ST SME PWS_1-22-20_TW changes.docx

Technical Subject Matter Expertise (SME) Performance Work Statement (PWS)

1.0 OBJECTIVE

The objective of this requirement is to acquire Advisory & Assistance Support (A&AS) expertise for the Defense Threat Reduction Agency (DTRA) in support of the Research and Development (RD) Directorate which requires technical and scientific expertise across the CBRNE and improvised threat spectrum and in countering weapons of mass destruction (CWMD), countering improvised threats (C-IT) and countering improvised threat networks (CTN) in support of the RD objectives.

2.0 BACKGROUND

DTRA's mission is to enable the DoD, the U.S. Government, and International Partners to counter and deter weapons of mass destruction, improvised threats and improvised threat networks. DTRA RD is the DTRA focal point for research, development, test, and evaluation (RDT&E) relevant to the mission of countering weapons of mass destruction (WMD), countering improvised threats (C-IT) and countering improvised threat networks (CTN). Following guidance and operational concepts of senior Department of Defense (DoD) officials, RD provides expertise across the full range of chemical, biological, radiological, nuclear and high-yield explosives (CBRNE) WMD, C-IT and CTN technologies to encompass understanding, detection, identification, characterization, denial, control, disabling, defeating, disposing, safeguarding the force, managing consequences, and test and evaluation in support of military and civilian operations.

The RD RDT&E activities include all possible RDT&E funding, from 6.1 to 6.5 funding. RD’s RDT&E activities, however, mainly focus on basic research through advanced component development and prototypes. RD’s activities beyond the advanced component development and prototype activities include system development and demonstration activities such as the Nuclear Arms Control Technologies (NACT) and other programs. In addition, RD directs and manages the Joint Science and Technology Office (JSTO) component of DoD’s Chemical and Biological Defense Program (CBDP), along with engaging in operational activities that are complementary to its R&D activities in order to support Combat Commands (CCMD) and customer requirements. Examples of these operational activities include Technical Reachback, various RD-CX activities and Nuclear Arms Control Technology (NACT) operations and maintenance of Comprehensive Nuclear Test Ban Treaty (CTBT) operation and maintenance (O&M) of CTBT internal monitoring stations which uses O&M funding. RD’s portfolio includes integration of technologies, Advanced Technology Demonstrations (ATDs), Joint Capabilities Technology Demonstrations (JCTDs), small business innovative research (SBIRS), Combatant Command (CCMD) engagement, Service support, Service support of Joint Urgent Operational Needs (JUON) and Joint Emerging Operational Needs (JEON) taskings and international collaborative efforts. Rapid development and demonstration of specialized WMD threat reduction capabilities, C-IT capabilities, CTN capabilities, to include their end-to-end support planning and activities may also occur. In addition, RD provides analytic and technical support to DTRA’s Combat Support Agency activities and the Intelligence Community (IC) via Technical Reachback, the Defense Threat Reduction Information Analysis Center (DTRIAC), the DTRA Operations Center and other mechanisms.

RD is DTRA’s lead in evaluating the potential for integration and/or synergy effects from all DTRA RDT&E activities among multiple Directorates. RD provides RDT&E, ranging from basic research through demonstration and validation, to providing unique testing and evaluation facilities; rapid and deliberate capability delivery; and inter-organizational cooperation to counter, combat, protect and mitigate against improvised threats, WMD, improvised threats and threat networks. RD performs all technical, managerial and staff functions required to plan, program, budget, and execute a comprehensive and integrated research and development program, to implement fiscal actions to meet DoD, CCMD and Service requirements and to support planning and programming actions for the DTRA Director. Performing this mission requires coordinating and managing extensive and complex RDT&E activities performed by, DoD and National Laboratories, industry, academia, Services other Government agencies, and foreign Governments.

DTRA enables Special Operations Command (USSOCOM), as the Unified Command CWMD Coordinator, the DoD, the U.S. Government, and International Partners to counter and deter weapons of mass destruction, improvised threats and improvised threat networks.

3.0 APPLICABLE DOCUMENTS

DTRA OPERATING INSTRUCTION, Research and Development Directorate, Enabling Capabilities Department, Operating Instruction 2 for Test Operations, October 23, 2019

4.0 SCOPE

The RD organization has a far-ranging scope in the types of roles, missions, functions, operations, and tasks it supports. This acquisition requires dedicated and unbiased A&AS support to act as a “trusted agent” for the agency both internally and externally in the course of daily execution of specified and implied missions. This requires close coordination within RD to effectively execute its programs, as well as across the agency’s Directorates. RD efforts are generally organized within six elements:

· RD Research & Development Operations Department (RD-OP),

· Chemical and Biological Technologies Department (RD-CB),

· Counter Weapons of Mass Destruction (WMD) Technologies Department (RD-CX),

· Enabling Capabilities Department (RD-EC),

· Nuclear Technologies Department (RD-NT),

· Counter Improvised Threat Technologies, Department (RD-TT).

The Scientific & Technical (S&T) Subject Matter Expertise (SME) A&AS contractor, hereafter referred to as the contractor, will work closely with the Program Management Office (PMO) A&AS contractor as an associate contractor. Any question or issue regarding interaction with the PMO A&AS contractor should be brought to the attention of the contracting officer’s representative (COR).

There is a planned minimum 120 day transition phase from contract award to program activity start date on 7 April 2021.

4.1 DISCIPLINES

The contractor shall provide personnel possessing the following disciplines, with appropriate security clearances to allow application of those disciplines:

· Physical Sciences:

· Nuclear Physics, Radiation Detection, Nuclear Forensics, Air Blast Physics, Mathematics, Chemistry (Organic, Physical, Analytic, Forensic), Meteorology, Statistics, Accelerator Sciences, Materials Sciences, GeoPhysics, Nuclear Weapons Effects

· Biological Sciences:

· Biology, Microbiology, Biochemistry, Pharmacology, Genetics, Virology, Bioinformatics, Immunology, Toxicology, Pathology, Physiology, Medical Science, Veterinarian Science, Health Physics

· Engineering:

· Mechanical Engineering, Chemical Engineering, Electrical Engineering, Civil Engineering, Materials Engineering, Test Engineering, Structural Engineering, Biological Engineering, Process Engineering, Nuclear Engineering, Seismic/Acoustic Engineering, Aeronautical Engineering

· Technical/Operational:

· Public Health Science, Environmental Science, Biosurveillance, Disaster Preparedness, Computer Modeling and Simulation, Optics, Hydrology, Blast and Explosives, Information Systems, Network Sciences, Logistics, Pulsed Power, Computer Sciences, Data Sciences, Information Science, Robotic Systems, Software Development, Test Diagnostics and Instrumentation, Archival Science, Data Architecture, Advanced Text and Image Analytics, Sensor deployment, multi-agency security responses and coordination

· Policy Support:

· Vaccine/Therapeutics Regulatory Processes and Requirements

4.2 PLACE OF PERFORMANCE

The government will provide office space for up to 29 S&T SME positions where performance is located at Ft. Belvoir (93%) and DTRA ALBQ (7%) in support of all DTRA S&T SME requirements with the exception of DTRA Crystal City (RD-TT). DTRA Crystal City will provide office space for 100% of the 43 S&T SME positions located at Crystal City.

Remote support from another location, temporary duty travel, or other means may be required occasionally for (but not limited to) Dugway Proving Ground, UT; White Sands Missile Range, NM; the Nevada National Security Site, NV; Yuma Proving Grounds, AZ and Naval Air Warfare Center – Weapons Division China Lake, CA

Contractor staffs using Government provided office spaces shall support security activities in DTRA workspaces, as per DTRA security standard operating procedures.

At Crystal City, the contractor staffs using Government provided office space, shall support end-of-day security checks in DTRA workspaces, escort duties for trash and cleaning activities, burn bag duties and open and closure of the 6th floor suites, per DTRA Security standard operating procedures.

5.0 TASKS

The contractor shall provide personnel with the required CBRNE, CWMD, C-IT or CTN scientific and technical expertise based on their assigned mission domain, to fulfill their assigned duties. The contractor shall perform as an associate contractor to the PMO A&AS contractor who shall be in an associate contractor role to the S&T SME contractor via an Associate Contractor Agreement (ACA). The contractor shall work closely with the PMO A&AS contractor to ensure all scientific and technical analyses, studies, reviews, requirements, etc., are correctly captured and tracked within the PMO tracking and status mechanisms, processes and procedures in the performance of their assigned tasks. The contractor shall perform the RD scientific and technical activities described below for all the organizations, departments and divisions within the RD Directorate:

5.1 Subject Matter Expertise (SME) Transition Support: The contractor shall ensure a smooth transition of support services with no degradation in capabilities during transition. Transition shall begin immediately at time of award with the transition date ending on 6 April 2021. PWS requirements shall be available and ready not later than 7 April 2021.The (Incoming) Management Plan and its execution shall ensure that all required PWS timelines and requirements are met.

· Execute the approved Transition In plan to ensure all PWS requirements are available and ready for program start date, 7 April 2019. Any changes to this baseline during the transition phase must be approved by the RD Contracting Officer Representative (COR).

· Develop a SME Transition-Out Plan for transitioning and delivering all material and information from this contract to the Government. The plan shall identify all Government Furnished and contractor Furnished Material (GFM/CFM) as well as information and tools developed during the contract that was used in the execution of this contract. A draft plan shall be submitted for Government approval 120 calendar days after notification that the government is not exercising an option and letting the contract expire or 120 days before the end of the contract after all options have been exercised. Upon incorporation of comments and Government acceptance, the contractor shall follow the plan to transfer all material, information, and rights thereto to the Government.

· The contractor shall facilitate and conduct transition-out activities. The contractor shall prepare a final Technical Report documenting the status of all ongoing technical and scientific efforts and projects, including a Smart Book/Turnover Binder containing copies of all plans, policies, procedures, points of contact, and other information required by the Government. A draft of the Technical Report is due NLT 120 calendar days prior to the end of the initial period of performance (Base Period) and an update NLT 120 days prior to the end of each Option Year. The contractor shall provide full cooperation to providing necessary operational knowledge transfer to the in-coming contractor. All documentation must be provided to Government personnel. Transition out shall include the following types of services:

· Project management processes,

· Points of contact,

· Location of technical and project management documentation,

· Status of ongoing technical initiatives,

· Contractor to contractor coordination with Government oversight to ensure a seamless transition,

· Transition of key personnel functions and information,

· Identify schedules and milestones,

· Identify actions required of the Government,

· Establish and maintain effective communication with the incoming and contractor/Government personnel for the period of the transition via weekly status meetings.

5.2 Scientific and Technical Expertise: The contractor shall provide scientific and technical expertise as defined in PWS 4.2, and support in-depth scientific analyses and technology assessments and activities across the spectrum of RD’s existing and emerging CBRNE, CTN, C-IT and CWMD science and technology related responsibilities, including assessing the soundness of alternative evolving scientific and technological approaches and evaluating research results. The contractor shall work closely with the PMO A&AS contractor to ensure all required scientific and technical recommendations, analyses, assessments, activities, etc., are fully integrated into all required programmatic documentation to ensure logical, defendable and executable plans. These activities include:

· Plan and prepare basic and fundamental research, applied research, experiments, investigations, observations, and related research studies into the phenomena associated with CWMD, CTN or C-IT and assist with the development of theories for understanding, characterizing, and organizing natural phenomena into systematic and meaningful patterns for advancement of emerging CWMD technologies.

· Design and plan systems focusing on integration of cross-cutting technologies and systems of systems; and support planning, preparation, definition, and execution of S&T programs.

· Using operations research and modeling and simulation capabilities, support development, dissemination, and successful execution of computational predictive physics-based models and tools that address a variety of CWMD, CTN, or C-IT related needs and challenges. Activities include:

· Develop and analyze concepts; explore alternative architectures; demonstrate systems and innovative components in exercise environments; and verify and validate system requirements, concepts, and designs.

· Plan, execute, and document results of wargames, modeling, and experimentation to assist Government validation and prioritization of requirements, definition of operational concepts, identification of capability gaps, and to provide alternative solutions.

· Support development of data, methods, and tools for risk-based planning and decision making. Enable research and analysis on operational effects capabilities to better focus S&T efforts.

· Support scientific and technical review, analysis, and implementation of the Assistant Secretary of Defense for Research and Engineering [ASD(R&E)] S&T Plan, to include all required inputs, recommendations and rationales from RD. Support includes Reliance 21 Executive Committee activities and processes, systems engineering methodologies and tools, modeling and simulation, and wargaming to develop requirements and conduct trade studies for candidate projects, assist in the establishing of S&T priorities for investment, using RD decision making processes, integrating and coordinating approved projects with DTRA internal and external customers through DTRA’s CCMD liaison officers and area desks, and supporting preparation of the RD S&T Plan consistent with the DTRA and other higher authority strategic plans.

· Provide scientific and technical expertise to support RD leadership in the development and integration of ASD(R&E) Communities of interest (COI). This task includes coordination of DTRA S&T with S&T activities in OSD, academia, other Government agencies, laboratories, universities, corporations, international symposia and the Interagency for the CWMD COI. Activities included in this effort include:

· Evaluate scientific and technical compliance with higher-level guidance regarding Global Nuclear Threat and other priority missions as it relates to the Directorate’s S&T function.

· Support needed interfaces with the State Department to facilitate foreign military sales, and define treaty verification technology needs that benefit from RD collaboration. Develop and recommend specific coordinating actions.

· Assist in identification and nurturing of fundamental and early applied science projects. In addition, the contractor shall provide advice on metrics and success criteria, evaluate and document research results and assist with transition planning and transition execution of projects.

· Provide strategic and technical expertise to assist with the development and management of the S&T portfolio. These activities will include assisting RD leadership to establish and maintain connections to the S&T community for WMD matters to identify program synergies, including universities, corporations, laboratories, international symposia, and Federal agencies.

· Assist in outreach across the Agency, other Government agencies, industry, academia, and international S&T partners to identify programs to use for RD objectives.

· Provide scientific and technical expertise to the RD and the CBD Small Business Innovative Research (SBIR), Small Business Technology Transfer (STTR), Rapid Innovation Funding (RIF_, and RD Broad Area Announcement (BAA) programs, to include:

· Provide scientific and technical expertise to assist in proposal assessments and evaluations written by all Technical Evaluation Team members, and contract administrative data (e.g., award dates, period of performance, funding amounts; option dates, other data as necessary and as required by the OSD OSBP in addition to the CBD SBIR PM).

· Provide scientific and technical expertise during the execution of SBIR, STTR, RIF and RD BAA projects managed by RD.

· Assist in identifying and developing new SBIR, STTR, RIF and RD BAA program topics.

· Assist in information technology (IT) development, test, and obtain CIO approval, integration and transition of architectures, hardware, and software systems for the S&T program. Activities included within this are:

· Assess state-of-the-art Information Technology (IT) capabilities for applicability into CWMD, CTN and C-IT S&T programs to improve, innovate and maintain state-of-the-art capabilities.

· Support software integration, network systems development, test and evaluation, software verification and validation, and version control for these activities.

· Support development, integration, and transition of CTN, C-IT and CWMD threat reduction concepts.

· Support efforts to solicit, evaluate, and award innovative projects and assist in the management and control of those projects.

· Assist in transition of developmental tools to operational application(s) for reachback applications. Assist with coordination and integration of plans with the DTRA Operations Center.

· Verify, and validate WMD lethality and vulnerability models and integrate them with computational tools. Activities include:

· Assist in identifying, defining, and integrating appropriate tests; to include parametric sensitivity analyses and other tools to improve test design.

· Assist in the coordination and evaluation of the high-fidelity analysis and precision test program for validating lethality and vulnerability models.

· Use validated tools such as Response Surface Mapping, IMEA, Warfighter Wizard, Portable Flight Planning Software, VAPO, and Conventional Weapons to provide independent verification of developer work, predict system performance, and inform test planning.

· Prepare documentation and coordinate with Government staff at Service labs, National laboratories, and operational organizations to streamline accreditation of planning tools.

· Use high-fidelity analysis results and results from tests to validate lethality and vulnerability models. Examples of acceptable tools include Paraview to perform large test data analyses.

· Assist with development and integration of WMD battlespace awareness programs such as BioISR, ChemISR, 3MUP, Advanced Materials, and Advanced Energetics.

· Provide scientific and technical expertise and support in- depth scientific analyses and technology assessments across the CBRNE spectrum of innovative translational S&T products to counter the threat of chemical, biological, radiological, nuclear and high explosive threats.

· Support agent defeat modeling and simulation, and technology development, including new agent defeat weapon concepts, such as Kinetic Fireballs and Agent Defeat Penetrator.

· Support the development of operational concept and implementation options, along with execution of approved plans to constitute a nuclear weapons effects network, to include support to the Urban Thermal Environment first principles and 3-D model development projects.

· Support advancing electromagnetic pulse (EMP) and high-altitude nuclear effects technology and high-power micro- wave effects and protection using industry standard tools such as Satellite Toolkit, Systems Engineering Analysis, and Testable Hardware Toolkit to provide independent verification of developer work, predict system performance, and inform program planning for the Radiation Hardened Microelectronics program. Assess technology development to produce radiation-tolerant, high-performance, high-reliability dual-use microelectronics and photonics. Review and evaluate hardening methodologies.

· Assist Nuclear Weapons Effects (NWE) experimental capabilities programs, help develop RD experimental capabilities, assist with improving Department of Energy and National Nuclear Security Agency coordination, and support the development of capability roadmaps.

· Support nuclear threat detection research efforts to develop innovative or new capabilities in standoff detection, location, and identification of radiological materials and nuclear targets of interest, and instrumentation requirements for operations in contaminated environments. Support the development of cutting edge radiation detection capabilities for search, isolation, threat characterization and mapping, combat maneuvering and contamination avoidance. Assist RD-NT in identifying and developing new materials and radiation sensors that address a wide range of operational requirements for interdiction and consequence management. Support helium-3 alternative technologies, nuclear forensics, arms control, monitoring and verification, and other related efforts as identified or directed.

· Support the identification and development of novel military capabilities to find, identify, track, and provide situational awareness of nuclear threats and networks with exceptional precision and confidence while not relying upon radiation detection.

· Advise and assist in the development, test, integration and transition of system architectures where cross functional technologies or applications are required. Provide recommendations and rationale for system architecture implementations to ensure cloud-ready capabilities for the user. Assist in planning, and execution to transition RD projects to development, integration and test, and operational cloud environments.

· Provide computer science, data science and information science expertise and support in managing RD programs and projects, to include developing, interfacing, integrating, testing artificial and evaluating artificial intelligence methodologies and capabilities. Activities include determining, verifying and validating the performance increase of the computer science and data science improvements. In addition, provide recommendations and rationale where artificial intelligence methodologies and capabilities should be targeting to improve performance of RD programs and projects, to include supporting the development of capability roadmaps.

· Support program planning activities consistent with high-level guidance and the Hard and Deeply Buried Target Defeat Science and Technology Master Plan. Assist in identifying, defining, integrating, and scheduling appropriate tests and analyze data resulting from these tests.

· Provide subject matter expertise in all technical matters regarding the counter and defeat improvised threat applications of the following scientific and technology efforts:

· For directed energy and device neutralization technologies. These applications include traditional and state of the art methods for emitting electromagnetic (EM) radiation in all regions of the EM spectrum, energy absorption and emission modeling and simulation, the use and development of electronic warfare systems, and size, weight and power analyses and optimizations.

· For systems utilized for the point, stand-off, and remote detection of explosives, explosive devices, electronic emissions from explosive devices and chemicals associated with their manufacture (i.e., homemade explosives and their precursors). Expertise should include knowledge of detection system application toward the various counter and defeat improvised threat subsets within RD-TT’s mission space, including ground-based detection, air-based detection, and threat network detection, imaging and video analysis.

· Provide expertise in all matters regarding the applications of nuclear forensics activities to include forensics processes and forensic DNA analysis methodologies for the exploitation of the improvised threats. The contractor will assist in planning, coordinating, and directing forensic science activities and maintain an awareness of current scientific developments within the national and international forensic science and technical communities. This includes identifying top scientists in the forensics and DNA community. Other duties include researching and providing professional analysis of systems currently fielded or in development within the forensics and biometrics communities.

· Provide subject matter expertise in all scientific and technical matters in support of System Survivability, the Nuclear Test Personnel Review, Nuclear Detection Technology, and Sensor Applications programs and activities.

· Provide technical support in development and management of integrated and advanced technology demonstrations to operationally assess and transition CBRNE technologies. Assist in early CCMD coordination and approval of technology demonstrations. Support planning and execution of demonstrations in CONUS and OCONUS. Provide demonstration technologies in support of events and contingencies on request. Assist in development of CONOPS that integrate advanced demonstration systems and technologies and concepts into theater campaign and support plans, enhance interoperability, and address the foreign policy objective of building partner capacity. Support evaluation and testing of technologies to include advanced and predictive bio-surveillance concepts, including environmental monitoring, disease vectors, and zoonotic diseases.

· Provide FDA regulatory expertise to support the medical countermeasure developmental lifecycle from drug discovery through FDA regulatory approval. The contractor shall assist in producing a drug development and regulatory strategy.

· Develop a robust, standardized methodology to develop target product profiles for medical countermeasure drug candidates. Effective business process re-engineering incorporating target product profile development will allow for the design of a future state that enables consistency, efficiency and improved operational outcomes for all medical countermeasures under development. Create documentation, structured implementation and focused roll-out activities to support organizational adoption and process sustainability.

· Support electronic filing with the FDA using an electronic data management system, currently the Clinical Data Interchange Standards Consortium Model, that will enable enterprise integration between DTRA-JSTO-CBD, JPEO-Medical Countermeasures Systems (MCS), US Army Medical Research & Materiel Command (USAMRMC) laboratories, and contract research organization. This system will include clinical data interchange consortium standards enabling the unrestricted, secure sharing of data and standard business processes via networked applications.

· Provide technical and scientific expertise to the Chemical and Biological programs to include:

· Develop innovative concepts and architectures to create a global biosurveillance awareness system that incorporates traditional surveillance approaches and new approaches and novel data sources. Provide expertise in data fusion and validation, zoonotic, vector-borne diseases, and environmental factors that influence disease propagation to develop predictive models. Data will be derived from classified and open sources, as well as intelligence, social, and cultural information important for consideration of counterterrorism and counter proliferation.

· Provide scientific and technical expertise to identify promising targets that may serve as the basis for research and development products of diagnostic science and informatics. Support the development and transition of CB diagnostics products, including assays, analytics and clinical tests to device development, and advance developers, including JPEO and other programs of record, or various customers. Support programs aimed at characterizing pathogens and pathogen unique biomarkers, biomarker signatures from interactions between humans and chemical agents (such as adducts), and host-parasite biomarkers (such as transcriptome or cytokine profiles), with a focus on pre-symptomatic biomarkers, and genomic and clinical informatics. Integrate diverse biomarker information to identify sensitive and specific biomarker signatures that support development of FDA-approved diagnostic assays or products. Provide systems biology support, especially regarding tools and techniques required for data organization, retrieval, integration, and synthesis. Support liaison with the FDA to provide ongoing assessment of biomarker suitability with respect to approval for diagnostic use.

· Provide technical expertise required to develop novel, rapid, and cost-effective sample preparation techniques. Emphasis will be on automated, miniaturized, ruggedized, thermostable, and ultimately reagentless sample preparation methods that can be directly integrated into the point-of-care diagnostic instruments and environmental detection platforms. Support development and assessment of analytic methods for identification of intoxication and infection biomarkers; assess commercially available platforms and prototype assays for integration into currently supported diagnostic devices or devices in the acquisition pipeline. Support development of mathematical algorithms that reveal and enhance significant signals and patterns in potentially noisy data, including improving assay sensitivity and reproducibility.

· Provide expertise and support development and assessments of environmental chemical and biological detection platforms that align to JPEO capability gaps and transition to programs of record.

· Support improved modeling and prediction of atmospheric and waterborne threat agents (chemical, biological, radiological dispersion), including dispersion in complex and urban terrains. Support integration of missile intercept models into hazard prediction capabilities. Assist in enhancing human effects modeling as part of the Joint Effects Model (JEM) suite. Support verification and validation (V&V) and configuration management of the Hazard Prediction and Assessment Capability (HPAC)/JEM S&T Prototype (JSTP) components.

· Support S&T projects supporting JEM/Joint Warning and Reporting Network (JWARN) development and integration and verification of JEM components into prototype synthetic environment architectures. Facilitate evaluation of latest S&T by selected users. Contribute to development of enhanced numerical weather modeling. Support modeling and validation of building interiors related to agent transport and dispersion.

· Support development of system performance models for test and evaluation to obviate the need for live testing by modeling suitability and effectiveness of test/equipment items (e.g., masks, suits, detectors, decontaminants, shelters) under varying environment and operational conditions. Assist in compilation and organization of chemical and biological defense data, methods, and tools into the Chemical and Biological Defense Manual Number 1 (CB-1).

· Provide technical and management support in development and management of programs focusing on programs within basic materials and imaging sciences, and applied novel materials programs that provide increased individual and collective protection capabilities. Assess new multifunctional material to address functional requirements, improve physiological tolerance, and reduce logistical burden. Support programs to develop decontamination technologies that are more logistically supportable, suitable for use on sensitive equipment, and are effective against a broad range of threat materials. Support design and development of integrated technologies and CONOPS for consequence management.

· Support development, assessment, and transition of prophylaxes, pretreatments, and therapeutics for chemical agents. Support S&T in developing catalytic bio-scavengers, receptor reactivators, enzyme modulators, and pharmaceutical products to pre-symptomatically mitigate chemical agent exposure. Provide SMEs to support S&T in developing pharmaceutical products to mitigate damage caused by chemical agents.

· Provide expertise in application of the Animal Rule. Provide technical and regulatory expertise to assess MCM readiness for FDA applications. Support studies to repurpose and extend label indications for existing FDA-approved drugs.

· Provide technical expertise to evaluate relevant new technologies to address gaps in fundamental and applied knowledge, especially new developments in Threat Agent Science and Medical Chemical Countermeasures. Assist Science & Technology Managers to define the environmental fate of physiological response (e.g., toxicology) and critical characterization of chemical and biological threats (NTA and non-NTA) and to support CONOPS development for decision makers.

· Support R&D involving new and advanced physical, analytical and computational methods for life science and agent fate programs. Evaluate applicability of bioinformatics and systems biology methods and tools, alternative spectrographic methods and signatures, and higher order mathematical tools for data interpretation and integration.

· Support development, assessment, and transition of high-yield, flexible vaccine expression platforms. Support S&T programs to develop vaccine adjuvants and host immune modulators. Provide technical and regulatory expertise to assess S&T product readiness for submission for investigational new drug status. Provide expertise in application of the Animal Rule. Assist in evaluation of novel approaches for in vitro/ex vivo assessment of human immune responses.

· Support programs to identify and develop post-exposure therapeutics for bacterial and viral pathogens as well as toxin threat agents. Assist in managing and evaluating S&T projects to develop antibiotics and small molecules that target pathogens or interfere with unique microbial biochemistry, viral replication proteins, and host targets required for infection, replication, pathogenesis, or intoxication. Assist in assessment of passive immunity or modulation of innate immunity to potentiate host response against pathogens. Provide expertise in application of the Animal Rule. Support reevaluation and label extension of existing FDA-approved drugs and antibiotics.

· Support development of technologies required to advance regulatory sciences leading to reduced reliance on animal studies, including in vivo, ex vivo human cell cultures, and tissue mimetics. Assist in evaluation of potential manufacturing technologies that are modular, disposable, scalable, and adaptable to production of multiple medical countermeasures. Support exploratory research programs addressing the potential of synthetic biology.

· Regulatory Strategy and Target Product Profile Development. Develop detailed target product profiles for medical countermeasures specific to CONOPs requirements as more broadly outlined in the JCIDS documents such as the Initial Capabilities Documents and the Capabilities Development Documents. This effort should be supported by travel to and consultation with the numerous DoD chemical biological defense enterprise stakeholders, including but not limited to: Joint Requirement Office (JRO); Joint Program Executive Office for Chemical and Biological Defense (JPEO-CBD); Defense Advanced Research Projects Agency (DARPA); Biomedical Advanced Research and Development Authority (BARDA); National Institutes of Health (NIH); Public Health Emergency Medical Countermeasures Enterprise (PHEMCE); Food and Drug Administration (FDA); and U.S. Army Medical Research and Materiel Command's (USAMRMC) laboratories.

5.4 Requirements Analysis Support: The contractor shall provide scientific and technical analysis and assessment support to the DTRA and RD Directorate Requirements Program, processes and procedures. The contractor shall work closely with the PMO A&AS contractor to ensure all required scientific and technical recommendations, analyses, assessments, activities, etc., are fully integrated into all required programmatic documentation to ensure logical, defendable and executable plans. Activities include:

· Develop and document technical methodologies and models to determine priorities for identified threats, operational needs, and requirements using existing data repository, requirements management and decision support tools in support of the requirements management and decision support activities.

· Support international collaboration, including investigating, analyzing, assessing, and identifying potential areas for future R&D collaboration; support to cooperative research and/or technology development; and support to existing and future information exchange agreements and project agreements.

· Enhance operational utility of the RD portfolios through proactive engagement in operational events.

· Lead the development of an interactive CBRNE, CWMD, C-IT and CTN threat and disruptive technology catalogue that is customer facing and can be used by the Joint Force in determining required solutions where demand exists. Familiarization with Combatant Commands (CCMD) Integrated Priority Lists (IPLs)/Science & Technology Integrated Priority required.

· Analyze, assess, and identify the most critical CBRNE, CWMD, CIT and CTN technologies, threats, disruptive capabilities, initiatives, potential innovations and gaps in support of the RD Requirements Program in a structured, methodical, repeatable technical process. Provide rationale and proposed recommendations to manage and mitigate these results. Assess soundness of scientific and technological recommendations.

· As required, coordinate with the Joint Staff (JS) and Services to develop requirement documents, to include requirement documents and staff KMDS.

· Monitor ongoing technical requirements documentation efforts across the DoD (via the Knowledge Management Decision Support KM/DS) ensuring RD’s interests are incorporated into relevant requirements documents. Coordinate, prepare, and conduct analysis of RD requirements for validation, as required to meet the DTRA Requirements Management process and procedures.

· Identify and support the development, analysis and assessment of warfighter requirements in support of the DTRA Requirements Management process and procedures. The contractor shall recommend potential requirements to the Government for approval, understand capability gaps, and assist the CCMDs with drafting Joint Urgent Operational Need (JUON), Joint Emergent Operational Need (JEON), or Request for Support (RFS) memorandums.

· Perform the following activities in support of CBRNE, CWMD, C-IT and CTN gap identification and vulnerability assessments:

· Collect and assess CBRNE, CWMD, C-IT and CTN threats and disruptive technology threshold and objective minimum values to assess performance of these programs and coordinate capability development goals with key stakeholders.

· Establish a view of the current state of the DoD portfolio of CBRNE, CWMD, C-IT and CTN threats and disruptive technology enablers, and assess the performance of the enablers against the objective minimum values.

· Identify and support the development, analysis and assessment of warfighter requirements in support of the DTRA Requirements Management process and procedures. The contractor shall recommend potential requirements to the Government for approval, understand capability gaps, and assist the CCMDs with drafting Joint Urgent Operational Need (JUON), Joint Emergent Operational Need (JEON), or Request for Support (RFS) memorandums.

· Rapidly respond to anticipate emerging operational requirements by providing scientific and technical expertise and support in-depth scientific analyses and technology assessments across the spectrum of RD’s CBRNE, CTN, C-IT and CWMD S&T-related responsibilities, including assessing the soundness of alternative scientific and technological approaches and evaluating research results.

· The contractor shall provide scientific and scientific expertise to perform the following activities in support of CWMD, C-IT and CTN threat technical analysis:

· Perform research and analysis of all-source data derived from, but not limited to, multiple and specialized databases, and prepare issue papers and recommendations based on analysis. Prepare input for inclusion Red Team products supporting emulative and task/concept analysis.

· Identify analyses, assessments and studies and in support of the PMO

· A&AS contractor, perform the following activities:

· Coordinate and archive DoD, Joint, Service, Federally Funded Research Facilities, industry and academic studies and assessments conducted in support of RD efforts.

· Maintain a catalog of studies and assessments, and archive reports of techniques and procedures against known technology capabilities.

· Work closely with the PMO A&AS contractor to schedule scientific and technical meetings and briefings, to include tracking and reporting on action item close-out, as needed.

· Provide required scientific and technical expertise to PMO A&AS contractor to maintain a database to track threat devices as well as red and blue teaming system progress and coordinate with RD.

· Ensure all proposed RD CWMD, C-IT and CTN countermeasure systems are considered for Technical Red/Blue Team analysis.

· Support reverse engineering, building and validation of electronic and mechanical devices efforts to be used in the CWMD, C-IT and CTN threat fight, and ensure such devices meet varying technical specifications required for the construction and delivery of such devices and systems.

· Coordinate the overall development of prototyping of possible future C-IT and CTN threat arming and triggering devices based on adaptations of commercial-off-the-shelf (COTS) technology.

· Serve as technical meeting coordinator, as required, to support proper scientific and technical communication between stakeholders.

· Prepare documents, as required in collaboration with the PMO A&AS contractor, supporting the Senior Integration Group (SIG) working groups and meetings.

· Assess counter improvised threat requirements based on their scientific and technical basis and provide recommendations to required leadership.

· Maintain regular communication with Service and key stakeholders on scientific and technical issues in support of the RD Requirements Program.

· Provide technical & scientific requirement inputs into battle rhythm events as required, including Global-Counter Improvised Threat Action Review (GCAR), Iraq/Afghanistan OPS Support. Maintain counter CWMD, C-IT and CTN threat knowledge base through field evaluations, industry visits, and conference attendance.

· Develop and document methodologies and models to determine priorities for identified threats, operational needs, and requirements.

· Each area Action Officer (AO) will prioritize their respective requirements for validation or re-validation.

· Work with the Joint Staff as requested regarding CWMD, C-IT and CTN threat programmatic issues.

· As required by the Government design and perform CWMD, C-IT and CTN threat related experiments, and data collection, to ensure the integrity, quality control and protocol compliance of offered solutions.

· Provide following support to C-IT acquisition efforts:

· Support technical Red Team analysis efforts for counter-improvised threat acquisition efforts for other elements of DoD as well as other Government agencies such as the following: Department Homeland Security (DHS), Transportation Security Administration (TSA), Federal Bureau Investigation (FBI), Border Patrol (BP), Immigration and Customs Enforcement (ICE), and United States Coast Guard (USCG) as directed by the Government.

· Support the technical vulnerability assessment/coordination efforts, to include:

· Support the Technical Red (enemy forces) and Blue (own forces) Team analysis of RD initiatives to identify potential risks, vulnerabilities and the validity/effectiveness of potential enemy responses to RD initiatives, mitigate system vulnerabilities, and provide methods to increase CWMD, C-IT and CTN threat system performance.

· Maintain a comprehensive list of emerging ideas, concepts, strategies, and technologies and provide analytical analysis and provide support services in the development of papers and briefings defining options for future operations.

· Support the initial vetting of technologies introduced to RD, the evaluation of prospective technologies and the assessment and development of current technologies. Utilize fundamental concepts, practices and procedures of the specialty scientific fields to perform research tasks evaluating emerging technologies which may be applicable to counter and defeat improvised threat operations. Efforts by other Government entities may be analyzed and evaluated for recommendation to the RD COR regarding applicability to RD initiatives.

5.5 Technical & Scientific Interfaces: The contractor shall establish and maintain technical interfaces with recognized technical experts and professional contacts with leaders in industry, academia, and Government arenas pertinent to CBRNE, CTN, C-IT and CWMD technologies. As needed, the contractor shall work closely with the PMO A&AS contractor to ensure all required technical interface planning and execution information is fully integrated into all required programmatic documentation to ensure logical, defendable and executable plans. Such interface activities include:

· Developing professional relationships with recognized experts and technology leaders in technologies pertinent to RD’s mission.

· Support S&T engagements across the CBRNE, CWMD, C-IT and CTN domain mission space to maintain cognizant of innovative and successful scientific and technical activities being performed within the federal government, academia, private contractors and allies. Such engagements include:

· Attendance at meetings, conferences, and symposia and maintaining a professional contact database pertinent to RD’s mission. Sources of these interfaces may also include presenting papers at symposia; organizing symposia for RD; planning RD-sponsored national conferences; visiting customer and performer sites in Government, industry, and academia, including internationally; supporting international collaborations such as the U.S.-U.K. Joint Working Groups (JOWOG Panels 6, 36, and 43) and international S&T partners; and organizing modeling and simulation workshops and exercises for RD.

· Provide PMO A&AS contractor with results and activities from science and technical international collaboration efforts, including investigating, analyzing, assessing, and identifying potential scientific and technical areas for future R&D collaboration; support to cooperative research and/or technology development; and support to existing and future scientific and technical information exchange agreements and project agreements.

· Support the PMO A&AS contractor in identifying, coordinating and managing S&T engagements with the CCMDs (requirement development, strategic planning, projects) and OP Area Desks/Regional Working Groups/Liaison Officers

· Support Foreign Disclosure Office (FDO) coordination approval of all required S&T materials and meeting classification requirements.

· Providing strategic and technical expertise to assist with the development and management of the S&T portfolio. Assisting RD leadership to establish and maintain connections to the S&T community for WMD matters to identify program synergies, including universities, corporations, laboratories, international symposia, and Federal agencies.

· Assist the test planning, coordinating, executing, and reporting support to RD support to the IC activities. Support includes targeting and IC technology and test, the Hard Target Research and Analysis Center (HTRAC), Counter WMD Analysis Cell (CWAC), and classified special projects.

· Provide strategic and technical advice and assistance to RD senior leadership for long-range S&T activities to demonstrate innovative technologies and capabilities that mitigate the threat and/or effects of nuclear, radiological, chemical, biological, and high-explosive events.

· Support development, integration, and transition of WMD threat reduction concepts, including support to efforts to solicit, evaluate, and award innovative projects, and assist in the…