Attachments_1-4_Waterpipe_Physical_Design.docx
DOCX document 37 KB Posted
- Solicitation number
- FDA-19-RFP-1209909
View the file
Other files
| File | Type | Posted |
|---|---|---|
| Q_&_A_Waterpipe_Physical_Design.docx | DOCX document | |
| RFP_Waterpipe_Physical_Design_Parameters.docx | DOCX document | |
| Attachment_6_Past_Performance_Questionnaire_Waterpipe.doc | DOC document | |
| Attachment_5_SB_Subcontracting_Plan_Waterpipd.doc | DOC document |
On GovTribe
Work with this file
- Download the original file
- Contacts named in this file
- Similar government files
- Ask GovTribe AI about this file
Text version
ATTACHMENT 1
Table 1. Waterpipe Regimen Parameters
| Publication |
| Total Time per Session (min) |
| Number of Puffs per Session |
| Mean Puff Duration (s) |
| Mean Puff Volume (L) |
| Mean Interpuff Interval (s) |
| Mean Flow Rate (L/s) |
| Total Smoke Inhaled (L) |
Shihadeh, 20048 (Beirut Method)
| 61 |
| 171 |
| 2.6 |
| 0.53 |
| 17 |
| Not measured |
| Not measured |
| Brinkman, 20167 |
| 70.4 ± 44.3 |
| 70.9 ± 37.3 |
| 4.5 ± 1.6 |
| 0.64 ± 0.31 |
| 26.2 ± 22.4 |
| 0.17 ± 0.05 |
| Not measured |
ATTACHMENT 2
Table 2. HPHCs in Waterpipe Smoke Acetaldehyde
Acrolein
Total Arsenic (As)
Benzene
Benzo[a]pyrene
Cadmium (Cd)
Carbon monoxide
Catechol
Chromium (Cr)
Crotonaldehyde
Formaldehyde
Free Nicotine
Isoprene
Lead (Pb)
Menthol (only for Task 9.1)
Nicotine (total)
Nicotine-derived nitrosamine ketone (NNK)
N-nitrosonornicotine (NNN) pH
Phenol
Total particulate matter (TPM)
ATTACHMENT 3
Table 3. Experimental Conditions
| Parameter |
| Condition 1 |
| Condition 2 |
| Condition 3 |
| Condition 4 |
| Condition 5 |
| Condition 6 |
| Condition 7 |
| Bowl Screen Material |
| Aluminum Foil |
| Bowl Screen |
| Stem Length (m) |
| 0.01 |
| 0.1 |
| 0.25 |
| 0.3 |
| 0.5 |
| Stem Depth (m) |
| 0.01 |
| 0.1 |
| 0.25 |
| 0.3 |
| 0.5 |
| Base Liquid Adulterants |
| None |
| 25 mL milk + water |
| Acidic juice |
| Ice water |
| Carbonated soda water |
| 100% Ethanol |
| Crushed mints in water |
| pH of Base Liquid |
| 6.5 |
| 7 |
| 7.5 |
| 8 |
| 8.5 |
| Hose Length (m) |
| 0.1 |
| 0.5 |
| 1 |
| 1.5 |
| 2 |
| 3 |
| Hose Inner Diameter (mm) |
| 3.5 |
| 6.5 |
| 9.5 |
| 12.5 |
| 15.5 |
| Hose Material |
| Plastic |
| Leather |
Shaded fields in gray represent parameters where no further conditions are needed
ATTACHMENT 4
References 1 Chattopadhyay A. Emperor Akbar as a Healer and His Eminent Physicians. Bull. Indian Inst. Hist. Med. 2000;30:151-158.
2 Schubert J, Heinke V, Bewersdorff J, Luch A, Schultz TG. Waterpipe Smoking: The Role of Humectants in the Release of Toxic Carbonyls. Arch. Toxicol. 2012;86:1309-1316.
3 Shihadeh A, Eissenberg T. Significance of Smoking Machine Toxicant Yields to Blood-Level Exposure in Water Pipe Tobacco Smokers. Cancer Epidem Biomar. 2011;20:2457–2460.
4 Shihadeh A, Salman R, Jaroudi E, Saliba N, Sepetdjian E, Blank MD, Cobb CO, Eissenberg T. Does Switching to a Tobacco-free Waterpipe Product Reduce Toxicant Intake? A Crossover Study Comparing CO, NO, PAH, Volatile Aldehydes, “Tar” and Nicotine Yields. Food Chem. Toxicol. 2012;50:1494–1498.
5 111 P.L. 31;123 Stat. 1776; 2009 Enacted H.R. 1256; 111 Enacted H.R. 1256 6 21 CFR Parts 1100, 1140, and 1143 Vol. 79 No. 80 7 Brinkman MC, Kim H, Gordon SM, Kroeger RR, Reyes IL, Deojay DM, Chitwood C, Lane TE, Clark PI. Design and Validation of a Research-Grade Waterpipe Equipped with Puff Topography Analyzer. Nic. & Tob. Res. 2016;18:785-93.
8 Shihadeh A, Azar S, Antonios C, Haddad A. Towards a Topographical Model of Narghile Water-Pipe Café Smoking: A Pilot Study in a High Socioeconomic Status Neighborhood of Beirut, Lebanon Pharmacol. Biochem. and Behav. 2004;79:75-82.
9 Monzer B, Sepetdjian E, Saliba N, Shihadeh A. Charcoal emissions as a source of CO and carcinogenic PAH in mainstream narghile waterpipe smoke. Food Chem Toxicol 2008; 46:2991-299
File details come from the government source that posted it.