DARPA-PA-27-02_Protein_Palace_Attachment_H_Schedule_of_Milestones_and_Payments.docx

DARPA-PA-27-02

Attachment H

SCHEDULE OF MILESTONES AND PAYMENTS

(NOTE: THIS DESCRIPTION IS INFORMATIONAL TO ADDRESS WHAT IS NECESSARY TO HAVE IN THE MILESTONE SCHEDULE. The following chart will detail the list of milestones. Each milestone will mark the completion of a measurable event (i.e., completing a baseline execution plan, completing development of a part of the prototype, completing a test plan, completing production of the prototype, completing and submitting the final report, etc.). The milestone description will show how the milestone will be demonstrably completed. Payments associated with each milestone must reflect the actual comprehensive costs to achieve milestone completion.)

A. Agreement Term:

The term of the Agreement commences on the effective date of the Agreement and continues for INSERT # OF MONTHS thereafter.

B. Deliverables and Payment Schedule:

Phase 1

Exit Criteria:

· Program kickoff event completed

· Identification of key technical risks, mitigation strategies, and dependencies

· Government concurrence on the performer’s refined technical approach, including research tasks, schedule, and risk assessment

· Submission of updated work plan incorporating Government feedback Deliverables:

· Kickoff slide package

· Detailed program execution plan including knowledge preservation plan

CLIN: 0001

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

PR: TBD

Funding Date: At time of award

Exit Criteria:

· Generation of initial protein characteristic data

· Demonstrated analysis of protein characteristics targeted for separation

· Identify required feedstocks and reagents and acquisition schedule

· Order long lead time equipment Deliverables:

· Initial results of protein characterization

· Technical report documenting progress toward the proposed protein purification approach

· Report outlining acquisition schedule for required reagents and equipment

CLIN: 0002

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Funding Date: At time of award

Exit Criteria:

· Successful demonstration of separation of first target protein Deliverables:

· Raw data, analysis, and report of purification demonstration

· Draft protocol for purification approach for IV&V team

CLIN: 0003

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Funding Date: TBD

Exit Criteria:

· Successful demonstration of separation of first target protein by IV&V team Deliverables:

· Materials and experimental support to IV&V team

· Raw data, analysis, and report of first target protein purification from IV&V team

CLIN: 0004

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Exit Criteria:

· Purification of at least three proteins by proposed approach Deliverables:

· Report detailing purification of three proteins to include protein characteristics utilized for separations, target protein functionality, and progress towards Phase 1 metrics

· All POA&M items associated with NIST SP 800-171 / CMMC Level 2 controls have been fully closed and operationalized

· Final self-assessment reflecting full compliance (SPRS score of 110) has been officially posted to SPRS with the required executive affirmation

CLIN: 0005

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Exit Criteria:

· Experimental or simulated data and analysis of protein separation of at least eight proteins Deliverables:

· Report describing experimental or simulated data and analysis of separation of at least eight proteins, including the scope of targeted protein characteristics

CLIN: 0006

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Exit Criteria:

· Successful presentation of Phase 2 plan to increase volume, throughput, yield, and purity Deliverables:

· Report describing proposed approach for achieving Phase 2 metrics of increased volume, throughput, yield, and purity, as well as methods for DARPA-directed proteins

CLIN: 0007

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Exit Criteria:

· Participation in Protein Pop-up event

· Protein Pop-up presentation for stakeholders Deliverables:

· Protein Pop-up presentation

· Technoeconomic analysis of commercial feasibility of approach developed in Phase 1 for purification of non-pharmaceutical grade proteins

· Initial transition and commercialization framework

CLIN: 0007

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Exit Criteria:

· Comprehensive characterization and measurement of all metrics

· Completion of work towards achieving end-of-phase metrics Deliverables:

· Report detailing purification of eight proteins to include protein characteristics utilized for separations, target protein functionality, and progress towards Phase 1 metrics

· Draft final report detailing technical progress, achievements, and lessons learned throughout Phase 1

CLIN: 0008

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Phase 2 (Option 1)

Exit Criteria:

· Updated identification of key technical risks, mitigation strategies, and dependencies

· Submission of performer’s refined technical approach, including research tasks, schedule, and risk assessment

· Submission of an updated work plan that reflects consideration of Government feedback provided during Phase 1

· Successful demonstration of progress increasing volume and throughput over Phase 1 constraints Deliverables:

· Detailed Phase 2 execution plan

· Report describing initial progress towards final program metrics for volume and throughput

CLIN: 0009

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Exit Criteria:

· Successful demonstration of progress in purification of challenge protein categories Deliverables:

· Report describing initial progress towards separation of hard to purify protein classes and the methods utilized

CLIN: 0010

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Exit Criteria:

· Presentation of transition and/or commercialization plan Deliverables:

· Report detailing specific paths for technology maturation and commercialization, and government and/or industry transition at both a research scale, applicable to DoW partners, and at a larger commercial scale enabling transition to industry

CLIN: 0011

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Exit Criteria:

· Successful demonstration of progress increasing both purity and yield over Phase 1 results Deliverables:

· Report describing methods utilized to characterize and purify protein with decreased development timeline

· Report detailing results of purification of DARPA-directed protein within one week timeline, including all methods

CLIN: 0012

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Exit Criteria:

· Successful demonstration of progress increasing both purity and yield over Phase 1 results Deliverables:

· Report describing methods utilized to reach final program purity and yield metrics

CLIN: 0013

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT

Exit Criteria:

· Comprehensive characterization and measurement of all metrics

· Completion of work towards achieving end-of-phase metrics Deliverables:

· Draft final report detailing technical progress, achievements, and lessons learned throughout the program

· Final transition and commercialization plan

CLIN: 0014

ACRN: XX

Funding Line:

Amount of Funding Obligated: THIS SECTION TO BE COMPLETED BY THE GOVERNMENT