Foa_Content_of_RFA-DP-22-003.pdf

Centers for Disease Control and Prevention

NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH

PROMOTION

Health Promotion and Disease Prevention Research Centers: 2022 Special Interest Project

Competitive Supplements (SIPS)

RFA-DP-22-003

03/04/2022

Table of Contents Section I. Funding Opportunity Description

Section II. Award Information

Section III. Eligibility Information

Section IV. Application and Submission Information

Section V. Application Review Information

Section VI. Award Administration Information

Section VII. Agency Contacts

Section VIII. Other Information

Overview Participating Organization(s) Centers for Disease Control and Prevention Components of Participating Organizations Components of Participating Organizations:

National Center for Chronic Disease Prevention and Health Promotion Notice of Funding Opportunity (NOFO) Title Health Promotion and Disease Prevention Research Centers: 2022 Special Interest Project Competitive Supplements (SIPS) Activity Code U48

Notice of Funding Opportunity Type New Agency Notice of Funding Opportunity Number

RFA-DP-22-003

Assistance Listings Number(s) 93.135 Category of Funding Activity HL - Health NOFO Purpose This Notice of Funding Opportunity (NOFO) will provide supplemental funding to Prevention Research Centers (PRCs), currently funded under CDC RFA-DP-19-001 to conduct Special Interest Projects (SIPs) to design, test, evaluate, disseminate and translate effective applied public health prevention research on interventions (i.e. programs, practices, policies, or strategies) and tools developed in real-world settings to address the leading causes of illness, disabilities, and death in the United States. Research projects announced in this NOFO align with public health priorities associated with Healthy People 2030 topic areas: Cancer and Adolescents; Cancer and Health Care Access and Quality; Children with Disabilities and Care Access and Quality; Environmental Health and Emergency Preparedness; Older Adults and Dementia; People with Disabilities and Mental Health and Mental Disorders; Women, Emergency Preparedness, and Health Care Access and Quality.

Key Dates Publication Date:

To receive notification of any changes to RFA-DP-22-003, return to the synopsis page of this announcement at www.grants.gov and click on the "Send Me Change Notification Emails" link.

An email address is needed for this service.

Letter of Intent Due Date:

The LOI date will generate once the Synopsis is published if Days or a Date are entered.

02/03/2022

Application Due Date:

03/04/2022 03/04/2022

On-time submission requires that electronic applications be error-free and made available to CDC for processing from the NIH eRA system on or before the deadline date. Applications must be submitted to and validated successfully by Grants.gov no later than 5:00 PM U.S. Eastern Time.

Applicants will use a system or platform to submit their applications through Grants.gov and eRA Commons to CDC. ASSIST, an institutional system to system (S2S) solution, or Grants.gov Workspace are options. ASSIST is a commonly used platform because it provides a validation of all requirements prior to submission and prevents errors.

For more information on accessing or using ASSIST, you can refer to the ASSIST Online Help Site at: https://era.nih.gov/erahelp/assist. Additional support is available from the NIH eRA Service desk via http://grants.nih.gov/support/index.html.

E-mail: commons@od.nih.gov Phone: 301-402-7469 or (toll-free) 1-866-504-9552.

Hours: Monday - Friday, 7 a.m. to 8 p.m. Eastern Time, excluding Federal holidays.

Note: HHS/CDC grant submission procedures do not provide a grace period beyond the application due date time to correct any error or warning notices of noncompliance with application instructions that are identified by Grants.gov or eRA systems (i.e., error correction window).

Scientific Merit Review:

04/26/2022 Secondary Review:

06/20/2022 Estimated Start Date:

https://www.grants.gov/ http://grants.nih.gov/support/index.html mailto:commons@od.nih.gov

09/30/2022 Expiration Date:

03/05/2022 Required Application Instructions It is critical that applicants follow the instructions in the How to Apply - Application Guide except where instructed to do otherwise in this NOFO. Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

Note:The Research Strategy component of the Research Plan is limited to 12 pages.

Page Limitations: Pages that exceed the page limits described in this NOFO will be removed and not forwarded for peer review, potentially affecting an application's score.

Applications that do not comply with these instructions may be delayed or may not be accepted for review.

Telecommunications for the Hearing Impaired: TTY 1-888-232-6348

Executive Summary Purpose. Public health practitioners need scalable, feasible interventions and tools.

Applied public health prevention researchers can engage communities to develop and evaluate health promotion and disease prevention interventions, disseminate new science, and translate proven effective interventions into public health practice and policy for population health benefit. This NOFO will provide supplemental funding to Prevention Research Centers (PRCs), currently funded under RFA-DP-19-001 to conduct Special Interest Projects (SIPs) to design, test, evaluate, disseminate, and translate effective applied public health prevention research strategies to include interventions (i.e., programs, practices, policies, or strategies) and tools developed in real-world settings to address the leading causes of illness, disability, and death in the United States. Research strategies align with public health priorities such as the Healthy People 2030 topic areas:

Cancer and Adolescents; Cancer and Health Care Access and Quality; Children with Disabilities and Care Access and Quality; Environmental Health and Emergency Preparedness; Older Adults and Dementia; People with Disabilities and Mental Health and Mental Disorders; Women, Emergency Preparedness, and Health Care Access and Quality.

Mechanism of Support. Cooperative Agreement Funds Available and Anticipated Number of Awards. The estimated total level of funding (direct and indirect for entire project period in dollars) that is available for the NOFO is $8,280,000. The estimated total funding (direct and indirect) for the first year (12-month budget period for all SIP proposals is $1,990,000. It is anticipated that up to 14 awards will be made. Awards issued under this NOFO are contingent upon availability of funds and a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is also anticipated that the size and duration of each award may also vary. The total amount https://grants.nih.gov/grants/how-to-apply-application-guide.html awarded, and the number of awards will depend upon the number, quality, duration and cost of the applications o Budget and Project Period. The estimated total funding (direct and indirect) for the first 12-month budget period, 9/30/2022 - 9/29/2023, is $1,990,000. The estimated total funding (direct and indirect) for the entire project period, 9/30/2022 to 9/29/2024, is $8,280,000. See Section VIII. Other Information - Special Interests Project Descriptions for the funding amount and project period for each individual SIP.

o Application Research Strategy Length: Page limits for the Research Strategy are clearly specified in Section IV. Application and Submission Information of this announcement.

Eligible Institutions/Organizations. Institutions/organizations listed in Section III, 1.A.

are eligible to apply.

Eligible Project Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support. NOTE:

CDC does not make awards to individuals directly only to institutions/organizations.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply.

Number of PDs/PIs. Applications may include more than one PI; however, the first PI listed on the application will be the contact PI for all correspondence (Note: the Core PRC PI should be listed as the PI on all SIP applications. The SIP PIs should be listed as CO-PIs). Any additional PIs are permitted but would be referred to as Co- PIs.

Number of Applications. Applicants may apply to more than one SIP; however, a separate application is required for each SIP. Multiple applications for the same SIP from the same institution are not permitted (e.g., only one application per SIP per institution is allowed).

Application Type. New Special Date(s). Pre-Application Informational Call is scheduled for January 18, 2022;

1:30-3:30pm. Call-in information to be provided.

Application Materials. See Section IV.1 for application materials. Please note that Form

F is to be used when downloading the application package, https://grants.nih.gov/grants/how-to-apply-application-guide/forms-f/research-forms-f.pdf

Section I. Funding Opportunity Description Statutory Authority Section 1706 of the Public Health Service Act, as amended, 42 U.S.C. 300u-5, academic health centers, as defined in 42 U.S.C. 300u-5(d) and Section 799B, as amended 42 U.S.C 295p.

http://www.cdc.gov/od/pgo/funding/grants/additional_req.shtm#SectionIV http://era.nih.gov/commons/index.cfm#SectionIII1A http://grants.nih.gov/grants/ElectronicReceipt/submit_app.htm#SectionIV1 https://grants.nih.gov/grants/how-to-apply-application-guide/forms-f/research-forms-f.pdf https://grants.nih.gov/grants/how-to-apply-application-guide/forms-f/research-forms-f.pdf

1. Background and Purpose The CDC Prevention Research Centers (PRC) Program was established by Congress in 1984 (Public Law 98-551) to conduct research in health promotion, disease prevention, and methods of appraising health hazards and risk factors.

Congress mandated that the centers be located at academic health centers capable of providing multidisciplinary faculty with expertise in public health, relationships with professionals in other relevant fields, graduate training and demonstrated curricula in disease prevention, and a capability for residency training in public health or preventive medicine. The PRCs also serve as demonstration sites for the use of new and innovative applied public health research and activities for disease prevention and health promotion.

CDC administers the PRC Program and provides leadership, technical assistance, and oversight.

Funded PRCs are able to compete for SIPs, research projects sponsored by CDC, HHS, and other federal agencies, to conduct research and other activities in priority areas. Funded PRCs are encouraged to apply for SIPs that expand and strengthen their PRC's mission and increase their applied public health research activities.

The purpose of the PRC program's SIP mechanism is to support supplemental projects in health promotion and disease prevention research. A major focus of this supplemental funding program is to design, test, evaluate, translate and/or disseminate effective applied public health prevention research strategies. The SIP mechanism, created in 1993, allows the PRCs to compete for research projects sponsored by CDC organizational units and other HHS agencies.

Prevention research includes applied public health research that develops and evaluates health promotion and disease prevention and control strategies that are community- and population-based. It can involve testing interventions for efficacy, effectiveness, or translational power; may focus on primary, secondary, or tertiary prevention; or may improve health and prevent disease through approaches that involve changes to individual behavior, policy or environmental structure, health systems, or socio-economic factors. Prevention research may provide initial evidence of the efficacy or effectiveness of a health promotion or prevention strategy, raise current evidence to a higher level, or provide evidence of the effectiveness of a practice-based strategy.

Healthy People 2030 and other National Strategic Priorities This NOFO supports efforts that align with the following public health priorities:

Healthy People 2030

Social Determinants of Health: health care access and quality Health topics and the associated SIPs:

o Cancer and Adolescents: 22-001 o Cancer and Health Care Access and Quality: 22-002 o Children with Disabilities and Care Access and Quality: 22-003 o People with Disabilities and Mental Health and Mental Disorders: 22-004 o Environmental Health and Emergency Preparedness: 22-005 o Older Adults and Dementia: 22-006 o Women, Emergency Preparedness, and Health Care Access and Quality: 22-007

CDC's Health Impact in 5 Years (HI-5) Initiative

Interventions addressing the social determinants of health, and interventions changing the context https://www.cdc.gov/policy/hst/hi5/interventions/index.html

National Center for Chronic Disease Prevention and Health Promotion's Four Domains of Chronic Disease Prevention

Domain 1: epidemiology and surveillance;

Domain 2: environmental approaches that promote health and support and reinforce healthful behaviors;

Domain 3: health care system interventions; and Domain 4: community programs linked to clinical services o https://www.cdc.gov/chronicdisease/center/nccdphp/how.htm

Public Health Impact Accomplishing the objectives of these projects will result in improvements in the delivery and outcomes of public health programs and practice:

SIP 22-001: Process, Outcome, and Cost Evaluation of Free Sunscreen Dispensers in Outdoor Community Settings This project will help to fill research gaps on the impact of free sunscreen dispensers on sun-safety knowledge, attitudes, beliefs, and behaviors. Findings from this project will help to inform best practices for future community-level skin cancer prevention efforts, including work being done by CDC-funded Comprehensive Cancer Control programs.

SIP 22-002: Electronic Health Record Study to Examine Factors and Diagnostic Pathways that Facilitate Early Ovarian Cancer Diagnoses This project will contribute to the evidence base for recommendations and best practices that clinicians and health care systems might use in identifying ovarian cancers earlier. Shifting the majority of ovarian cancer cases to earlier stages at diagnosis may lead to significant population-based increases in survival.

SIP 22-003: Improving and evaluating measures to identify tics and tic disorders including Tourette syndrome in children in epidemiologic studies and clinical settings This project will help to (a) Improve early identification and treatment of tics to improve outcomes among people with tic disorders and co-occurring conditions; and (b) Improve how tic disorders, including Tourette syndrome (TS), are defined and measured to improve our understanding of how many people have TS, particularly among minority and underserved populations through testing and evaluating the use and accuracy of measures to identify tics and tic disorders in a demographically diverse sample of children from the general population.

Improved measures can improve epidemiologic and surveillance work to better understand the prevalence of tic disorders including Tourette syndrome. If available accurate tic screeners could improve the identification and referral for treatment not only for tic disorders including TS, but also might improve identification of common mental, emotional, and behavioral disorders like attention-deficit/hyperactivity disorder (ADHD)and obsessive-compulsive disorder (OCD). Early identification and treatment may lead to improved outcomes among children with these disorders.

https://www.cdc.gov/policy/hst/hi5/interventions/index.html

SIP 22-004: Disability and Health Data Collaborative: Using Data to Promote the Health and Wellness of People with Disabilities This project will allow for improved characterization and evaluation of the health and wellness of people with disabilities. Improving access to disability data will provide an evidence-base for informed health care policy and resource allocation. Over time, increased data linkages and collaborators may use this resource to evaluate interventions designed to improve the health and well-being of people with disabilities, particularly if implemented early in the life course with the aim of promoting positive adult outcomes.

SIP 22-005: Building Resilience Against Climate Effects (BRACE): Enhancing Practical Guidance to Support Climate and Health Adaptation Planning This project would improve the utility of the BRACE conceptual framework, by providing expanded and enhanced guidance, resources, and tools to empower communities to prepare for climate change, and address hazards such as heat waves, flooding events, and vector-borne disease. This will particularly help disproportionately impacted communities directly experiencing the inequitable health impacts of climate change. An improved BRACE package will also enhance the technical assistance Climate and Health Program (CHP) is able to provide to Climate-Ready States and Cities Initiative (CRSCI) grant recipients and other partners.

SIP 22-006: Dementia Risk Reduction Research Network – Collaborating Centers This project will fund the Dementia Risk Reduction Research Network, a national network of academic, public health, and community partners that will improve interventions and management for people at increased risk for developing Alzheimer’s disease and related dementias (ADRD) with the ultimate goal of reducing the burden of ADRD, especially for populations disproportionately impacted.

SIP 22-007: COVID-19 and Women: An Assessment of Challenges and Lessons Learned to Enhance Public Health Emergency Preparedness for Women and Families This project seeks to obtain unique insights from women to help federal entities, stakeholder organizations, and local, statewide, and tribal communities develop effective preparedness and response plans and implement mitigation strategies to reach women and families put at increased risk in public health emergencies.

Relevant Work As appropriate, this information will be provided for each SIP in the individual descriptions contained in Section VIII. Other Information - Special Interests Project Descriptions of this announcement.

2. Approach Specific information for the following is provided in Section VIII- Other Information - Special Interests Project Descriptions for each SIP:

Objectives/Outcomes Public Health Priorities Target Population

Collaboration/Partnerships Recruitment Plan Annual Action Plan Evaluation/Performance Measurement Dissemination Plan Translation Plan References

SIP recipients may be asked to participate in the PRC Program Evaluation Reporting System (PERS) to collect data that are used to evaluate Special Interest Projects.

Objectives/Outcomes Specific information for each SIP is provided in Section VIII- Other Information - Special Interests Project Descriptions for each SIP.

Target Population Specific information for each SIP is provided in Section VIII- Other Information - Special Interests Project Descriptions for each SIP.

Collaboration/Partnerships Specific information for each SIP is provided in Section VIII- Other Information - Special Interests Project Descriptions for each SIP.

Evaluation/Performance Measurement Specific information for each SIP is provided in Section VIII- Other Information - Special Interests Project Descriptions for each SIP.

Translation Plan Specific information for each SIP is provided in Section VIII- Other Information - Special Interests Project Descriptions for each SIP.

3. Funding Strategy Section II. Award Information Funding Instrument Type:

CA (Cooperative Agreement) A support mechanism used when there will be substantial Federal scientific or programmatic involvement. Substantial involvement means that, after award, scientific or program staff will assist, guide, coordinate, or participate in project activities.

Application Types Allowed:

New - An application that is submitted for funding for the first time. Includes multiple submission attempts within the same round.

Estimated Total Funding:

$8,280,000 Anticipated Number of Awards:

The anticipated number of awards for each SIP is shown in Section VIII. Other Information - Special Interests Project Descriptions of this announcement.

SIP funding will be awarded as a supplement to recipients currently funded under RFA-DP-19- 001.

Awards issued under this NOFO are contingent on the availability of funds and submission of a sufficient number of meritorious applications.

Award Ceiling:

$0 Per Budget Period

Award Floor:

$0 Per Budget Period

Total Period of Performance Length:

2 year(s)

Throughout the Period of Performance, CDC's commitment to continuation of awards will depend on the availability of funds, evidence of satisfactory progress by the recipient (as documented in required reports), and CDC’s determination that continued funding is in the best interest of the Federal government.

HHS/CDC grants policies as described in the HHS Grants Policy Statement (https://www.hhs.gov/sites/default/files/grants/grants/policies-regulations/hhsgps107.pdf) will apply to the applications submitted and awards made in response to this NOFO.

If you are successful and receive a Notice of Award, in accepting the award, you agree that the award and any activities thereunder are subject to all provisions of 45 CFR Part 75, currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions.

Section III. Eligibility Information

1. Eligible Applicants Eligibility Category:

06 (Public and State controlled institutions of higher education)

20 (Private institutions of higher education)

Additional Eligibility Category:

The following types of Higher Education Institutions are always encouraged to apply for CDC support as Public or Private Institutions of Higher Education:

Hispanic-serving Institutions

Historically Black Colleges and Universities (HBCUs) https://www.hhs.gov/sites/default/files/grants/grants/policies-regulations/hhsgps107.pdf

Tribally Controlled Colleges and Universities (TCCUs)

Alaska Native and Native Hawaiian Serving Institutions

2. Foreign Organizations Foreign Organizations are not eligible to apply.

Foreign components of U.S. Organizations are not eligible to apply.

For this announcement, applicants may include collaborators or consultants from foreign institutions. All applicable federal laws and policies apply.

3. Additional Information on Eligibility Competition is limited to the 26 institutions currently funded under CDC RFA-DP-19-001.

CDC Grant # PRC Recipient

U48 DP006377 Emory University

U48 DP006393 Georgia State University

U48 DP006376 Harvard University

U48 DP006384 Johns Hopkins University

U48 DP006411 Morehouse School of Medicine

U48 DP006396 New York University School of Medicine - CUNY

U48 DP006404 University of Alabama at Birmingham

U48 DP006413 University of Arizona

U48 DP006374 University of California, San Francisco

U48 DP006399 University of Colorado, Denver

U48 DP006392 University of Illinois, Chicago

U48 DP006389 University of Iowa

U48 DP006382 University of Maryland, College Park

U48 DP006381 University of Massachusetts Medical School, Worcester

U48 DP006397 University of Michigan, Ann Arbor

U48 DP006414 University of Minnesota

U48 DP006379 University of New Mexico

U48 DP006400 University of North Carolina Chapel Hill

U48 DP006394 University of Rochester

U48 DP006401 University of South Carolina at Columbia

U48 DP006408 University of Texas Houston

U48 DP006398 University of Washington

U48 DP006383 University of Wisconsin, Madison

U48 DP006395 Washington University at St. Louis

U48 DP006391 West Virginia University

U48 DP006380 Yale University

The institution name, EIN, and DUNS of the SIP applicant must match the information of the institution funded under RFA-DP-19-001 as listed in the Notice of Award.

For an applicant to be even considered they must be responsive to the information here.

Special eligibility requirement(s) may apply to each SIP proposal (see Section VIII. Other Information for Special Interest Project Descriptions).

If an application is incomplete or does not meet the responsiveness criteria in the special eligibility requirements listed in this section, it will be deemed non-responsive and will not enter into the peer review process.

4. Justification for Less than Maximum Competition Competition is limited to recipients funded under RFA-DP-19-001 because they are uniquely positioned to perform, oversee, and coordinate applied public health promotion and chronic disease prevention research due to their established relationships with community partners.

5. Responsiveness A SIP application will be responsive if it meets the following requirements:

Each SIP application, and SF 424 (R&R) must be submitted as a New Application (field 8) and must include the following:

Field 4a. Enter the SIP number and the current PRC Award number (e.g., DP00123) Field 4b. Enter Title of SIP (e.g., enter as much of the SIP Title as allowable) Field 4c. leave field blank

SIP 22-001: Process, Outcome, and Cost Evaluation of Free Sunscreen Dispensers in Outdoor Community Settings

SIP 22-002: Electronic Health Record Study to Examine Factors and Diagnostic Pathways that Facilitate Early Ovarian Cancer Diagnoses

SIP 22-003: Improving and evaluating measures to identify tics and tic disorders including Tourette syndrome in children in epidemiologic studies and clinical settings

SIP 22-004: Disability and Health Data Collaborative: Using Data to Promote the Health and Wellness of People with Disabilities

SIP 22-005: Building Resilience Against Climate Effects (BRACE): Enhancing Practical Guidance to Support Climate and Health Adaptation Planning

SIP 22-006: Dementia Risk Reduction Research Network – Collaborating Centers SIP 22-007: COVID-19 and Women: An Assessment of Challenges and Lessons Learned to Enhance Public Health Emergency Preparedness for Women and Families

The institution name, EIN, DUNS, and System for Award Management (SAM) registration of the SIP applicant must match the information of the PRC institution funded under RFA-DP-19- 001, as listed in the Notice of Award.

The PRC PI/PD of record, as listed on the Core Notice of Award, must be listed as the SIP PI/PD on the SIP application. Additional SIP PI/PD are permitted but must be listed as the SIP Co- PI/PD on the application and would be referred to as the SIP Co-PI/PD. Other SIP Investigators may be listed as Co-Investigators on the application.

The Research Strategy component of the Research Plan is limited to 12 pages.

If an application requests a funding amount greater than the ceiling for the first 12 months for the specific SIP, HHS/CDC will consider the application non-responsive and it will not enter into the review process (see Section VIII. Other Information - Special Interest Project Descriptions- Availability of Funds). HHS/CDC will notify the applicant that the application did not meet the submission requirements.

Special eligibility requirement(s) apply to the following SIP proposals (see Section VIII. Other Information - Special Interest Project Descriptions).

SIP 22-006

The applicant’s PI and/or key personnel/members of the senior team must have expertise within the field of dementia or cognitive decline, as demonstrated by at least 3 peer-reviewed publications in biosketch, since 2016, focusing in this topic area.

The applicant’s PI and/or key personnel/members of the senior team must have expertise within the field of the ADRD risk factor selected for the project, as demonstrated by at least 3 peer-reviewed publications in biosketch, since 2016, focusing on their selected ADRD risk factor.

The applicant must provide a current Memorandum of Understanding (MOU) or collaborator letter of support describing access to study population(s) in which the project will be conducted. The applicant must document evidence of access to a population consistent with the target population description contained within this NOFO.

This evidence should be documented in Appendix A.

SIP 22-007

Access to the proposed study population(s) as evidenced by a Memorandum of Agreement (MOA) or other documentation. This evidence should be placed in Appendix A.

If an application is incomplete or does not meet these requirements, it will be considered non-responsive and will not enter into the peer review process.

6. Required Registrations Applicant organizations must complete the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. Applicants must have a valid Dun and Bradstreet Universal Numbering System (DUNS) number in order to begin each of the following registrations.

PLEASE NOTE: For applications due on or after January 25, 2022, applicants must have a unique entity identifier (UEI) at the time of application submission. Grant application forms and instructions will be updated to reflect and require UEI instead of DUNS. If already registered in SAM.gov, a UEI was automatically generated for your entity and is visible in both SAM.gov and Grants.gov. Entities registering in SAM.gov prior to April 2022 must still obtain a DUNS number before registering in SAM and a UEI will be assigned during SAM.gov registration.

(Foreign entities only): Special Instructions for acquiring a Commercial and Governmental Entity (NCAGE) Code:

https://eportal.nspa.nato.int/AC135Public/Docs/US Instructions for NSPA NCAGE.pdf

System for Award Management (SAM) – must maintain current registration in SAM (the replacement system for the Central Contractor Registration) to be renewed annually, SAM.gov.

Grants.gov eRA Commons

All applicant organizations must register with Grants.gov. Please visit www.Grants.gov at least 30 days prior to submitting your application to familiarize yourself with the registration and submission processes. The one-time registration process will take three to five days to complete.

However, it is best to start the registration process at least two weeks prior to application submission.

All Senior/Key Personnel (including Program Directors/Principal Investigators (PD/PIs) must also work with their institutional officials to register with the eRA Commons or ensure their existing Principal Investigator (PD/PI) eRA Commons account is affiliated with the eRA commons account of the applicant organization. All registrations must be successfully completed and active before the application due date. Applicant organizations are strongly encouraged to start the eRA Commons registration process at least four (4) weeks prior to the application due date. ASSIST requires that applicant users have an active eRA Commons account in order to prepare an application. It also requires that the applicant organization's Signing Official have an active eRA Commons Signing Official account in order to initiate the submission process.

During the submission process, ASSIST will prompt the Signing Official to enter their Grants.gov Authorized Organizational Representative (AOR) credentials in order to complete the submission, therefore the applicant organization must ensure that their Grants.gov AOR credentials are active.

7. Universal Identifier Requirements and System for Award Management (SAM) All applicant organizations must obtain a DUN and Bradstreet (D&B) Data Universal Numbering System (DUNS) number as the Universal Identifier when applying for Federal grants or cooperative agreements. The DUNS number is a nine-digit number assigned by Dun and Bradstreet Information Services. An AOR should be consulted to determine the appropriate number. If the organization does not have a DUNS number, an AOR should complete the US D&B D-U-N-S Number Request Web Form or contact Dun and Bradstreet by telephone directly at 1-866-705-5711 (toll-free) to obtain one. A DUNS number will be provided immediately by telephone at no charge. Note this is an organizational number. Individual Program Directors/Principal Investigators do not need to register for a DUNS number.

https://eportal.nspa.nato.int/AC135Public/Docs/US%20Instructions%20for%20NSPA%20NCAGE.pdf https://sam.gov/content.gov https://grants.gov https://public.era.nih.gov/commons https://www.Grants.gov http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform unique entity identifier (UEI) at the time of application submission. Grant application forms and instructions will be updated to reflect and require UEI instead of DUNS. If already registered in SAM.gov, a UEI was automatically generated for your entity and is visible in both SAM.gov and Grants.gov. Entities registering in SAM.gov prior to April 2022 must still obtain a DUNS number before registering in SAM and a UEI will be assigned during SAM.gov registration.

Additionally, all applicant organizations must register in the System for Award Management (SAM). Organizations must maintain the registration with current information at all times during which it has an application under consideration for funding by CDC and, if an award is made, until a final financial report is submitted or the final payment is received, whichever is later.

SAM is the primary registrant database for the Federal government and is the repository into which an entity must provide information required for the conduct of business as a recipient.

Additional information about registration procedures may be found at the SAM internet site at SAM.gov and the SAM.gov Knowledge Base.

If an award is granted, the recipient organization must notify potential sub-recipients that no organization may receive a subaward under the grant unless the organization has provided its DUNS number to the recipient organization.

8. Eligible Individuals (Project Director/Principal Investigator) in Organizations/Institutions Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Project Director/Principal Investigator (PD/PI) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for HHS/CDC support.

9. Cost Sharing This NOFO does not require cost sharing as defined in the HHS Grants Policy Statement (http://www.hhs.gov/sites/default/files/grants/grants/policies-regulations/hhsgps107.pdf).

10. Number of Applications As defined in the HHS Grants Policy Statement,(https://www.hhs.gov/sites/default/files/grants/grants/policies-regulations/hhsgps107.pdf), applications received in response to the same Notice of Funding Opportunity generally are scored individually and then ranked with other applications under peer review in their order of relative programmatic, technical, or scientific merit. HHS/CDC will not accept any application in response to this NOFO that is essentially the same as one currently pending initial peer review unless the applicant withdraws the pending application.

Only PRC institutions currently funded under RFA-DP-19-001 are eligible to apply for Special Interest Projects (SIPs) supplemental funding detailed in this NOFO.

Each currently funded PRC institution may only submit one application per SIP. The institution https://sam.gov/content/home https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.fsd.gov%2Fgsafsd_sp%3Fid%3Dgsa_kb_view2%26kb_id%3Df66d8e6cdb76d4100d73f81d0f9619c6&data=04%7C01%7Ccshifflett%40dminc.com%7C8eee7a2adab549a3b3c008d925e9a364%7Cdb7ac9ef779d46e59bca00509580ad6b%7C0%7C0%7C637582507851821018%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=UrR%2B%2FM2wWF2fZG05Z8O6JS2C3FXXSl%2F7B3%2FB45XHRrg%3D&reserved=0 https://www.hhs.gov/sites/default/files/grants/grants/policies-regulations/hhsgps107.pdf name, EIN, DUNS, and System for Award Management (SAM) registration of the SIP applicant must match the information of the PRC institution funded under RFA-DP-19-001, as listed in the Notice of Award.

For CDC grants management purposes, the PRC PI/PD of record, as listed on the Core Notice of Award, must be listed as the SIP PD/PI on the SIP application. Additional SIP PI/PD are permitted but must be listed as the SIP Co-PI/PD on the application and would be referred to as the SIP Co-PI/PD. Other SIP Investigators may be listed as Co-Investigators on the application.

Section IV. Application and Submission Information

1. Address to Request Application Package Applicants will use a system or platform to submit their applications through Grants.gov and eRA Commons to CDC. ASSIST, an institutional system to system (S2S) solution, or Grants.gov Workspace are options. ASSIST is a commonly used platform because, unlike other platforms, it provides a validation of all requirements prior to submission and prevents errors.

To use ASSIST, applicants must visit https://public.era.nih.gov where you can login using your eRA Commons credentials, and enter the Notice of Funding Opportunity Number to initiate the application, and begin the application preparation process.

If you experience problems accessing or using ASSIST, you can refer to the ASSIST Online Help Site at: https://era.nih.gov/erahelp/assist. Additional support is available from the NIH eRA Service desk via: http://grants.nih.gov/support/index.html

Email: commons@od.nih.gov Phone: 301-402-7469 or (toll-free) 1-866-504-9552.

Hours: Monday - Friday, 7 a.m. to 8 p.m. Eastern Time, excluding Federal holidays.

2. Content and Form of Application Submission Applicants must use FORMS-G application packages for due dates on or after January 25, 2022 and must use FORMS-F application packages for due dates on or before January 24, 2022.

Application guides for FORMS-G application packages will be posted to the How to Apply - Application Guide page no later than October 25, 2021.

It is critical that applicants follow the instructions in the SF-424 (R&R) Application Guide How to Apply - Application Guide except where instructed in this Notice of Funding Opportunity to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review. The package associated with this NOFO includes all applicable mandatory and optional forms. Please note that some forms marked optional in the application package are required for submission of applications for this NOFO. Follow the instructions in the SF-424 (R&R) Application Guide to ensure you complete all appropriate “optional” components.

When using ASSIST, all mandatory forms will appear as separate tabs at the top of the https://public.era.nih.gov http://grants.nih.gov/support/index.html https://grants.nih.gov/grants/how-to-apply-application-guide.html https://grants.nih.gov/grants/how-to-apply-application-guide.html

Application Information screen; applicants may add optional forms available for the NOFO by selecting the Add Optional Form button in the left navigation panel.

Duplication of Effort

Applicants are responsible for reporting if this application will result in programmatic, budgetary, or commitment overlap with another application or award (i.e. grant, cooperative agreement, or contract) submitted to another funding source in the same fiscal year.

Programmatic overlap occurs when (1) substantially the same project is proposed in more than one application or is submitted to two or more funding sources for review and funding consideration or (2) a specific objective and the project design for accomplishing the objective are the same or closely related in two or more applications or awards, regardless of the funding source. Budgetary overlap occurs when duplicate or equivalent budgetary items (e.g., equipment, salaries) are requested in an application but already are provided by another source. Commitment overlap occurs when an individual's time commitment exceeds 100 percent, whether or not salary support is requested in the application. Overlap, whether programmatic, budgetary, or commitment of an individual's effort greater than 100 percent, is not permitted.

Any overlap will be resolved by the CDC with the applicant and the PD/PI prior to award.

Report Submission: The applicant must upload the report in Grants.gov under Other Attachment Forms. The document should be labeled: "Report on Programmatic, Budgetary, and Commitment Overlap.

Do not include hyperlinks in any part of your submission, as they do not show when the application is uploaded into Grants.gov.

Separate Application Submissions Required

Applicants must submit a separate application package for each selected Special Interest Project (SIP) through www.Grants.Gov, including pertinent, required PDF attachments.

Applicants must submit only one application per SIP. If an applicant submits more than one application for the same SIP, CDC will only accept the application with the later timestamp.

A revision to an already submitted SIP application is allowable, but it will replace the previously submitted application.

SF 424 Research & Related (R&R) Face Page Form

Instructions for completing the SF 424 Research and Related (R&R) Face Page form are provided in the SF 424 (R&R) Application Guide.

Each SIP application, and SF 424 (R&R) must be submitted as a New Application (field 8) and must include the correct SIP number in Field 4.a (Federal Identifier), and the SIP Title Field 4.b (Agency Routing Identifier). In Box 4c. of the SF 424 (R&R), applicant must enter the currently funded PRC grant number (refer to Section III. Eligibility Information, 3. Additional Information on Eligibility, for the grant number).

http://www.grants.gov/

3. Letter of Intent Due Date for Letter Of Intent 01/21/2022

01/21/2022 Although a letter of intent (LOI) is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows CDC staff to estimate the potential review workload and plan the peer review.

By the date listed above and in Part 1. Overview Information, prospective applicants are asked to submit an LOI electronically that includes the following information:

o Name of Applicant (PRC Institution) o SIP number and title o Descriptive title of proposed SIP research project o Name, address, and telephone number PRC PD/PI and SIP Co-PD/PI o Names of other key personnel o Participating institutions o Number and title of this notice of funding opportunity: RFA-DP-22-003, Health

Promotion and Disease Prevention Research Centers 2022 Supplemental Special Interest Projects (SIPS)

The LOI should be sent electronically to:

Natalie Darling, MPH Scientific Program Official

Extramural Research Program Operations and Services (ERPOS)

Centers for Disease Control and Prevention

4770 Buford Highway, NE Mailstop F-80

Atlanta, GA 30341 Email: researchnofo@cdc.gov

4. Required and Optional Components A complete application has many components, both required and optional. The forms package associated with this NOFO in Grants.gov includes all applicable components for this NOFO, required and optional. In ASSIST, all required and optional forms will appear as separate tabs at the top of the Application Information screen.

5. PHS 398 Research Plan Component The SF424 (R&R) Application Guide includes instructions for applicants to complete a PHS 398 Research Plan that consists of components. Not all components of the Research Plan apply to all Notices of Funding Opportunities (NOFOs). Specifically, some of the following components are for Resubmissions or Revisions only. See the SF 424 (R&R) Application Guide at How to Apply

- Application Guide for additional information. Please attach applicable sections of the following Research Plan components as directed in Part 2, Section 1 (Notice of Funding Opportunity Description).

Follow the page limits stated in the SF 424 unless otherwise specified in the NOFO. As applicable to and specified in the NOFO, the application should include the bolded headers in mailto:researchnofo@cdc.gov this section and should address activities to be conducted over the course of the entire project, including but not limited to:

1. Introduction to Application (for Resubmission and Revision ONLY) - provide a clear description about the purpose of the proposed research and how it addresses the specific requirements of the NOFO.

2. Specific Aims – state the problem the proposed research addresses and how it will result in public health impact and improvements in population health.

3. Research Strategy – the research strategy should be organized under 3 headings:

Significance, Innovation and Approach. Describe the proposed research plan, including staffing and time line.

4. Progress Report Publication List (for Continuation ONLY)

Other Research Plan Sections

5. Vertebrate Animals

6. Select Agent Research

7. Multiple PD/PI Leadership Plan.

8. Consortium/Contractual Arrangements

9. Letters of Support

10. Resource Sharing Plan(s)

11. Authentication of Key Biological and/or Chemical Resources

12. Appendix

All instructions in the SF424 (R&R) Application Guide at How to Apply - Application Guide must be followed along with any additional instructions provided in the NOFO.

Applicants that plan to collect public health data must submit a Data Management Plan (DMP) in the Resource Sharing Plan section of the PHS 398 Research Plan Component of the application.

A DMP is required for each collection of public health data proposed. Applicants who contend that the public health data they collect or create are not appropriate for release must justify that contention in the DMP submitted with their application for CDC funds.

The DMP may be outlined in a narrative format or as a checklist but, at a minimum, should include:

A description of the data to be collected or generated in the proposed project;

Standards to be used for the collected or generated data;

Mechanisms for, or limitations to, providing access to and sharing of the data (include a description of provisions for the protection of privacy, confidentiality, security, intellectual property, or other rights - this section should address access to identifiable and de-identified data);

Statement of the use of data standards that ensure all released data have appropriate documentation that describes the method of collection, what the data represent, and potential limitations for use; and

Plans for archiving and long-term preservation of the data, or explaining why long-term preservation and access are not justified (this section should address archiving and preservation of identifiable and deidentified data).

CDC OMB approved templates may be used (e.g. NCCDPHP template https://www.cdc.gov/chronicdisease/pdf/nofo/DMP-Template-508.docx)

Other examples of DMPs may be found here: USGS, http://www.usgs.gov//products/data-and-tools/data-management/data-management-plans

Applicants must use FORMS-G application packages for due dates on or after January 25, 2022 and must use FORMS-F application packages for due dates on or before January 24, 2022.

Application guides for FORMS-G application packages will be posted to the How to Apply - Application Guide page no later than October 25, 2021.

Data Management Plan

CDC requires awardees for projects that involve the collection or generation of public health data with federal funds to submit a Data Management Plan (DMP) prior to the initiation of generating or collecting public health data unless CDC will aggregate and disseminate the data. Public health data means digitally recorded factual material commonly accepted in the scientific community as a basis for public health findings, conclusions, and implementation. In initial funding applications, the DMP should be addressed within the Resource Sharing Plan section of the PHS 398 Research Plan Component of the application, either as a stand-alone DMP within this section or with a statement explaining why a DMP is not included. The DMP must be updated and submitted to CDC at least annually, or whenever plans for data collection or generation activities change. Costs associated with developing and implementing a DMP, including costs of sharing, archiving and long-term preservation, may be included in the budget submissions for grants and cooperative agreements. The contents of the DMP are described in AR-25. Visit link https://www.cdc.gov/chronicdisease/programs-impact/nofo/index.htm for DMP Template and Guidance.

Public health data are expected to be made freely available to the public (in a de-identified format) and archived long-term unless there are compelling reasons not to do so. When it is not feasible to make data freely available to the public, it may be possible to make data available to users on a restricted basis. The DMP should describe the expected level of public access, if any, and must justify the planned access level and describe how privacy and confidentiality will be protected. The final version of a collected and/or generated data set intended for release or sharing should be made available within thirty (30) months after the end of the data collection or generation, except surveillance data from ongoing surveillance systems which should be made accessible within 12 months of the end of a collection cycle.