cdc-rfa-jg-26-0052_modforposting.pdf

Division of Global Health Protection

Notice of Funding Opportunity

Application due Friday, October 2, 2026

Expanding global health security though local partnerships in Tanzania Opportunity number: CDC-RFA-JG-26-0052

Contents

Step 1: Review the Opportunity 4

Basic information 5

Eligibility 9

Agency priorities 11

Program description 14

Step 2: Get ready to apply 31

Get registered 32

Find the application package 33

Help applying 33

Step 3: Build Your Application 34

Application checklist 35

Application contents and format 37

Step 4: Understand Review, Selection, and Award 49

Application review 50

Award notices 52

Step 5: Submit Your Application 53

Submission and deadlines 54

Step 6: Learn What Happens After Award 56

Post-award requirements and administration 57

Contacts and Support 63

Before you begin 3

Contents 2

Before you begin If you believe you are a good candidate for this funding opportunity, secure your SAM.gov and Grants.gov registrations now. If you are already registered, make sure your registrations are active and up to date.

SAM.gov registration (this can take several weeks) You must have an active account with SAM.gov. This includes having a Unique Entity Identifier (UEI).

See Step 2: Get ready to apply

Grants.gov registration (this can take several days) You must have an active Grants.gov registration. Doing so requires a Login.gov registration as well.

See Step 2: Get ready to apply

Apply by the application due date Applications are due by 11:59 p.m. Eastern Time on Friday, October 2, 2026.

To help you find what you need, this NOFO uses internal links. In Adobe Reader, you can go back to where you were by pressing Alt + Left Arrow (Windows) or Command + Left Arrow (Mac) on your keyboard.

Before you begin 3 https://sam.gov/ https://grants.gov/

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1:

Review the Opportunity

In this step

Basic information 5

Eligibility 9

Agency priorities 11

Program description 14

Basic information Centers for Disease Control and Prevention (CDC)

Global Health Center

Division of Global Health Protection

Making America safer, stronger, and more prosperous by strengthening global health security through surveillance, prevention, and response through local partnerships in Tanzania.

Have questions?

See Contacts and Support.

Key facts

Opportunity name:

Expanding global health security though local partnerships in Tanzania

Opportunity number:

CDC-RFA-JG-26-0052

Assistance listing:

93.318: Protecting and Improving Health Globally: Building and Strengthening Public Health Impact, Systems, Capacity, and Security

NOFO version: Original

Key dates

Application submission deadline: October 2, Expected award and start date:

October 30, 2026

We will inform you of your application status by the end of October 2026.

Summary The purpose of this NOFO is to support efforts that prevent, detect, notify, and respond to health threats in Tanzania. These efforts promote Global Health Security (GHS) in collaboration with Tanzania’s Ministry of Health (MOH). The CDC will work with partners and other U.S. Government (USG) agencies to strengthen surveillance systems and improve laboratory capacity.

This work supports preparedness and response to public health threats and helps build a skilled health workforce.

Through this NOFO, we will work with the MOH to:

• Detect and reduce biothreats.

• Respond to public health emergencies.

• Improve data sharing.

• Engage in regional and global health security efforts.

By stopping outbreaks at their source and strengthening global defenses, these efforts make America safer and stronger by reducing the risk of dangerous diseases crossing borders and threatening U.S. communities.

Step 1: Review the Opportunity 5

Funding details Funding type: Cooperative agreement

Expected total NOFO funding for Year 1: $3,000,000 This is the expected total Year 1 funding for all awards made under this NOFO.

Expected awards: 2-3 The number of awards is subject to available funds and program priorities.

Exact amounts for each award under this NOFO will be determined upon award.

We plan to award projects for five 12-month budget periods for a five-year period of performance.

Funding strategy

Funding amounts We encourage you to submit an application that includes a budget and work plan for each required component, consistent with the applicable component ceilings. For Year 1, applicants must submit separate budgets and work plans for all three components, not exceeding each component ceiling, although only Component 1 core activities are expected to be funded initially and Components 2 and 3 may be approved but unfunded pending future availability of funds.

Funding amounts for Years 2 through 5 will be set at continuation. We will continue funding based on:

• Availability of funds.

• Evidence of satisfactory progress, as documented in your required reports.

• The determination that continued funding is in the best interest of the federal government.

Component funding

Overview

We fund all Global Health Security (GHS) cooperative agreements using component funding. You must apply for all components and include a budget and work plan for each. Note: For the purposes of this NOFO, component 1 is considered the core component, meaning it supports baseline GHS activities

Step 1: Review the Opportunity 6 that are not dependent on emergency funding. This does not change the requirement that applicants apply for all components.

Component funding allows us to provide funding as it becomes available. To do so, we fund sets of activities by project (such as emergency or routine), when necessary.

CDC may fund one or more of your components to start the budget period, and then consider other components based on available funding later. If we can’t yet fund your other components, we will designate the remaining components as “approved but unfunded.” This allows us to award more funding later. We include approved but unfunded components for public health emergencies in all awards. These components are funded when a disease outbreak or other public health emergency requires additional funding.

Component 1 is for activities related to core global health security priorities.

When funding is available, this NOFO will support activities for a moderate (component 2) or a substantial (component 3) response to a disease outbreak or other public health emergency.

The emergency components follow the same logic model, with identical overarching strategies and activities.

Setting up components

You must set up your components in your application. While preparing your application:

• Review the expectations for Year 1 activities in the strategies and activities section.

• Group your activities under the anticipated components. Only include the activities planned for Year 1.

◦ Component 1: Core Global Health Security Priorities

◦ Component 1 Ceiling: $1,000,000

◦ Component 2: Rapid Small-Scale Response to Infectious Disease Outbreaks or other Public Health Emergencies

◦ Component 2 Ceiling: $2,000,000

◦ Component 3: Rapid Large-Scale Response to Infectious Disease Outbreaks or other Public Health Emergencies

◦ Component 3 Ceiling: $2,000,000

For information on how to incorporate component funding into your application, see the following sections:

Step 1: Review the Opportunity 7

• Budget narrative

• Component funding instructions for SF-424A

Local partner funding preference This NOFO includes a funding preference for local partners. Your organization will receive 15 extra points during the selection process if you both:

• Meet the local partner definition.

• Document your status as a local partner.

Step 1: Review the Opportunity 8

Eligibility Statutory authority This program is authorized under:

• Section 307 of the Public Health Service Act [42 USC 242l].

• Section 301(a) [42 USC 241(a)] of the Public Health Service Act.

Eligible applicants Only these types of organizations may apply.

• State governments.

• County governments.

• City or township governments.

• Special district governments.

• Independent school districts.

• Public and state-controlled institutions of higher education.

• Native American tribal governments (federally recognized).

• Public housing authorities and Indian housing authorities.

• Native American tribal organizations, other than federally recognized tribal governments.

• Nonprofits having a 501(c)(3) status, other than institutions of higher education.

• Nonprofits without 501(c)(3) status, other than institutions of dhigher education.

• Private institutions of higher education.

• For-profit organizations other than small businesses.

• Small businesses.

• Foreign or non-U.S. based entities.

Other required qualifying factors

Delivery location You must conduct the project in Tanzania.

Responsiveness criteria We will review your application to make sure it meets these requirements.

Step 1: Review the Opportunity 9

These are the basic requirements you must meet to move forward in the competition. We won’t consider an application that:

• Is from an organization that doesn’t meet all eligibility criteria. See requirements in Eligibility.

• Is submitted after the deadline.

• Proposes research activities. See the definition of research.

• Requests funding that exceeds the applicable Year 1 component ceilings described in the Funding Strategy section.

• Exceeds the 30-page limit for the project narrative (see the Project narrative section for what counts toward the page limit).

• Does not include all components.

• Is not in English.

• Includes a budget or budget narrative that uses a currency other than U.S. dollars.

• Does not respond to or is outside the scope of this NOFO.

See the Application checklist to understand which elements of your application are part of the responsiveness criteria.

Application limits You must follow these limits on the number of applications your organization can submit.

Under this NOFO, you may submit only one application under your organization’s UEI.

Cost sharing and matching funds This program has no cost-sharing or matching funds requirement. We will not consider cost-sharing fund contributions during your application review.

However, if you submit voluntary cost-sharing funds and we fund your project, we will require you to report on these funds.

Post-award requirements Before you apply, make sure you understand the requirements that come with an award.

See Step 6: Learn What Happens After Award for information on regulations that apply, reporting, and more.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 10 https://www.cdc.gov/grants/additional-requirements/ar-31.html

Agency priorities Required alignment with CDC priorities The recipient of this award must implement any funds awarded under this NOFO to effectuate program goals or agency priorities in accordance with the Centers for Disease Control and Prevention (CDC) Priorities when authorized (for a full description of the CDC Priorities, please follow the provided hyperlink).

Funded activities must:

• Align with CDC’s core priorities by demonstrating a commitment to gold-standard science, transparency, and evidence-based practices.

• Support CDC’s mission to protect Americans from infectious and chronic diseases, strengthen public health systems, and advance innovation in health data and infrastructure.

• Contribute to rapid, science-driven responses to health threats, promote global health leadership, and adhere to principles of integrity, accountability, and compliance with applicable laws and federal priorities.

Consistent with CDC’s values, in carrying out any project funded under this NOFO, the recipient must adhere to the following principles where consistent with the authority and scope of the award and its activities:

• A commitment to gold-standard science and ensuring trust, transparency, and credibility: To build trust and improve CDC’s ability to lead during health crises, CDC will increase transparency, be more accountable, and follow strict, gold-standard scientific practices that are open, unbiased, and based on clear evidence.

• A commitment to global leadership: With staff in 63 countries and supporting 20 more, CDC’s Global Health Center:

◦ Fights HIV, tuberculosis, vaccine-preventable diseases, and emergency and refugee health.

◦ Detects health threats early, sends response teams, trains health workers, and provides personal protective equipment, vaccines, and medicines.

◦ Tests disease samples from around the world to prepare for flu and other serious outbreaks.

◦ Has strengthened systems to better protect people at home and abroad after the COVID-19 outbreak.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 11 https://www.cdc.gov/about/cdc/index.html

• A commitment to ensuring rapid, evidence-based responses to crises:

During public health emergencies, ensuring rapid, science-driven responses is critical to minimizing harm, maintaining public trust, and restoring stability. To meet this goal, CDC must continue to strengthen its emergency response systems by:

◦ Streamlining internal processes.

◦ Improving risk communication strategies.

◦ Ensuring that laboratory capacity is fully equipped and tested—capable of rapidly developing and deploying scalable diagnostics during crises.

◦ Embedding structures for real-time learning, independent after-action reviews, and the application of lessons learned will ensure that each crisis response is smarter, faster, and more effective than the last.

• A commitment to vaccine safety and efficacy research: CDC will apply “gold-standard” science to all of its vaccine safety and effectiveness research. It will make vaccine data, research methods, and related datasets publicly available through simple data use agreements to improve transparency, accountability, and trust.

• A commitment to advancing our understanding of the causes of autism spectrum disorder (ASD), neurodevelopmental disorders (NDDs), and chronic disease: CDC conducts research and works with partners to better understand the causes of autism spectrum disorder, neurodevelopmental disorders, and chronic diseases. It will use new and existing data to study the rise in these conditions, including the increase in autism diagnoses from 1 in 150 to nearly 1 in 31 over the past 25 years.

• A commitment to modernizing public health infrastructure and enhancing our approach to health data: CDC will modernize public health infrastructure to create a faster, more efficient health system that can detect and respond to outbreaks in real time. This effort includes:

◦ Replacing data silos with integrated systems.

◦ Using advanced technology.

◦ Strengthening partnerships with states to ensure shared responsibility and strong local health data systems.

◦ Emphasizing collaboration across federal and state partners, resilient and adaptable systems, and accountability for funded programs to ensure they align with these priorities and federal requirements.

Step 1: Review the Opportunity 12

• Conflicts of interest: CDC will deprioritize funding programs with conflicts of interest and ensure its work is based on transparent, unbiased science.

• Immigration: CDC funds will not be used to support or encourage illegal immigration, consistent with federal law.

• Protecting life and the family: CDC funds will not be used to support elective abortions, consistent with the Hyde Amendment, and will promote maternal health, the dignity of life, and strong families.

• Ending disorder on America’s streets: CDC will prioritize evidence-based programs that reduce homelessness, drug use, and public disorder. It will support comprehensive services for people with serious mental illness and substance use disorder. CDC will deprioritize housing first strategies, harm-reduction or safe consumption sites, or related activities. To the extent allowable by federal law, CDC intends to give priority to grantees in States and municipalities that have laws and policies that support and enforce CDC’s priorities.

• Gender ideology and protecting children: CDC will not fund medical interventions for minors seeking gender transition and will define sex based on biological criteria.

• DEI: CDC will deprioritize DEI initiatives based on group identity and focus on merit-based, evidence-driven approaches to improve health outcomes.

• Parental rights: CDC will support policies that protect parental authority, promote transparency, and give parents greater control over their children’s education.

The recipient must demonstrate ongoing compliance with the full description and listing of CDC values and priorities, in all programs that are authorized to advance them, through program design, implementation, reporting, and evaluation.

Failure to meaningfully align funded activities with the applicable requirements may result in corrective action, additional reporting requirements, or other enforcement actions consistent with federal grant regulations found at 2 CFR Part 200 and the terms and conditions of this award. The full CDC Priorities Statement can be found here: Centers for Disease Control and Prevention (CDC) Priorities.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 13

Program description Background, overview, and related work Overview of Tanzania’s health and ecological context Tanzania is one of the 12 mega-diverse countries, with 40% of its land mass designated as forests, reserves, and marine or game parks. It borders eight countries including the Great Lakes region, has a population of 61 million, and is home to 20% of Africa’s large mammals. This ecology, however, creates vulnerabilities, such as cross-border disease transmission and various endemic, emerging, and re-emerging diseases, including zoonotic diseases.

Addressing these potential threats requires partnerships with organizations that understand the Tanzanian environment and health needs.

Tanzania’s commitment to progress in Global Health Security With over two million tourist visitors annually, Tanzania recognizes the critical importance of GHS. This NOFO aims to promote multisector partnerships and strengthen systems and workforce capacity. This approach supports efforts to prevent, detect, notify, and respond to health threats. By fostering strong collaborations, we ensure that public health interventions are appropriate, sustainable, and effective.

Since 2015, CDC Tanzania has made significant strides in building workforce, surveillance, and laboratory capacities for priority pathogens. Data modernization projects and emergency management initiatives have strengthened outbreak responses in Tanzania. This NOFO builds on past efforts to create a sustainable, resilient public health system and to secure meaningful progress in global health security.

In recent years, CDC-supported detection of high-consequence pathogens has highlighted the need for enhanced biosafety and biosecurity (BSS) and surveillance system best practices. For example, this includes detecting the March 2023 and January 2025 Marburg Virus Disease outbreaks.

Strengthening BSS practices is critical for protecting frontline workers who face significant public health threats. Solid surveillance systems serve as an early warning for the U.S., helping to prevent dangerous pathogens from spreading and protecting Americans’ health and security.

Step 1: Review the Opportunity 14

Building on past achievements The NOFO builds on progress from a successful five-year Cooperative Agreement (GH20-2102) that significantly strengthened Tanzania’s public health systems. Key achievements include:

• Making progress towards establishing a National Public Health Institute (NPHI), a critical development for African public health.

• Training over 1,000 epidemiologists through Tanzania’s Field Epidemiology and Laboratory Training Program (FELTP).

• Modernizing disease surveillance by transitioning the integrated disease surveillance and response (IDSR) to an electronic platform.

• Creating one national and five regional emergency operation centers.

CDC Tanzania also supported new vaccine initiatives, integrating COVID-19 and HPV vaccines into routine care. These advancements directly benefit the U.S. by creating stronger early warning systems and reducing the possibility of uncontrolled cross-border outbreaks. They also foster global collaboration that ultimately protects Americans’ health, security, and economic stability.

Outcomes Main outcomes of this NOFO include:

• Strengthening surveillance systems that incorporate epidemiology, clinical, and laboratory data to detect the emergence of disease threats safely and accurately. These threats can come from known and unknown causes, including naturally occurring outbreaks and intentional or accidental release of dangerous pathogens.

• Strengthening a multidisciplinary workforce for prevention, detection, and response activities conducted effectively and sustainably.

• Improving the management and coordination of the response to outbreaks and emergencies, using coordinated multi-sectoral operations across all levels.

• Fostering strong partnerships with local and indigenous organizations to ensure culturally appropriate and community-led approaches to public health interventions.

By focusing on these areas, Tanzania aims to build a resilient public health system that addresses current and future health challenges, safeguarding the well-being of its people and contributing to global health security.

Step 1: Review the Opportunity 15

Public health priorities and strategies Your funded activities must also align with CDC’s global health priorities.

These priorities guide how we build, carry out, and evaluate our global health work. We use it to measure progress and impact and make informed decisions about global health activities across CDC. The goals include:

• Stop health threats at their source before they spread to the United States and other countries.

• Contain disruptive outbreaks of disease across the globe.

• Use global data to prevent and mitigate disease in the United States and other countries.

• Save lives and improve health globally.

To make progress on these goals, we encourage you to:

• Strengthen national public health bulletins, health alert notices, CDC’s Morbidity and Mortality Weekly Report and Health Alert Network, and other emergency risk communication strategies.

• Share timely, credible, useful public health information with healthcare and public health professionals locally and nationally within our partner countries.

• Develop civil registration, vital statistics systems, and mortality surveillance systems so our partner countries know what is causing deaths in their population and whether interventions to reduce them are working.

• Additionally, the effectiveness of your work should be demonstrated in results from timeliness analyses (like the 7-1-7 framework) for early detection and response. For example, the 7-1-7 target provides a standardized benchmark for evaluating the effectiveness of outbreak detection and response systems globally. The framework outlines a timeline to aim for in response to a suspected outbreak:

◦ Within 7 days of emergency: Detect the outbreak.

◦ Within 1 day of detection: Notify public health authorities and start the investigation.

◦ Within 7 days of notification: Begin responding effectively to the emergency.

Step 1: Review the Opportunity 16

• We also recommend using these supporting strategies and frameworks:

◦ CDC’s strategy for improving GHS, based on three core parts of the agency’s mission to protect public health worldwide:

▪ Prevent.

▪ Detect.

▪ Respond.

◦ Global Health Security Agenda (GHSA) framework.

◦ The Department of State America First Global Health Strategy.

◦ United States Global Health Security Strategy.

Purpose The purpose of this NOFO is to promote GHS by partnering with the MOH to strengthen Tanzania’s public health systems. It focuses on improving disease surveillance, building laboratory capacity, enhancing the public health workforce, and establishing resilient emergency response systems. It seeks to equip Tanzania to prevent, detect, notify, and respond to infectious disease outbreaks. It also works to secure borders and manage public health emergencies and other health threats effectively.

Approach Program logic model The following logic model includes the expected strategies under this NOFO.

The logic model also includes the program’s expected outcomes. Outcomes are the results that you intend to achieve and usually show the intended direction of change, such as increase or decrease.

The asterisked (*) outcomes are those we expect you to achieve or substantially contribute to during the five-year period of performance. You must report on these outcomes.

Not all outcomes apply to all strategies. The table shows how they apply. You will use these outcomes as a guide for developing performance measures.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 17 https://www.cdc.gov/global-health/topics-programs/global-health-security.html?CDC_AAref_Val=https://www.cdc.gov/globalhealth/security/index.htm https://globalhealthsecurityagenda.org/ https://www.state.gov/america-first-global-health-strategy/ https://www.state.gov/releases/office-of-the-spokesperson/2025/09/america-first-global-health-strategy

Table: Strategies and outcomes

Strategies and activities Short-term outcomes Intermediate outcomes Long-term outcomes

Strategy 1:

Strengthen early warning systems and data-driven surveillance and response.

Increased timely alert reporting from community and facility levels.*

Increased surveillance data use at community and facility levels to inform decisions.*

Strengthened indicator-based surveillance (IBS) and event-based surveillance (EBS) at the national and sub-national levels.*

Improved data linkages between surveillance and laboratory data from human and animal health sectors.*

Strengthened surveillance systems that incorporate epidemiology, clinical, and laboratory data to safely and accurately detect emergence of disease threats from both known and unknown threats.

Strengthened multidisciplinary workforce for surveillance, detection, and rapid response to contain an outbreak at the source.*

Improved effectiveness and sustainability of prevention, detection, and response activities.

Improved management and coordination of the response to outbreaks and emergencies utilizing coordinated multisectoral responses across all levels.

Strategy 2:

Improve lab capacity for early rapid detection of epidemics, including biological threats.

Improved rapid diagnostic testing for priority diseases.*

Strategy 3:

Strengthen public health workforce capacity.

Increased availability of field epidemiologists and laboratory leaders to meet the global target population for effective outbreak responses.*

Improved country use of multisectoral workforce strategies.*

Improved capacity among epidemiologists and laboratorians to use data to detect, notify and respond to public health threats.*

Strengthened multidisciplinary rapid response teams at the national and sub-national levels.*

Increased linkages between sub-national Emergency Operation Centers networks and national Public Health Emergency Operation Centers in coordinating multisectoral

Strategy 4:

Build resilience in public health institutions and systems for improving public health.

Improved coordination and integration of public health functions at the national and subnational levels.*

Step 1: Review the Opportunity 18 responses across all levels.*

Strategies and activities This section elaborates on the strategies described in the logic model by providing expected activities for Year 1 and details about how we expect you to implement your program.

The following are strategies and the required activities under this NOFO. You may also propose additional related strategies and activities to achieve the expected outcomes.

Strategy 1: Strengthen early warning systems and data-driven surveillance and response.

• Build capabilities among surveillance officers, community health workers (CHWs), and healthcare workers (HCWs) on surveillance systems. These systems, including mortality surveillance, detect and respond to events and incorporate timely data analytics for action at the community and facility levels using a One Health (OH) approach in select regions.

• Strengthen the capacity of facility, district, and regional IDSR focal points on the eIDSR Outbreak Management module.

• Support the integration of regional referral hospitals’ electronic systems to enhance real-time surveillance and reporting of immediately notifiable diseases, enabling early warning and response.

◦ Strengthen cross-border collaborations in disease surveillance, population movement, and response coordination in border districts and neighboring countries.

◦ Enhance Point of Entry health officers’ capacity to use the Traveler Surveillance System (Afya Msafiri) to enable early detection and response for both incoming and outgoing travelers.

Strategy 2: Improve lab capacity for early rapid detection of epidemics, including biological threats.

• Strengthen the diagnostic capacity for priority and novel pathogens for fast disease detection.

• Introduce innovative methods, including wastewater surveillance and platforms using mobile labs to speed up novel pathogen and variant detection.

Step 1: Review the Opportunity 19

• Establish a quality assessment program for laboratories that creates diagnostics of diseases with epidemic potential at the national or central level.

• Strengthen diagnostic capacities and laboratory surveillance data generation used for multi-pathogen diseases.

• Strengthen BSS by monitoring pathogens within facilities and developing a BSS regulatory framework.

• Strengthen functionality of the regional laboratory response network (LRN) through the current East African Public Health Laboratory Network.

Strategy 3: Strengthen public health workforce capacity.

• Strengthen workforce development through FELTP and the Global Lab

Leadership Program (GLLP).

• Actively engage FELTP residents (district, regional, and national levels) in local emergency response activities.

• Run Continuous Professional Education (CPE) programs for a multidisciplinary workforce.

Strategy 4: Build resilience in public health systems and institutions for improving public health.

• Establish a National Public Health Institute (NPHI) to coordinate public health activities in mainland Tanzania and on Zanzibar.

• Strengthen the capacity across key public health functions to use the Public Health Emergency Operations Center (PHEOC) to improve preparedness, coordination, and response during health emergencies.

• Support the development of a PHEOC module to enhance preparedness, coordination, and response during health emergencies.

• Strengthen multi-disciplinary surge staff capacity to improve on reaching a standardized benchmark target, e.g., the 7-1-7 target (detecting public health events within 7 days, notifying within 1 day, and responding within 7 days) at the national and sub-national levels.

• Support drills and simulation exercises to test multi-hazard emergency responses for multiple-country events. Develop after-action reviews to improve operational capabilities.

• Support policies and innovative preventive measures for pandemic response strategies, including novel tests and emergency vaccinations.

We expect you to provide copies of and/or access to all data, software, tools, training materials, guidelines, and systems you develop under this NOFO to

Step 1: Review the Opportunity 20 the Ministry of Health, CDC, and other relevant stakeholders for appropriate use consistent with underlying authorities.

Related guidance Your activities under this project should follow CDC’s global health priorities.

You might also be asked to follow other strategies, guidance, or planning documents that are released later.

Geographic focus If the program or GHS priorities change during the period of performance, you may be asked to change the geographic area of your activities.

Outcomes We expect you to achieve or substantially contribute to the outcomes asterisked ( * ) in the logic model by the end of the five-year period of performance. You will be expected to report on these outcomes.

Organizational capacity You must include a heading in your project narrative titled “Organizational capacity.” In this section, briefly describe your organizational capacity to carry out these strategies and activities.

You must also provide supporting documentation in your attachments. See the attachments section for full instructions.

Collaborations If funded, we will expect you to collaborate with:

• The Government of Tanzania, including the MOH, the President’s Office of Regional Administration and Local Government (PORALG), and other USG partners.

• Other CDC programs and CDC-funded organizations, including non-governmental organizations, universities, the MOH, and other host governmental bodies and multi-lateral organizations. You should ensure their proposed activities do not duplicate existing CDC-funded activities.

• Other organizations not funded by CDC, including partner governments working towards the objectives of this NOFO. We will expect you to work with other stakeholders at the country and global levels, including government entities, universities, civil society, the private sector, and other USG agencies.

Step 1: Review the Opportunity 21

Data, monitoring, and evaluation CDC strategy CDC collects and reports on indicators to measure progress toward achieving the activities and outcomes. CDC will also use results for program planning, improvement, accountability, and reporting. CDC will share the results with key parties.

CDC will work with you throughout the life of this award to ensure that all activities and expected outcomes align with your strategies and goals, and those of the U.S. government.

Your strategies and goals will be monitored and evaluated. You should dedicate some of the NOFO’s funds to evaluate and monitor the performance of your project. You and CDC will agree on the final funding amount, but we expect that you will dedicate approximately 5 to 10% of your project’s funding to monitoring, reporting, and evaluation activities.

Required performance measures While completing your work plan, identify indicators within the partner-level indicator list that best align with your proposed activities for each component.

You can find the separate list within the application package on grants.gov.

These indicators are your performance measures. You will also include these indicators in your initial evaluation and performance measurement plan (EPMP). If awarded, we will work with you to finalize the partner-level indicators that will best measure your funded strategies and activities. We will provide a more detailed description of the indicators when you are awarded.

You will report on your performance measures in the annual progress report.

While you will be responsible for reporting on your partner-level indicators, you can use additional indicators to assess your program. You’re encouraged topropose additional relevant indicators that you will monitor over the course of the project.

Evaluation and performance measurement plan You must submit an initial draft of your EPMP plan with your application. In your EPMP, you will identify which of the partner-level indicators you plan to report on in your annual performance report). These indicators will be finalized with CDC.

You must submit a more detailed plan within the first six months of the award. See Reporting.

Step 1: Review the Opportunity 22

Be sure to align your evaluation and performance measurement plan with host country, agency, and program requirements and priorities.

Include the following elements in your evaluation and performance measurement plan.

Methods Describe how you will:

• Collect the performance measures.

• Respond to the evaluation topics.

• Use evaluation findings for continuous program quality improvement.

• Incorporate evaluation and performance measurement into planning, implementing, and reporting project activities.

Additionally, explain:

• How key program partners will participate in the evaluation and performance measurement process.

• How feasible it will be to collect appropriate evaluation and performance data.

• How you will share evaluation findings with communities and stakeholders.

• Other relevant information, such as performance measures you propose.

Data management plan For all public health data you plan to collect, you must have a data management plan (DMP). For a definition of “public health data” and more information about CDC’s policy on the DMP, see Data Management and Access.

You must submit an initial draft of your DMP with your application. You will submit a more detailed plan within the first six months of the award.

See Reporting.

Submit your DMP with your application and include:

• The data you will collect or generate, and what its sources will be.

• Who can access the data and how you will protect and secure it.

• Data standards that explain what documentation the released data will have. Documentation should describe collection methods, what the data represents, and data limitations.

• Archival and long-term data preservation plans.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 23 https://www.cdc.gov/grants/additional-requirements/ar-25.html https://www.cdc.gov/grants/additional-requirements/ar-25.html

• Any reasons why you cannot share data collected or generated under this award with CDC. These could include legal, regulatory, policy, or technical reasons.

• How you will update the DMP as new information becomes available over the life of the project. You will provide updates to the DMP in annual reports.

In addition to the other requirements listed, also include:

• Cybersecurity plans.

• How you will protect personally identifiable information (PII) when you collect, store, transfer, and use this data.

• How you will remove information from the data that could reveal participants’ identities (de-identify the data) in intermediate and final data sets.

CDC will inform you of data you need to share with us and how and when it should be shared.

Evaluation activities You must carry out at least one evaluation for each cooperative agreement during your funding. The evaluation can be one of these:

• A process evaluation, which measures:

◦ How you delivered the services.

◦ What worked and what did not.

◦ The differences between who you intended to serve and who you actually served.

◦ Who could access your services.

• An outcome evaluation, which measures how the intervention affected changes in knowledge, attitudes, or behavior.

• An economic evaluation, which measures:

◦ How much the intervention cost.

◦ What caused these costs.

◦ Cost effectiveness.

◦ Efficiency.

◦ The economic impact of the intervention.

Step 1: Review the Opportunity 24

Describe:

• The type of evaluations (process, outcome, and/or economic).

• Key evaluation questions these evaluations will address.

• Other information, such as measures and data sources.

Work plan You must provide a work plan for each component for your project. For each component, provide a detailed work plan for the first year and a high-level work plan for later years. The work plan connects your performance outcomes, strategies and activities, and measures. It provides more detail on how you will measure outcomes and processes. A sample work plan is provided below.

Table: Sample format

Activities you will implement

Progress or process measures

From the Data, monitoring, and evaluation section.

Relevant period of performance outcomes

From the Outcomes section.

Responsible position or party

Completion date

Strategy 1:

1.

2.

3.

Strategy 2:

1.

2.

3.

Step 1: Review the Opportunity 25

Paperwork Reduction Act Any activities involving information collection from 10 or more individuals or organizations may require Paperwork Reduction Act (PRA) approval. The PRA requires review and approval of the information collection by the White House Office of Management and Budget (OMB). For further information to determine if a proposed activity requires PRA approval, contact your project officer.

Collections include items like surveys and questionnaires. If you have collections requiring PRA approval, CDC is responsible for working with OMB to gain the approval.

For more information about CDC’s requirements under PRA see CDC Paperwork Reduction Act Compliance.

Dissemination of evaluation results By the end of the period of performance, your evaluation and performance measures will yield findings to demonstrate the value of your projects. You will disseminate these findings through the Annual Performance Report (APR).

You are expected to pursue additional dissemination in public domains and through informal channels. Dissemination channels could include:

• Local and international conferences and forum abstract presentations.

• Conference poster displays.

• Public health and global health journals.

• Manuscripts.

• Bulletins.

• Reports.

• Presentations to technical working groups and stakeholder meetings.

• Other approved products in print and electronic media, including websites and newsletters.

Program interest holders will be the primary intended users of your evaluation results and findings.

CDC and interest holders will use your evaluation findings during the five-year project period to share and implement key recommendations to strengthen program implementation, effectiveness, sustainability, and continued improvement after the award ends.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 26 https://www.cdc.gov/scientific-integrity/php/public-information-collection/ https://www.cdc.gov/scientific-integrity/php/public-information-collection/

Funding policies and limitations Changes in HHS regulations As of October 1, 2025, HHS adopted 2 CFR 200, with some exceptions included in 2 CFR 300. These regulations replace those in 45 CFR 75. You can find details in HHS Summary of Regulatory Changes, which is posted in the Grants.gov Related Documents tab for this opportunity.

General guidance

• Your budget is arranged in eight categories: salaries and wages, fringe benefits, travel, equipment, supplies, contractual, other (includes consultant costs), and indirect costs.

• You may use funds only for reasonable program purposes consistent with the award, its terms and conditions, and federal laws and regulations that apply to the award. If you have questions about this determination, ask the grants management officer.

• Generally, you may not use funds to purchase furniture or equipment.

Clearly identify and justify any such proposed spending in the budget.

• All requests for funds contained in the budget should be stated in U.S.

dollars.

• Cost increases due to changes in exchange rates are allowed if enough funding is available. If an increase in the exchange rate would reduce the scope of the project or cause you to need more federal funding, you must get prior approval for exchange rate fluctuations.

• Support beyond the first budget year will depend on:

◦ Appropriation of funds.

◦ Satisfactory progress in meeting your project’s objectives.

◦ A decision that continued funding is in the government’s best interest.

• If we receive more funding for this program, we will consider:

◦ Funding more applicants.

◦ Extending the period of performance.

◦ Awarding supplemental funding.

See also program-specific limitations.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 27 https://www.ecfr.gov/current/title-2/part-200 https://www.ecfr.gov/current/title-2/subtitle-B/chapter-III/part-300 https://ecfr.io/Title-45/Part-75 https://www.law.cornell.edu/definitions/index.php?width=840&height=800&iframe=true&def_id=13f24ea1f961f5f0d14b87ec1b39b25f&term_occur=999&term_src=Title:45:Chapter:A:Subchapter:A:Part:75:Subpart:E:Subjgrp:39:75.440

Unallowable costs You may not use funds for:

• Research.

• Clinical care, except as allowed by law.

• Pre-award costs, unless we give you prior written approval.

• Other than for normal and recognized executive-legislative relationships:

◦ Publicity or propaganda purposes, including preparing, distributing, or using any material designed to support or defeat the enactment of legislation before any legislative body.

◦ The salary or expenses of any grant or contract recipient, or agent acting for such recipient, related to any activity designed to influence the enactment of legislation, appropriations, regulation, administrative action, or executive order proposed or pending before any legislative body.

◦ See Anti-Lobbying Restrictions for CDC Recipients.

• For guidance on some types of costs that we restrict or do not allow, see 2 CFR Part 200 Subpart E - General Provisions for Selected Items of Cost.

Indirect costs Indirect costs are those shared across multiple projects and not easily separated. Learn more at CDC Budget Preparation Guidelines.

To charge indirect costs you can select one of two methods:

Method 1 — Approved rate. If you currently have an indirect cost rate approved by your cognizant federal agency, you may use that rate.

Enclose a copy of the current approved rate agreement in your attachments.

Method 2 — De minimis rate. If you have never received a negotiated indirect cost rate, you may elect to charge a de minimis rate (see 2 CFR 200.414(f)). If you choose this method, costs included in the indirect cost pool must not be charged as direct costs. This rate is 15% of modified total direct costs (MTDC). See the definition of MTDC (2 CFR 200.1). You can use this rate indefinitely.

Foreign organizations and foreign public entities Indirect costs on awards to foreign organizations and foreign public entities performed fully outside of the U.S. and its territories may be paid to support the costs of complying with federal requirements.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 28 https://www.cdc.gov/grants/documents/Anti-Lobbying-Restrictions.pdf https://www.ecfr.gov/current/title-2/part-200/subject-group-ECFRed1f39f9b3d4e72 https://www.cdc.gov/grants/documents/budget-preparation-guidance.pdf https://www.ecfr.gov/current/title-2/section-200.414 https://www.ecfr.gov/current/title-2/section-200.414 https://www.ecfr.gov/current/title-2/part-200#p-200.1(Modified%20Total%20Direct%20Cost%20(MTDC))

This rate is fixed at 8% of MTDC exclusive of tuition and related fees, direct expenditures for equipment, and subawards in excess of $25,000.

Negotiated indirect costs may be paid to the American University, Beirut, and the World Health Organization.

See 2 CFR § 300.414.

Other indirect cost policies

• As described in 2 CFR 200.403(d), you must consistently charge items as either indirect or direct costs and may not double charge.

Indirect costs may include the cost of collecting, managing, sharing, and preserving data.

Salary rate limitation The salary rate limitation in the current appropriations act applies to this program. As of January 2026, the salary rate limitation is $228,000. We will update this limitation in future years.

Program income If you earn any money from your award-supported project activities (known as program income), you must use it for the purposes and under the conditions of the award. Find more about program income at 2 CFR 200.307.

Program-specific limitations

Human and animal subjects restriction CDC requires you to use protocols for technical review and for review of your institutional plans to protect human or animal subjects if you plan to create public reports based on:

• Collecting data from people, animals, or personal records.

• Collecting and testing laboratory specimens.

We will not provide funds to implement these activities until you have obtained all necessary approvals of your institutional protocols. We may provide funds for preparatory activities (such as protocol development, training, equipment, reagents, and site preparation) before protocol approval.

To make sure you have funds available, your budget and narrative should indicate which activities are preparatory.

You must submit data collection protocols required for the release of these funding restrictions to the CDC Global Health Center, Division of Global

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 29 https://www.ecfr.gov/current/title-2/subtitle-B/chapter-III/part-300/subpart-E/section-300.414 https://www.ecfr.gov/current/title-2/part-200#p-200.403(d) https://www.ecfr.gov/current/title-2/section-200.307

Health Protection (DGHP) Science Office within six months of being notified of these restrictions. You must submit these protocols by the end of the first budget year at the latest. You can submit requests for exceptions to these deadlines in writing to the project officer.

You should obtain all protocol approvals by the end of the next budget period after the award or continuation has been made, unless you have received an exception.

Host country laws and regulations If funded, we expect you to follow applicable host country laws and regulations related to the strategies under this NOFO. If there are conflicts with this award, contact the grants management officer.

Program income prior approval If you earn any money from your award-supported project activities (known as program income), you must use it for the purposes and under the conditions of the award. If applicable, the disposition of program income must have written prior approval from the Grants Management Officer. Find more about program income at 2 CFR 200.307.

Expanded authority For more information on expanded authority and pre-award costs, see the HHS Grants Policy Statement and speak to the grants management contact.

Pre-award costs may be allowable as an expanded authority, but only if we authorize the costs.

1. Review 2. Get Ready 3. Build 4. Understand 5.