Combined_syn_solAcquisition of Thermo Scientific Orbitrap Astral Zoom Mass Spectrometer with Evosep Eno LC .docx

Hospital and Laboratory Support Division Office of Logistics and Operations (OLAO) Office of Acquisition and Logistics Management (OALM)

Title Orbitrap Astral Zoom Mass Spectrometer Evosep Eno

Combined Synopsis Solicitation

Synopsis No. PCA-NINDS-09562

COMBINED SYNOPSIS / SOLICITATION WORKFORM

(1) Action Code: Combined Synopsis/Solicitation

(2) Date: August 12

(3) Year: 2026

(4) Contracting Office Zip Code: 20892

(5) Classification Code: 6640

(6) Contracting Office Address:

6701 Rockledge Drive Bethesda, MD 20817

(7) Subject/Title: Orbitrap Astral Zoom Mass Spectrometer Evosep Eno LC

(8) Solicitation Number: PCA-NINDS-09562

(9) Closing Response Date: August 24, 2026 @ 6:00 A.M. Eastern Daylight Time (EDT)

(10) Questions Due Date: August 14, 2026 at 12:00 P.M Eastern Daylight Time (EDT)

(11) Contact Point(s): Lynda Cole, Contracting Officer

(12) Contract Award Type: Firm Fixed Price

(13) Contract Award: TBD

(14) Contract Award Dollar Amount: TBD

(15) Contract Line Item Number(s): TBD

(16) Contractor Award Date: TBD

(17) Contractor Name: TBD

(18) Brand Name or Equal Acquisition (FAR 52.211-6): Yes

(19) Description:

(20) • Proprietary Orbitrap Astral Zoom MS architecture with quadrupole isolation, Orbitrap HRAM MS1/MS2 acquisition, and Astral HRAM MS/MS acquisition operating in parallel for synchronized high-quality data acquisition.

(21) • Astral analyzer MS/MS scan rates up to 270 Hz, enabling high-throughput narrow-window DIA and other fast proteomics workflows that are central to the PCF mission.

(22) • High-field Orbitrap analyzer capabilities, including resolving power from 7,500 up to 480,000 FWHM at m/z 200, m/z range of 40-6000, enhanced dynamic range mode, and up to 40 Hz spectral acquisition rate.

(23) • Enhanced Astral analyzer performance, including high-sensitivity, high-dynamic-range HRAM MS/MS spectra with resolution up to 80,000 FWHM at m/z 524 and TMT HR mode supporting increased resolution for TMTpro multiplexing workflows.

(24) • Support for advanced proteomics workflows required by PCF, including narrow-window DIA, DDA, SQUAD, Hybrid DIA, PRM, and TMTpro multiplexing up to 35 samples.

(25) • Low-input mode and enhanced spectral processing to support deeper coverage and higher confidence for low-input and complex proteomics samples.

(26) • EASY-IC ion source/internal calibration functionality for real-time mass calibration and mass accuracy performance.

(27) • OEM-provided Xcalibur and Ardia Platform integration, including on-premises Ardia Advanced Tower Server, data transfer/management, archival/backup capabilities, and software support/maintenance.

(28) • OEM installation, instrument qualification, training, warranty/service coverage, and access to certified field service engineers and manufacturer-certified parts.

(29) • Integrated acquisition with Evosep LC system and compatible installation, basic user training, instrument qualification, performance service, freight, and support as quoted.

(i) “This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued.”

(ii) The solicitation number and a statement that the solicitation is issued as a request for quote (RFQ).

(iii) The solicitation document, the incorporated provisions, and clauses are those in effect through Federal Acquisition Circular 2024-07, effective August 29, 2024.

(iv) This solicitation is being released unrestricted. The NAICS code is 541940, and the small business size standard is 10.0M. This acquisition is being conducted in accordance with the procedures of FAR Part 12 and FAR Part 13.

(v) The Statement of Work and any terms and conditions relevant to the requirement are included as attachments.

(vi) The provisions at FAR Clause 52.212-1, Instructions to Offerors – Commercial Items, applies to this acquisition. The following addendum related to the Instructions to Offerors is included:

· Addendum to FAR Clause 52.212-1, Instructions to Offerors – Commercial Items. Please refer to this addendum for additional attachments, including the Statement of Work and other relevant information.

(vii) Evaluations will be conducted in accordance with the provision at FAR Clause 52.212-2. Offerors will be evaluated as follows:

EVALUATION-COMMERCIAL ITEMS (OCT 2014)

(a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate offers:

· Technical Proposal/Program Plan

· Organizational Experience

· Past Performance

· Personnel Experience and Availability

The Government will make award to the responsible vendor whose quote represents the best value to the Government, considering technical factors, past performance, and price. The Government may select a higher-priced quote if it is determined that the additional technical merit or lower performance risk warrants the price premium.

(b) Options. The Government will evaluate offers for award purposes by adding the total price for all options to the total price for the basic requirement. The Government may determine that an offer is unacceptable if the option prices are significantly unbalanced. Evaluation of options shall not obligate the Government to exercise the option(s).

(c) A written notice of award or acceptance of an offer, mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer’s specified expiration time, the Government may accept an offer (or part of an offer), whether or not there are negotiations after its receipt, unless a written notice of withdrawal is received before award.

Please refer to the addendum for additional evaluation information.

(viii) Each Offeror must include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications – Commercial Items, with its offer.

Please note, each Offeror shall complete only paragraph (b) of this provision if the Offeror has completed the annual representations and certification electronically via the System for Award Management (SAM) website located at https://www.sam.gov/portal.

(ix) FAR Clause 52.212-4, Contract Terms and Conditions – Commercial Items, applies to this acquisition. The terms and conditions outlined in the following addendum also apply:

· Addendum to FAR Clause 52.212-4, Contract Terms and Conditions – Commercial Items. Please refer to this addendum for additional terms and conditions related to the requirement.

(x) FAR Clause 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders – Commercial Items, applies to this acquisition. The full text version of FAR 52.212-5 included in the addenda as Attachment 5 indicate which FAR clauses and provisions are applicable to this acquisition.

(xi) Evaluation of Options Provision, The Government will evaluate offers for award purposes by adding the total price for all options to the total price for the basic award. This solicitation notified offerors that the award will include the Government's unilateral option to extend performance for an additional period up to six months under FAR 52.217-8, during which the pricing and terms of the period in which the option was exercised would apply. The Government cannot predict if or when the option may be exercised. Because any exercise of the Government's option extends the pricing and terms of the period in which the option was exercised, the Government expressly and affirmatively evaluates pricing for the option to extend under 52.217-8 co-extensive with the Government's price evaluation for each of the base and option periods of this award. Because pricing for each period subject to possible extension under the 52.217-8 has been evaluated, pricing for any possible future use of that option to extend has, likewise, been evaluated and would apply in strict accordance with this evaluation in the event of the Government’s exercise of the option to extend services. (End of Provision)

(xii) Contact Information:

Contracting Officer: Lynda Cole Email: Lynda.cole@nih.gov

(30) Place of Contract Performance: Bethesda, MD

(31) Set-aside Status: N/A image1.png