Foa_Content_of_RFA-CE-24-029.pdf

Centers for Disease Control and Prevention

NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

Grants to Support New Investigators in Conducting Research Related to Preventing Interpersonal Violence Impacting Children and Youth

RFA-CE-24-029

12/01/2023

Table of Contents Section I. Funding Opportunity Description

Section II. Award Information

Section III. Eligibility Information

Section IV. Application and Submission Information

Section V. Application Review Information

Section VI. Award Administration Information

Section VII. Agency Contacts

Section VIII. Other Information

Overview

Participating Organization(s)

Centers for Disease Control and Prevention Components of Participating Organizations

Components of Participating Organizations:

National Center for Injury Prevention and Control Notice of Funding Opportunity (NOFO) Title

Grants to Support New Investigators in Conducting Research Related to Preventing Interpersonal Violence Impacting Children and Youth Activity Code

K01 - Mentored Research Scientist Development Awards

Notice of Funding Opportunity Type

Reissue of RFA-CE-23-003 Agency Notice of Funding Opportunity Number

RFA-CE-24-029

Assistance Listings Number(s)

93.136 Category of Funding Activity

HL - Health NOFO Purpose

The purpose of the Centers for Disease Control and Prevention National Center for Injury Prevention and Control (NCIPC) Mentored Research Scientist Development Award (K01) is to provide support for an intensive, supervised (mentored) career development experience in violence prevention research leading to research independence. NCIPC supports K01 grants to help ensure the availability of an adequate number of trained scientists to address critical public health research questions to prevent violence and injury.

Applicants must propose a research project that addresses at least one of the research priorities in the interpersonal violence prevention section of the NCIPC Research Priorities (www.cdc.gov/injury/researchpriorities/index.html) as they relate to violence impacting children or youth (from birth through age 17). These research priorities include:

Cross-cutting violence prevention Adverse childhood experiences Child abuse and neglect Youth violence Intimate partner violence (teen dating violence) Sexual violence

Applicants are also encouraged to address the following:

Multiple forms of violence impacting children or youth Firearm-related behavior, crime, injuries, and deaths among children and youth The social or structural conditions that contribute to violence and health inequities across population groups

Applicants should explicitly state the research priorities their application intends to address.

Key Dates

Publication Date:

To receive notification of any changes to RFA-CE-24-029, return to the synopsis page of this announcement at www.grants.gov and click on the "Send Me Change Notification Emails" link.

An email address is needed for this service.

Letter of Intent Due Date:

The LOI date will generate once the Synopsis is published if Days or a Date are entered.

Due date: 11/1/2023. Although a letter of intent is not required, is not binding, and does not enter into the review of an application, the information that it contains assists NCIPC with planning for scientific and technical merit peer review.

Application Due Date:

12/01/2023 12/01/2023

On-time submission requires that electronic applications be error-free and made available to CDC for processing from the NIH eRA system on or before the deadline date. Applications must https://www.cdc.gov/injury/researchpriorities/index.html https://www.grants.gov/ be submitted to and validated successfully by Grants.gov no later than 11:59 PM U.S. Eastern Time.

Applicants will use a system or platform to submit their applications through Grants.gov and eRA Commons to CDC. ASSIST, an institutional system to system (S2S) solution, or Grants.gov Workspace are options. ASSIST is a commonly used platform because it provides a validation of all requirements prior to submission and prevents errors.

For more information on accessing or using ASSIST, you can refer to the ASSIST Online Help Site at: https://era.nih.gov/erahelp/assist. Additional support is available from the NIH eRA Service desk via http://grants.nih.gov/support/index.html.

E-mail: commons@od.nih.gov Phone: 301-402-7469 or (toll-free) 1-866-504-9552 Hours: Monday - Friday, 7 a.m. to 8 p.m. Eastern Time, excluding Federal holidays

Note: HHS/CDC grant submission procedures do not provide a grace period beyond the application due date time to correct any error or warning notices of noncompliance with application instructions that are identified by Grants.gov or eRA systems (i.e., error correction window).

Scientific Merit Review:

03/20/2024 This is an estimated date.

Secondary Review:

04/18/2024 This is an estimated date.

Estimated Start Date:

09/30/2024 This is an estimated date.

Expiration Date:

02/01/2024 Required Application Instructions

It is critical that applicants follow the instructions in the How to Apply - Application Guide except where instructed to do otherwise in this NOFO. Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

Note:The Research Strategy component of the Research Plan is limited to 12 pages.

Page Limitations: Pages that exceed the page limits described in this NOFO will be removed and not forwarded for peer review, potentially affecting an application's score.

Applications that do not comply with these instructions may be delayed or may not be accepted for review.

http://grants.nih.gov/support/index.html mailto:commons@od.nih.gov https://grants.nih.gov/grants/how-to-apply-application-guide.html

Telecommunications for the Hearing Impaired: TTY 1-888-232-6348

Executive Summary

CDC and NCIPC are committed to achieving the health promotion and disease prevention objectives of "Healthy People 2030" and to measuring program performance as stipulated by the Government Performance and Review Act (GPRA). The proposed program of research addresses the Healthy People 2030 priority area of injury and violence prevention and is in alignment with NCIPC's performance goal to conduct a targeted program of research to prevent injuries and violence and reduce their consequences. The intent of the NCIPC extramural violence prevention research program is to:

Build the scientific base for the prevention of violence by helping to expand and advance our understanding of new and innovative strategies for the primary prevention of violence.

Encourage professionals from a wide spectrum of disciplines (including epidemiology, behavioral and social sciences, medicine, biostatistics, public health, health economics, law, and criminal justice) to conduct research that informs violence prevention efforts.

Purpose The purpose of the Centers for Disease Control (CDC) National Center for Injury Prevention and Control Mentored Research Scientist Development Award (K01) is to provide support for an intensive, supervised (mentored) career development experience in violence prevention research leading to research independence. NCIPC supports K01 grants to help ensure the availability of an adequate number and trained scientists to address critical public health research questions to prevent violence and injury.

Applicants must propose a research project that addresses at least one of the research priorities in the interpersonal violence prevention section of the NCIPC Research Priorities (www.cdc.gov/injury/researchpriorities/index.html) as they relate to violence impacting children or youth (from birth through age 17). These research priorities include:

Cross-cutting violence prevention Adverse childhood experiences Child abuse and neglect Youth violence

Applicants are also encouraged to address the following:

Multiple forms of violence impacting children or youth Firearm-related behavior, crime, injuries and deaths among children and youth The social or structural conditions that contribute to violence and health inequities across population groups

Applicants should explicitly state the research priorities their application intends to address.

http://www.cdc.gov/injury/researchpriorities/index.html

Mechanism of Support: The funding mechanism for this Notice of Funding Opportunity (NOFO) will be a K01 Mentored Research Scientist Development Award.

Funds Available and Anticipated Number of Awards: NCIPC intends to commit up to $600,000 (direct and indirect costs) in FY2024 to support up to four applications for this NOFO.

The total funding and the number of awards is contingent upon availability of funds and a sufficient number of meritorious applications.

Budget and Project Period: The maximum award amount will be $150,000 per award for the first 12-month budget period. This includes both direct and indirect costs. For this award, the indirect costs are limited to 8% of Modified Total Direct Cost.

Applicants may request a project period of up to three (3) years. The maximum total project funding is $450,000 (direct and indirect) per award, over the project period. The project period is expected to be 09/30/2024 to 09/29/2027. The total award will depend upon the project quality, duration, and cost proposed.

Application Research Strategy Length: Page limits for the Research Strategy are clearly specified in Section IV. Application and Submission Information of this announcement.

Eligible Institutions/Organizations: Institutions/organizations listed in Section III. Eligibility Information 1. Eligible Applicants are eligible to apply.

Eligible Project Directors/Principal Investigators: Individuals with the skills, knowledge, and resources necessary to carry out the proposed research as the contact PD/PI are invited to work with their institution/organization and mentor to develop an application for support. NOTE: CDC does not make awards to individuals directly.

The purpose of the NCIPC Mentored Research Scientist Development Award (K01) is to provide support for an intensive, supervised/mentored career development experience in violence prevention research leading to research independence. NCIPC supports K01 grants to help ensure the availability of an adequate number of trained scientists to address critical public health research questions to prevent violence and injury:

Applicant contact PD/PIs must have a qualifying (relevant to the field of study) research or health- professional doctoral or medical degree (specifically PhD, ScD, DO, DrPH, MD, DVMD, PharmD, DDS, DMD, PsyD, DPT), from an accredited institution of higher learning. Applications that do not demonstrate that the contact PD/PI has a qualifying (relevant to the field of study) research or health professional doctoral or medical degree (such as PhD, ScD, DO, DrPH, MD, DVM, PharmD, DDS, DMD, PsyD, DPT) from an accredited institution of higher learning, as evidenced by their SF-424 Biographical Sketch, will be considered nonresponsive and will not be forwarded for peer review.

At the time of the NOFO application due date, applicant contact PD/PIs must have less than five years of post-graduate research experience as a researcher in the violence prevention field, as documented on the contact PD/PI’s SF-424 Biographical Sketch. The

5-year period will be calculated from the completion of the qualifying degree (e.g., a research or health-professional doctoral or medical degree [specifically PhD, ScD, DO, DrPH, MD, DVM, PharmD, DDS, DMD, PsyD, DPT] from an accredited institution of higher learning). The Positions and Employment section of SF-424 Biographical Sketch is expected to clearly document all of the contact PD/PI’s relevant research experience.

Applications that do not demonstrate that the contact PD/PI has less than five years of post-graduate experience as a researcher in the violence prevention field, as evidenced by their SF-424 Biographical Sketch, will be considered nonresponsive to the NOFO and will not be forwarded for peer review.

Time periods for significant breaks in employment or employment in areas unrelated to violence prevention should be clearly documented. Only the years where any violence prevention research was conducted after the completion of the qualifying degree will count towards the limit of five years of research experience. Research conducted during undergraduate or pre-graduate training does not count towards the five-year research time

- even if the applicant contact PD/PI authored or co-authored a paper relevant to the research prior to completion of the qualifying degree.

This funding opportunity may support individuals who propose to train in a new field or individuals who have had a hiatus in their research career due to circumstances such as, but not limited to, illness or pressing family circumstances. Applicant contact PD/PIs who are changing their career trajectory to violence prevention must clearly document the start date of their post-graduate emphasis in violence prevention in their SF-424 Biographical Sketch and must clearly demonstrate that they have less than five years of post-graduate experience as a researcher in the violence prevention field. Applications from contact PD/PIs who completed their qualifying degree prior to December 01, 2018 and do not clearly document their relevant post-graduate research experience in violence prevention (including breaks in employment or research in other areas) will be considered nonresponsive to the NOFO and will not be forwarded for peer review.

Individuals who are identified as the contact PD/PI on a current and/or former CDC or National Institutes of Health (NIH) grant or cooperative agreement award from any of the following excluded independent research assistance mechanisms defined below, as documented by their eRA Commons PD/PI Grant History profile, are NOT eligible for funding under this NOFO. The excluded assistance mechanisms are: CDC or NIH research project (R01 or U01), program project (P01), center grant (R49, P50), sub-project of program project (P01), sub-project of center grant (R49, P50), or other major individual career development award (e.g., K01, K07, K08, K22, K23, K25, K76, K99/R00). Applications with a contact PD/PI eRA Commons Grant History profile that reflects a current or former award in any of the named excluded independent research assistance mechanisms will be considered nonresponsive and will not be forwarded for peer review.

Individuals with current or former funding on the following CDC or NIH training award assistance mechanisms ARE eligible to apply as contact PD/PIs to this NOFO: CDC or NIH Small Grant (R03), Exploratory/Developmental Grant (R21), Dissertation Award (R36 or R49), SBIR/STTR (R41, R42, R43, or R44), Transition Scholar (K38) awards, National Research Service Awards (F30, F31, F32) and individuals appointed to institutional K (K12, KL2), T

(T32) programs.

At the time of award, the contact PD/PI must be a citizen, a non-citizen national of the United States, or have been lawfully admitted for permanent residence (i.e., possess a currently valid Permanent Resident Card USCIS Form I-551, or other legal verification of such status).

At the time of the NOFO application due date, the contact PD/PI must have a full-time position at the eligible applicant institution, as evidenced by inclusion of a Candidate Eligibility Statement (e.g. an institutional letter of attestation) that is signed by the eligible applicant institution’s Authorized Representative that explicitly verifies the contact PD/PI’s full time employment status. This should be included in the Institutional Commitment to Candidate’s Research Career Development section of the application. The contact PD/PI is not required to have a tenure track appointment at the eligible applicant institution in order to be eligible for this NOFO. Applications that do not include a Candidate Eligibility Statement that: (1) explicitly verifies the contact PD/PI’s full time employment status and (2) is signed by the applicant institution’s Authorized Representative will be considered nonresponsive and will not be forwarded for peer review.

Applicant contact PD/PIs are required to commit a minimum of 60% of full-time professional effort (i.e., a minimum of 7.3 person-months/year) to their research project and career development for the entirety of the project period. The budget, budget justification, and PHS 398 Career Development Award sections of the application must clearly describe the contact PD/PI’s commitment. Applications that do not demonstrate contact PD/PI commitment to a minimum of 60% of full-time professional effort to their research project and career development for the entirety of the project period, as evidenced by the application’s SF-424 Research and Related Budget effort of at least 7.3 person-months/year for the contact PD/PI, will be considered nonresponsive and will not be forwarded for peer review.

Number of PDs/PIs: There can be only one PD/PI listed in the SF-424 Senior/Key Personnel project role category. Additional Senior/Key Personnel project roles are limited to Mentor, Co- Investigator, Consultant and Other. Multiple PD/PI (i.e., M-PD/PI) and Co-Principal Investigators (Co-PD/PI) project roles are not allowed for this announcement.

Number of Applications: Eligible applicant organizations/institutions may submit more than one application, provided that each application is scientifically distinct. However, applicant institutions can submit only one grant application with the same contact PD/PI in response to this NOFO. Additionally, applicant institutions can submit only one grant application with the same individual designated in a Mentor project role in the application in response to this NOFO. Only one application per contact PD/PI will be reviewed or funded under this announcement; only one application per Mentor will be reviewed or funded under this announcement. If two or more applications from the same contact PD/PI are received, the only application that will be submitted for review will be the last application received based on the document's time and date stamp in Grants.gov (https://www.grants.gov). If two or more applications identifying same Mentor are received, the only application that will be submitted for review will be the last application received based on the document's time and date stamp in Grants.gov (https://www.grants.gov). Applicant institutions submitting applications with essentially the https://www.grants.gov https://www.grants.gov same proposed research to two or more CDC/ATSDR NOFOs will not be funded under more than one NOFO. Applicant institutions submitting multiple applications with essentially the same proposed research to this announcement will not be funded more than once. Contact PD/PIs submitting applications to this NOFO and any other CDC/ATSDR NOFO will not be funded under more than one NOFO.

Application Type: New

Special Date(s)

A pre-application teleconference call will be conducted on Wednesday, October 25, 2023 to address questions from prospective applicants regarding NOFO RFA-CE-24-029: Grants to Support New Investigators in Conducting Research Related to Preventing Interpersonal Violence Impacting Children and Youth. The call will begin at 2PM Eastern Standard Time (EST) and end at 3PM Eastern Standard Time (EST), or sooner if all questions are addressed. Questions and answers from the discussion will be included in an amended NOFO approximately 3 weeks after the call.

Participant Access Information:

Call Date: Wednesday, October 25, 2023 Call Start Time: 2PM Eastern Standard Time (EST) Call End Time: 3PM Eastern Standard Time (EST) Call Leader: Celeste Sanders, PhD, Scientific Program Official Toll-Free Number: 1-866-600-6035 Use Passcode 23198543# when prompted

Application Materials: See Section IV.1 for application materials.

Section I. Funding Opportunity Description

Statutory Authority Section 301 (a) [42 U.S.C. 241(a)] of the Public Health Service Act, and Section 391 (a) [42 U.S.C. 280 b (a)] of the Public Health Service Act, as amended.

1. Background and Purpose

Background Adverse childhood experiences (ACEs), child abuse and neglect, youth violence, teen dating violence, and sexual violence are major public health issues impacting children and youth. The mission of the National Center for Injury Prevention and Control (NCIPC) is to prevent injuries and violence through surveillance, research and evaluation, and prevention action. CDC's NCIPC uses the same scientific methods to prevent injuries and violence that have been used to prevent disease: carefully describing the problem through surveillance, studying factors that increase or decrease risk for violence or injury, designing and evaluating prevention strategies that address these risk and protective factors, and taking steps to ensure that proven strategies are implemented in communities nationwide.

For 30 years, CDC's NCIPC has studied injuries and violence and investigated the best ways to prevent them. We translate science into real-world solutions to prevent violence and injuries before they happen. Research is fundamental to our success in violence prevention, because good research is essential in making sound, smart investments in prevention action. Research provides the knowledge that we need to understand what is possible, what is not, and the best way to progress in our prevention efforts.

The CDC has developed a suite of resources for action to help states and communities leverage the best available evidence to prevent multiple forms of violence (see:

https://www.cdc.gov/violenceprevention/communicationresources/pub/technical-packages.html).

CDC has also developed a prevention resource to prevent adverse childhood experiences (ACEs) that draws upon these resources for action (see:

https://www.cdc.gov/violenceprevention/pdf/preventingACES.pdf). Strong, innovative, and relevant research is fueled by a diverse field of qualified researchers. NCIPC values supporting new investigators to build capacity to grow the field of violence prevention and become experienced independent investigators. New investigator awards support career trajectories to prepare new investigators to conduct independent research later as a principal investigator of research grants (R01) and cooperative agreements (U01).

The intent of Notice of Funding Opportunity (NOFO) RFA-CE-24-029 is to contribute to the development of new researchers in the field of violence prevention. By providing resources to new investigators, they can develop and conduct research that addresses NCIPC's interpersonal violence prevention research priorities and acquire new skills. The NCIPC Research Priorities serve as a foundation for NCIPC's research funding and briefly describe key gaps in the field of violence prevention that need to be addressed to inform prevention activities (https://www.cdc.gov/injury/researchpriorities/index.html).

This NOFO is specifically focused on addressing the interpersonal forms of violence impacting children or youth from birth through age 17 (i.e., ACEs, child abuse and neglect, youth violence, teen dating violence, and sexual violence). Applicants may propose research that focuses on a subset of ages between 0 and 17. Applicants may also include participants outside this age range, but the application should describe how the research question and results are relevant to those ages 0-17. Applicants must propose violence prevention research that focuses on at least one of the interpersonal violence prevention research gaps in the NCIPC Research Priorities and examines one or more forms of violence impacting children and youth.

Exposure to violence or other ACEs can negatively affect health and development across the lifespan. Multiple forms of violence affect children and youth, including child abuse and neglect, youth violence, teen dating violence, and sexual violence. These forms of violence often share risk and protective factors. Despite these linkages, research is often focused on a specific form of violence in ways that limit our understanding of whether prevention strategies have cross-cutting impacts. CDC's Division of Violence Prevention's Strategic Vision includes "addressing factors that cut across multiple forms of violence" as a guiding principle (see https://www.cdc.gov/violenceprevention/publichealthissue/strategicvision.html). Applicants are https://www.cdc.gov/violenceprevention/communicationresources/pub/technical-packages.html https://www.cdc.gov/violenceprevention/pdf/preventingACES.pdf https://www.cdc.gov/violenceprevention/publichealthissue/strategicvision.html encouraged to address multiple forms of violence impacting children or youth when possible.

Importantly, the majority of children and youth aged 0-17 who are victims of homicide die from firearm-related injuries. Thus, applicants are encouraged to examine firearm-related behavior, crime, injuries, and deaths among children and youth or include firearm-related behavior, crime, injuries, and deaths among children and youth as outcomes.

Using the public health approach, NCIPC is committed to supporting research to eliminate inequities in risk for violence across groups. The social and structural conditions in which people are born, grow, live, work, and age can be shaped by the distribution of resources, which is influenced in part by policies. Social and structural determinants of health (e.g., concentrated poverty, structural racism, high rates of unemployment limited access to high-quality education and/or affordable, high-quality child care) contribute to health inequities, including differences in health status seen across population groups (Solar & Irwin, 2010; Yearby 2020). Research related to addressing the social or structural conditions that contribute to violence and health inequities across population groups is highly encouraged.

Purpose The purpose of this NCIPC Mentored Research Scientist Development Award (K01) is to provide support for an intensive, supervised (mentored) career development experience in violence prevention research leading to research independence. NCIPC supports K01 grants to help ensure the availability of an adequate number and trained scientists to address critical public health research questions to prevent violence and injury.

Applicants must propose a research project that addresses at least one of the research priorities in the interpersonal violence prevention section of the NCIPC Research Priorities (https://www.cdc.gov/injury/researchpriorities/index.html) as they relate to violence impacting children or youth (from birth through age 17). These research priorities include:

Cross-cutting violence prevention Adverse childhood experiences Child abuse and neglect Youth violence Intimate partner violence (teen dating violence) Sexual violence

Applicants are encouraged to address the following:

Multiple forms of violence impacting children or youth Firearm-related behavior, crime, injuries and deaths among children and youth The social or structural conditions that contribute to violence and health inequities across population groups

Applications proposing to address research focused on addressing the social and structural conditions that contribute to violence and health inequities, including differences in health status, as evidenced by the Research Strategy section of the application's research plan, may be considered during the second level of review to broaden distribution of awards. Applications proposing to address research focused on firearm-related behavior, crime, injuries and deaths among children and youth, as evidenced by the Research Strategy section of the application's research plan, may also be considered during the second level of review to broaden distribution of awards (see Section V. Application Review Information 4. Review and Selection Process).

Applicants should explicitly state the research priorities their application intends to address.

References

1. CDC NCIPC Research Priorities https://www.cdc.gov/injury/researchpriorities/index.html

2. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Web-based Injury Statistics Query and Reporting System (WISQARS) Fatal Injury Data. (2023)

3. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Web-based Injury Statistics Query and Reporting System (WISQARS) Nonfatal Injury Data. (2023)

4. Merrick MT, Ford DC, Ports KA, et al. Vital Signs: Estimated Proportion of Adult Health Problems Attributable to Adverse Childhood Experiences and Implications for Prevention — 25 States, 2015–2017. MMWR Morb Mortal Wkly Rep 2019;68:999- 1005. DOI: https://dx.doi.org/10.15585/mmwr.mm6844e1.

5. U.S. Department of Health and Human Services, Administration for Children and Families, Administration on Children, Youth and Families, Children's Bureau, Child Maltreatment 2018 (2020). (https://www.acf.hhs.gov/cb/report/child-maltreatment-2018)

6. CDC NCIPC Violence Prevention at CDC:

https://www.cdc.gov/violenceprevention/index.html

7. CDC NCIPC Technical Packages for Violence Prevention: Technical Packages for Violence Prevention |Violence Prevention|Injury Center|CDC

8. CDC ACEs Prevention Resource:

https://www.cdc.gov/violenceprevention/acestudy/index.html

9. Solar O, Irwin A. A conceptual framework for action on the social determinants of health. Social Determinants of Health Discussion Paper 2 (Policy and Practice). Geneva, Switzerland: World Health Organization; 2010.

https://www.who.int/social_determinants/publications/9789241500852/en/

10. Yearby R. Structural racism and health disparities: Reconfiguring the social determinants of health framework to include the root cause. Journal of Law, Medicine & Ethics. 2020;

48.3: 518-526.

Healthy People 2030 and other National Strategic Priorities The National Center for Injury Prevention and Control at CDC within HHS is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2030" as described in: https://www.healthypeople.gov/. This research addresses multiple violence-related objectives across the Healthy People 2030 Violence Prevention topic area. The proposed research on violence prevention will ultimately add to the existing evidence base on effective strategies for the prevention of multiple forms of violence.

https://www.cdc.gov/injury/researchpriorities/index.html https://dx.doi.org/10.15585/mmwr.mm6844e1 https://www.cdc.gov/violenceprevention/index.html https://www.cdc.gov/violenceprevention/communicationresources/pub/technical-packages.html https://www.cdc.gov/violenceprevention/communicationresources/pub/technical-packages.html https://www.who.int/social_determinants/publications/9789241500852/en/ https://www.healthypeople.gov/

Public Health Impact Expanding the pool of public health researchers in the field of violence prevention will increase opportunities for developing innovative and impactful solutions for violence prevention. New investigators will contribute to our knowledge about the best ways to prevent and address violence impacting children or youth from birth through age 17 (e.g., child abuse and neglect, youth violence, intimate partner violence (teen dating violence), or sexual violence).

Relevant Work For 30 years, NCIPC has been the nation's leading public health authority on violence and injury prevention. NCIPC's approach involves three elements: a focus on prevention, a science-driven approach to identify risk and patterns that influence risk and protective factors, and multidisciplinary collaboration to address the problem and keep people safe, healthy, and productive.

NCIPC's Division of Violence Prevention has developed and published resources for action to help states and communities take advantage of the best available evidence to prevent violence (https://www.cdc.gov/violenceprevention/pub/technical-packages.html). The strategies and approaches in the resources for action represent different levels of the social ecology with efforts intended to impact individual behaviors as well as the relationship, family, school, community, and societal factors that influence risk and protective factors for violence. CDC has also released an ACEs prevention resource that highlights six ACEs prevention strategies drawn from CDC resources for action (https://www.cdc.gov/violenceprevention/pdf/preventingACES.pdf).

NCIPC's research priorities (https://www.cdc.gov/injury/researchpriorities/index.html) and the Division of Violence Prevention's Strategic Vision (https://www.cdc.gov/violenceprevention/publichealthissue/strategicvision.html) support the need for prevention strategies that address multiple forms of violence and advance economic, gender, and racial equity. A key goal of CDC's research is to enhance the effects of violence prevention activities by focusing on the interconnections across the different forms of violence.

Cross-cutting violence prevention activities can use resources more effectively and help achieve health equity by focusing on the underlying conditions that contribute to increased risk.

Examples of previously-funded research and descriptions of violence prevention initiatives are available on NCIPC's website:

https://www.cdc.gov/violenceprevention/publichealthissue/fundedprograms/research-awards.html

2. Approach

NCIPC's overall goal is to increase the number and diversity of experienced violence prevention research professionals available to conduct independent violence prevention research. The purpose of this research grant program is to support the development of new researchers who have not yet served as a contact PD/PI on a specified major CDC or NIH research award and address NCIPC's violence prevention research priorities for interpersonal violence impacting children or youth from birth through age 17. These research priorities include cross-cutting violence prevention; adverse childhood experiences; child abuse and neglect; youth violence;

intimate partner violence (teen dating violence); and sexual violence.

https://www.cdc.gov/violenceprevention/pub/technical-packages.html https://www.cdc.gov/violenceprevention/pdf/preventingACES.pdf https://www.cdc.gov/injury/researchpriorities/index.html https://www.cdc.gov/violenceprevention/publichealthissue/strategicvision.html https://www.cdc.gov/violenceprevention/publichealthissue/fundedprograms/research-awards.html https://www.cdc.gov/violenceprevention/publichealthissue/fundedprograms/research-awards.html

Contact PD/PI Requirements

1. Applicant contact PD/PIs must have a qualifying (relevant to the field of study) research or health-professional doctoral or medical degree (such as PhD, ScD, DO, DrPH, MD, DVM, PharmD, DDS, DMD, PsyD, DPT), from an accredited institution of higher learning. Applications that do not demonstrate that the contact PD/PI has a qualifying (relevant to the field of study) research or health professional doctoral or medical degree (such as PhD, ScD, DO, DrPH, MD, DVM, PharmD, DDS, DMD, PsyD, DPT) from an accredited institution of higher learning, as evidenced by their SF-424 Biographical Sketch, will be considered nonresponsive and will not be forwarded for peer review.

2. At the time of the NOFO application due date, applicant contact PD/PIs must have less than five years of post-graduate research experience as a researcher in the violence prevention field, as documented on the contact PD/PI’s SF-424 Biographical Sketch. The 5-year period will be calculated from the completion of the qualifying degree (e.g., a research or health-professional doctoral or medical degree [such as PhD, ScD, DO, DrPH, MD, DVM, PharmD, DDS, DMD, PsyD, DPT] from an accredited institution of higher learning). The Positions and Employment section of SF-424 Biographical Sketch is expected to clearly document all of the contact PD/PI’s relevant research experience.

Applications that do not demonstrate that the contact PD/PI has less than five years of post-graduate experience as a researcher in the violence prevention field, as evidenced by their SF-424 Biographical Sketch, will be considered nonresponsive to the NOFO and will not be forwarded for peer review.

3. Time periods for significant breaks in employment or employment in areas unrelated to violence prevention should be clearly documented. Only the years where any violence prevention research was conducted after the completion of the qualifying degree will count towards the limit of five years of research experience. Research conducted during undergraduate or pre-graduate training does not count towards the five-year research time

- even if the applicant contact PD/PI authored or co-authored a paper relevant to the research prior to completion of the qualifying degree.

4. This funding opportunity may support individuals who propose to train in a new field or individuals who have had a hiatus in their research career due to circumstances such as, but not limited to, illness or pressing family circumstances. Applicant contact PD/PIs who are changing their career trajectory to the violence prevention field must clearly document the start date of their post-graduate emphasis in violence prevention in their SF-424 Biographical Sketch and must clearly demonstrate that they have less than five years of post-graduate experience as a researcher in the violence prevention field.

Applications from contact PD/PIs who completed their qualifying degree prior to December 01, 2018 and do not clearly document their relevant post-graduate research experience in violence prevention (including breaks in employment or research in other areas) will be considered nonresponsive to the NOFO and will not be forwarded for peer review.

Individuals who are identified as the contact PD/PI on a current and/or former CDC or National Institutes of Health (NIH) grant or cooperative agreement award from any of the following excluded independent research assistance mechanisms defined below, as documented by their eRA Commons PD/PI Grant History profile, are NOT eligible for funding under this NOFO. The excluded assistance mechanisms are: (R01 or U01), program project (P01), center grant (R49, P50), sub- project of program project (P01), sub-project of center grant (R49, P50), or other major individual career development award (e.g., K01, K07, K08, K22, K23, K25, K76, K99/R00). Applications with a contact PD/PI eRA Commons Grant History profile that reflects a current or former award in any of the named excluded independent research assistance mechanisms will be considered nonresponsive and will not be forwarded for peer review.

Individuals with current or former funding from the following CDC or NIH training award assistance mechanisms ARE eligible to apply as contact PD/PIs to this NOFO: CDC or NIH Small Grant (R03), Exploratory/Developmental Grant (R21), Dissertation Award (R36 or R49), SBIR/STTR (R41, R42, R43, or R44), Transition Scholar (K38) awards, National Research Service Awards (F30, F31, F32) and individuals appointed to institutional K (K12, KL2), T (T32) programs.

At the time of award, the contact PD/PI must be a citizen, a non-citizen national of the United States, or have been lawfully admitted for permanent residence (i.e., possess a currently valid Permanent Resident Card USCIS Form I-551, or other legal verification of such status).

At the time of the NOFO application due date, the contact PD/PI must have a full-time position at the eligible applicant institution. The application must include a Candidate Eligibility Statement (e.g., an institutional letter of attestation) that is signed by the eligible applicant institution’s Authorized Representative that explicitly verifies the contact PD/PI’s full time employment status. This should be included in the Institutional Commitment to Candidate’s Research Career Development section of the application. The contact PD/PI is not required to have a tenure track appointment at the eligible applicant institution in order to be eligible for this NOFO. Applications that do not include a Candidate Eligibility Statement that: (1) explicitly verifies the verifies the contact PD/PI’s full time employment status and (2) is signed by the applicant institution’s Authorized Representative will be considered nonresponsive and will not be forwarded for peer review.

Applicant contact PD/PIs are required to commit a minimum of 60% of full-time professional effort (i.e., a minimum of 7.3 person-months/year) to their research project and career development for the entirety of the project period. The budget, budget justification, and PHS 398 Career Development Award sections of the application must clearly describe the contact PD/PI’s commitment. Applications that do not demonstrate contact PD/PI commitment to a minimum of 60% of full-time professional effort to their research project and career development for the entirety of the project period, as evidenced by the application’s SF-424 Research and Related Budget effort of at least 7.3 person-months/year for the contact PD/PI, will be considered nonresponsive and will not be forwarded for peer review.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for HHS/CDC support.

Mentor Requirements Awards funded under NOFO RFA-CE-24-029 are expected to support the applicant contact PD/PI in conducting relevant and meaningful research in collaboration with an experienced research mentor or mentors that will lead to the applicant's research independence. Applicant contact PD/PIs are expected to identify a primary mentor who will supervise the proposed career development and research experience funded under this NOFO. The primary mentor must be an active investigator in the area of the violence prevention research proposed in the research strategy of the application and must be committed both to the career development of the contact PD/PI and to the direct supervision of the contact PD/PI's research throughout the entirety of the project period. The mentor should clearly document the availability of sufficient research support and facilities for high-quality research.

Applicant contact PD/PIs are encouraged to identify more than one mentor, i.e., a mentoring team (or advisory committee), if this is deemed advantageous for providing expert advice in all aspects of the research career development program and research proposal. However, only one individual can be identified as the primary mentor who will coordinate the contact PD/PI's research. The contact PD/PI must work with the selected mentor(s) in preparing the application.

The primary mentor and all members of the mentoring team should have a successful track record of mentoring individuals at the contact PD/PI's career stage. The mentor(s) must demonstrate appropriate expertise, experience, and ability to guide the contact PD/PI in the organization, management, and implementation of the proposed interpersonal violence prevention research impacting children or youth from birth through age 17. The application must also include evidence that each member of the mentoring team has the commitment, experience, and institutional support to provide both career development and research support to the candidate. The primary mentor and each co-mentor must be clearly identified in the Mentor project role category in the SF-424 Senior/Key Personnel section of the application.

The Plans and Statements of Mentor and Co-Mentor(s) section of the application should provide:

1) detailed information on each mentor's research qualifications and previous experience as a research supervisor; 2) a plan that describes the nature of the supervision and mentoring that will occur during the proposed award period; 3) a plan for career progression for the contact PD/PI to move from the mentored stage of his/her career to independent research investigator status during the project period of the award; 4) a plan for monitoring the contact PD/PI's research, publications, and progression towards independence; and 5) a plan to provide annual evaluations of the contact PD/PI's progress as required in the annual progress report.

The application must describe the relationship between the proposed research and each mentor's current research and research expertise. The mentor should be recognized as an accomplished investigator in the proposed violence prevention research area and should have sufficient research support to cover the costs of the proposed research project in excess of the allowable costs of this award. This award does not include funds for mentor research assistance support.

Mentor Letter(s) of Support: Each proposed mentor must provide a distinct Letter of Support in the Plans and Statements of Mentor and Co-Mentor(s) section of the application. Each mentor's Letter of Support must describe in detail the partnership between the contact PD/PI and mentor, the nature and extent of the relationship, and the specific roles and responsibilities of the contact PD/PI and the mentor. Applications that do not include a letter of support from the primary mentor in which the primary mentor commits to supporting the contact PD/PI throughout the entirety of the project period will be considered nonresponsive and will not be forwarded for peer review.

If more than one mentor is proposed, the respective areas of expertise and responsibility of each mentor must be described in the mentor's respective Letter of Support. Co-mentors should clearly describe how they will coordinate the mentoring of the applicant among all mentors. If the primary or co-mentor does not have an appointment at the applicant institution, a statement must be provided describing the mechanism(s) and frequency of communication with the contact PD/PI, including the frequency of face-to-face meetings.

Letters of Support from other participating collaborators or consultants, if applicable, should be included in the Letters of Support from Collaborators, Contributors, and Consultants section of the application. The Letter of Support should clearly document the role and responsibilities of the collaborator/consultant.

The application is expected to describe the institutional support of the applicant's career development plan and proposed research in the Description of Institutional Environment and Institutional Commitment to Candidate's Research Career Development.

Research Strategy Requirements Under NOFO RFA-CE-24-029 NCIPC intends to support meritorious research projects that address at least one of the research priorities in the interpersonal violence prevention section of the NCIPC Research Priorities (https://www.cdc.gov/injury/researchpriorities/index.html) as they relate to violence impacting children or youth (from birth through age 17). These research priorities include: cross-cutting violence prevention, adverse childhood experiences, child abuse and neglect, youth violence, intimate partner violence (teen dating violence), and sexual violence. The application must clearly state the NCIPC interpersonal violence research priority or priorities to be addressed by the proposed research in the Specific Aims section of the application. Applications that do not clearly propose to address at least one interpersonal violence prevention research priority impacting children or youth (from birth through age

17) and related to cross-cutting violence prevention, adverse childhood experiences, child abuse and neglect, youth violence, intimate partner violence (teen dating violence), and/or sexual violence, as evidenced by the Research Strategy section, will be considered nonresponsive and will not be forwarded for peer review.

The application should clearly describe the proposed research approach including: 1) the data source(s) and data access plans, 2) the planned analyses and how the analytic approach is well suited to the data source including estimated sample size, and a power analysis for outcomes of interest clearly specified), and 3) the research plan. Research plans must describe: the research question(s) of interest, the proposed hypothesis for the study, the proposed aims and objectives, the research study design used to test the hypothesis, and the expected outcomes to be evaluated.

Analytic plans should anticipate and evaluate the effects of threats to the internal and external validity of the specified research design. Rigorous research designs using quantitative or mixed methods that are appropriate to address the research questions are preferred. Applicants must propose studies that can feasibly be completed within the requested budget and project period.

Proposed research projects could include an expansion of a current investigation in which the researcher is involved or analyses of secondary data.

The budget, budget justification, and PHS 398 Career Development Award sections of the application must clearly describe the contact PD/PI's commitment to dedicating at least 7.3 person-months per year (60% effort) to the proposed research and career development and training activities for the entirety of the project period. The proposed activities should demonstrate a coordinated approach to prepare for conducting future independent research in the field of violence prevention. Applications that do not demonstrate contact PD/PI commitment to a minimum of 60% of full-time professional effort to their research project and career development for the entirety of the project period, as evidenced by the application's SF-424 Research and Related Budget effort of at least 7.3 person-months/year for the contact PD/PI, will be considered nonresponsive and will not be forwarded for peer review.

Applicatio…