cdc-rfa-dp-26-0227.pdf

Division of Population Health

Notice of Funding Opportunity

Application due Friday, June 26, 2026

Public Health Strategies to Address Alzheimer's Disease and Related Dementias:

The National Healthy Brain Initiative, BOLD Public Health Centers of Excellence, and Public Health Adoption Accelerator Opportunity number: CDC-RFA-DP-26-0227

Contents

Step 1: Review the Opportunity 4

Basic information 5

Eligibility 7

Agency priorities 10

Program description 13

Step 2: Get Ready to Apply 43

Get registered 44

Find the application package 45

Help applying 45

Step 3: Build Your Application 46

Application checklist 47

Application contents and format 49

Step 4: Understand Review, Selection, and Award 66

Application review 67

Award notices 69

Step 5: Submit Your Application 70

Submission requirements and deadlines 71

Step 6: Learn What Happens After Award 72

Post-award requirements and administration 73

Termination 76

Contacts and Support 77

Before you begin 3

Contents 2

Before you begin If you believe you are a good candidate for this funding opportunity, secure your SAM.gov and Grants.gov registrations now. If you are already registered, make sure your registrations are active and up-to-date.

SAM.gov registration (this can take several weeks) You must have an active account with SAM.gov. This includes having a Unique Entity Identifier (UEI).

See Step 2: Get Ready to Apply

Grants.gov registration (this can take several days) You must have an active Grants.gov registration. Doing so requires a Login.gov registration as well.

See Step 2: Get Ready to Apply

Apply by the application due date Applications are due by 11:59 p.m. Eastern Time on Friday, June 26, 2026.

To help you find what you need, this NOFO uses internal links. In Adobe Reader, you can go back to where you were by pressing Alt + Left Arrow (Windows) or Command + Left Arrow (Mac) on your keyboard.

Before you begin 3 https://sam.gov/ https://grants.gov/

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1:

Review the Opportunity

In this step

Basic information 5

Eligibility 7

Agency priorities 10

Program description 13

Basic information Centers for Disease Control and Prevention (CDC)

National Center for Chronic Disease Prevention and Health Promotion

Division of Population Health

Advancing public health efforts and promoting data-driven strategies to address Alzheimer’s disease and related dementias (ADRD).

Have questions?

Go to Contacts and Support.

Key facts

Opportunity name:

Public Health Strategies to Address Alzheimer’s Disease and Related Dementias: The National Healthy Brain Initiative, BOLD Public Health Centers of Excellence, and Public Health Adoption Accelerator

Opportunity number:

CDC-RFA-DP-26-0227

Assistance listing:

93.334

NOFO version: Original

Key dates

Application submission deadline:

Friday, June 26, 2026

Expected award date:

August 29, 2026

Expected start date:

September 30, 2026

See Submit Your Application for other time frames that may apply to this NOFO.

Summary This NOFO will fund several organizations to build and translate the evidence base for promoting brain health to support nationwide adoption and use of this evidence to address the needs of all people affected by Alzheimer’s disease and related dementias (ADRD).

Funded organizations will provide expertise to state, tribal, local, and territorial (STLT) public health agencies, including Building Our Largest Dementia (BOLD) public health programs (funded through CDC-RFA- DP-23-0010 [PDF]). Their input will assist these agencies in implementing the Healthy Brain Initiative (HBI) State and Local Road Map for Public Health:

2023–2027 [PDF] to advance the goals of the Building Our Largest Dementia (BOLD) Infrastructure for Alzheimer’s Act (P.L. 115-406) [PDF] .

This NOFO will fund three integrated components to accomplish these goals.

Funding details Funding type: Cooperative agreement

Expected awards: At least seven

Period of performance: Five years in 12-month budget periods.

Expected total program funding over the performance period: $35,000,000

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 5 https://apply07.grants.gov/apply/opportunities/instructions/PKG00279311-instructions.pdf https://apply07.grants.gov/apply/opportunities/instructions/PKG00279311-instructions.pdf https://www.cdc.gov/aging-programs/media/pdfs/2024/06/HBI-State-and-Local-Road-Map-for-Public-Health-2023-2027-508-compliant.pdf https://www.cdc.gov/aging-programs/media/pdfs/2024/06/HBI-State-and-Local-Road-Map-for-Public-Health-2023-2027-508-compliant.pdf https://uscode.house.gov/statutes/pl/115/406.pdf

Minimum and maximum award amounts over the period of performance:

• Component 1: $12,500,000 to $15,000,000.

• Component 2: $3,750,000 to $5,000,000.

• Component 3: $3,750,000 to $6,000,000.

Expected funding per applicant per 12-month budget period: $5,200,000

Funding range per applicant per budget period:

• Component 1: $2,500,000 to $3,000,000.

• Component 2: $750,000 to $1,000,000.

• Component 3: $750,000 to $1,200,000.

The number of awards is subject to available funds and program priorities.

Funding strategy We will award at least seven recipients for the three NOFO components.

Current recipients funded under DP-23-0010 are not eligible to apply to CDC-

RFA-DP-26-0227.

Component 1 We will fund at least two recipients. Component 1 applicants may apply for up to $3,000,000. Component 1 applicants may also apply for Component 2, Component 3, or both.

Component 2 We will fund at least two recipients. Component 2 applicants may apply for up to $1,000,000. Component 2 applicants may only apply for one topic-specific area. Component 2 applicants may also apply for Component 1, Component 3, or both.

Component 3 We will fund up to two recipients. Component 3 applicants may apply for up to $1,200,000. Component 3 applicants may also apply for Component 1, Component 2, or both.

Step 1: Review the Opportunity 6

Eligibility Eligible applicants Only these types of organizations may apply.

This is an open competition. Eligibility is unrestricted. Your organization may be any entity type, but you must meet the requirements noted in the initial review. State, territorial, local, and tribal government organizations may also opt to select a bona fide agent to apply on their behalf.

These types of organizations may apply:

• State governments.

• County governments.

• City or township governments.

• Special district governments.

• Independent school districts.

• Public and state-controlled institutions of higher education.

• Native American tribal governments (federally recognized).

• Public housing authorities and Indian housing authorities.

• Native American tribal organizations, other than federally recognized tribal governments.

• Nonprofits having a 501(c)(3) status, other than institutions of higher education.

• Nonprofits without 501(c)(3) status, other than institutions of higher education.

• Private institutions of higher education.

• Faith-based organizations.

• For-profit organizations other than small businesses.

• Small businesses.

Bona fide agents must submit documentation that demonstrates their arrangement with the eligible applicant. See attachments.

Step 1: Review the Opportunity 7

Responsiveness criteria We will review your application to make sure it meets these requirements.

These are the basic requirements you must meet to move forward in the competition. We won’t consider an application that:

• Is from an organization that doesn’t meet all eligibility criteria. See requirements in eligibility.

• Is submitted after the deadline.

• Proposes research activities. See the definition of research.

• Proposes budget above the maximum amount within the award range per component: $3,000,000 for Component 1, $1,000,000 for Component 2, or $1,200,000 for Component 3.

◦ Applicants may apply for one or more components (Components 1, 2, or 3) but must submit separate applications for each component.

◦ Single applications requesting funding for multiple components will be considered non-responsive and will not receive further review..

See the application checklists to understand which elements of your application are part of the responsiveness criteria.

Application limits You must follow these limits on the number of applications your organization can submit.

Under this NOFO, you may submit only one application per component under your organization’s Unique Entity Identifier (UEI).

Cost sharing and matching funds This program has no cost-sharing requirement, meaning you do not need to contribute to the costs of this project.

If you choose to include cost-sharing funds, we won’t consider it during review. If you receive an award, we will include your voluntary commitment in the award, and you must report on the funds.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 8 https://www.cdc.gov/grants/additional-requirements/ar-31.html

Post-award requirements

Before you apply, make sure you understand the requirements that come with an award.

See Step 6: Learn What Happens After Award for information on regulations that apply, reporting, and more.

Step 1: Review the Opportunity 9

Agency priorities Required alignment with CDC priorities The recipient of this award must implement any funds awarded under this NOFO to effectuate program goals or agency priorities in accordance with the Centers for Disease Control and Prevention (CDC) Priorities when authorized (for a full description of the CDC Priorities, please follow the provided hyperlink).

Funded activities must:

• Align with CDC’s core priorities by demonstrating a commitment to gold-standard science, transparency, and evidence-based practices.

• Support CDC’s mission to protect Americans from infectious and chronic diseases, strengthen public health systems, and advance innovation in health data and infrastructure.

• Contribute to rapid, science-driven responses to health threats, promote global health leadership, and adhere to principles of integrity, accountability, and compliance with applicable laws and federal priorities.

Consistent with CDC’s values, in carrying out any project funded under this NOFO, the recipient must adhere to the following principles where consistent with the authority and scope of the award and its activities:

• A commitment to gold-standard science and ensuring trust, transparency, and credibility: To build trust and improve CDC’s ability to lead during health crises, CDC will increase transparency, be more accountable, and follow strict, gold-standard scientific practices that are open, unbiased, and based on clear evidence.

• A commitment to global leadership: With staff in 63 countries and supporting 20 more, CDC’s Global Health Center:

◦ Work to prevent disease and advance emergency response.

◦ Detect health threats early, send response teams, train health workers, and provide personal protective equipment, vaccines, and medicines.

◦ Test disease samples from around the world to prepare for flu and other serious outbreaks.

◦ Has strengthened systems to better protect people at home and abroad after the COVID-19 outbreak.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 10 https://www.cdc.gov/about/cdc/index.html

• A commitment to ensuring rapid, evidence-based responses to crises:

During public health emergencies, ensuring rapid, science-driven responses is critical to minimizing harm, maintaining public trust, and restoring stability. To meet this goal, CDC must continue to strengthen its emergency response systems by:

◦ Streamlining internal processes.

◦ Improving risk communication strategies.

◦ Ensuring that laboratory capacity is fully equipped and tested—capable of rapidly developing and deploying scalable diagnostics during crises.

◦ Embedding structures for real-time learning, independent after-action reviews, and the application of lessons learned will ensure that each crisis response is smarter, faster, and more effective than the last.

• A commitment to vaccine safety and efficacy research: CDC will apply “gold-standard” science to all of its vaccine safety and effectiveness research. It will make vaccine data, research methods, and related datasets publicly available through simple data use agreements to improve transparency, accountability, and trust.

• A commitment to advancing our understanding of the causes of autism spectrum disorder (ASD), neurodevelopmental disorders (NDDs), and chronic disease: CDC conducts research and works with partners to better understand the causes of autism spectrum disorder, neurodevelopmental disorders, and chronic diseases. It will use new and existing data to study the rise in these conditions, including the increase in autism diagnoses from 1 in 150 to nearly 1 in 31 over the past 25 years.

• A commitment to modernizing public health infrastructure and enhancing our approach to health data: CDC will modernize public health infrastructure to create a faster, more efficient health system that can detect and respond to outbreaks in real time. This effort includes:

◦ Replacing data silos with integrated systems.

◦ Using advanced technology.

◦ Strengthening partnerships with states to ensure shared responsibility and strong local health data systems.

◦ Emphasizing collaboration across federal and state partners, resilient and adaptable systems, and accountability for funded programs to ensure they align with these priorities and federal requirements.

Step 1: Review the Opportunity 11

• Conflicts of interest: CDC will not support funding programs with conflicts of interest and ensure its work is based on transparent, unbiased science.

• Immigration: CDC funds will not be used to support or encourage illegal immigration, consistent with federal law.

• Protecting life and the family: CDC funds will not be used to support elective abortions, consistent with the Hyde Amendment, and will promote maternal health, the dignity of life, and strong families.

• Ending disorder on America’s streets: CDC will prioritize evidence-based programs that reduce homelessness, drug use, and public disorder. It will support comprehensive services for people with serious mental illness and substance use disorder. CDC will not support housing first strategies, harm-reduction or safe consumption sites, or related activities. To the extent allowable by federal law, CDC intends to give priority to grantees in States and municipalities that have laws and policies that support and enforce CDC’s priorities.

• Gender ideology and protecting children: CDC will not fund medical interventions for minors seeking gender transition and will define sex based on biological criteria.

• DEI: CDC will not support DEI initiatives based on group identity and focus on merit-based, evidence-driven approaches to improve health outcomes.

• Parental rights: CDC will support policies that protect parental authority, promote transparency, and give parents greater control over their children’s education.

The recipient must demonstrate ongoing compliance with the full description and listing of CDC values and priorities, in all programs that are authorized to advance them, through program design, implementation, reporting, and evaluation.

Failure to meaningfully align funded activities with the applicable requirements may result in corrective action, additional reporting requirements, or other enforcement actions consistent with federal grant regulations found at 2 CFR Part 200 and the terms and conditions of this award. The full CDC Priorities Statement can be found here: Centers for Disease Control and Prevention (CDC) Priorities.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 12 https://opa.hhs.gov/sites/default/files/2025-11/gender-dysphoria-report.pdf

Program description Background Alzheimer’s disease and related dementias (ADRD) are a growing public health concern among older Americans, with modifiable risk factors — including tobacco use, high blood pressure, cardiovascular disease, diabetes, physical inactivity, obesity, low educational attainment, excessive alcohol consumption, head injury, and hearing impairment — offering significant opportunities for prevention. This NOFO advances a comprehensive, population-level approach to brain health guided by the Healthy Brain Initiative (HBI) Roadmap Series. Funded activities will strengthen infrastructure, policies, and partnerships; support workforce development;

improve data collection and evaluation; and leverage proven public health frameworks from tobacco control, cardiovascular health, injury prevention, and related fields to lessen ADRD and promote cognitive health across the lifespan.

Overview Alzheimer’s disease, the most common form of dementia, is a progressive disease that begins with mild memory loss and may lead to the inability to carry on conversations and respond to one’s environment. The prevalence of Alzheimer’s disease is rising as the U.S. population ages.

• In 2022, Alzheimer’s disease was the sixth leading cause of death [PDF- 6.5MB] for people aged 65 years or older in the U.S., as well as the seventh leading cause of death overall, with death rates continuing to rise.

• By 2060, the Alzheimer’s Association projects that approximately 15 million Americans will have Alzheimer’s disease, a nearly two-fold increase.

• Caregivers for people living with dementia are also of crucial importance to addressing dementia. In 2024, family members and friends provided 19 billion hours of unpaid care to people with Alzheimer’s and other dementias, at an economic value of $413 billion.

• About 1 in 3 dementia caregivers [PDF - 2MB] report their health has gotten worse due to care responsibilities, compared with 1 in 5 caregivers of other older adults.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 13 https://www.alz.org/getmedia/ef8f48f9-ad36-48ea-87f9-b74034635c1e/alzheimers-facts-and-figures.pdf https://www.alz.org/getmedia/ef8f48f9-ad36-48ea-87f9-b74034635c1e/alzheimers-facts-and-figures.pdf https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1016/j.jalz.2017.10.009 https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1016/j.jalz.2017.10.009 https://www.alz.org/alzheimers-dementia/facts-figures https://www.caregiving.org/wp-content/uploads/2020/05/Dementia-Caregiving-Report-2017_Research-Recommendations_FINAL.pdf

While much federal investment has focused on biomedical research and direct services for dementia, implementing a coordinated, systematic public health approach to bridge these two sectors has received less attention. With its unique strength and capacity to advance awareness about the connections between brain health and physical health, public health can:

• Build on infrastructure, policies, and partnerships.

• Contribute to workforce development.

• Improve data collection, use, and evaluation.

• Educate the public.

• Harness public health messages from other public health fields, such as tobacco, blood pressure, cardiovascular health, diabetes, physical activity, obesity, education level, alcohol consumption, head injury, hearing impairment, and injury prevention, to reduce the risk of dementia and cognitive decline.

The CDC Alzheimer’s Disease Program, through the National HBI and its funded partners (CDC-RFA-DP20-2003, CDC-RFA-DP20-2005, CDC-RFA- DP-23-0010, and CDC-RFA-PW-24-0080), provides data and information to promote brain health, address cognitive impairment, and meet caregivers’ needs through evidence-based public health action. This funding opportunity aligns with actions described in the Healthy Brain Initiative Road Map series, including the State and Local Road Map for Public Health: 2023–2027 [PDF - 20.4MB] and the Road Map for American Indian and Alaska Native Peoples [PDF -17.5MB]. The series and its supporting materials will guide your activities during this project.

This funding opportunity also aligns with the activities described in the Building Our Largest Dementia (BOLD) Infrastructure for Alzheimer’s Act (P.L.115-406) [PDF - 312KB], which directs CDC to establish Alzheimer’s Disease and Related Dementias Public Health Centers of Excellence, provide funds to support public health departments, and increase data analysis and timely reporting.

This opportunity is made up of three components:

• Component 1: The National Healthy Brain Initiative

• Component 2: BOLD Public Health Centers of Excellence

• Component 3: ADRD Public Health Adoption Accelerator

You can apply for more than one component.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 14 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0/fulltext#:~:text=We%20reconvened%20the%20Lancet%20Commission%20on%20dementia%20prevention, https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0/fulltext#:~:text=We%20reconvened%20the%20Lancet%20Commission%20on%20dementia%20prevention, https://www.cdc.gov/aging-programs/?CDC_AAref_Val=https://www.cdc.gov/aging/index.html https://simpler.grants.gov/opportunity/17477611-05c0-4785-a104-07eb66c73824 https://simpler.grants.gov/opportunity/5a1f60b7-8076-48b5-8b3b-e0e2fb180df4 https://simpler.grants.gov/opportunity/6be84f80-0807-4005-b831-532493cceab3 https://simpler.grants.gov/opportunity/6be84f80-0807-4005-b831-532493cceab3 https://simpler.grants.gov/opportunity/958d3a1e-f6ab-4a7c-bcd3-d294d9c67c78 https://www.cdc.gov/aging-programs/php/nhbi/?CDC_AAref_Val=https://www.cdc.gov/aging/nationalinitiatives/national-healthy-nhbi.html https://www.alz.org/getmedia/94815e3a-0764-4b73-a0fb-cce66afd5730/healthy_brain_initiative_road_map_2023_2027.pdf https://www.alz.org/getmedia/94815e3a-0764-4b73-a0fb-cce66afd5730/healthy_brain_initiative_road_map_2023_2027.pdf https://www.alz.org/getmedia/0174f6d9-af2d-423d-84c6-c6fdc0aab804/hbi-road-map-american-indian-alaska-native-peoples.pdf https://www.alz.org/getmedia/0174f6d9-af2d-423d-84c6-c6fdc0aab804/hbi-road-map-american-indian-alaska-native-peoples.pdf https://www.alz.org/professionals/public-health/models-frameworks/hbi-road-map

Related work

• CDC-RFA-DP20-2003: The National Healthy Brain Initiative

• CDC-RFA-DP20-2005: BOLD Public Health Centers of Excellence to Address Alzheimer’s Disease and Related Dementias

• CDC-RFA-DP-23-0010: BOLD Public Health Programs to Address Alzheimer’s Disease and Related Dementias

• CDC-RFA-PW-24-0080: Strengthening Public Health Systems and Services through National Partnerships to Improve and Protect the Nation’s Health

National public health priorities and strategies CDC-RFA-DP-26-0227 supports the following national public health priorities and strategies:

• National Alzheimer’s Project Act (Public Law 111-375)

• BOLD Infrastructure for Alzheimer’s Act (Public Law 115-406) [PDF -

312KB]

• 2022 National Strategy to Support Family Caregivers

Purpose This opportunity will fund selected organizations to build and translate the evidence base for promoting brain health and addressing the needs of all people affected by Alzheimer’s disease and related dementias (ADRD), so it can be used nationwide. This includes helping STLT public health agencies, including BOLD public health programs, to implement the Road Map Series and fulfill the aim of the Building Our Largest Dementia (BOLD) Infrastructure for Alzheimer’s Act (P.L. 115-406) [PDF - 312KB].

The three components funded in this NOFO are described below.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 15 https://simpler.grants.gov/opportunity/17477611-05c0-4785-a104-07eb66c73824 https://simpler.grants.gov/opportunity/5a1f60b7-8076-48b5-8b3b-e0e2fb180df4 https://simpler.grants.gov/opportunity/6be84f80-0807-4005-b831-532493cceab3 https://simpler.grants.gov/opportunity/958d3a1e-f6ab-4a7c-bcd3-d294d9c67c78 https://aspe.hhs.gov/collaborations-committees-advisory-groups/napa https://uscode.house.gov/statutes/pl/115/406.pdf https://uscode.house.gov/statutes/pl/115/406.pdf https://acl.gov/CaregiverStrategy

Approach Overview

Component 1:

The National Healthy Brain Initiative The purpose of Component 1 is to fund at least two organizations to develop and implement public health strategies guided by the National HBI Road Map Series.

The HBI Road Map Series advances brain health as an integral component of public health. It uses an action agenda, outlining how public health agencies and their partners can prepare all communities to act quickly and strategically by pursuing changes in policies, systems, and environments.

To achieve this goal, funded organizations, in collaboration with CDC and Component 2 and 3 recipients, will:

• Develop evidence-informed training materials for current and future health care and public health professionals about the importance of ADRD and caregiving.

• Increase the availability and use of public health surveillance information to address cognitive impairment, cognitive decline, and caregiver support. These activities include supporting the adoption and revision of the Behavioral Risk Factor Surveillance System (BRFSS) subjective cognitive decline and caregiver optional modules.

• Lead coordination of other recipients funded under this cooperative agreement, along with other national partners funded by the CDC Alzheimer’s Disease Program, to address ADRD through the HBI Collaborative.

Component 2:

BOLD Public Health Centers of Excellence The purpose of Component 2 is to fund at least two Public Health Centers of Excellence that will specialize in one of three topic-specific areas:

• Dementia risk reduction.

• Early detection and management of dementia.

• Dementia caregiving.

We will fund only one Public Health Center of Excellence for each topic-specific area.

Step 1: Review the Opportunity 16

These funded centers will:

• Support and determine the needs of BOLD public health programs and other public health agencies.

• Identify, share, and promote best practices.

• Translate promising research findings into useful tools and resources for the practice field.

• Increase professional education in ADRD.

• Develop and adapt materials to address specific individual needs to improve health outcomes.

The funded centers will provide expert guidance and technical assistance to BOLD public health programs. They will build on public health infrastructure and collaborate with national experts to make sure evidence-informed practices for their topic areas are available, shared, adopted, and evaluated.

Component 3:

ADRD Public Health Adoption Accelerator The purpose of Component 3 is to fund up to two organizations to serve as public health strategy adoption accelerator programs. These programs will use strategies for implementing and disseminating a broad range of resources to tackle ADRD.

Funded organizations will:

• Work closely with CDC staff and those working on other components of this announcement to create a prioritized list of ADRD approaches and strategies.

◦ High-priority approaches and strategies will include those that are most likely to have the greatest health impact, are most ready to be scaled up, and meet the needs of populations at highest risk for

ADRD.

• Use proven strategies to engage partners, health care organizations, and policy makers on a national scale to enhance uptake and implementation, accelerating the impact of ADRD efforts.

◦ Advise and partner with the Component 1 and 2 recipients of this NOFO, provide technical assistance to promote and share their work for maximum impact across all components.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 17 https://www.cdc.gov/aging-programs/php/bold/php-recipients.html?CDC_AAref_Val=https://www.cdc.gov/aging/funding/php/

Program logic models The following logic models includes the strategies and activities required under this NOFO.

The logic model also includes the program’s expected outcomes. Outcomes are the results that you intend to achieve. They usually show the intended direction of change, such as increase or decrease.

The asterisked (*) outcomes are those we expect you to achieve during the 5-year period of performance. You are required to report on these outcomes.

Component 1 Logic Model:

The National Healthy Brain Initiative

Strategies and activities Short-term outcomes Intermediate outcomes Long-term outcomes

Strategy 1: Educate the public and both current and future health care and public health professionals on brain health, ADRD, and caregiving.

Increased awareness of ADRD and caregiving among the public and current and future health care and public health professionals.

Increased use of ADRD and caregiving knowledge and skills among the public and current and future health care and public health professionals.

Improved risk reduction, early detection of, and caregiving for ADRD.

Strategy 2: Support the availability and use of public health surveillance information to address cognitive impairment, cognitive decline, and caregiver support.

Increased adoption of high-quality, timely ADRD public health surveillance information.

Increased use of ADRD surveillance data to inform public health decision-making.*

Increased sustainability of data-informed ADRD public health programs.

Strategy 3: Increase the adoption, implementation, and evaluation of the HBI Public Health Road Map series.

Increased community partnerships and integration with other chronic disease efforts among BOLD public health programs and others.

Increase coordination across STLT areas to support dementia and caregiving efforts.*

Increased policies, systems, and environmental changes to support brain health and reduce the burden of

ADRD.

Strategy 4: Enhance coordination among

Increased collaboration among

Increased prioritization, Improved integration and uptake of

Step 1: Review the Opportunity 18

Strategies and activities Short-term outcomes Intermediate outcomes Long-term outcomes national partners to address ADRD and caregiving.

national partners to address ADRD and caregiving.* integration, and uptake of activities to address ADRD and caregiving.

activities across ADRD topics among public health and national partners.

Component 2 Logic Model:

BOLD Public Health Centers of Excellence

Strategies and activities Short-term outcomes Intermediate outcomes Long-term outcomes

Strategy 1: Provide training and technical assistance to BOLD public health programs and other ADRD public health programs within the selected topic area.

Increased reach of training, technical assistance, and resources to support ADRD public health programs.*

Increased public health capacity to address ADRD public health actions within topic area.

Increased resilience and use of evidence-informed public health strategies to address ADRD.

Strategy 2: Support translation of ADRD research into practice within the selected topic area.

Increased adoption of actionable materials, resources, and strategies to address ADRD, informed by promising research findings.

Increased use of actionable materials, resources, and strategies to address ADRD, informed by promising research findings.*

Improved ADRD risk reduction, early detection, and caregiving practices.

Strategy 3: Develop and share topic-specific professional education and workforce training within the selected topic area.

Increased reach of opportunities for health professionals to develop and enhance their knowledge on ADRD.*

Increased integration of ADRD content within clinical, health care, and workforce curriculum and training.*

Increased competency and use of ADRD knowledge and skills by the health professional workforce.

Step 1: Review the Opportunity 19

Component 3 Logic Model:

ADRD Public Health Adoption Accelerator

Strategies and activities Short-term outcomes Intermediate outcomes Long-term outcomes

Strategy 1: Use established dissemination and implementation science principles to help increase use of those evidence-based strategies most likely to improve population health.

Increased adoption of prioritized programs and evidence-informed practices at the national level.

Increased sharing and implementation of prioritized programs and evidence-informed practices at the national level.*

Increased policy action, sharing, and implementation to address ADRD.

Strategy 2: Enhance the capacity of Component 1 and 2 recipients to promote, share, and increase uptake of tools and resources developed under this program at the STLT level.

Increased adoption of developed tools and resources at the STLT level.

Increased spread and use of evidence-informed practices at the STLT level.*

Improved public health practice informed by the use of topic-specific best practices and proven strategies.

Strategy 3: Apply communications and marketing strategies for highlighted tools and resources to ensure continuity, focus, and nationwide reach.

Increased national sharing of prioritized tools and resources through marketing and communications.*

Increased use and integration of prioritized tools and resources nationwide.

Improved risk reduction, early detection of, and caregiving for ADRD.

* Indicates outcomes you are required to report on.

Strategies and activities This section elaborates on the strategies and activities described in the logic model and provides details about how we expect you to implement your program.

Step 1: Review the Opportunity 20

If you receive funds, we will require you to implement the following strategies and activities over the five-year period of performance. If you already have any of the activities in place, we expect you to continue and expand them over that period.

You may apply for one or more of the following components:

Component 1:

The National Healthy Brain Initiative (HBI)

Strategy 1: Educate the public and both current and future health care and public health professionals on brain health, ADRD, and caregiving.

Required activities include:

• Developing broad, topic-based training materials for both current and future health care and public health professionals on the importance of ADRD and caregiving.

• Implementing related communications and other activities to increase awareness of these education materials.

• Evaluating the effectiveness and use of these education materials.

• Providing a robust web presence with national resources for both current and future health care and public health professionals.

Strategy 2: Support the availability and use of public health surveillance information to address cognitive impairment, cognitive decline, and caregiver support.

Required activities include:

• Assisting with adoption, review, and potential revision of the BRFSS cognitive decline and caregiver modules.

• Promoting adoption and implementation of the BRFSS cognitive decline and caregiver modules among states and territories.

• Forming a panel of subject matter experts with different expertise for review and potential revision of BRFSS modules.

• Assisting with Healthy People objective analysis related to cognitive impairment, including ADRD.

Step 1: Review the Opportunity 21

Strategy 3: Increase the adoption, implementation, and evaluation of the HBI Public Health Road Map series.

Required activities include:

• Supporting implementation of the fourth HBI Road Map for State and Local Public Health and the Road Map for American Indian and Alaska Native Peoples.

• Developing action-based implementation guides, specific to the complex needs population, to support state and local public health implementation of the HBI Road Map Series actions.

• Evaluating the fourth HBI Road Map for State and Local Public Health and the Road Map for American Indian and Alaska Native Peoples.

• Developing and sharing the next update of the State and Local Public Health Road Map and the HBI Road Map for American Indian and Alaska Native Peoples, along with additional Road Map products such as topic-specific maps or language-specific products.

Strategy 4: Enhance coordination among national partners to address ADRD and caregiving.

Required activities include:

• Leading and actively participating in the HBI Collaborative. The HBI Collaborative brings together recipients of all three components to coordinate and align on common goals.

• Convening the HBI Collaborative on a regular basis to share ongoing planning and implementation efforts related to the cooperative agreement. Looking for ways to combine and use activities and resources to make the biggest impact.

Component 2:

BOLD Public Health Centers of Excellence You may apply for only ONE of the following topic-specific Public Health Centers of Excellence:

• Public Health Center of Excellence on Dementia Risk Reduction.

• Public Health Center of Excellence on Early Detection and Management of Dementia.

• Public Health Center of Excellence on Dementia Caregiving.

Step 1: Review the Opportunity 22

Strategy 1: Provide training and technical assistance to BOLD public health programs and other ADRD public health programs within the selected topic area.

Required activities include:

• Assessing and identifying differences in training, technical assistance, and support needs among BOLD public health programs.

• Providing technical assistance and support to BOLD public health programs and other STLT public health agencies with Road Map implementation within topic area.

• Developing and expanding available content in their topic specific area for use by BOLD public health programs and other STLT public health agencies and making it publicly available.

• Coordinating with national partners and other federally funded BOLD Public Health Centers of Excellence.

• Coordinating with the other BOLD Public Health Centers of Excellence to convene an annual national meeting or summit to bring together public health professionals and others to promote, discuss, and understand new and emerging science, and to discuss comprehensive public health approaches to addressing dementia within each topic area.

• Participating in the HBI Collaborative as an active member to share and inform ongoing planning and implementation efforts related to the cooperative agreement.

Strategy 2: Support translation of ADRD research into practice within the selected topic area.

Required activities include:

• Identifying, and sharing promising research findings, and translating them into actionable activities, materials, and resources for use by BOLD public health programs and other public health agencies.

• Evaluating the effectiveness and use of tools and resources developed for public health. Ensuring effective tools are clearly identified and widely shared to relevant audiences.

Step 1: Review the Opportunity 23

Strategy 3: Develop and share topic-specific professional education and workforce training within the selected topic area.

Required activities include:

• Identifying and addressing specific knowledge and skills needs within your topic-specific area among health care professionals, community health workers, patient navigators, and other relevant professionals.

• Coordinating with relevant organizations and institutions to expand the reach and uptake of professional education and workforce training for their topic-specific area.

• Evaluate effectiveness and reach of the education and workforce training being delivered, including changes in policies and practices.

• Updating materials and training as needed to keep pace with evolving landscape in the topic area.

Component 3:

ADRD Public Health Adoption Accelerator During the period of performance, you will conduct activities under the three main strategies:

Strategy 1: Use established dissemination and implementation science principles to help increase the use of those evidence-based strategies most likely to improve population health.

Required activities include:

• Working with CDC to develop a process to identify the potential strategies or materials most likely to have the greatest health impact on outcomes of interest among all populations.

• Working with CDC and other funded partners to identify variations in the use of evidence-based practices (or practice-based evidence) and impediments and facilitators to using prioritized strategies.

• Developing criteria and creating a prioritized list of evidence-informed materials for targeted action.

• Working with CDC and other partners to develop a detailed sharing and implementation plan for each prioritized strategy or material.

Step 1: Review the Opportunity 24

Strategy 2: Enhance the capacity of Component 1 and 2 recipients to promote, share, and increase uptake of tools developed under this program at the STLT level.

Required activities include:

• Providing training and technical assistance to Component 1 and 2 recipients to help them prioritize and develop approaches to knowledge translation, intervention implementation, product and tool promotion, and dissemination strategies to maximize reach, uptake, and effective use.

• Participating in the HBI Collaborative as an active member to share and inform ongoing planning and implementation efforts related to the cooperative agreement.

Strategy 3: Apply communications and marketing strategies for highlighted products to ensure continuity, focus, and nationwide reach.

Required activities include:

• Developing a marketing and communications plan to enhance sharing and uptake of highlighted products from Component 1 and 2 recipients and other sources to ensure continuity, focus, and nationwide reach.

• Implementing the marketing and communications plan.

• Evaluating agreed-upon aspects of the marketing and communications plan.

All recipients will use the State and Local Public Health Partnerships to Address Dementia: The 2023-2027 Road Map (RM) [PDF - 20.4MB] and the Road Map for American Indian and Alaska Native Peoples [PDF - 17.5MB] as a resource for their work.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 25 https://www.cdc.gov/aging-programs/media/pdfs/2024/06/HBI-State-and-Local-Road-Map-for-Public-Health-2023-2027-508-compliant.pdf https://www.cdc.gov/aging-programs/media/pdfs/2024/06/HBI-State-and-Local-Road-Map-for-Public-Health-2023-2027-508-compliant.pdf https://www.cdc.gov/aging-programs/media/pdfs/road-map/AIAN-Peoples-Roadmap-2024-508.pdf https://www.cdc.gov/aging-programs/media/pdfs/road-map/AIAN-Peoples-Roadmap-2024-508.pdf

Outcomes This section includes information about the outcomes we expect you to report progress on and achieve within the performance period.

For all recipients, as presented in the logic model for your component, we expect that you will achieve the asterisked short-term and intermediate outcomes during the period of performance. These outcomes include:

Component 1: The National Healthy Brain Initiative

• Increased use of ADRD-related surveillance to inform public health decision making.

• Increased coordination across jurisdictions for dementia and caregiving work.

• Increased collaboration among national partners to address ADRD and support caregiving.

Component 2: BOLD Public Health Centers of Excellence

• Increased reach of training, technical assistance, and resources to ADRD public health programs.

• Increased use of actionable materials, resources, and strategies to address ADRD, informed by promising research findings.

• Increased reach of opportunities for health professionals to develop and enhance their knowledge on ADRD.

• Increased integration of ADRD content in clinical, health care, and workforce education programs and training.

Component 3: ADRD Public Health Adoption Accelerator

• Increased implementation of selected programs and evidence-informed practices at the national level.

• Increased spread and use of evidence-informed practices at the STLT level.

• Increased national sharing of highlighted tools and resources through marketing and communications.

Step 1: Review the Opportunity 26

Work plan You must provide a work plan for your project. The work plan connects your performance outcomes, strategies and activities, and measures. It provides more detail on how you will measure outcomes and processes.

You must provide a detailed work plan for Year 1 of your project, and a high-level work plan for Years 2 through 5. The work plan assists the CDC project officer in monitoring recipient activities and reflects activities supported by the annual budget award.

Please provide additional details for these activities in the Project narrative section of your application, where indicated.

The work plan connects your period of performance outcomes, strategies and activities, and measures. It provides more detail on how you will measure outcomes and processes.

We do not require a specific work plan format, as long as it is clear to reviewers how the components in the work plan relate to the strategies and activities, outcomes, and the evaluation and performance measures presented in the logic model and the narrative sections of the NOFO.

The table below provides an example to show how you can present your work plan. If you choose to use a different format, you must include the information below.

Step 1: Review the Opportunity 27

Table: Sample format

Activities you will implement

Progress or process measures

From the Data, monitoring, and evaluation section.

Relevant period of performance outcomes

From the Outcomes section.

Responsible position or party

Completion date

Strategy 1: (Use

SMART*

objectives for each strategy)

1.

2.

3.

Strategy 2: (Use

SMART*

objectives for each strategy)

1.

2.

3.

* SMART – Specific, Measurable, Attainable, Realistic, Timely.

For each strategy, the work plan will include activities, appropriate and relevant process measures (from the Evaluation and performance measurement plan), responsible team members, and planned start and end dates.

CDC will provide feedback and technical assistance to finalize the work plan activities post-award.

Complete the strategy and activities table as shown here for each of the strategies listed in the Program logic model.

Step 1: Review the Opportunity 28

Data, monitoring, and evaluation CDC strategy CDC collects and reports on indicators to measure progress toward achieving the activities and outcomes. CDC will also use results for program planning, improvement, accountability, and reporting. CDC will share the results with key parties.

CDC will work with you throughout the life of an award to ensure that all activities and expected outcomes align with your strategies and goals, and those of the U.S. government.

You should dedicate some of award funds to evaluate and monitor the performance of your project. You and CDC will agree on the final funding amount, but we expect that you will dedicate approximately 5 to 10% of your project’s funding to monitoring, reporting, and evaluation activities.

Evaluation and performance measurement help to:

• Demonstrate achievement of program outcomes.

• Build a stronger evidence base for specific strategies and activities.

• Clarify how the evidence base applies to different populations and contexts.

• Drive continuous improvement.

CDC will use evaluation findings to:

• Ensure progress and ongoing agreement.

• Show progress toward short-term outcomes and program goals.

• Improve and inform ongoing and future activities.

CDC will also use existing data sources, in addition to performance measurement data submitted by recipients, to conduct a comprehensive evaluation that will:

• Assess progress toward NOFO outcomes.

• Identify areas for improvement.

• Inform future efforts to enhance the reach and effectiveness of funded initiatives.

Step 1: Review the Opportunity 29

Required performance measures This section describes the draft performance measures you will need to report on after award. We will likely refine the required measures for this program. If so, we will work with you and finalize them before we require you to submit any data.

You must track evaluation and performance measures and report process to CDC using a CDC-defined format and timeline.

Component 1: The National Healthy Brain Initiative

Outcomes you must report on Performance measure

Increased use of ADRD surveillance to inform public health decision making.

Number and category of public health agencies using ADRD-related surveillance, including the optional BRFSS cognitive decline and caregiver modules.

Increased coordination across jurisdictions for dementia and caregiving work.

Number of Road Map actions implemented by state, local, and territorial health departments, tribes and tribal organizations.

Increased collaboration among national partners to address ADRD and caregiving.

Number and category of national partners engaged in collaborative activities.

Step 1: Review the Opportunity 30

Component 2: BOLD Public Health Centers of Excellence

Outcomes you must report on Performance measure

Increased reach of training, technical assistance, and resources to ADRD public health programs.

Number of STLT public health agencies reached with ADRD evidence-informed tools, trainings, and technical assistance.

Increased use of actionable materials, resources, and strategies to address ADRD, informed by promising research findings.

Number and type of state, local, and tribal public health agencies and other partners using or adopting topic-specific tools and materials.

Increased reach of opportunities for health professionals to develop and enhance their knowledge of ADRD.

Number and categories of entities reached with topic-specific professional education and workforce development materials.

Increased integration of ADRD content within clinical, health care, and workforce curriculum and training.

Number and categories of ADRD content integrated within clinical, health care, and workforce curriculum and training.

Component 3: Public Health Adoption Accelerator

Outcomes you must report on Performance measure

Increased implementation of selected programs and evidence-informed practices at the national level.

Number and categories of evidence-informed tools, trainings, and other practices used by organizations at the national level.

Increased spread and use of evidence-informed practices at the STLT level.

Number and categories…