phase 3 III Technology Transfer Package End of Phase 3 End of program Final Technical Report End of PoP
Table 1: B-SAFE notional deliverables by Phase
Technical Area Metric CD1 CD2 CD3
TA1 Potency >50% >75% >99%
Broad-spectrum >50% >75% >99%
Number of inhibitors
Any number <8 ≤2
TA2 Novel inhibitors Demonstrate discovery
Validate pipeline
Expansion of inhibition
Adding at least one new USG-defined enzyme to existing inhibitor
Table 4: Notional B-SAFE capability demonstration performance metrics
Section III: Submission Information
This announcement allows for multiple award instrument types to include Procurement Contracts, Cooperative Agreements, and Other Transaction Research and Prototype. Some award instrument types have specific cost-sharing requirements. The following websites are incorporated by reference and contain additional information regarding overall proposer instructions, general terms and conditions, and each specific award instrument type.
Proposers must review the following links below:
o Proposer Instructions and General Terms and Conditions: Proposer Instructions and General Terms and Conditions o Procurement Contracts: Procurement Contracts o Cooperative Agreements: Cooperative Agreements o Other Transaction Agreements: Other Transactions
This announcement contains an abstract phase. Abstracts are required and must be submitted to be eligible to submit a full proposal. Additional instructions for abstract submission are contained within Attachments A and B.
Full proposals are due August 12, 2024 at 4:00 p.m. as stated in the Overview section.
Attachments C, D, E, F, and G contain specific instructions and templates and constitute a full proposal submission. Please visit Proposer Instructions and General Terms and Conditions for specific information regarding submission methods through the Broad Agency Announcement Tool (BAAT) and grants.gov (as applicable).
BAA Attachments:
o (required) Attachment A: Abstract Summary Slide Template o (required) Attachment B: Abstract Instructions and Template o (required) Attachment C: Proposal Summary Slide Template o (required) Attachment D: Proposal Instructions and Volume I Template (Technical and
Management) o (required) Attachment E: Proposal Instructions and Volume II Template (Cost) o (required) Attachment F: MS Excel™ DARPA Standard Cost Proposal o (required) Attachment G: MS Excel™ Risk Register https://www.darpa.mil/work-with-us/proposer-instructions https://www.darpa.mil/work-with-us/proposer-instructions https://www.darpa.mil/work-with-us/procurement-contracts https://www.darpa.mil/work-with-us/grant-cooperative-agreements https://www.darpa.mil/work-with-us/other-transaction-agreements https://www.darpa.mil/work-with-us/proposer-instructions https://www.darpa.mil/work-with-us/proposer-instructions
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