2018-0530_NIH_NCATS_POR_BOOK_FINAL.pdf

May 30, 2018

National Center for Advancing Translational Sciences

(NIH-NCATS)

Program of Requirements Contract No. HHSN292201500003I

Task Order no. HHSN29200005

NIH-NCATS PROGRAM OF REQUIREMENTS

MAY 30, 2018

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PROGRAM OF REQUIREMENTS (POR) FOR

THE NATIONAL INSTITUTES OF HEALTH

NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

Division of Policy and Program Assessment

DHHS/NIH/ORF

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TABLE OF CONTENTS

I. EXECUTIVE SUMMARY 1

A. Project Description 1

B. Background Information 1

C. Objectives of the Program of Requirements 2

D. Introduction to the Final Program of Requirements 3

II. DESIGN STANDARDS 5

A. Applicable Codes and Standards: 5

B. Applicable Federal Regulations: 5

C. Utility Company Regulations 5

D. Industry Codes & Standards 6

III. SPACE AND OCCUPANCY REQUIREMENTS 7

A. Activity Analysis 7

B. General Space Parameters 9

C. Space Descriptions 9

D. Space Program List 17

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IV. BUILDING CRITERIA AND DESIGN REQUIREMENTS 155

A. General Requirements 155

B. General Design and Construction Guidelines 155

C. Architectural Criteria 160

D. Sustainability 160

E. Signage 161

F. Laboratory Design Criteria 161

G. Structural 163

H. Mechanical Systems 164

I. Plumbing Systems 169

J. Life Safety/ Fire Prevention 172

K. Electrical 174

L. Communications/Telephone and Data 178

M. Security - Access Control System 179

N. Equipment List 180

V. APPENDIX 183

A. Abbreviations 184

B. Drawing Reference Symbols 186

C. Room Finish Class Group Key (Architectural Requirements) 188

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I. EXECUTIVE SUMMARY Page 1

I. EXECUTIVE SUMMARY

A. Project Description

Th e National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) was offi cially established in fi scal year 2012 to transform the translational science process so that new treatments and cures for disease can be delivered to patients faster. NCATS, one of 27 Institutes and Centers (ICs) at NIH, strives to develop innovations to reduce, remove or bypass costly and time-consuming bottlenecks in the translational research pipeline in an eff ort to speed up the delivery of new drugs, diagnostics, and medical devices to patients. 1

Translation is the process of turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public — from diagnostics and therapeutics to medical procedures and behavioral changes. Translational science is the fi eld of investigation focused on understanding the scientifi c and operational principles underlying each step of the translational process. NCATS studies translation on a system-wide level as a scientifi c and operational problem. 2

NCATS currently occupies leased lab and offi ce space in Rockville, Maryland. Because of continued growth in programs and staffi ng, the NIH seeks to lease new clinical research space for NCATS to complement the existing laboratories and provide effi cient facilities to meet the needs of NCATS both today and into the future.

Th e new NCATS lease will occupy approximately 19,700 usable square feet of leased space in the northern metropolitan Washington, DC area. Th e new lease shall be located within the delineated area defi ned in the NIH Request for Lease Proposal (RLP).

B. Background Information

NCATS is comprised of six components; the Bioprinting Group, Soft ware Development, Small Molecule Repository,Incubator Lab, Freezer Repository and IC Storage Facility, and Intramural Administrative Services/ Acquisitions. Several of these components have outgrown their original space and future projections indicate a continuing growth in staff and program activities.

1 NCATS history from website www.ncats.NIH.gov/about/center 2 Translational Science explanation from website www.ncats.NIH.gov/about/center

I. EXECUTIVE SUMMARY Page 2

Because of space constraints the Intramural Administrative Services and Acquisitions group has been physically separated to a second leased facility. Th is separation has resulted in reduced effi ciencies and separated a vital support group of NCATS from their customers.

Because of space constraints at the main NCATS facility, additional space is also being leased at two remote locations for freezer and refrigeration storage. Th e remote freezer and refrigeration locations also have a negative impact on the effi ciency of the NCATS operations.

To meet current and future needs NCATS program components require more space to eff ectively fulfi ll their objectives and meet the increase in scientifi c demand. A new leased facility is needed to supplement the existing clinical research facility, allow for the relocation of the Intramural Administrative Services and Acquisitions group, and provide freezer storage capacity.

Th is Program of Requirements (POR) has been developed to defi ne the space needs and technical requirements for a new NCATS lease.

C. Objectives of the Program of Requirements

Th e ultimate objective of this POR is to defi ne the requirements for a lease that will provide an innovative and fl exible work environment that can evolve over the next 15 years to meet tomorrow’s NIH and NCATS workforce requirements by increasing workfl ow effi ciencies, enhancing collaboration and increasing morale.

Th e activities and requirements defi ned in this POR are for three of the groups within NCATS: Compound Management, Tissue Printing and Intramural Administrative Services and Acquisitions. Th ese three groups will be occupying the new lease.

NCATS is comprised of a diverse staff who guide the Center’s translational research activities. A total of up to 49 staff are expected to utilize the new NCATS lease as described in this POR. A breakdown of staffi ng is included in Section III of this POR.

Th e POR has been developed collaboratively with the NIH and NCATS to compile and include all necessary technical requirements including chemical lists and other features for BSL-2 Laboratories and needed offi ce space. Th e POR incorporates requirements and guidelines from the NIH Design Requirements Manual (DRM) along with other applicable codes, standards, and requirements.

Th e POR is intended to be used for the purpose of soliciting lease proposals, and as the basis of design for the fi nal design and construction of the leased space.

I. EXECUTIVE SUMMARY Page 3

D. Introduction to the Final Program of Requirements

Th e following Program of Requirements (POR) provides documentation of the programing process to identify the space needs and technical requirements of the new NCATS lease space for the National Institutes of Health (NIH). Th is POR refl ects information and criteria gathered from the NIH, additional data collection from equipment suppliers, site visits to the existing facility, and meetings and interviews with the NCATS personnel aff ected.

Th is POR was reviewed and updated in collaboration with the NIH and NCATS through an interactive process of input and reviews as the the fi nal document was developed.

A 100% cost estimate was developed for the project and forwarded to the NIH under a separate transmittal.

I. EXECUTIVE SUMMARY Page 4 Page 4

II. DESIGN STANDARDS Page 5

II. DESIGN STANDARDS

A. Applicable Codes and Standards:

Th e fi nal design and contract documents for the NCATS lease shall comply with all applicable Federal Regulations, the National Institutes of Health (NIH) Design Requirements Manual (DRM), the NIH leasing agreement, and all applicable Building Codes and Standards. In case of confl icts between adopted or selected codes or standards and the DRM, the most stringent, technically appropriate, and conservative criteria shall apply unless directed otherwise by the NIH Project Offi cer. Where it is unclear which set of requirements is applicable, consult the Authority Having Jurisdiction (AHJ) and the NIH Project Offi cer for direction.

Once a building location is selected and a lease is executed, a detailed code analysis shall be performed be the lessor’s architect and engineer.

Th e most current edition of each code, regulation and standard shall be applicable to the design, contract documents and construction of the new leased space. Th e most current edition should be interpreted as: (a) For County/City Code compliance purposes for permitting, design must comply with the jurisdiction’s most recently adopted edition of each. (b) For NIH leased facilities, design must comply with the most current published edition of Codes and applicable Federal Regulations, as of the time of design, even if not yet locally adopted

B. Applicable Federal Regulations:

Th e preparation of the design and contract documents for the NCATS leased space shall be in accordance with all applicable Federal and agency regulations and standards, including but not limited to: Volume I and Volume II of the Health and Human Services (HHS) Facilities Program Manual, the NIH Design Requirements Manual (DRM), the NIH Architectural and Engineering Design Policies and Guidelines, and the NIH Planning and Programmatic Guidelines.

C. Utility Company Regulations

Th e following industry standards are used as references: American Society of Heating, Refrigeration and Air Conditioning Engineers (ASHRAE), various sections of American National Standards Institute (ANSI), American Society of Mechanical Engineers (ASME), National Electrical Manufacturer Association (NEMA), National Electric Code (NEC), International Plumbing Code (IPC), and local utility requirements from Potomac Electric Power Company (PEPCO), Washington Suburban Sanitary Commission (WSSC), and Washington Gas (WG). Also, utilities and utility work are subject to Federal, State, and local government regulations in the State of Maryland.

II. DESIGN STANDARDS Page 6

D. Industry Codes & Standards

Th ere are numerous industry guidelines and standards that must be followed in concert with the codes and standards listed in this POR and the NIH DRM. Th e designer of the fi nal NCATS lease space must be cognizant of all requirements of the DRM and its referenced documents, and all requirements for Bio-Safety Level 2 (BSL-2) laboraotries. Several other codes, industry guidelines and standards are referenced in other sections of this POR.

III. SPACE AND OCCUPANCY REQUIREMENTS Page 7

III. SPACE AND OCCUPANCY REQUIREMENTS

A. Activity Analysis

Th e National Center for Advancing Translational Sciences (NCATS) provides leadership for a national program to advance the discipline of translational science and to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. NCATS conducts intramural research and supports and coordinates research projects through research grants, contracts, and other mechanisms as well as supports training in translational sciences. In addition, NCATS collaborates with organizations and other institutions engaged in translational research and training activities, and collects and disseminates research fi ndings and related information.

Th e activities and spaces described in this POR for the NCATS lease will involve three specifi c groups: Compound Management, Automated Chemistry/IT (Incubator/ Bio-printing) and Intramural Administrative Services and Acquisitions.

Compound Management oversees the Molecular Libraries Program which off ers public sector biomedical researchers access to large scale screening capacity necessary to iden-tify small molecules that can be optimized as chemical probes. Th ese probes are then used to study the functions of genes, cells and biochemical pathways which leads to new discoveries in the functions of genes and signaling pathways. A key activity is collecting samples for high throughput biological screening and distributing those to respective collaborators. Th e new lease will allow NIH to bring this work in-house under NCATS.

Automated Chemistry/IT (Incubator/Bio-printing) responds to new research initiatives resulting from national and international health crises such as the British Petroleum spill, the Ebola epidemic, and recent Zika outbreaks. In all of these cases, the pilot phase, or entire body of work, was initiated quickly using existing space and without external funding. Public health emergencies will continue and this group will continue the rapid initiation of new research eff orts in response to these outbreaks.

Intramural Administrative Services/Acquisitions support the activities of the NCATS Intramural Program by providing comprehensive administrative and management support for NCATS. Th e support services provided include managing budget, personnel, procurement, space and facilities, travel, property, and other administrative functions as necessary to ensure the effi cient and eff ective implementation and operation of the programs within NCATS. Th is group also develops, analyzes and implements policies, guidelines, and procedures on matters relating to administrative management and disseminates to relevant staff ; and advises the staff of NCATS of administrative policies and practices.

Activity Analysis

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Figure III-1 NCATS Laboratory Primary and Secondary Activities Diagram

Figure III-2 NCATS Flow Diagram

Activity Analysis

SHARED

SUPPORT

(COLLABORATION)

BUILDING

LOADING

DOCK

CHEMICAL

STORAGEWASTE

OFFICE ZONE

LABORATORY ZONE

COMPOUND

MANAGEMENT

& TISSUE

PRINTING

NCATS

FRONT DOOR

COMPOUND MANAGEMENT

LABORATORY

TISSUE PRINTING

LABORATORY

SHARED LABORATORY

SUPPORT

INTRAMURAL

SERVICES

OFFICES

BBBUU

LO

CCH

S

BBBORAORAORATORTORTORY ZY ZY ZONEONEONE

LA

PRINTING

NCATSTSNCACATTTTS

BBBLLLALAA

LOL

COMOMPOG

ST

AF

F

CL

EA

N

DI

RT

Y

ST

AF

F

V

IS

IT

O

R

LABORATORY ZONE

LABORATORY SERVICE CORRIDOR

OPEN LABORATORY SPACE

LAB

SUPPORT

SPACE

LAB

SUPPORT

SPACE

LAB

SUPPORT

SPACE

LAB

SUPPORT

SPACE

LINEAR

EQUIP’T

ROOM

LINEAR

EQUIP’T

ROOM

RR

ROOROOOOOOOOOOOOMMMME RR SMMM

NEAR

ROOOOMM

LAB LAB

RR SMM

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B. General Space Parameters

All spaces described in this POR are to be in a single facility. All spaces shall be contiguous and contained within their own secured perimeter, and within a secured perimeter for the NCATS leased space. Refer to the Space Description-Guideplates later in this section for specifi c technical requirements of the individual spaces listed below and the Appendix (Figure V-1) for Master Equipment List.

C. Space Descriptions

Th e following information describes the various space types within the NCATS lease space.

Th e space types are divided into four main categories; Laboratory, Laboratory Support, Offi ce/Offi ce Support, and Building Support.

1. Laboratory Th is is the main laboratory space that will function primarily for molecular biology.

Th is area shall be a large, open space, free of columns. Th e lab will be furnished with an adaptable casework system - similar to “Solution” by Air Master Systems, “Enterprise” by Kewaunee Scientifi c, or “EVO2” by OC River - to allow for confi guration of larger, fl oor mounted robotic equipment. Th e casework will consist of mobile benches with upper shelves, mobile or suspended cabinets below the bench top. Laboratory grade metal casework meeting the Scientifi c Equipment and Furniture Association (SEFA) standards is required. Sinks, fume hoods and biosafety cabinets requiring fi xed connections to building systems shall be located strategically at the perimeter of the space to allow the lab to function well yet allow for future adaptability.

All materials used in the lab (cabinetry, shelving, fl ooring and etc.) shall be corrosion resistant to facilitate cleaning and combat the growth of bacteria. Non-absorbing materials such as stainless steel sinks, epoxy counter tops, and acid resistant plastic laminates are required. Services provided in the space shall include: potable water (for emergency shower/eyewashes) and industrial cold and hot water, laboratory waste and vent, deionized or distilled water, carbon dioxide (CO2), vacuum, compressed air, telephone, local area network for computers and electric power. Th ese services shall be carefully organized in a repetitive, modular discipline, on overhead racks, fed from above. Points of connection to each building system shall be located at consistent, predetermined, and recurring positions to allow the laboratory to be reconfi gured easily to accept new equipment.

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2. Laboratory Support Th e support space shall be designed using the same design parameters as are used in the laboratory, i.e. the same planning module and same fi nishes. Th e following are descriptions of the various laboratory support spaces specifi c to NCATS.

Brooks Compound Storage (Guideplate I.B.1) Th is space will house the Brooks Life Science Systems Sample Store II. Th is will be housed in the open laboratory. Refer to the “Space Description – Guideplates" for additional information. NCATS is considering an automated assay ready plate handler to be added to the front of the Brooks equipment. Space shall be provided for this additional unit. Power that feeds the equipment and all mechanical components shall be on emergency power and UPS as the Brooks System cannot lose power during an outage. Th e weight of this system is substantial and will require a location that is slab-on-grade of suffi cient slab depth to support the weight (refer to the fl oor loading data in the Appendix under Brooks Life Science Systems). If the selected building requires the lab to be on an upper fl oor, the fl oor must be reinforced to support the load and access to a freight elevator of minimum size of 10'-0" x 14'-0" is required.

Kardex Compound Storage (Guideplate I.C.2) Th is space will house the Kardex Remstar Shuttle XP. Th is space shall be immediately adjacent to the open laboratory space. Power that feeds the equipment and all mechanical components shall be on emergency power and UPS as the system cannot lose power during an outage. Th e Kardex Remstar Shuttle XP shall have redundant cooling in the event of a primary cooling system failure.

-20 Degree Freezer Room on Emergency Power (Guideplate I.C.3) Th is is a controlled environmental room with a set-point of -20 degrees Celsius.

Th is room is used for storing samples only and will not be used for any temperature controlled work. Th e fl oor of the room is insulated and is several inches thick. Th e room will require either a depressed slab or a ramp to access the room. Th e depth of the depression or size of the ramp shall be coordinated with the fi nal unit selected. Th e plan layout will maximize the amount of wire shelving units to be stored inside. Th e room shall be lockable but the door shall have the largest possible view window. All mechanical components shall be accessible and serviceable from outside the room in an adjacent space. Th e refrigerant lines shall not to exceed 100 linear feet between the mechanical equipment and the room. A high and low temperature monitoring and alarm system shall be connected to a central equipment alarm system. Provide conduit pathways within the building for this room to be connected to the Rees equipment monitoring system (a NIH system). All gaps between the room and adjacent construction shall be sealed air tight. A manual door release shall be provided inside the environmental room. Th is room shall be on emergency power backup.

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Equipment Room (Guideplate I.C.4) Th e equipment room will house ultra-low temperature (-80 °C) freezers that are currently stored off -site. Th is space will have high heat loads and high noise levels so provisions shall be made to keep the space cool to extend freezer life. Utilities for this space include HVAC with supplemental cooling, electric in both 120 and 208 volt, on emergency power and connected to an equipment monitoring system.

Hood Room (Guideplate I.C.5) Th is room is needed for working with hazardous reagents and measuring out powder compounds. Th e room consists of four fume hoods and one vented Electrostatic Dissipative (ESD) workstation. In addition, there are mobile benches with shelving above and casework below. A sink, emergency shower, and eyewash shall be provided.

Flammable/ Chemical storage cabinets shall be provided. Refer to the Appendix for a list of chemicals and quanities to be stored in this room.

4 Degree Cold Room on Emergency Power (Guideplate II.C.1) Th is is a controlled environmental room with a set-point of 4 degrees Celsius. Th is room is used for storing samples and reagents as well as long-term experiments requiring temperature controlled work and will include a stainless steel bench on one side and wire shelving units on the opposite wall. Th e fl oor of the room is insulated and is several inches thick. Th e room will require either a depressed slab or a ramp to access the room.

Th e depth of the depression or size of the ramp shall be coordinated with the fi nal unit selected. Th e room shall be lockable. All mechanical components shall be accessible and serviceable from outside of the room in an adjacent space. Th e refrigerant lines shall not to exceed 100 linear feet between the mechanical equipment and the room.

A high and low temperature monitoring and alarm system shall be connected to a central equipment alarm system. Provide conduit pathways within the building for this room to be connected to the Rees equipment monitoring system (a NIH system). All gaps between the room and adjacent construction shall be sealed air tight. A manual door release shall be provided inside the environmental room. Th is room shall be on emergency power backup.

Tissue Culture Room (Guideplate II.C.3) Th e tissue culture room is a shared space that includes two Bio-Safety Cabinets (BSCs), multiple stacked CO2 incubators with central CO2 access, an adjacent sink, deep shelf storage space for plastic ware storage, two refrigerators and a tabletop centrifuge. Th ere is working bench space near the sink to prepare media. Th e bench space between the BSCs will hold microscopes for viewing slides. A house vacuum is required to serve this space.

Histology Room (Guideplate II.C.4) Th e histology room is a shared space that will be similar to the tissue culture space but is used for the preparation of tissues for study. Th ere is working bench space throughout the room to provide directional fl ow for the processing of tissue specimens. A house vacuum is required to serve this space.

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Tissue Printing Room (Guideplate II.C.5) Th e tissue printing room is similar in design to the tissue culture room in that it is a shared space. Th e room includes eight BSCs; four to house tissue printers and four BSC for general culture work. Similar to the tissue culture room, this space will house multiple stacked CO2 incubators, a sink, deep shelf storage, 2-3 refrigerators, a tabletop centrifuge, and a microscope bench. A house vacuum is required to serve this space.

Consumables Storage (Guideplate IV.C.1) Th is area will provide space for high density wire shelving to store kits for the various robotic instruments, gloves, pipettes and other consumable supplies and equipment.

Hazardous Waste Room (Guideplate IV.C.2) Th is room is a collection point for all chemical waste that will leave the facility. Th e room shall be located close to the building’s loading dock, yet still within the NCATS controlled lease space. Th e room shall have card key access, proper HVAC, spill containment, and an emergency shower/ eye wash. If NCATS is located on a fl oor above the ground fl oor then access to a service elevator of minimum 10'-0" x 14'-0" size is required.

Chemical Storage Room (Guideplate IV.C.3) Th is room is where all incoming fl ammable chemicals will be stored before being distributed to the laboratory spaces. Refer to the Appendix for a list of chemicals and quanities expected to be stored.

LN2 and CO2 Room (Guideplate IV.C.4) Th is room houses the in-use cylinders and dewars used as the source for nitrogen and CO2. Space for empty cylinders and spares shall also be provided.

Glasswash / Autoclave Room (Guideplate IV.C.5) Th is space serves as a central glass wash facility and will house two glassware washers and two medium-sized sterilizers. Th e intent for duplicating units is to provide redundancy so the facility can still operate if one of each type unit goes down for servicing. All joints between adjacent materials and fi nishes in this space shall to be thoroughly caulked and sealed. Th e space shall have a fi xed (non-accessible) ceiling of gypsum wallboard with an epoxy, water resistant fi nish. Th e space shall also have non-slip epoxy fl oors, and have cleanable walls to withstand moisture and prevent pest infestation. Discharge from Autoclave chamber and from Sterilizer chamber must fi rst be cooled to 140 degrees F or below before being allowed to enter fl oor drain thru open-site drain. Provide funnel on fl oor drain grate to allow drain to receive spillage. Drain piping is lab waste piping to Acid Neutralizing Tank. Acid neutralization tank requires space, chemicals storage, controls, monitoring, discharge to sanitary, and ventilation. Space is provided for staging clean and dirty glassware.

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3. Offi ce and Offi ce Support NCATS is not in need of a formal reception area but the lease space shall have a secured “front door” where visitors, guests, and vendors can be met and escorted accordingly.

Th is space can be combined with the Transmitting (Shipping/Receiving) Station noted below. NCATS shall have one offi ce suite for all lab and non-lab users to facilitate sharing of resources. Th e offi ce suite shall be adjacent to the laboratory spaces. If the selected leased space does not allow all offi ces to be located together then the offi ces for laboratory staff shall be adjacent to their labs. Daylighting of interior occupied work spaces is required. Open workstations shall be located near the exterior windows to maximize daylight and views for all staff . Private offi ces should have glazing at doors and walls to allow daylight into offi ce space yet still provide some acoustic privacy.

Private Offi ce Private offi ces shall be provided for the NCATS staff , guest researchers, and other visitors to the leased space as indicated in the Space Program. Offi ces are required for group or team leaders, area supervisors and specifi c administrative staff . Provisions shall be made for privacy at offi ces as required by the NIH-DRM, including full height partitions, doors and baffl ing of mechanical systems that penetrate the space. Ergonomic systems furniture shall be used in all offi ce spaces.

Workstation Open offi ce space is provided for Research Associates, purchasing agents, program assistants and other administrative personnel. Th ese personnel will be located in open offi ce style workstations with 54 inches partitioning, built in work surfaces, and built in electrical, data, and communications distribution with outlets. Appropriate provisions shall be made for privacy by using sound absorbing fi nishes on all workstation partitions, and utilization of a sound absorbing ceiling system. Ergonomic systems furniture shall be used in all open offi ce spaces.

Mail / Sorting Station (Shared with Copy Room Guideplate IV.A.3) Th is is a location where incoming mail and outgoing packages can be sorted and processed. Th is station could be combined with the Transmitting Station below. Th e space should include a counter with mail cubbies for incoming mail, space for outgoing mail and space for a mobile mail cart. Th e NIH has specifi c requirements , rules and regulations governing mail. Th e mail sorting and distribution equipment must be compliant with all NIH rules and regulations. Requirements for NIH mail distribution equipment can be found in Section 4.6.1.7 of the NIH DRM.

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Conference Room (Guideplate IV.A.1) A conference room is needed to house up to 30 people for formal and informal meetings of staff and for periodic training. Th e conference area shall be utilized on a shared basis and be designed in accordance with National Fire Protection Association (NFPA) occupant loads. Th e conference room shall be equipped to accommodate fl exible seating arrangements. Provide white boards, electrical connections for audio visual equipment, a audio visual screen, adjustable overhead lighting, and data and telephone lines. Th e minimum ceiling height shall be 9'-0" with lay-in acoustical ceiling tiles.

Transmitting Station (Shipping/Receiving - Guideplate IV.A.2) Th is is a multi-purpose station that processes all incoming and outgoing packages. Th is station should be located near the “front door” of the facility and can include reception duties as well.

Copy / Supply Room (Shared with Mail/Sorting Station Guideplate IV.A.3) Space shall be provided for copying machines, FAX machines, fi les, shelves and other routine offi ce equipment. In addition, space is required for central computer systems.

Th is area does not have the stringent air change requirements that the laboratory areas have. File rooms shall be lockable.

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Space Descriptions - Guideplates

4. Building Support While the selected building will have spaces that support NCATS and other tenants, the following areas are intended to be exclusive spaces for the function of NCATS within the leased space.

Break Room (Guideplate IV.B.1) A break room shall be provided for NCATS staff to take coff ee breaks and eat lunches.

Th ere shall be a plastic laminate fi nished counter top with built-in stainless steel sink, and overhead and below counter cabinets for storage. Th ere shall be space provided for a residential size refrigerator with ice maker (the refrigerator to be provided by others).

Th ere shall also be space provided for two microwave ovens (provided by others), and under-counter waste bins and recycling receptacles (provided by others). Seating and tables for up to 12 NCATS staff shall also be provided (seating and tables to be provided by others).

Mechanical Room HVAC and plumbing systems, with their respective redundancies, and all utilities are required to be provided as base building systems located in the main building mechanical equipment room(s). Th e main building mechanical equipment room(s) shall be located outside of and in addition to the proposed NCATS lease space of 19,7000 SF, but is a requirement as part of the overall leased facility. Primary HVAC and plumbing system requirements and required redundancies are further described in the Mechanical Systems summary in Section IV.

Compressed air and laboratory vacuum with redundancy are two systems required to be provided as base building systems through all NCATS lab and lab support spaces (the nitrogen and carbon dioxide systems are listed under Laboratory Support). If the required compressed air and laboratory vacuum systems in the base building are not adequate to handle the needs of NCATS lease, mechanical space is required to be provided in the base building mechanical room(s) located outside of the NCATS lease space to house these supplemental systems, so they are not located in laboratory space.

Similarly, a RO/DI water system is required in some NCATS labs and lab support spaces.

Th e RO/DI water system equipment shall be located in the base building mechanical room(s), outside of the NCATS leased space.

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Space Descriptions - Guideplates

Electrical/UPS Room Th e NCATS lease space has a large number of robotic equipment, both large and small, that cannot experience loss of power in the event of a power outage. Th e building containing the NCATS lease space may have UPS power but typically these systems are specifi c to the needs of the tenants and may not be adequate for NCATS.

Th e electrical NCATS UPS room is meant to house a UPS system dedicated to NCATS. In addition any electrical sub-panels or transformers dedicated to NCATS lease space will be located here.

MDF/IDF

NCATS will be connected to the NIH IT network using a cloud-based strategy. Th is room will house any cabling and equipment needed to connect to the cloud as well as equipment and cabling needed for a wireless network. Th is shall be a secured space for NCATS access only.

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Space Descriptions - Guideplates

NCATS Space Program List Continued

D. Space Program List

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Space Descriptions - Guideplates

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*FOR INFORMATION ONLY

OFFICE - GROUP

LEAD

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

OFFICE - GROUP

LEAD

OFFICE - HOTELING

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

COPY/ SUPPLY/ MAIL

PHONE/ HUDDLE ROOM

KITCHENETTE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

*FOR INFORMATION ONLY

GUIDEPLATE SKETCH

DRAWING TITLE

DRAWING SCALEDRAWING NUMBER

PROJECT NAME

PROJECT NUMBER

DRAFT

1" = 10'-0"

COMPOUND MANAGEMENT - CONCEPTUAL ORGANIZATION AND

ADJACENCY PLAN FOR OFFICES

I.A.0

10217_NIH NCATS R17 Guide Plates

10217.000

0 10' 20'

OFFICE SUITE ENTRANCE

COMPOUND MANAGEMENT OFFICES

ADMIN SERVICES CORRIDOREXIT TO LABORATORY ZONE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

OFFICE - GROUP

LEAD

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Space Descriptions - Guideplates

GUIDEPLATE SKETCH

SMITHGROUP JJR 1700 NEW YORK AVENUE NW, SUITE 100, WASHINGTON, DC 20006 T. 202.842.2100 www.smithgroupjjr.com

DRAWING TITLE

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PROJECT NUMBER

DRAFT

OFFICE - GROUP LEAD - 3D VIEW

I.A.1-3D

10217_NIH NCATS R17 Guide Plates

10217.000

III. SPACE AND OCCUPANCY REQUIREMENTS Page 24

Space Descriptions - Guideplates

LATERAL FILE STORAGE

WHITE BOARD

WORKSTATION

CREDENZA

TACK BOARD

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1/4" = 1'-0"

OFFICE - GROUP LEAD

I.A.1

10217_NIH NCATS R17 Guide Plates

0 4' 8'

III. SPACE AND OCCUPANCY REQUIREMENTS Page 25

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WORKSTATION - RESEARCH ASSOCIATE - 3D VIEW

I.A.2-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 28

Space Descriptions - Guideplates

PD

LATERAL FILE STORAGE BELOW

WORKSTATION

WORKSTATION PANEL

COLLABORATION SPACE

BEYOND

WHERE INDICATED IN AN EXISTING FLOOR, PROVIDE CORE DRILL PACKAGE TO MAINTAIN FIRE

RATING OF FLOOR. EXTEND CONDUIT AND WIRING IN CEILING SPACE OF FLOOR BELOW TO

ELECTRICAL CLOSET OR PANELBOARD.

COMBINATION POWER AND TELECOMMUNICATIONS FLOORPD

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1/4" = 1'-0"

WORKSTATION - RESEARCH ASSOCIATE

I.A.2

10217_NIH NCATS R17 Guide Plates

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Space Descriptions - Guideplates

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DRAFT

OPEN LABORATORY - 3D VIEW

I.B.1-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 32

Space Descriptions - Guideplates

OVERHEAD SERVICE

CARRIER (TYP) - (2)

CAPPED EXHAUST, UPS

POWER, (3) CA/SIDE,

QUICK CONNECT FITTINGS

ENTRANCE TO

COMPOUND

STORAGE

(KARDEX)

ACOUSTIC REFORMATTER STATION

FUTURE WORKFLOW AUTOMATION (TECAN) -

FRONT OF UNIT

COMPOUND STORAGE (BROOKS)

(4) N2

(4) N2

(3) LCMS

OPEN

EQUIPMENT

ZONE

OPEN

EQUIPMENT

ZONE (TYP)

DRY ICE

STORAGE

MOVABLE TABLE

AND CART ZONE

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1/16" = 1'-0"

OPEN LABORATORY

I.B.1

10217_NIH NCATS R17 Guide Plates

0 16' 32'

III. SPACE AND OCCUPANCY REQUIREMENTS Page 33

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DRAFT

COMPOUND STORAGE (KARDEX) - 3D VIEW

I.C.2-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 36

Space Descriptions - Guideplates

KARDEX REMSTAR

SHUTTLE XP - HD 500

NOTES:

- KARDEX UNIT REQUIRES MINIMUM CLEAR SPACE - CONFIRM

WITH FINAL SELECTION BY GOVERNMENT

- DUE TO HIGH DENSITY STORAGE, STRUCTURAL

ACCOMMODATION OF UNIT WEIGHT, UP TO 27,088

(HORIZONTAL ORIENTATION) TOTAL POUNDS IS REQUIRED

- LOCATED IN CLOSE PROXIMITY TO THE FH ROOM AND

IDEALLY ACCESSED FROM THE LINEAR EQUIPMENT ROOM OFF

OF THE OPEN LAB

FLOOR SINK - UNIT

CONDENSATE

FOOTPRINT OF

LINEAR EQUIPMENT

ROOM

OPEN LAB

BROOKS

FUME

HOOD

ROOM KARDEX

ENTRANCES

LER

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As indicated

COMPOUND STORAGE (KARDEX)

I.C.2

III. SPACE AND OCCUPANCY REQUIREMENTS Page 37

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Space Descriptions - Guideplates

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-20 DEGREE FREEZER ROOM - 3D VIEW

I.C.3-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 40

Space Descriptions - Guideplates

WIRE SHELVING UNITS (GFGI)

NOTES:

- COMPRESSOR/CONDENSER SHALL BE LOCATED IN CLOSET OR

MECHANICAL SPACE WITHIN 100 LF OF ROOM FOR WATER COOLED

UNIT

- AIR COOLED UNIT CAN BE PLACED ON THE ROOF WITHIN 100 LF OF

ROOM

- ROOM AND EQUIPMENT SHALL BE ON BACK-UP POWER AND

CONNECTED TO REES EQUIPMENT MONITORING SYSTEM

- LONG TERM STORAGE

- COULD BE ACCESSED FROM WITHIN THE 4-DEGREE FREEZER ROOM

TO REDUCE TEMPERATURE SWINGS

COLD ROOM EVAPORATOR

4 DEGREE FREEZER ANTE-

ROOM (SHOWN GREY FOR

REFERENCE

COMPRESSOR /

CONDENSER

UNIT

FLOOR SINK FOR CONDENSATE

THE DOOR BETWEEN THE 4

DEGREE AND -20 TO HAVE A

LARGE VIEW WINDOW WITH

DEFROST HEATING

ELEMENT

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1/8" = 1'-0"

-20 DEGREE FREEZER ROOM

I.C.3

10217_NIH NCATS R17 Guide Plates

0 8' 16'

III. SPACE AND OCCUPANCY REQUIREMENTS Page 41

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EQUIPMENT ROOM (-80FREEZERS) - 3D VIEW

I.C.4-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 44

Space Descriptions - Guideplates

-80

-80

-80

-80

-80

-80

-80

-80

-80

-80

-80

-80 -80

FREEZERS (GFGI)

ELECTRICAL

RACEWAY ON

BOTH WALLS

AND ON

OHSC

OVERHEAD SERVICE CARRIER WITH

120V DEDICATED AND 208V SINGLE

PHASE RECEPTACLES

-80

NOTES:

- ROOM TO STORE APPROXIMATELY (18) -80

FREEZERS THAT ARE CURRENTLY STORED

OFF-SITE

- DEPENDING ON SELECTED BUILDING, THIS

ROOM COULD BE RECONFIGURED INTO A

LINEAR LAYOUT

- ALL POWER FOR FREEZERS TO BE ON UPS

AND REES EQUIPMENT MONITORING

FLOOR DRAIN

FOR DEFROSTING

FREEZERS

FUTURE

FREEZERS

(GFGI)

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EQUIPMENT ROOM (-80 FREEZERS)

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10217_NIH NCATS R17 Guide Plates

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DRAFT

HOOD ROOM - 3D VIEW

I.C.5-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 48

Space Descriptions - Guideplates

ELECTRICAL

RACEWAY - TYP AT

FIXED BENCH

OPEN STORAGE

SINK,

CW, HW, EW

(1) FUME HOOD - ANALITICAL

BALANCE, N2, CA, POWER (TYP)

(3) VENTED WORKSTATION

WITH ESD WORKTOP -

CONNECT TO BUILDING

EXHAUST

CART STORAGE

CONSUMABLE STORAGE

CONSUMABLE STORAGE

EWES

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HOOD ROOM

I.C.5

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III. SPACE AND OCCUPANCY REQUIREMENTS Page 50

OFFICE - GROUP

LEAD

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

OFFICE - GROUP

LEAD

OFFICE - HOTELING

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

COPY/ SUPPLY/ MAIL

PHONE/ HUDDLE ROOM

KITCHENETTE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

*FOR INFORMATION ONLY

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DRAFT

1" = 10'-0"

TISSUE PRINTING - CONCEPTUAL ORGANIZATION AND

ADJACENCY PLAN FOR OFFICES

II.A.0

10217_NIH NCATS R17 Guide Plates

10217.000

0 10' 20'

OFFICE SUITE ENTRANCE

TISSUE PRINTING OFFICES

ADMIN SERVICES CORRIDOREXIT TO LABORATORY ZONE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

WORKSTATION -

RESEARCH

ASSOCIATE

OFFICE - GROUP

LEAD

OFFICE - HOTELING

*FOR INFORMATION ONLY

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OFFICE - GROUP LEAD - 3D VIEW

II.A.1-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 52

Space Descriptions - Guideplates

LATERAL FILE STORAGE

WHITE BOARD

WORKSTATION

CREDENZA

TACK BOARD

GUIDEPLATE SKETCH

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1/4" = 1'-0"

OFFICE - GROUP LEAD

II.A.1

10217_NIH NCATS R17 Guide Plates

III. SPACE AND OCCUPANCY REQUIREMENTS Page 53

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OFFICE - HOTELING - 3D VIEW

II.A.2-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 56

Space Descriptions - Guideplates

WORKSTATION

WHITE BOARD

WORKSTATION

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1/4" = 1'-0"

OFFICE - HOTELING

II.A.2

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III. SPACE AND OCCUPANCY REQUIREMENTS Page 59

Space Descriptions - Guideplates

OPEN TO WORKSTATIONS

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WORKSTATION - RESEARCH ASSOCIATE - 3D VIEW

II.A.3-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 60

Space Descriptions - Guideplates

PD

LATERAL FILE STORAGE BELOW

WORKSTATION

WORKSTATION PANEL

COLLABORATION SPACE

BEYOND

WHERE INDICATED IN AN EXISTING FLOOR, PROVIDE CORE DRILL PACKAGE TO MAINTAIN FIRE

RATING OF FLOOR. EXTEND CONDUIT AND WIRING IN CEILING SPACE OF FLOOR BELOW TO

ELECTRICAL CLOSET OR PANELBOARD.

COMBINATION POWER AND TELECOMMUNICATIONS FLOORPD

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1/4" = 1'-0"

WORKSTATION - RESEARCH ASSOCIATE

II.A.3

10217_NIH NCATS R17 Guide Plates

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OPEN LABORATORY - 3D VIEW

II.B.1-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 64

Space Descriptions - Guideplates

CEILING PREFERENCE:

1. NO CELING WITH SERVICE PLATE (21 TOTAL)

2. CEILING WITH SERVICE STRIP

SINK,

HW, CW, EWES

EXHAUST PROVISIONS:

- FUTURE CAPACITY FOR (8) 6' FUME HOODS

- MAIN TRUNK TO THE OPEN LAB, NO

ADDITIONAL DISTRIBUTION WITHIN THE LAB

OVERHEAD SERVICES (TYP):

- CO2

- VACUUM

- CA (110 PSI) WITH REGULATOR

- (2) 4" EXHAUST PORTS PER MODULE

- (1) DEDICATED OUTLET ON UPS

- 120V AND 208V POWER

- DATA

SINK,

HW, CW, RO, DI

SINK,

HW, CW, EWES

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1/16" = 1'-0"

OPEN LABORATORY

II.B.1

10217_NIH NCATS R17 Guide Plates

0 16' 32'

III. SPACE AND OCCUPANCY REQUIREMENTS Page 65

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DRAFT

4 DEGREE COLD ROOM - 3D VIEW

II.C.1-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 68

Space Descriptions - Guideplates

STAINLESS STEEL WIRE

SHELVING UNITS (GFGI)

FREEZER CONTROL PANEL

(4 DEGREE COLD ROOM)

NOTES:

- COMPRESSOR/CONDENSER SHALL BE

LOCATED IN CLOSET OR MECHANICAL SPACE

WITHIN 100' LF OF ROOM

- ROOM AND EQUIPMENT SHALL BE ON BACK-

UP POWER AND CONNECTED TO REES

EQUIPMENT MONITORING SYSTEM

COLD ROOM EVAPORATOR

COMPRESSOR /

CONDENSER UNIT

DOOR TO -20 COLD ROOM

-20 COLD ROOM (SHOWN GREY

FOR REFERENCE)

FREEZER CONTROL PANEL

(-20 DEGREE COLD ROOM)

THE DOOR BETWEEN THE 4

DEGREE AND ADJACENT

SPACE TO HAVE A LARGE

VIEW WINDOW WITH

DEFROST HEATING ELEMENT

FLOOR SINK FOR

CONDENSATE

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1/8" = 1'-0"

4 DEGREE COLD ROOM

II.C.1

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TISSUE CULTURE - 3D VIEW

II.C.3-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 72

Space Descriptions - GuideplatesSpace Descriptions - Guideplates

ELECTRICAL RACEWAY

6' BSC CLASS 2 TYPE A2

EXIT TO OPEN LAB

MOVABLE TABLES

6' BSC CLASS 2 TYPE A2

INCUBATOR (STACKED) -

GFGI, CO2

FIXED BENCH

REFRIGERATOR - GFGI

SINK, CW, HW, RO, DI,

EWES

CONSUMABLE STORAGE

MICROSCOPE - GFGI

OVERHEAD SERVICE

CARRIER

INCUBATOR (STACKED) -

GFGI, CO2

INCUBATOR (STACKED) -

GFGI, CO2

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1/8" = 1'-0"

TISSUE CULTURE

II.C.3

10217_NIH NCATS R17 Guide Plates

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No

Yes

Yes

Yes

No

No

Yes

No No

No

No

No No

Yes

Yes

No

No

Yes

No

No

NoYes

No

No

No Yes

No

Yes

No

Yes

No

No

Yes

TISSUE CULTURE II.C.3

TISSUE CULTURE

470 SF

Open Lab

OFFICE AREA

TISSUE PRINTING

21' - 4"

10' - 0" 22' - 0"

GROUP 4

Yes - Key Card

No No

RJ45 CAT6 Ethernet, Wireless

No n/a

73°F (SUMMER), 70°F (WINTER) +/- 2°F. ALL LABS TO BE

NEGATIVELY PRESSURIZED WITH SINGLE PASS AIR. (6) ACH IS

MINIMUM. A HIGHER ACH MAY BE REQUIRED DEPENDING ON

USE.

YES

CO2 IS REQUIRED TO ALL INCUBATORS

Negative

50% +/- 5% RH

Standard

(Per DRM Below)

75-100 FC

III. SPACE AND OCCUPANCY REQUIREMENTS Page 74

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HISTOLOGY

II.C.4-3D

III. SPACE AND OCCUPANCY REQUIREMENTS Page 76

Space Descriptions - Guideplates

ELECTRICAL RACEWAY

6' FUME HOOD - CONNECT

TO BUILDING EXHAUST

EXIT TO OPEN LAB

MOVABLE TABLES

6' FUME HOOD - CONNECT

TO BUILDING EXHAUST

INCUBATOR (STACKED) -

GFGI, CO2

FIXED BENCH

REFRIGERATOR - GFGI

SINK, CW, HW, EWES

CONSUMABLE STORAGE

GROSSING STATION

MICROSCOPE - GFGI

OVERHEAD SERVICE

CARRIER

INCUBATOR (STACKED) -

GFGI, CO2

INCUBATOR (STACKED) -

GFGI,…