DARPA-PA-27-02_Protein_Palace_Attachment_G_Task_Description_Document_TDD_Template.docx
DOCX document 40 KB Posted
- Attached to
- Protein Palace
- Solicitation number
- DARPA-PA-27-02
About this file
This is a Task Description Document (TDD) template for DARPA-PA-27-02 Protein Palace, a solicitation seeking innovative approaches to tunable protein purification from complex feedstocks. The program aims to develop a single, reconfigurable platform capable of purifying virtually any target protein on demand with high specificity, purity, and yield, breaking the current tradeoff between specificity and generalizability that characterizes existing protein purification methods. The Defense Advanced Research Projects Agency (DARPA) is seeking revolutionary advances that go beyond evolutionary improvements to current state-of-practice purification techniques.
The template outlines the required structure for performer proposals, including sections for program background, project overview, technical tasks and deliverables organized by phase with specified start/end dates in program months, responsible personnel and organizations, program management tasks, meeting and travel requirements, and Government Furnished Information (GFI) or Government Furnished Property (GFP) assumptions. Performers must clearly identify technical goals, approaches, milestones, and metrics aligned with their proposed efforts. The document indicates that no GFI or GFP is anticipated at program start, though this would be reconciled in the final Agreement.
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DARPA-PA-27-02
Attachment G
TASK DESCRIPTION DOCUMENT
FOR
PROTEIN PALACE
BY
<<PERFORMER>>
<<DATE>>
1. Program Background Protein purification represents one of the most challenging chemical separation problems because the target protein exists at a very low concentration within a highly complex mixture of soluble and insoluble components. The current state of the art for protein purification is highly specific, relying on a lock-and-key, one protein, one ligand paradigm for product capture that involves several additional steps to remove impurities and host proteins from the mixture. The development of downstream processing methods can be lengthy with no guarantee of success. Conventional biochemical purification design assumes there is no universal means of protein purification today because of our inability to create highly specific and tunable systems for molecular separation. Protein Palace aims to break the tradeoff of specificity and generalizability and deliver a single unit and reconfigurable platform capable of purifying virtually any target protein on demand with high specificity, purity, and yield, ensuring timely DoW access to proteins for current and emerging applications.
2. Project Overview
This section is focused on defining the specific project and should include a description that aligns with the technical proposal. Though not meant to be extensive (usually two to three paragraphs will suffice), it should capture: (1) what is the project about; (2) why it matters; (3) goals and objectives; (4) Government and performer defined metrics.
3. Technical Tasks & Deliverables
This section should clearly and accurately identify the tasks and deliverables associated with the proposed effort. Each (sub)task must identify the technical goals and approach, start and end dates in program months, responsible person(s) and their organization(s), and contribution to program milestones, deliverables and/or metrics. Please do not copy/paste charts or images into this section. Details on deliverable format or specific content should be contained here (versus the Milestone Plan Document). Tasks and deliverables must be delineated by Phase.
The Performer shall accomplish the below described research tasks.
4. Program Management
This Section should include any applicable program management tasks (to include subcontractor management, status reports, final report/s, etc.).
5. Meeting & Travel Requirements
This Section can be utilized for any required meeting and travel requirements from the Program Announcement.
6. Government Furnished Information (GFI)/Government Furnished Property (GFP)
This Section can be utilized to capture any assumptions regarding GFI/GFP. Anything contained here would need to be reconciled with the GFP Article in the final Agreement. At the start of the program, it is expected that there will be no GFI/GFP.
Attachment G: DARPA-PA-26-03 Page 1 of 2
File details come from the government source that posted it. Updated .