Foa_Content_of_CDC-RFA-GH22-2272.pdf

Centers for Disease Control and Prevention

Center for Global Health

Informing global polio eradication efforts through innovative modeling approaches

CDC-RFA-GH22-2272

05/06/2022

Table of Contents A. Funding Opportunity Description

B. Award Information

C. Eligibility Information

D. Application and Submission Information

E. Review and Selection Process

F. Award Administration Information

G. Agency Contacts

H. Other Information

I. Glossary

Part I. Overview Applicants must go to the synopsis page of this announcement at www.grants.gov and click on the "Subscribe" button link to ensure they receive notifications of any changes to CDC-RFA- GH22-2272. Applicants also must provide an e-mail address to www.grants.gov to receive notifications of changes.

A. Federal Agency Name:

Centers for Disease Control and Prevention (CDC) / Agency for Toxic Substances and Disease Registry (ATSDR) B. Notice of Funding Opportunity (NOFO) Title:

Informing global polio eradication efforts through innovative modeling approaches C. Announcement Type: New - Type 1:

This announcement is only for non-research activities supported by CDC. If research is proposed, the application will not be considered. For this purpose, research is defined at https://www.gpo.gov/fdsys/pkg/CFR-2007-title42-vol1/pdf/CFR-2007-title42-vol1-sec52- 2.pdf. Guidance on how CDC interprets the definition of research in the context of public health can be found at https://www.hhs.gov/ohrp/regulations-and-policy/regulations/45-cfr- 46/index.html (See section 45 CFR 46.102(d)).

D. Agency Notice of Funding Opportunity Number:

CDC-RFA-GH22-2272

E. Assistance Listings Number:

93.185 F. Dates:

1. Due Date for Letter of Intent (LOI):

03/28/2022

2. Due Date for Applications:

https://www.grants.gov/ https://www.grants.gov/ https://www.gpo.gov/fdsys/pkg/CFR-2007-title42-vol1/pdf/CFR-2007-title42-vol1-sec52-2.pdf https://www.gpo.gov/fdsys/pkg/CFR-2007-title42-vol1/pdf/CFR-2007-title42-vol1-sec52-2.pdf https://www.hhs.gov/ohrp/regulations-and-policy/regulations/45-cfr-46/index.html https://www.hhs.gov/ohrp/regulations-and-policy/regulations/45-cfr-46/index.html

05/06/2022 11:59 p.m. U.S. Eastern Standard Time, at www.grants.gov.

3. Due Date for Informational Conference Call:

N/A

G. Executive Summary:

1. Summary Paragraph This NOFO will build and strengthen poliovirus outbreak response efforts and poliovirus surveillance capacity at global, regional, and national program levels and build capacity for a future public health workforce. Current outbreaks of circulating vaccine-derived poliovirus require innovative approaches offered by statistical and mathematical modeling to assess strategies to interrupt transmission efficiently and cost-effectively. Furthermore, identification and implementation of sustainable, long-term, sensitive poliovirus surveillance systems and approaches is critical upon global eradication of wild poliovirus to quickly detect emergence of vaccine-derived polioviruses and poliovirus containment breaches. Modeling would inform the optimal mix of surveillance systems and activities to ensure a polio-free world. Fundamental to this is engaging students to promote and cultivate a diverse workforce that can meet the increasing need of modeling to inform public health strategies and goals. This NOFO may also support modeling for other vaccine-preventable diseases (VPDs) as needed.

a. Eligible Applicants:

Open Competition

b. Funding Instrument Type:

CA (Cooperative Agreement)

c. Approximate Number of Awards

d. Total Period of Performance Funding:

$1,750,000 This NOFO does not have an award ceiling. The total period of performance funding amount has been provided as an estimate for applicants.

e. Average One Year Award Amount:

$175,000 This NOFO does not have an annual budget period ceiling. The average one year award amount is provided as an estimate to assist applicants with the preparation of their budget.

f. Total Period of Performance Length:

g. Estimated Award Date:

August 30, 2022

h. Cost Sharing and / or Matching Requirements:

No Cost sharing or matching funds are not required for this program. Although no statutory matching requirement for this NOFO exists, leveraging other resources and related ongoing efforts to promote sustainability is strongly encouraged.

https://www.grants.gov/

Part II. Full Text A. Funding Opportunity Description

1. Background

a. Overview The Global Polio Eradication Initiative (GPEI) began in 1988 with the objective of wild poliovirus (WPV) eradication and ultimate eradication of all polioviruses, including vaccine-derived polioviruses (VDPV). The Centers for Disease Control and Prevention (CDC) is one of the founding partners of the GPEI, providing technical and financial support (https://polioeradication.org/). Polio eradication remains an agency-wide priority; CDC's Emergency Operations Center (EOC) has been activated since December 2011 to support global polio response activities.

The GPEI has made tremendous progress toward global WPV eradication yet continues . to face two major challenges: 1) continued transmission of WPV1 in Pakistan and Afghanistan and 2) increasing number of circulating vaccine-derived poliovirus (cVDPVs) which result from prolonged transmission in under-immunized communities of the live weakened virus from the oral poliovirus vaccine (OPV). GPEI’s newest strategy, Polio Eradication Strategy 2022-2026:

Delivering on a Promise, outlines how the partnership intends to address these challenges.

Concurrently, GPEI must begin planning now for the future of a polio-free world. Current planning is that within 12 months of certification of WPV eradication, all OPVs will be removed from essential immunization programs (i.e., OPV cessation). The risk of emergence of VDPVs will be highest in the first two years after OPV cessation as intestinal mucosal immunity needed to stop virus transmission wanes. The risk of accidental introduction in communities and the environment by a containment breach from a poliovirus essential facility (PEF), such as a vaccine manufacturer, will persist as long as live polioviruses are maintained at facilities.

Numerous key questions remain about interrupting cVDPV transmission in the near-term, and the long-term needs of poliovirus surveillance. For cVDPV interruption, the focus is on which factor or combination of factors would optimize field-level response strategies to quickly interrupt transmission and associated costs. Questions on long-term surveillance include the optimal mix of poliovirus surveillance systems and activities that will be sustainable yet sensitive to detect VDPV emergence and associated costs. In countries with PEFs, questions focus on the types of surveillance activities needed to ensure surveillance sensitivity around the PEF.

Statistical and mathematical modeling would be an informative approach to address these complex questions and modeling has been used to inform GPEI policymaking. Further expansion of the portfolio of models available to CDC is needed to include models that inform the most efficient and cost-effective field-level operations for outbreak response, and poliovirus surveillance needs in the post-certification era. Modeling for other vaccine-preventable diseases (VPDs) is also needed.

In parallel, there is a recognized need for expanding the role of modeling to inform public health strategies and goals. CDC supports the growth of a diverse public health workforce and aims to provide collaborative opportunities to students to gain hands-on training and translation of their work to action.

https://polioeradication.org/ https://polioeradication.org/gpei-strategy-2022-2026/ https://polioeradication.org/gpei-strategy-2022-2026/

b. Statutory Authorities Section 307 of the Public Health Service Act, as amended [42 USC 242l]; Section 301(a) of the Public Health Service Act, as amended [42 USC 241 (a)] Section 317(k)(1)of the Public Health Service Act, as amended [42 USC 247b(k)(1)].

c. Healthy People 2030 This announcement addresses the Healthy People 2030 focus area(s) of Immunization and infectious Diseases.

https://health.gov/healthypeople/objectives-and-data/browse-objectives/vaccination ;

https://health.gov/healthypeople/objectives-and-data/browse-objectives/infectious-disease/maintain-elimination-measles-rubella-congenital-rubella-syndrome-and-polio-iid-01

d. Other National Public Health Priorities and Strategies CDC has a major role in the following national strategies:

CDC Global Immunization strategic Framework 2021- 2030 https://www.cdc.gov/globalhealth/immunization/framework/index.html Global Health Security Agenda (GHSA): https://www.cdc.gov/globalhealth/security/index.htm Vaccines - National Strategic Plan for the US, 2021-2025:

https://www.hhs.gov/vaccines/index.html Immunization Agenda 2030: http://www.immunizationagenda2030.org/

e. Relevant Work Polio Eradication Strategy 2022-2026: Delivering on a Promise:

https://polioeradication.org/gpei-strategy-2022-2026/ Polio Post-Certification Strategy: A risk mitigation strategy for a polio-free world:

https://polioeradication.org/polio-today/preparing-for-a-polio-free-world/transition-planning/polio-post-certification-strategy/ WHO Global Action Plan to minimize poliovirus facility-associated risk after type-specific eradication of wild polioviruses and sequential cessation of oral polio vaccine use https://polioeradication.org/polio-today/preparing-for-a-polio-free-world/containment/containment-resources/ CDC-RFA-GH21-2101,Support of Global Polio Eradication Initiative (GPEI) Using Integrated Modeling

2. CDC Project Description

a. Approach

Bold indicates period of performance outcome.

CDC-RFA-GH22-2272 Logic Model: Informing global polio eradication efforts through innovative modeling approaches Bold indicates period of performance outcom

Strategies and Activities

Short-term Outcomes

Intermediate Outcomes

Long-Term Outcomes

Inform the development of effective outbreak response

Improved understanding of the effectiveness of different outbreak

Improved data-informed use of effective outbreak response strategies by

Improved policy development and implementation, and vaccine supply https://health.gov/healthypeople/objectives-and-data/browse-objectives/vaccination https://health.gov/healthypeople/objectives-and-data/browse-objectives/infectious-disease/maintain-elimination-measles-rubella-congenital-rubella-syndrome-and-polio-iid-01 https://health.gov/healthypeople/objectives-and-data/browse-objectives/infectious-disease/maintain-elimination-measles-rubella-congenital-rubella-syndrome-and-polio-iid-01 https://www.cdc.gov/globalhealth/immunization/framework/index.html https://www.cdc.gov/globalhealth/security/index.htm https://www.hhs.gov/vaccines/index.html http://www.immunizationagenda2030.org/ https://polioeradication.org/gpei-strategy-2022-2026/ https://polioeradication.org/polio-today/preparing-for-a-polio-free-world/transition-planning/polio-post-certification-strategy/ https://polioeradication.org/polio-today/preparing-for-a-polio-free-world/transition-planning/polio-post-certification-strategy/ https://polioeradication.org/polio-today/preparing-for-a-polio-free-world/containment/containment-resources/ https://polioeradication.org/polio-today/preparing-for-a-polio-free-world/containment/containment-resources/ strategies for cVDPV2 outbreaks

Identify optimal poliovirus surveillance approaches post-certification

Identify surveillance strategies to effectively detect containment breaches

Support efforts to create a diverse public health workforce with capacity in statistical and mathematical modeling response approaches to interrupt virus transmission

Improved understanding of the costs of different outbreak response approaches to quickly end polio outbreaks

Improved understanding of optimal surveillance approaches to ensure sensitive poliovirus surveillance

Improved understanding of the costs of optimal surveillance approaches to ensure sensitive poliovirus surveillance

Improved understanding of surveillance strategies to detect containment breaches promptly and effectively

Improved workforce capacity for statistical and mathematical modeling global and regional partners

Improved ability to adapt cVDPV2 model to inform response strategies for outbreaks of cVDPV1 and cVDPV3

Improved poliovirus surveillance approaches used by global and regional partners

Improved surveillance strategies for detection of containment breaches used by global and regional partners effectively and promptly

Improved understanding among US public health agencies about optimal surveillance strategies to detect containment breaches effectively and promptly management towards cVDPV2 interruption per Goal 2 of the GPEI 2022-2026 strategy

Maximized allocation of donor funding for achieving polio eradication

Improved implementation of effective response strategies for cVDPV1 and cVDPV3 outbreaks

Increased adoption of policies for cost-effective integration of poliovirus surveillance with other vaccine-preventable diseases based on model findings

Improved data-informed use of strategies to effectively manage US risks around containment by US public health agencies

Improved capacity in modeling for public health practice for a diverse workforce

i. Purpose

This NOFO will provide critical disease modeling to inform decision making on the development of strategies for cVDPV2 outbreak response, optimal surveillance upon global WPV eradication, and surveillance to detect containment breaches. It will also build capacity for a diverse public health workforce of statistical and mathematical modelers. Additionally, models will assess economic implications of outbreak response and surveillance strategies, while developing workforce capacity for students in statistical and mathematical modeling for polio and other VPDs.

ii. Outcomes Short-term Outcomes:

Improved understanding of the effectiveness of different outbreak response approaches to interrupt virus transmission.

Improved understanding of the costs of different outbreak response approaches to quickly end outbreaks

Improved understanding of optimal surveillance approaches to ensure sensitive poliovirus surveillance

Improved understanding of the costs of optimal surveillance approaches to ensure sensitive poliovirus surveillance

Improved understanding of surveillance strategies to detect containment breaches promptly and effectively

Improved workforce capacity for statistical and mathematical modeling

Intermediate Outcomes:

Improved ability to adapt cVDPV2 model to inform response strategies for outbreaks of cVDPV1 and cVDPV3

Improved poliovirus surveillance approaches used by global and regional partners Improved surveillance strategies for detection of containment breaches used by global and regional partners effectively and promptly Improved understanding among US public health agencies about optimal surveillance strategies to detect containment breaches effectively and promptly

Long-term Outcomes:

Improved policy development and implementation, and vaccine supply management towards cVDPV2 interruption per Goal 2 of the GPEI 2022-2026 strategy

Increased adoption of policies for cost-effective integration of poliovirus surveillance based on model findings

Improved data-informed use of strategies to effectively manage US risks around containment by US public health agencies

iii. Strategies and Activities To address the strategies and activities listed below, CDC will facilitate access to the Global Polio Eradication Initiative (GPEI) data; data collection by the participant will not be necessary.

Models may be global-, WHO region-, or country-specific.

Inform the development of effective outbreak response strategies for cVDPV2 outbreaks

Build an infectious disease model of cVDPV2 transmission that predicts the impact of different outbreak response strategies on curtailing transmission in affected areas.

Evaluate and disseminate findings from the infectious disease model of cVDPV2 transmission through presentations at meetings, written reports, and peer-reviewed publications.

Evaluate the cost effectiveness of specific outbreak response strategies identified through the infectious disease model of cVDPV2 transmission. Disseminate findings through presentations at meetings, written reports, and peer-reviewed publications.

Identify optimal poliovirus surveillance approaches post-certification

Build a model that identifies optimal surveillance approaches to ensure sensitive poliovirus surveillance

Evaluate and disseminate findings of optimal surveillance approaches through presentations at GPEI meetings, written reports, and peer-reviewed publications.

Evaluate the cost effectiveness of optimal surveillance approaches. Disseminate findings through presentations at meetings, written reports, and peer-reviewed publications.

Identify surveillance strategies to effectively detect containment breaches

Build a model to assess containment breaches and course of spread to inform surveillance strategies

Evaluate and disseminate findings of surveillance approaches that effectively detect containment breaches

Support efforts to create a diverse public health workforce with capacity in statistical and mathematical modeling

Create practical training opportunities for statistical and mathematical modeling students to enter public health careers

1. Collaborations

a. With other CDC projects and CDC-funded organizations:

Recipient is required to collaborate closely with the Centers for Disease Control and Prevention’s National Center for Immunization and Respiratory Diseases/Division of Viral Diseases. Recipients are encouraged to collaborate with other CDC-funded poliovirus modeling groups.

b. With organizations not funded by CDC:

Recipient is required to collaborate with other modeling groups working on polio. The recipient may also collaborate with other external organizations such as National Ministries of Health, HHS/CDC and/or other USG agencies, GPEI partners, universities and NGOs. Applicant is requested to submit Letters of Support, MOUs or MOAs to verify collaborations. Applicants must file the MOU or MOA, as appropriate, name the file "MOUs/MOAs", and upload it as a PDF file at www.grants.gov.

2. Target Populations Populations in all countries that are under-immunized against poliovirus experiencing circulating vaccine-derived poliovirus outbreaks, countries with wild poliovirus, at high risk of vaccine-related poliovirus transmission after certification of wild poliovirus eradication, or at risk of a containment breach from poliovirus holding facilities (e.g., polio vaccine manufacturers, laboratories).

a. Health Disparities Applicants are encouraged to describe how populations at greatest risk for poliovirus will be served through activities supported by this NOFO, including description of targeted approaches.

iv. Funding Strategy N/A

b. Evaluation and Performance Measurement

i. CDC Evaluation and Performance Measurement Strategy

Throughout the NOFO period, CDC will work with recipient to assess whether funded activities are leading to the following intended outcomes bolded in the NOFO logic model.

The purpose of evaluation and performance measurement is to help CDC recipients: (1) Monitor the extent to which activities were successfully completed; (2) Demonstrate progress toward achieving program outcomes; and (3) Inform decisions about future programming that drive continuous program improvement for more efficient and effective program performance (e.g.

What and how could things be improved?).

An Evaluation and Performance Measurement Plan (EPMP) is required as part of this NOFO to measure NOFO accomplishments. The primary objective of the EPMP implementation is to determine the progress of activities under this NOFO and indicate how they relate to the desired outcomes. The results will be used for program improvement, accountability and reporting, and for sharing with partners and other stakeholders.

Outcomes and process measures suggested for inclusion in the EPMP to track implementation of recipient strategies and activities that are performed and determine progress on achieving expected outcomes are listed below. The recipient will be required to provide biannual reports (i.e., every 6-months) to CDC that includes the bolded process and outcomes measures; non-bolded measures are to be reported on an annual basis.

Process Measures

Number and listing of completed presentations and published manuscripts that disseminate model-based findings, cost effectiveness evaluations, and recommendations

Number and type of practical training opportunities established for statistical and mathematical modeling for graduate students

Outcome Measures

Cost estimate available for outbreak response activities that optimize polio outbreak response strategies

Cost estimate available for surveillance strategies that optimize poliovirus surveillance as part of integrated disease surveillance systems

Ability to adapt cVDPV2 model to inform response strategies for outbreaks of cVDPV1 and cVDPV3

Number of instances where model outputs are referenced in GPEI meeting reports, strategy documents, standard operating procedures, budget/cost estimates, vaccine supply management, and other programmatic documents

Number and type of US Government reports or meetings that reference model-based recommendations, particularly surveillance strategies to promptly detect containment breaches.

Number and status of countries' implementation of model-based recommendations CDC use of model inputs (including costs) to guide global-level recommendations and approaches for outbreak response activities at the field level CDC use of model outputs (including costs) to guide understanding of optimal surveillance approaches in the post-certification era to ensure sustainable, sensitive poliovirus surveillance

CDC use of model outputs to guide understanding of effective surveillance strategies to promptly detect containment breaches

Completed modeling projects that demonstrate understanding of statistical and mathematical modeling by graduate students

ii. Applicant Evaluation and Performance Measurement Plan Applicants must provide an evaluation and performance measurement plan that demonstrates how the recipient will fulfill the requirements described in the CDC Evaluation and Performance Measurement and Project Description sections of this NOFO. At a minimum, the plan must describe:

How the applicant will collect the performance measures, respond to the evaluation questions, and use evaluation findings for continuous program quality improvement.

How key program partners will participate in the evaluation and performance measurement planning processes.

Available data sources, feasibility of collecting appropriate evaluation and performance data, and other relevant data information (e.g., performance measures proposed by the applicant)

Plans for updating the Data Management Plan (DMP) as new pertinent information becomes available. If applicable, throughout the lifecycle of the project. Updates to DMP should be provided in annual progress reports. The DMP should provide a description of the data that will be produced using these NOFO funds; access to data;

data standards ensuring released data have documentation describing methods of collection, what the data represent, and data limitations; and archival and long-term data preservation plans. For more information about CDC’s policy on the DMP, see https://www.cdc.gov/grants/additional-requirements/ar-25.html.

Where the applicant chooses to, or is expected to, take on specific evaluation studies, the applicant should be directed to:

Describe the type of evaluations (i.e., process, outcome, or both).

https://www.cdc.gov/grants/additional-requirements/ar-25.html

Describe key evaluation questions to be addressed by these evaluations.

Describe other information (e.g., measures, data sources).

Recipients will be required to submit a more detailed Evaluation and Performance Measurement plan, including a DMP, if applicable, within the first 6 months of award, as described in the Reporting Section of this NOFO.

A DMP is not requested.

c. Organizational Capacity of Recipients to Implement the Approach Applicants must describe:

Technical expertise in developing and applying statistical, mathematical, and economical modeling to the applicant's poliovirus and cost models, adjusting the models as needed, interpreting and presenting results, and publishing research articles in biomedical journals. Two sets of documentation should be provided to describe technical expertise and upload as PDF at www.grants.gov: 1) CVs of technical experts who will be engaged in activities, bolding all skills and experiences relevant to statistical, mathematical, and economical modeling. CVs should be labeled as “<Last name, First initial>_Technical Expert in Modeling”; and 2) Bibliography of publications in peer-reviewed journals since January 2019 by the applicant that includes original statistical, mathematical, and economical models and results. The bibliography should be labeled as “Bibliography of modeling publications since 2019”.

Ready access to a pool of diverse graduate students (masters or doctorate students) and capable of providing direct technical guidance to the students on the development of the models as detailed in a document (no more than 2 pages) that summarizes the mechanism in which graduate students will be available (e.g., type or linkage to an accredited academic institution, or another mechanism) and how the applicant will provide direct technical guidance to the student (e.g., advisor, practicum, etc). Label this document as “Direct technical guidance to students for modeling” and upload as a PDF at www.grants.gov.

Project management, staffing and administration capacity and experience, documented by the project organizational chart, staff roles, and CVs/Resumes for key staff.

Collaboration in public health programs with entities such as National Ministries of Health, HHS/CDC and/or other USG Agencies, GPEI partners, universities, and NGOs.

The ability to manage grants and contracts with a financial management system that will allow proper funds management and segregation of funds by program, and meet the requirements as stated in the Uniform Administrative Requirements, Cost Principles, and Audit Requirements for HHS Awards: https://www.ecfr.gov/cgi-bin/text-idx?node=pt45.1.75#se45.1.75_1302"45 CFR 75.302 The financial system should permit the preparation of reports required by general and program-specific terms and conditions; and the tracing of funds to a level of expenditure adequate to establish that such funds have been used according to the federal statutes, regulations, and terms and conditions of the federal award.

Applicant must upload all additional documentation in Grants.gov under Other Attachment Forms. Documents should be labeled as above in these categories:

"CVs/Resumes", “Bibliography”, “Technical Guidance” and "Organizational Charts".

https://www.ecfr.gov/cgi-bin/text-idx?node=pt45.1.75%23se45.1.75_1302%2245%20CFR%2075.302 https://www.ecfr.gov/cgi-bin/text-idx?node=pt45.1.75%23se45.1.75_1302%2245%20CFR%2075.302

d. Work Plan The work plan allows the project officer to monitor implementation of activities and progress on period of performance outcomes. Applicants should provide a detailed work plan for the first year of the project and a high-level work plan for subsequent years.

No specific work plan format is required, as long as it is clear how the components in the work plan crosswalk to the strategies and activities, outcomes, and evaluation and performance measures presented in the logic model and the narrative sections of the NOFO.

A sample work plan format is presented below to show how a traditional work plan aligns with the logic model and narrative. In this format, the table would be completed for each period of performance outcome. If a particular activity leads to multiple outcomes, it should be described under each outcome measure.

Period of Performance Outcome:

[from Outcomes section and/or logic model]

Outcome Measure:

[from Evaluation and Performance Measurement section]

Strategies and Activities

Process Measure [from Evaluation and Performance Measurement section]

Responsible Position / Party

Completion Date

1.

2.

3.

4.

5.

6.

e. CDC Monitoring and Accountability Approach Monitoring activities include routine and ongoing communication between CDC and recipients, site visits, and recipient reporting (including work plans, performance, and financial reporting).

Consistent with applicable grants regulations and policies, CDC expects the following to be included in post-award monitoring for grants and cooperative agreements:

Tracking recipient progress in achieving the desired outcomes.

Ensuring the adequacy of recipient systems that underlie and generate data reports.

Creating an environment that fosters integrity in program performance and results.

Monitoring may also include the following activities deemed necessary to monitor the award:

Ensuring that work plans are feasible based on the budget and consistent with the intent of the award.

Ensuring that recipients are performing at a sufficient level to achieve outcomes within stated timeframes.

Working with recipients on adjusting the work plan based on achievement of outcomes, evaluation results and changing budgets.

Monitoring performance measures (both programmatic and financial) to assure satisfactory performance levels.

Monitoring and reporting activities that assist grants management staff (e.g., grants management officers and specialists, and project officers) in the identification, notification, and management of high-risk recipients.

Recipient is required to collaborate closely with CDC/CGH Global Immunization Division and CDC/NCIRD Division of Viral Diseases

Throughout the five-year period of performance, CDC will engage in the following monitoring activities:

Monthly calls to review program progress, determine needs for technical assistance, and review administrative actions

Annual site visits to review programmatic progress and to plan for the following budget period; site visits will include a review of recipient program and financial reporting

Technical review of annual workplans and budgets, with written feedback provided to the recipient

Review of financial and programmatic reports submitted by the recipient

f. CDC Program Support to Recipients

CDC staff will be substantially involved in the program activities outlined in this NOFO to include:

Providing technical assistance to recipient in support of the activities implemented under this agreement

Collaborating with recipient to provide programmatic support to national governments for planning, implementing, and evaluating polio eradication, measles mortality reduction, rubella control/elimination and other globally agreed VPD control activities.

Assisting in providing technical training, support, and consultation to expert staff hired by recipient to assist in the polio eradication, measles mortality reduction, rubella control/elimination strategies.

Providing expertise for the maintenance and development of disease surveillance structures, including assessment, strategy design, evaluation and assistance in priority countries.

Providing laboratory expertise to recipient for the strengthening and expansion of laboratory-based surveillance systems.

Provide input to the recipient(s) to guide prioritization of specific projects to pursue based on emergent global/regional needs based on polio epidemiology

Collaborating with and providing technical assistance to recipient to determine appropriate strategies to address other mutually agreed global health priorities that may be addressed through this agreement if required.

B. Award Information

1. Funding Instrument Type:

CA (Cooperative Agreement) CDC's substantial involvement in this program appears in the CDC Program Support to Recipients Section.

2. Award Mechanism:

U2R

3. Fiscal Year:

4. Approximate Total Fiscal Year Funding:

$350,000

5. Total Period of Performance Funding:

$1,750,000 This amount is subject to the availability of funds.

This NOFO does not have an award ceiling. The total period of performance funding amount has been provided as an estimate for applicants.

Estimated Total Funding:

$1,750,000

6. Total Period of Performance Length:

year(s)

7. Expected Number of Awards:

8. Approximate Average Award:

$175,000 Per Budget Period

This NOFO does not have an annual budget period ceiling. The average one year award amount is provided as an estimate to assist applicants with the preparation of their budget.

9. Award Ceiling:

$0 Per Budget Period

This amount is subject to the availability of funds.

There is no budget period ceiling.

10. Award Floor:

$0 Per Budget Period

There is no budget period floor.

11. Estimated Award Date:

August 30, 2022

12. Budget Period Length:

12 month(s)

Throughout the project period, CDC will continue the award based on the availability of funds, the evidence of satisfactory progress by the recipient (as documented in required reports), and the determination that continued funding is in the best interest of the federal government. The total number of years for which federal support has been approved (project period) will be shown in the “Notice of Award.” This information does not constitute a commitment by the federal government to fund the entire period. The total period of performance comprises the initial competitive segment and any subsequent non-competitive continuation award(s).

13. Direct Assistance Direct Assistance (DA) is not available through this NOFO.

If you are successful and receive a Notice of Award, in accepting the award, you agree that the award and any activities thereunder are subject to all provisions of 45 CFR part 75, currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions.

C. Eligibility Information

1. Eligible Applicants Eligibility Category:

99 (Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility")

02 (City or township governments)

04 (Special district governments)

05 (Independent school districts)

06 (Public and State controlled institutions of higher education)

07 (Native American tribal governments (Federally recognized))

08 (Public housing authorities/Indian housing authorities)

11 (Native American tribal organizations (other than Federally recognized tribal governments))

12 (Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education)

13 (Nonprofits without 501(c)(3) status with the IRS, other than institutions of higher education)

20 (Private institutions of higher education)

22 (For profit organizations other than small businesses)

23 (Small businesses)

25 (Others (see text field entitled "Additional Information on Eligibility" for clarification))

00 (State governments)

01 (County governments)

2. Additional Information on Eligibility N/A

3. Justification for Less than Maximum Competition

4. Cost Sharing or Matching Cost Sharing / Matching Requirement:

No Cost sharing or matching funds are not required for this program. Although no statutory matching requirement for this NOFO exists, leveraging other resources and related ongoing efforts to promote sustainability is strongly encouraged.

5. Maintenance of Effort Maintenance of effort is not required for this program.

D. Application and Submission Information

1. Required Registrations An organization must be registered at the three following locations before it can submit an application for funding at www.grants.gov.

PLEASE NOTE: For applications due on or after April 4, 2022, applicants must have a unique entity identifier (UEI) at the time of application submission (SF-424, field 8c). In preparation for the federal government’s April 4, 2022 transition to the Unique Entity Identifier (UEI) from the Data Universal Numbering System (DUNS), applicants must obtain a UEI. The UEI is generated as part of SAM.gov registration. Current SAM.gov registrants have already been assigned their UEI and can view it in SAM.gov and grants.gov. Entities registering in SAM.gov prior to April 4, 2022 must still obtain a DUNS number before registering in SAM.gov registration. Additional information is available on the GSA website, SAM.gov, and Grants.gov- Finding the UEI.

a. Data Universal Numbering System:

All applicant organizations must obtain a Data Universal Numbering System (DUNS) number to register in SAM.gov prior to April 4, 2022. A DUNS number is a unique nine-digit identification https://www.grants.gov/ https://www.gsa.gov/about-us/organization/federal-acquisition-service/office-of-systems-management/integrated-award-environment-iae/iae-systems-information-kit/unique-entity-identifier-update https://sam.gov/content/home https://grantsgovprod.wordpress.com/2021/09/14/how-to-find-an-applicants-uei-within-grants-gov/ https://grantsgovprod.wordpress.com/2021/09/14/how-to-find-an-applicants-uei-within-grants-gov/ number provided by Dun & Bradstreet (D&B).

The applicant organization may request a DUNS number by telephone at 1-866-705-5711 (toll free) or internet at http:// fedgov.dnb. com/ webform/ displayHomePage.do. The DUNS number will be provided at no charge.

If funds are awarded to an applicant organization that includes sub-recipients, those sub-recipients must provide their DUNS numbers before accepting any funds.

b. System for Award Management (SAM):

The SAM is the primary registrant database for the federal government and the repository into which an entity must submit information required to conduct business as a recipient. All applicant organizations must register with SAM, and will be assigned a SAM number and a Unique Entity Identifier (UEI). All information relevant to the SAM number must be current at all times during which the applicant has an application under consideration for funding by CDC.

If an award is made, the SAM information must be maintained until a final financial report is submitted or the final payment is received, whichever is later. The SAM registration process can require 10 or more business days, and registration must be renewed annually. Additional information about registration procedures may be found at SAM.gov and the SAM.gov Knowledge Base.

c. Grants.gov:

The first step in submitting an application online is registering your organization at www.grants.gov, the official HHS E-grant Web site. Registration information is located at the "Applicant Registration" option at www.grants.gov.

All applicant organizations must register at www.grants.gov. The one-time registration process usually takes not more than five days to complete. Applicants should start the registration process as early as possible.

Step System Requirements Duration Follow Up

Data Universal Number System

(DUNS)

(Required until April 4, 2022)

1. Click on http:// fedgov.dnb.com/ webform

2. Select Begin DUNS search/request process

3. Select your country or territory and follow the instructions to obtain your DUNS 9-digit #

4. Request appropriate staff member(s) to obtain DUNS number, verify & update information under DUNS number

1-2 Business Days

To confirm that you have been issued a new DUNS number check online at (http:// fedgov.dnb.com/ webform) or call 1-866-705-http://fedgov.dnb.com/webform/displayHomePage.do https://sam.gov/content/home https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.fsd.gov%2Fgsafsd_sp%3Fid%3Dgsa_kb_view2%26kb_id%3Df66d8e6cdb76d4100d73f81d0f9619c6&data=04%7C01%7Ccshifflett%40dminc.com%7C8eee7a2adab549a3b3c008d925e9a364%7Cdb7ac9ef779d46e59bca00509580ad6b%7C0%7C0%7C637582507851821018%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=UrR%2B%2FM2wWF2fZG05Z8O6JS2C3FXXSl%2F7B3%2FB45XHRrg%3D&reserved=0 https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.fsd.gov%2Fgsafsd_sp%3Fid%3Dgsa_kb_view2%26kb_id%3Df66d8e6cdb76d4100d73f81d0f9619c6&data=04%7C01%7Ccshifflett%40dminc.com%7C8eee7a2adab549a3b3c008d925e9a364%7Cdb7ac9ef779d46e59bca00509580ad6b%7C0%7C0%7C637582507851821018%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=UrR%2B%2FM2wWF2fZG05Z8O6JS2C3FXXSl%2F7B3%2FB45XHRrg%3D&reserved=0 https://grants.gov/ https://www.grants.gov/ http://www.grants.gov/ https://www.grants.gov/ http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform

System for Award Management

(SAM)

1. Retrieve organizations DUNS number (required until April 4, 2022)

2. Go to SAM.gov and designate an E-Biz POC (You will need to have an active SAM account before you can register on grants.gov). The UEI is generated as part of your registration.

3-5 Business Days but up to 2 weeks and must be renewed once a year

For SAM Customer Service Contact https://fs d.gov/ fsd-gov/ home.do Calls: 86 6-606-8220

3 Grants.gov

1. Set up an individual account in Grants.gov using organization new DUNS number to become an authorized organization representative

(AOR)

2. Once the account is set up the E-BIZ POC will be notified via email

3. Log into grants.gov using the password the E-BIZ POC received and create new password

4. This authorizes the AOR to submit applications on behalf of the organization

Same day but can take 8 weeks to be fully registered and approved in the system (note, applicants MUST obtain a DUNS number and SAM account before applying on grants.gov)

Register early!

Log into grants.gov and check AOR status until it shows you have been approved

2. Request Application Package Applicants may access the application package at www.grants.gov.

3. Application Package Applicants must download the SF-424, Application for Federal Assistance, package associated with this notice of funding opportunity at www.grants.gov.

4. Submission Dates and Times If the application is not submitted by the deadline published in the NOFO, it will not be processed. Office of Grants Services (OGS) personnel will notify the applicant that their application did not meet the deadline. The applicant must receive pre-approval to submit a paper application (see Other Submission Requirements section for additional details). If the applicant is authorized to submit a paper application, it must be received by the deadline provided by OGS.

a. Letter of Intent Deadline (must be emailed)

03/28/2022

b. Application Deadline

05/06/2022 11:59 pm U.S. Eastern Standard Time, at www.grants.gov. If Grants.gov is inoperable and cannot receive applications, and circumstances preclude advance notification of an extension, https://sam.gov/content/home https://fsd.gov/fsd-gov/home.do https://fsd.gov/fsd-gov/home.do https://fsd.gov/fsd-gov/home.do https://www.grants.gov/ then applications must be submitted by the first business day on which grants.gov operations resume.

Due Date for Information Conference Call N/A

5. Pre-Award Assessments Risk Assessment Questionnaire Requirement

CDC is required to conduct pre-award risk assessments to determine the risk an applicant poses to meeting federal programmatic and administrative requirements by taking into account issues such as financial instability, insufficient management systems, non-compliance with award conditions, the charging of unallowable costs, and inexperience. The risk assessment will include an evaluation of the applicant’s CDC Risk Questionnaire, located at https://www.cdc.gov/grants/documents/PPMR-G-CDC-Risk-Questionnaire.pdf, as well as a review of the applicant’s history in all available systems; including OMB-designated repositories of government-wide eligibility and financial integrity systems (see 45 CFR 75.205(a)), and other sources of historical information. These systems include, but are not limited to: FAPIIS (https://www.fapiis.gov/), including past performance on federal contracts as per Duncan Hunter National Defense Authorization Act of 2009; Do Not Pay list; and System for Award Management (SAM) exclusions.

CDC requires all applicants to complete the Risk Questionnaire, OMB Control Number 0920- 1132 annually. This questionnaire, which is located at https://www.cdc.gov/grants/documents/PPMR-G-CDC-Risk-Questionnaire.pdf, along with supporting documentation must be submitted with your application by the closing date of the Notice of Funding Opportunity Announcement. If your organization has completed CDC’s Risk Questionnaire within the past 12 months of the closing date of this NOFO, then you must submit a copy of that questionnaire, or submit a letter signed by the authorized organization representative to include the original submission date, organization’s EIN and DUNS.

When uploading supporting documentation for the Risk Questionnaire into this application package, clearly label the documents for easy identification of the type of documentation. For example, a copy of Procurement policy submitted in response to the questionnaire may be labeled using the following format: Risk Questionnaire Supporting Documents _ Procurement Policy.

Duplication of Efforts

Applicants are responsible for reporting if this application will result in programmatic, budgetary, or commitment overlap with another application or award (i.e. grant, cooperative agreement, or contract) submitted to another funding source in the same fiscal year. Programmatic overlap occurs when (1) substantially the same project is proposed in more than one application or is submitted to two or more funding sources for review and funding consideration or (2) a specific objective and the project design for accomplishing the objective are the same or closely related in two or more applications or awards, regardless of the funding source. Budgetary overlap occurs when duplicate or equivalent budgetary items (e.g., equipment, salaries) are requested in an application but already are provided by another https://www.cdc.gov/grants/documents/PPMR-G-CDC-Risk-Questionnaire.pdf https://www.cdc.gov/grants/documents/PPMR-G-CDC-Risk-Questionnaire.pdf source. Commitment overlap occurs when an individual’s time commitment exceeds 100 percent, whether or not salary support is requested in the application. Overlap, whether programmatic, budgetary, or commitment of an individual’s effort greater than 100 percent, is not permitted. Any overlap will be resolved by the CDC with the applicant and the PD/PI prior to award.

Report Submission: The applicant must upload the report in Grants.gov under “Other Attachment Forms.” The document should be labeled: "Report on Programmatic, Budgetary, and Commitment Overlap.”

6. Content and Form of Application Submission Applicants are required to include all of the following documents with their application package at www.grants.gov.

7. Letter of Intent A Letter of Intent (LOI) is requested but not required. The purpose of an LOI is to allow CDC program staff to estimate the number of and plan for the review of submitted applications. The LOI should be on organizational letterhead and should state that the applicant intends to submit an application for this funding opportunity. Please include the following information:

Name, address, telephone number, and email address of the Principal Investigator or Project Director, or both

Name, address, telephone number, and e-mail address of the primary contact for writing and submitting this application

Number and title of this NOFO

LOI must be sent via U.S. express mail, delivery service or email to:

Mary Mulholland, Project Officer CDC, Center for Global Health Address: 1600 E. Clifton Rd. NE, Mailstop H24-2, Atlanta, GA 30333 Telephone number: 404-553-7371 Email address: ZQL0@cdc.gov

If the LOI is sent by email, please use the subject line "Letter of Intent to Apply to CDC-RFA-

GH22-2272"

8. Table of Contents (There is no page limit. The table of contents is not included in the project narrative page limit.): The applicant must provide, as a separate attachment, the “Table of Contents” for the entire submission package.

Provide a detailed table of contents for the entire submission package that includes all of the documents in the application and headings in the "Project Narrative" section. Name the file "Table of Contents" and upload it as a PDF file under "Other Attachment Forms" at www.grants.gov.

9. Project Abstract Summary A project abstract is included on the mandatory documents list and must be submitted at www.grants.gov. The project abstract must be a self-contained, brief summary of the proposed https://www.grants.gov/ mailto:ZQL0@cdc.gov project including the purpose and outcomes. This summary must not include any proprietary or confidential information. Applicants must enter the summary in the "Project Abstract Summary" text box at www.grants.gov.

10. Project Narrative (Unless specified in the "H. Other Information" section, maximum of 20 pages, single spaced, 12 point font, 1-inch margins, number all pages. This includes the work plan. Content beyond the specified page number will not be reviewed.)

Applicants must submit a Project Narrative with the application forms. Applicants must name this file “Project Narrative” and upload it at www.grants.gov. The Project Narrative must include all of the following headings (including subheadings): Background, Approach, Applicant Evaluation and Performance Measurement Plan, Organizational Capacity of Applicants to Implement the Approach, and Work Plan. The Project Narrative must be succinct, self-explanatory, and in the order outlined in this section. It must address outcomes and activities to be conducted over the entire period of performance as identified in the CDC Project Description section. Applicants should use the federal plain language guidelines and Clear Communication Index to respond to this Notice of Funding Opportunity. Note that recipients should also use these tools when creating public communication materials supported by this NOFO.