CDC-RFA-DP19-001AmendmentPublication.pdf

Centers for Disease Control

National Center for Chronic Disease Prevention and Health Promotion Extramural Research

Program Office

Health Promotion and Disease Prevention Research Centers

RFA-DP-19-001

Application Due Date: 06/25/2018

Health Promotion and Disease Prevention Research Centers

RFA-DP-19-001

TABLE OF CONTENTS

Part 1. Overview Information Key Dates Required Application Instructions Executive Summary

Part 2. Full Text Section I. Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII. Other Information

Part 1. Overview Information Participating Organization(s) Centers for Disease Control Components of Participating Organizations National Center for Chronic Disease Prevention and Health Promotion Extramural Research Program Office (NCCDPHP ERPO) National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP) Notice of Funding Opportunity (NOFO) Title Health Promotion and Disease Prevention Research Centers Activity Code U48 Amendment 1 - Part1. Overview, Executive Summary, Special Date(s). Informational conference calls for eligible applicants.

Revised instructions for informational conference call scheduled April 24, 2018, 1pm-2:30pm Eastern Time:

Web Ex Instructions: Phone Dial in number: 888-282-0374 Passcode: 6473996 WebEx Required Download: To use WebEx for your operator-assisted conferences, presenters and participants alike must have the WebEx Event Manager installed prior to joining. To download the Event Manager, see the instructions on the WebEx Downloads page.

For Participants: URL: https://www.mymeetings.com/nc/join/ Conference number:

PWXW7372148 Audience passcode: 6473996 Participants can join the event directly at: https://www.mymeetings.com/nc/join.php?i=PWXW7 372148&;p=6473996&;t=c

Notice of Funding Opportunity Type New Agency Notice of Funding Opportunity Number

RFA-DP-19-001

Catalog of Federal Domestic Assistance (CFDA) Number(s) 93.135 Category of Funding Activity:

Health NOFO Purpose This Notice of Funding Opportunity (NOFO) will provide funding to academic research centers to participate in the network of Health Promotion and Disease Prevention Research Centers (PRC Network) to:

Establish and maintain a multi-disciplinary prevention research center (Center) that conducts high-quality applied health promotion and disease prevention research;

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Conduct one (1) applied public health prevention research project (Core Research Project) using a community engagement approach to address a major cause of disease, disability, injury, or death in a population experiencing health disparities;

Disseminate research findings to community, practice, and academic audiences;

Translate evidence-based interventions for sustainability and widespread scale-up; and Serve as a resource, as part of the PRC Network, for developing, implementing, evaluating, disseminating, and translating evidence-based public health interventions at local, state, tribal, or national levels.

Key Dates Publication Date: To receive notification of any changes to RFA-DP-19-001, return to the synopsis page of this announcement at www.grants.gov and click on the "Send Me Change Notification Emails" link. An email address is needed for this service.

Letter of Intent Due Date: 05/25/2018 05/25/2018

Application Due Date: 06/25/2018 06/25/2018

On-time submission requires that electronic applications be error-free and made available to CDC for processing from eRA Commons on or before the deadline date. Applications must be submitted to and validated successfully by Grants.gov/eRA Commons no later than 5:00 PM U.S. Eastern Time. Note: HHS/CDC grant submission procedures do not provide a period of time beyond the application due date to correct any error or warning notices of noncompliance with application instructions that are identified by Grants.gov or eRA systems (i.e., error correction window).

Scientific Merit Review: 08/31/2018 August 2018

Secondary Review: 09/28/2018 September 2018

Estimated Start Date: 09/30/2019

Expiration Date: 06/26/2018 Due Dates for E.O. 12372: Executive Order 12372 does not apply to this program.

Required Application Instructions It is critical that applicants follow the instructions in the SF 424 (R&R) Application Guide except where instructed to do otherwise in this NOFO. Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific https://www.grants.gov http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_General_VerC.pdf instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

Note: The Research Strategy component of the Research Plan is limited to 25 pages.

Applications that do not comply with these instructions may be delayed or not accepted for review.

Telecommunications for the Hearing Impaired: TTY 1-888-232-6348 Note: The Research Strategy component of the Research Plan is limited to 25 pages (10 pages should address the Center activities and 15 pages should address the Core Research Project activities.) See Section 5.5 of the SF 424 (R&R) Application Guide for components of the Research Plan and Part 2, Section IV, 7. Page Limitations).

Applications that do not comply with these instructions may be delayed or not accepted for review.

A link to this NOFO and applicant Questions and Answers will be available at CDC Notice of Funding Opportunity/NCCDPHP/Health Promotion and Disease Prevention Research Centers.

Executive Summary

Purpose. This NOFO will provide funding to academic research centers to participate in the network of Health Promotion and Disease Prevention Research Centers (PRC Network) to:

Establish, and maintain a multi-disciplinary prevention research center (Center) that conducts high-quality applied health promotion and disease prevention research;

Conduct one (1) applied public health prevention research project (Core

Research Project) using a community engagement approach to address a major cause of disease, disability, injury or death in a population experiencing health disparities;

Disseminate research findings to community, practice, and academic audiences;

Translate evidence-based interventions for sustainability and widespread scale-up; and Serve as a resource, as part of the PRC Network, for developing, implementing, evaluating, disseminating, and translating evidence-based public health interventions and strategies at local, state, tribal, or national levels.

Mechanism of Support. Cooperative Agreement Funds Available and Anticipated Number of Awards. The CDC intends to commit a total of approximately $75,000,000 - $112,500,000 (direct and indirect costs) for the entire project period. It is anticipated that 20-30 awards will be made. Awards issued under this NOFO are contingent upon availability of funds and a sufficient number of meritorious applications. Because the nature and scope of the proposed research will https://www.cdc.gov/chronicdisease/about/foa/prcs/index.htm https://www.cdc.gov/chronicdisease/about/foa/prcs/index.htm https://www.cdc.gov/chronicdisease/about/foa/prcs/index.htm vary from application to application, it is also anticipated that the size and duration of each award may also vary. The total amount awarded and the number of awards will depend upon the number, quality, duration and cost of the applications received.

Budget and Project Period. The estimated approximate total funding (direct and indirect) for the first 12-month budget period, September 30, 2019 - September 29, 2020, is $750,000. The estimated total funding (direct and indirect costs) for the entire 5-year project period, September 30, 2019 - September 29, 2024, is approximately $3,750,000.

Application Research Strategy Length: Page limits for the Research Strategy are clearly specified in Section IV. Application and Submission Information of this announcement.

Eligible Institutions/Organizations. Institutions/organizations listed in Section III, 1.A.

are eligible to apply.

Eligible Project Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and resources necessary to carry out the proposed Center are invited to work with their institution/organization to develop an application for support. NOTE:

CDC does not make awards to individuals directly, but to institutions/organizations.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply.

Number of PDs/PIs. Applications may include more than one PI; however, the first PI listed on the application will be the contact PI for all correspondence. Any additional PIs are permitted, but would be referred to as Co-PIs.

Number of Applications. Only one application per institution (normally identified by having a unique DUNS number) is allowed.

Application Type. New Special Date(s). Informational conference calls for eligible applicants:

o April 24, 2018 at 1-2:30pm Eastern Time.

Web Ex Instructions: Phone Dial in number: 888-282-0374 Passcode:

6473996 WebEx Required Download: To use WebEx for your operator-assisted conferences, presenters and participants alike must have the WebEx Event Manager installed prior to joining. To download the Event Manager, see the instructions on the WebEx Downloads page.

For Participants: URL: https://www.mymeetings.com/nc/join/ Conference number: PWXW7372148 Audience passcode: 6473996 Participants can join the event directly at: https://www.mymeetings.com/nc/join .php?i=PWXW7372148&;p=6473996&;t=c

Application Materials. See Section IV.1 for application materials. Please note that Form E is to be used when downloading the application package. http://grants.nih.gov /grants/funding/424/index.htm#inst

Hearing Impaired. Telecommunication for the hearing impaired are available at: TTY:

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Part 2. Full Text Section I. Funding Opportunity Description

Statutory Authority Section 1706 of the Public Health Services Act, as amended, 42 U.S.C. 300u-5, academic health centers, as defined in 42 U.S.C 300u-5(d) and Section 799B, as amended 42 U.S.C. 295p.

1. Background and Purpose Public health practitioners need scalable, feasible interventions (i.e. programs, practices, policies, or strategies) and tools developed in real-world practice settings to address the leading causes of illness, injury, disability, and death in the United States. Applied public health prevention researchers can engage communities to develop and evaluate disease prevention and health promotion interventions, disseminate new science, and translate proven effective prevention interventions into public health practice and policy for community-wide benefit.

Academic research centers can meet the needs of public health practitioners by applying their expertise to:

o Increase knowledge of the factors that support the implementation of effective system-level public health interventions.

o Increase knowledge of factors necessary to support widespread translation/adoption, sustainability, and scale-up of evidence-based interventions, including how to maintain strong outcomes as interventions are taken to scale.

o Collaborate with public health practitioners to examine the effectiveness of public health practice-based strategies being pursued in real-world settings.

o Assist local, state, tribal or national agencies with efforts to reduce health disparities in affected populations and improve health equity and the quality of life in underserved communities.

Congress established the Prevention Research Centers Program in 1984 (Public Law 98-551) to undertake research and demonstration projects in health promotion, disease prevention, and improved methods of appraising health hazards and risk factors, and serve as demonstration sites for the use of new and innovative research in public health techniques to prevent chronic disease. Congress mandated that the centers be located in academic health centers. CDC administers the Prevention Research Centers Program and provides leadership, technical assistance, and oversight of the PRC Network. Funded academic health centers are defined as an accredited school of public health, and an accredited school of medicine or accredited school of osteopathy with an accredited Preventive Medicine Residency Program. PRC Network members are able to compete for Special Interest Projects (SIPs) - applied prevention research projects sponsored by CDC, HHS, and other federal agencies - to conduct research and other activities that advance evidence-based practice and answer important and timely practice-based questions identified by sponsors.

CDC's PRC Network serves a vital role within the public health system. PRCs develop, test, and evaluate public health interventions that can be applied widely, particularly in underserved communities, based on the latest science. They have the expertise needed to provide scientific services such as program evaluation to public health efforts at the local, state, tribal, and national levels, and play a vital role in training the public health workforce.

The scientific literature has long documented a vast gap between current knowledge and practice in the area of implementation research. Implementation science has more recently become an area of intense national interest, in reference to the need for translation of new findings into practice within both clinical and public health arenas and their intersections.

Brownson, Fielding, and Green recently summarized key areas of need in the translation gap between research and practice in public health that, if addressed, would increase use of evidence-based public health by practitioners, and increase relevance of public health research to practitioners. Addressing translation gaps between research and practice in public health increases likelihood of higher uptake and bringing to scale of evidence-based programs, policies, and systems-wide public health strategies.

Achieving lasting impact in health outcomes requires a focus not just on individual behaviors and patient care but on community-wide approaches aimed at improving population health. The Institute of Medicine report, The Future of the Public s Health in the 21st Century, states "Taking into account the environmental and social determinants of health is essential to creating effective population-level interventions for health improvement". The socio-ecological model of health emphasizes the influence of multiple factors, beyond individual behaviors, that promote and support health. The CDC Health Impact Pyramid illustrates the value of community-based interventions focused on contextual factors and the social determinants of health for achieving the greatest effect on population health outcomes. Like the social-ecological model, the Health Impact Pyramid suggests, interventions that reach broader segments of society tend to be more effective and have the greatest potential public health benefit. Moreover, these population-level interventions are potentially more sustainable and are not impacted by limits in scalability of individual-level focused interventions. Rigorous investigations of population level interventions that consider the social context of communities and address the social determinants of health are needed to inform public health practice.

This NOFO will serve to outline the goals and objectives for the next 5-year cycle of the PRC Program. This NOFO replaces RFA-DP14-001 that ends September 2019. The intent of this NOFO is to support a network of Health Promotion and Disease Prevention Research Centers (PRCs) across the country to conduct applied public health prevention research to address the leading causes of illness, injury, disability and death and improve health outcomes of populations experiencing health disparities.

This NOFO increases emphasis on translation of Core Research Project findings and specifies translation expectations. It promotes investigation of community level interventions to improve population health outcomes and reduce health disparities, including linkages between health and community economic development. It also incorporates a PRC Network-wide evaluation with common reporting requirements across recipients, to be provided through the PRC Program Evaluation Reporting System (PERS).

PRCs funded under this NOFO will build on the strong achievements of previous PRC Network members and advance the PRC Program's mission and prevention research activities. It is anticipated that the network of PRCs and each PRC supported by this NOFO will conduct innovative and important studies in applied public health prevention research that are relevant for public health practice and will result in improved health for people across the United States.

Healthy People 2020 and other National Strategic Priorities This NOFO supports efforts that align with the following public health priorities:

Healthy People 2020 -o Social Determinants of Health: economic stability; education; social and community context; health and health care, neighborhood and built environment o Health topics: adolescent health; arthritis, osteoporosis, and chronic back conditions; cancer, dementia including Alzheimer s disease; diabetes; disability and health (includes epilepsy); educational and community based programs;

health-related quality of life and well-being; hearing; heart disease and stroke;

HIV; maternal, infant and child health; nutrition and weight status; older adults;

oral health; physical activity; respiratory diseases (includes C.O.P.D.); sexually transmitted disease; sleep and health; tobacco use; vision.

CDC's Health Impact in 5 Years (HI-5) initiative interventions addressing the social determinants of health, and interventions changing the context, https://www.cdc.gov /policy/hst/hi5/interventions/index.html.

National Center for Chronic Disease Prevention and Health Promotion's Four Domains of Chronic Disease Prevention - epidemiology and surveillance;

environmental approaches that promote health and support and reinforce healthful behaviors; health system interventions to improve the effective delivery and use of clinical and other preventive services; and strategies to improve community-clinical linkages, https://www.cdc.gov/chronicdisease/resources/publications/four-domains.htm

Public Health Impact CDC's Prevention Research Centers Program links university researchers and health agencies, community-based organizations, and national, tribal, state, and local nonprofit organizations to ensure that promising research findings result in practical, cost-effective and innovative interventions. The PRCs use community engagement approaches to fill critical gaps in public health science and identify effective strategies to address health disparities in underserved communities.

Achieving lasting impact in health outcomes requires a focus not just on patient care but on community-wide approaches aimed at improving population health. Public health practitioners need scalable, feasible interventions (i.e. programs, practices, policies, or strategies) and tools developed in real-world practice settings to address the leading causes of illness, injury, disability and death in the United States. A successful PRC will:

increase availability of evidence-based strategies, interventions, and implementation tools increase translation of evidence-based research into practice increase adoption of evidence-based programs and policies and implementation of effective systems-wide public health strategies

Increased availability and use of evidence by public health practitioners, and increased https://www.cdc.gov/policy/hst/hi5/interventions/index.html https://www.cdc.gov/policy/hst/hi5/interventions/index.html https://www.cdc.gov/chronicdisease/resources/publications/four-domains.htm translation of evidence-based research to practice, if done well, will lead to widespread, sustained and scaled-up use of evidence-based programs and systems-wide public health strategies, which will contribute to improved population health and elimination of health disparities.

This NOFO also invests in strengthening national capacity in applied public health prevention research and positions PRCs to provide training, expertise, and services to health departments, businesses and employers, community development and economic planning enterprises and other entities. Training can include public health practice competency training to practitioners and applied prevention research training to students and community partners. Expertise can include investigation of the relationship between community economic improvement and health status. Services provided can include public health needs assessment, identification of community economic development opportunities that drive health outcomes and evaluation of efforts conducted by local, state, tribal or national agencies. These elements are critical to undergird our national public health infrastructure, improve the delivery of public health services, and ultimately to improve population health.

Relevant Work PRCs have made substantial progress in improving the quality of people's lives by preventing and controlling disease, injury, and disability. PRCs have been at the forefront of engaging community members and partners to use local knowledge to understand health problems, effectively design and implement prevention research, and interpret research results to ensure population health impacts through sustainable and potentially scalable public health programs and interventions. The PRCs have contributed to efforts to eliminate health disparities, create healthy communities and improve public health practice.

The PRC Program strives to find new ways to improve the health of all Americans in economically responsible ways through scientific research, community participation, collaborative partnerships, practical application, dissemination of scientific findings, and translation of evidence-based interventions into public health products and practice.

2. Approach The intent of this NOFO is to support a network of Health Promotion and Disease Prevention Research Centers (PRCs) across the country to conduct applied public health prevention research to address the leading causes of illness, injury, disability and death in populations experiencing health disparities. The research activities should test systems-level approaches, community-clinical interventions, or evaluate policy strategies, including community economic development, to address the health needs of underserved communities and populations experiencing health disparities.

The purpose of this NOFO is to establish, and maintain multi-disciplinary Prevention Research Centers that conducts high-quality applied health promotion and disease prevention research.

Each Center will:

Conduct one (1) applied public health prevention research project (Core Research Project) using a community engagement approach to address a major cause of disease, disability, injury, or death in a population experiencing health disparities;

Disseminate research findings to community, practice, and academic audiences;

Translate evidence-based interventions for sustainability and widespread scale-up; and As part of the PRC Network, serve as a resource for developing, implementing, evaluating, disseminating, and translating evidence-based public health interventions at local, state, tribal, or national levels.

PRCs will be located in accredited Schools of Public Health and accredited Schools of Medicine or Osteopathy with a Preventive Medicine Residency Program that have multidisciplinary faculty with expertise in public health, and have working relationships with relevant groups in such fields as medicine, psychology, nursing, social work, education, community economic development and business. PRC will have core faculty in epidemiology, biostatistics, social sciences, behavioral and environmental health sciences and health administration, have graduate training programs relevant to disease prevention, have demonstrated curriculum in disease prevention, and have capacity for residency training in public health or preventive medicine.

The following logic model outlines goals for a Prevention Research Center and expected short-term, intermediate-term, and long-term outcomes. Also, see Appendix 1.

Objectives/Outcomes Recipients are expected to contribute to the NOFO outcomes by the conclusion of the funding period (9/29/2024). Short term, intermediate term, and long term outcomes expected to be accomplished because of this NOFO are listed in the NOFO logic model and will be evaluated using the PRC Program Evaluation Reporting System. Recipients are expected to achieve short term and intermediate term outcomes within the 5-year funding period.

Long Term Outcomes:

Improved population health, elimination of health disparities, and achievement of health equity

Increased widespread, sustained and scaled-up use of evidence-based programs and systems-wide population health strategies

Intermediate Term Outcomes:

Increased adoption of evidence-based programs and policies Increased implementation of effective systems-wide strategies that improve population health Increased translation of evidence-based research into practice

Short Term Outcomes:

Expanded capacity nationally for applied prevention research Expanded engagement between researchers and organizations with implementation capacity Expanded translation activity and infrastructure bridging research and practice Expanded awareness of effective population health approaches amongst public health, medical and private sector practitioners Expanded knowledge from one core research project Expanded availability of evidence-based strategies, interventions, and implementation tools Expanded community capacity for research and translation Expanded activity to achieve large-scale adoption of core research project findings and products

This NOFO will support achievement of short term, intermediate term, and long-term outcomes through the following activities:

Center Component:

1. Establish and maintain PRC infrastructure (including Community Advisory Board)

2. Establish a Center research and translation agenda

3. Build and maintain expertise in applied prevention research and public health practice in order to leverage this capacity for expanded Center activity

4. Engage translation partners to increase translation of research findings into public health practice

5. Disseminate knowledge and translation products of the Center

6. Conduct activities to support translation of Center products

7. Train public health and medical practitioners and students, and multisector practitioners

8. Communicate about Center activities and products

9. Participate in the PRC Network

Core Research Project Component

1. Engage community members, governmental, non-governmental, and private sector partners to build community capacity for the Core Research Project

2. Complete Core Research Project

3. Disseminate Core Research Project findings and products

4. Initiate translation activities to achieve large-scale adoption of effective interventions

This NOFO will support activities that achieve short term, intermediate term, and long-term outcomes identified in the Prevention Research Centers Program Logic Model for DP19-001, including both a Center Component and Core Research Project Component.

Center Component This NOFO will support the following Center activities:

1. Establish and maintain PRC infrastructure (including Community Advisory Board) Academic institutions should provide institutional support to establish, sustain, or enhance the organizational infrastructure and facilities needed to operate the PRC. Institutional support is critical to sustaining the scientific and financial administration of the PRC. Commitment by the academic institution to support the PRC is demonstrated by sharing of resources, i.e. additional funding, or other resources, return of Facilities & Administration costs as defined by CDC policy and regulations. Additional infrastructure of the PRC would consist of the PRC Administrative team and the Community Advisory Board.

The PRC Principal Investigator (PI) attracts and leads multidisciplinary faculty and staff to accomplish the goals and objectives of the PRC and support long-range planning and implementation of the PRC's research and translation agenda. The PI develops a unified operating infrastructure that ensures resources and processes are in place to conduct and monitor center activities and promote career development among faculty and staff.

PRC faculty and staff should possess the capacity and experience to administer a high-quality prevention research center and conduct rigorous applied public health prevention research in community settings.

The PRC's administrative team should consist of required key personnel - Principal Investigator/Project Director (PI/PD), Authorized Official Representative (AOR), the Signing Official (SO) and Administrative Official (AO), PRC Deputy Director, and Core Research Project PI. Additional staff may provide expertise in evaluation, communication, dissemination, translation, and estimating cost of the intervention.

This administrative capacity can be demonstrated by a Center level organizational chart, institutional support, and the proposed application budget and budget justification.

Community Advisory Board

The PRC will maintain a Community Advisory Board (CAB) to advise the Center on its research and translation agenda, translation plan, Center activities, and Core Research Project. The CAB should have the capacity and experience working with the target populations and community.

The Community Advisory Board (CAB) should have Standard Operating Procedures with defined roles, responsibilities, operating guidelines and procedures, and training and knowledge requirements.

The CAB should include a member of the community and population where the Core

Research Project will occur, multisector partners, and other key stakeholders with experience working in the proposed research topic who can provide input on Center activities and the Core Research Project design, implementation, dissemination activities and execution of the translation plan.

The CAB should develop expertise and commitment to the PRC's area of focus.

The contribution of the CAB can be demonstrated by signed Memorandum of

Understanding (MOU) or Memorandum of Agreement (MOA) from existing or prospective community advisory board members. The MOU or MOA should clearly specify the activities to be conducted by the board member, roles and responsibilities of the PRC, the roles and responsibilities of the board, and the expected goals of the collaboration.

2. Establish a Center research and translation agenda

Identify proposed prevention research center's area(s) of focus The PRC will develop a 5-year applied prevention research and translation agenda to guide its Center activities, Core Research Project, and other projects to expand its research portfolio. The research and translation agenda would build on the expertise of faculty and staff and address the needs of community partners.

The research and translation agenda should describe the high-level strategies the recipient will undertake to translate the findings and products of the Core Research Project and other Center research, and projects or initiatives into public health practice.

The PRC's research and translation agenda should be provided as part of the application and included in the Appendix section.

3. Build and maintain expertise in applied prevention research and public health practice in order to leverage this capacity for expanded Center activity

PRC faculty and staff should possess the capacity to conduct high quality applied public health prevention research on approaches and strategies that improve population health outcomes, and provide services such as public health practice competency training to practitioners, applied prevention research training to students, public health needs assessment, and evaluation services to local, state, tribal or national agencies and CDC funded state and local health departments.

The PRC should identify and promote main areas of expertise to partners and practitioners so these areas of expertise are widely known.

The PRC can leverage this expertise to expand Center activities.

4. Engage translation partners to increase translation of research findings into public health practice

The PRC is expected to collaborate with key stakeholders to test interventions, implement program strategies, sustain outcomes, and exchange of information between experts working in various areas of public health, governmental, and non-governmental sectors.

The PRC is expected to collaborate with stakeholders vital to development of the

Center's research and translation agenda, and Core Research Project through the planning, implementation, analyses/evaluation, dissemination, and translation stages of research.

These key stakeholders should be identified in the Translation Plan with explanation of how the stakeholders would be involved in the research and translation processes.

Key stakeholders may include community organizations, multi-sectoral partners, non-profit organizations, health departments, and other agencies.

Engage stakeholders with the capacity to take effective interventions to scale.

5. Disseminate knowledge and translation products of the Center

Conduct targeted distribution of both research findings and translation products that result from effective research findings to community, practice and academic audiences.

Dissemination of research findings could include peer-reviewed journal articles, peer-reviewed conference presentations, and books or book chapters. Products could include research tools, public health practice tools, and packaged evidence based interventions.

6. Conduct activities to support translation of Center products

Use a translation framework (i.e. Knowledge into Action Framework) to guide planning for Center translation activities.

Collaborate with key stakeholders to identify strategies to translate the findings and products of Center research for widespread use.

7. Train public health and medical practitioners and students, and multisector partners

Serve as a training resource for public health students, medical students, preventive medicine residents, and multisector partners to expand awareness of effective population health approaches to address health disparities and promote health equity.

Provide prevention research training for public health students, medical students, or postdoctoral fellows to establish a pipeline of applied prevention researchers skilled in community engagement.

Provide practitioners and communities with training in areas such as how to implement effective interventions, use translation products, evaluate programs and practices, or conduct public health system assessments to improve population health outcomes.

Trainings would include practicum, internships, fellowships, and workshops for community members and stakeholder organizations.

Allocate not more than seven percent (7%) of proposed application budget (direct and indirect costs) to support training activities. Academic instruction and large scale public health training programs are not supported under this NOFO.

8. Communicate about Center activities and products

The PRC should promote its skills, knowledge, areas of expertise, and products within the institution and to external key audiences.

Communication channels would include the development and maintenance of PRC branded website, electronic and print materials, social media and any innovative channels to describe the Center's research, activities, products, and resources.

9. Participate in the PRC Network The intent of this NOFO is to support a network of Health Promotion and Disease Prevention Research Centers (PRCs) across the country. PRCs funded under this NOFO will build on the strong achievements of previous PRC Network members and advance the PRC Program's mission and prevention research activities.

PRCs are expected to participate as a member of the PRC Network by:

Participating in PRC Network activities and committees, such as the steering committee, operations committee, community committee, and Communities of Practice.

Collaborating with tribal, territorial, state, or local health departments to provide technical assistance and subject matter expertise to develop, enhance, or improve public health practice, programs or activities.

Collaborating with partner organizations to promote applied public health prevention research and its contribution to public health practice, e.g. Association of Schools and Programs of Public Health (ASPPH), American College of Preventive Medicine (ACPM), Association of American Medical Colleges (AAMC), Association State and Territorial Health Officers (ASTHO), National Association for County Community and Economic Development (NACCED), etc.

Collaborating with partner organizations to advance community engaged research and prevention implementation science, e.g. CTSAs, PCORIs, PBRNs, etc.

Collaborating with other network members to increase the PRC Network's collective impact in applied public health prevention research and public health practice to improve population health outcomes.

To ensure adequate resources are committed to this component, at least thirty percent (30%) of the funding (direct and indirect costs) provided through this NOFO should be used to support the Center Component activities.

Core Research Project Component The NOFO will support one (1) applied public health prevention research project (Core Research Project) which uses a community engagement approach to address a major cause of disease, disability, injury, or death in a population experiencing health disparities.

The Core Research Project should address one of the three prevention research categories listed below:

Intervention research - research that addresses a significant gap in the evidence of effective health promotion and disease prevention interventions such as those outlined in each review found in the Guide to Community Preventive Services, or as outlined in the 2016 (or subsequent years) Community Preventive Services Task Force (CPSTF), Annual Report to Congress. Approximately twenty percent (20%) of selected applications/awards.

o Examples of Intervention research might include research that tests the effectiveness of an intervention in improving population health outcomes by using community economic development approaches, or for health topics where effective interventions have not previously been identified or for which previous interventions have not been effective and effective interventions do not currently exist.

Implementation research - research that tests the processes by which a previously proven intervention is translated into public health practice during implementation;

research that identifies facilitators and barriers to effectiveness in systems of public health practice, which can include small or large-scale implementation. Approximately forty percent (40%) of selected applications/awards.

o Examples of Implementation research might include research examining organizational or community barriers and facilitators to participation in an intervention; factors in effectiveness while expanding implementation of an effective intervention to multiple localities; examination of costs and other factors impacting decisions to adopt; identification of facilitators to widespread adoption and scale-up, etc. (These examples are intended to be illustrative and are not exhaustive of this category).

Public health practice-based evidence research - research that examines the effectiveness of public health practice-based strategies and interventions that are being used in the field, but which have not been fully tested and evaluated, or for which substantial and consistent evidence has not yet been established. Approximately forty percent (40%) of selected applications/awards.

o An example of a Public Health Practice-based research project would be a rigorous study to test whether an existing program in a practice-based environment is effective in improving population health outcomes. Additionally, through the rigorous study of the program's delivery, potentially compared with standard practice or some other control environment, facilitators and barriers to effective program delivery would be identified, and recommendations on whether the program has sufficient evidence of effectiveness can be determined.

Research in all three categories should be designed with the goal of sustainability and scalability of strategies and interventions that are found to be effective. The Core Research Project must reflect one of these three categories of public health research. Etiological research will not be supported by this NOFO.

An important component of all study types would be the evaluation of the cost of implementation and/or scaling of the research intervention through an economic analysis. The addition of economic evaluation of the cost of implementing the intervention is integral to public health professionals, practitioners, and organizations decision to adopt related to which interventions offer the most improvement of health while minimizing costs.

This NOFO will support the following Core Research Project activities:

1. Engage community members, governmental, non-governmental, and private sector partners to build community capacity for the Core Research Project

The Core Research Project should use a community engagement approach to address a major cause of disease, disability, injury, or death in a population experiencing health disparities.

The PRC should collaborate with the PRC Community Advisory Board (CAB) in all phases of the Core Research Project including project design, implementation, dissemination activities, execution of the translation plan, and long-term sustainability of the intervention.

Members of the defined community and population addressed by the Core Research Project should be represented on the CAB and fully engaged in all phases of the Core Research Project.

Core Research Project findings should be shared with the relevant targeted community.

2. Complete Core Research Project

Develop a project timeline that incorporates strategies for the completion of the Core Research Project including recruitment, data collection and analyses, dissemination of research findings, determination of effectiveness, decision to translate, and translation of the project at the local, regional or state level within the five-year project period.

3. Disseminate Core Research Project findings and products

Dissemination of Core Research Project findings and products should occur for each of the three categories of research.

Seek venues for dissemination of Core Research Project findings and products in databases of effective interventions, and systematic and policy reviews such as but not limited to the following:

o Cochrane Reviews, http://www.cochranelibrary.com/cochrane-database-of-syste matic-reviews/ o National registry of evidence-based programs and practices, http://www.nrepp .samhsa.gov/ o Research tested intervention programs, http://rtips.cancer.gov/rtips/index.do;

o CDC database of evidence-based interventions, https://effectiveinterventions.cdc

.gov/en/AboutDebi.aspx o What Works for Child and Youth Development: Tools for Improving Services to

Children and Youth (Child Trends), https://www.childtrends.org/what-works /program-descriptions/ o AHRQ Innovations Exchange, https://innovations.ahrq.gov/about-us Create dissemination products to share information about research findings with key audiences in creative formats (e.g. infographics, etc.).

Publish and present Core Research Project findings through peer-reviewed channels.

Disseminate Core Research Project findings to relevant targeted community, practice, and academic audiences.

Dissemination products could include books and book chapters, peer-reviewed journal articles and peer-reviewed presentations, and evaluated research tools and public health http://www.cochranelibrary.com/cochrane-database-of-systematic-reviews/ http://www.cochranelibrary.com/cochrane-database-of-systematic-reviews/ http://www.nrepp.samhsa.gov/ http://www.nrepp.samhsa.gov/ http://rtips.cancer.gov/rtips/index.do https://effectiveinterventions.cdc.gov/en/AboutDebi.aspx https://effectiveinterventions.cdc.gov/en/AboutDebi.aspx https://www.childtrends.org/what-works/program-descriptions/ https://www.childtrends.org/what-works/program-descriptions/ https://innovations.ahrq.gov/about-us practice tools.

Post peer-reviewed publications and other dissemination products on the Center?s website.

4. Initiate translation activities to achieve large-scale adoption of effective interventions

Provide a translation plan which describes the anticipated strategies and activities you will undertake to translate the findings and products of effective Core Research Project into practice.

The Translation Plan should include the following:

o The plan should consider factors that organizations often consider in their decision to adopt interventions.

o Include key stakeholders and potential adopters/implementers, resources needed for start-up and sustainability in the implementation setting, and partnerships for potential scale-up.

o The Core Research Project should be guided by a translation framework (e.g.

Knowledge into Action Framework, see Appendix 2) to guide planning for translation activities.

o Engage the core research project community to participate in design and completion of the project and collaborate for long-term sustainability of the intervention by the partner.

o Packaging of research findings into implementation products, e.g. programs, policies, toolkits, guidelines, training guides for use by implementers and potential adopters.

o Engage additional partners that have the ability to adopt the intervention for widespread, sustained and scaled-up implementation.

o Consider what technical support is needed by adopters for successful implementation and what entities would best provide this support.

o For effective research projects that will be translated, quantify the cost of implementation of the research intervention through a cost analysis.

To ensure adequate resources are committed to this component, at least fifty percent (50%) of the funding (direct and indirect costs) provided through this NOFO should be used to support the design, development, implementation, dissemination, and translation of the Core Research Project Component activities A portion of Core Research Project funding may include costs of developing translation products.

Objectives/Outcomes Recipients are expected to contribute to the NOFO outcomes by the conclusion of the funding period (9/29/2024). Short term, intermediate term, and long term outcomes expected to be accomplished because of this NOFO are listed in the NOFO logic model and will be evaluated using the PRC Program Evaluation Reporting System. Recipients are expected to achieve short term and intermediate term outcomes within the 5-year funding period.

Long Term Outcomes:

Improved population health, elimination of health disparities, and achievement of health equity Increased widespread, sustained and scaled-up use of evidence-based programs and systems-wide population health strategies

Intermediate Term Outcomes:

Increased adoption of evidence-based programs and policies Increased implementation of effective systems-wide strategies that improve population health Increased translation of evidence-based research into practice

Short Term Outcomes:

Expanded capacity nationally for applied prevention research Expanded engagement between researchers and organizations with implementation capacity Expanded translation activity and infrastructure bridging research and practice Expanded awareness of effective population health approaches amongst public health, medical and private sector practitioners Expanded knowledge from one core research project Expanded availability of evidence-based strategies, interventions, and implementation tools Expanded community capacity for research and translation

Expanded activity to achieve large-scale adoption of core research findings and products

Target Population

The PRC program aims to improve population health outcomes and contribute to the elimination of health disparities. This NOFO addresses the public health needs of population groups that exhibit incidences of disease, which are most amenable to prevention intervention such as the following populations and communities:

Populations experiencing health disparities due to race, ethnicity, gender identity, sexual orientation, geography (rural, urban), socioeconomic status, disability status, primary language, health literacy, and other relevant dimensions (e.g., tribal communities).

Communities disadvantaged by social determinants of health that…