CDC-RFA-CK21-2105 rev1.pdf

Centers for Disease Control and Prevention

National Center for Emerging and Zoonotic Infectious Diseases

Strengthening animal health systems to enhance prevention, detection and response to emerging zoonotic diseases

CDC-RFA-CK21-2105

Application Due Date: May 28, 2021

Table of Contents A. Funding Opportunity Description

B. Award Information

C. Eligibility Information

D. Application and Submission Information

E. Review and Selection Process

F. Award Administration Information

G. Agency Contacts

H. Other Information

I. Glossary

Part I. Overview Applicants must go to the synopsis page of this announcement at www.grants.gov and click on the "Subscribe" button link to ensure they receive notifications of any changes to CDC-RFA- CK21-2105. Applicants also must provide an e-mail address to www.grants.gov to receive notifications of changes.

A. Federal Agency Name:

Centers for Disease Control and Prevention (CDC) / Agency for Toxic Substances and Disease Registry (ATSDR) B. Notice of Funding Opportunity (NOFO) Title:

Strengthening animal health systems to enhance prevention, detection and response to emerging zoonotic diseases C. Announcement Type: New - Type 1 This announcement is only for non-research activities supported by CDC. If research is proposed, the application will not be considered. For this purpose, research is defined at https://www.gpo.gov/fdsys/pkg/CFR-2007-title42-vol1/pdf/CFR-2007-title42-vol1-sec52- 2.pdf. Guidance on how CDC interprets the definition of research in the context of public health can be found at https://www.hhs.gov/ohrp/regulations-and-policy/regulations/45-cfr- 46/index.html (See section 45 CFR 46.102(d)).

D. Agency Notice of Funding Opportunity Number:

CDC-RFA-CK21-2105

E. Assistance Listings Number:

93.318 F. Dates:

1. Due Date for Letter of Intent (LOI):

NA

https://www.grants.gov/ https://www.grants.gov/ https://www.gpo.gov/fdsys/pkg/CFR-2007-title42-vol1/pdf/CFR-2007-title42-vol1-sec52-2.pdf https://www.gpo.gov/fdsys/pkg/CFR-2007-title42-vol1/pdf/CFR-2007-title42-vol1-sec52-2.pdf https://www.hhs.gov/ohrp/regulations-and-policy/regulations/45-cfr-46/index.html https://www.hhs.gov/ohrp/regulations-and-policy/regulations/45-cfr-46/index.html

2. Due Date for Applications:

05/28/2021 11:59 p.m. U.S. Eastern Standard Time, at www.grants.gov.

3. Due Date for Informational Conference Call:

N/A

G. Executive Summary:

1. Summary Paragraph The purpose of the program is to support recipient activities that will build capacities of national governments and regional authorities to address emerging infectious diseases, including zoonoses, at the animal-human-environment interface and other public health threats, as well as strengthen animal health and public health services. These capacities will help countries and regions conduct disease surveillance, monitoring and response; improve data sharing across sectors; map, identify and predict disease risks; prevent and control disease emergence and re-emergence in animal populations and subsequent spread into human populations; and develop effective evidence-based guidance and national standards to effectively address emerging infectious diseases.

a. Eligible Applicants:

Single

b. Funding Instrument Type:

CA (Cooperative Agreement)

c. Approximate Number of Awards

d. Total Period of Performance Funding:

$ 3,000,000

e. Average One Year Award Amount:

$ 1,000,000 The average award in year 1 will be $1,000,000.

f. Total Period of Performance Length:

g. Estimated Award Date:

July 01, 2021

h. Cost Sharing and / or Matching Requirements:

No Cost sharing or matching funds are not required for this program. Although no statutory matching requirement for this NOFO exists, leveraging other resources and related ongoing efforts to promote sustainability is strongly encouraged.

Part II. Full Text A. Funding Opportunity Description https://www.grants.gov/

1. Background

a. Overview The Centers for Disease Control and Prevention intends to establish a cooperative agreement with the recipient as part of the CDC strategy to address emerging infectious diseases at the animal-human-environment interface. Over 60% of all diseases known to infect humans are zoonotic, or transmissible between animals and humans. Approximately 75% of emerging or re-emerging infectious diseases and 80% of those with bioterrorism potential are zoonotic, and an estimated 20% of human illness and death in the least developed countries are due to endemic zoonotic disease. The majority of these diseases also have negative effects on animal health and livestock production, and thereby impact food safety and security, environmental health, and threaten trade and travel. These impacts make human and animal health sector collaboration and a One Health approach integrating public health, agriculture, wildlife and environmental sector activities essential for zoonotic disease control and prevention.

This NOFO will allow CDC to further its global public health programs and leverage the recipient’s expertise, networks and programs by collaborating with and funding activities including zoonotic disease surveillance; workforce development and training; development of national and regional capacity for outbreak response and disease control; development of laboratory diagnostic capacity; strengthening or establishing One Health platforms; and prevention or control of disease spillover at the human-animal interface. High-impact animal diseases of concern may include but are not limited to H5N1 and other zoonotic influenza viruses, coronaviruses (such as SARS-CoV-2 and MERS-CoV), rabies, Rift Valley Fever, anthrax, brucellosis, zoonotic tuberculosis, and other emerging and re-emerging zoonotic or infectious pathogens of public health importance.

b. Statutory Authorities Public Health Service Act sections 301(a) and 307, as amended,42 U.S.C. §§ 241 and 242l

c. Healthy People 2030 Increase the number of individuals trained globally to prevent, detect, or respond to public health threats — GH-D01 - Healthy People 2030 | health.gov Increase the number of globally important public health events that are tracked and reported — GH-D02 - Healthy People 2030 | health.gov Increase laboratory diagnostic testing capacity, surveillance, and reporting globally — GH-D03 - Healthy People 2030 | health.gov

d. Other National Public Health Priorities and Strategies Global Health Security Agenda (ghsagenda.org) International Health Regulations, WHO(2005) Third Edition (who.int) WHO | National Action Plan for Health Security Terrestrial Code: OIE - World Organisation for Animal Health IHR-PVS National Bridging Workshop | Strategic Partnership for IHR and Health

Security (SPH) (who.int)

e. Relevant Work This NOFO builds upon ongoing CDC activities to improve global health and protect the United States from threats originating at the animal-human-environment interface, including building capacity to detect, identify and contain emerging infectious diseases through Global Disease https://health.gov/healthypeople/objectives-and-data/browse-objectives/global-health/increase-number-individuals-trained-globally-prevent-detect-or-respond-public-health-threats-gh-d01 https://health.gov/healthypeople/objectives-and-data/browse-objectives/global-health/increase-number-individuals-trained-globally-prevent-detect-or-respond-public-health-threats-gh-d01 https://health.gov/healthypeople/objectives-and-data/browse-objectives/global-health/increase-number-globally-important-public-health-events-are-tracked-and-reported-gh-d02 https://health.gov/healthypeople/objectives-and-data/browse-objectives/global-health/increase-number-globally-important-public-health-events-are-tracked-and-reported-gh-d02 https://health.gov/healthypeople/objectives-and-data/browse-objectives/global-health/increase-laboratory-diagnostic-testing-capacity-surveillance-and-reporting-globally-gh-d03 https://health.gov/healthypeople/objectives-and-data/browse-objectives/global-health/increase-laboratory-diagnostic-testing-capacity-surveillance-and-reporting-globally-gh-d03 https://ghsagenda.org/ https://www.who.int/publications/i/item/9789241580496 https://www.who.int/ihr/procedures/health-security-national-action-plan/en/ https://www.oie.int/standard-setting/terrestrial-code/ https://extranet.who.int/sph/ihr-pvs-bridging-workshop https://extranet.who.int/sph/ihr-pvs-bridging-workshop

Detection Centers (10+ Years of CDC’s Global Disease Detection Program - A Model for Strong Regional Capabilities in Building Global Health Security) and Global Health Security partnerships (About Global Health Security | Division of Global Health Protection | Global Health | CDC) around the world; workforce development to address the worldwide shortage of skilled epidemiologists and veterinarians (http://www.cdc.gov/globalhealth/healthprotection/fetp/); and laboratory and epidemiological research and policy development to prevent and control zoonotic diseases reportable to the World Organisation for Animal Health (OIE) (OIE-Listed diseases 2020: OIE - World Organisation for Animal Health).

2. CDC Project Description

a. Approach Bold indicates period of performance outcome.

Strategies and Activities

Short-Term Outcomes

Intermediate Outcomes Long-Term Outcomes

1. Surveillance

2. Workforce Development

3. Laboratory Capacity Building

4. Facilitate Development of One Health Platforms

5.

Organizational Capacity Building

6. Special One Health/ Public Health Projects

7. Develop capacity and implement response activities for rapidly

- Established mechanisms for surveillance and monitoring information and data exchange across animal and public health authorities

- Increased availability of guidance materials to support investigation of and response to zoonotic and TAD outbreaks

- Increased knowledge and skills of animal health and veterinary public health services workforce

- Improved capacity of

- Rapid acquisition and exchange of surveillance and monitoring information and data by public health and veterinary authorities

- Improved ability of veterinary and public health services to control and rapidly respond to outbreaks of zoonotic diseases and TADs

- Improved animal and veterinary public health infrastructure which is integrated with human health disease surveillance and control

- Improved timeliness and accuracy of sample analysis and reporting by national veterinary laboratories to support routine diagnostics, surveillance and

- Prevent and control zoonotic and TAD disease emergence and re-emergence in animal populations before they cross into and spread in human populations

-Decreased morbidity and mortality related to zoonotic diseases and TADs among animal and human populations

- Enhanced capacities of national governments and regional authorities to address emerging and re-emerging zoonotic diseases and TADs at the animal-human-environment interface

- Improved mutual support, cooperation and coordination of surveillance and response between animal health and https://www.cdc.gov/globalhealth/healthprotection/gdd/10-plus-years-gdd.html https://www.cdc.gov/globalhealth/healthprotection/gdd/10-plus-years-gdd.html https://www.cdc.gov/globalhealth/healthprotection/ghs/about.html https://www.cdc.gov/globalhealth/healthprotection/ghs/about.html http://www.cdc.gov/globalhealth/healthprotection/fetp/ https://www.oie.int/en/animal-health-in-the-world/oie-listed-diseases-2020/ https://www.oie.int/en/animal-health-in-the-world/oie-listed-diseases-2020/ emerging zoonotic and transboundary animal disease (TAD)s

8. Enhance animal vaccination activities national veterinary services and laboratory services for disease surveillance, recognition, and control

- Improved coordination and cooperation of animal health and public health authorities and other relevant partners on shared animal and public health issues

- Increased availability of assessment tools for agriculture, animal health and public health ministries and agencies to evaluate resources and capabilities

- Increased support for animal health ministries to identify vaccination program gaps response

- Improved veterinary services workforce ability to detect and respond to outbreaks of zoonotic diseases and TADs

- Zoonotic diseases and TADs are prioritized using a One Health approach, mapped and risks identified public health ministries and agencies, and between national, regional and international authorities and agencies

- National veterinary laboratories assist regional laboratories to develop diagnostic capacity

i. Purpose The purpose of the program is to support recipient activities that will build capacities of national governments and regional authorities to address emerging infectious diseases at the animal-human-environment interface and other public health threats, as well as strengthen animal health and public health services. These capacities will help countries and regions conduct disease surveillance, monitoring and response; map, identify and predict disease risks; and prevent and control disease emergence and re-emergence in animal populations and subsequent spread to human populations.

ii. Outcomes Short-Term Outcomes

Established mechanisms for surveillance and monitoring information and data exchange across animal and public health authorities

Increased availability of guidance materials to support investigation of and response to zoonotic and transboundary animal disease (TAD) outbreaks

Increased knowledge and skills of animal health and veterinary public health services workforce

Improved capacity of national veterinary services and laboratory services for disease surveillance, recognition, and control

Improved coordination and cooperation of animal health and public health authorities and other relevant partners on shared animal and public health issues

Increased availability of assessment tools for agriculture, animal health and public health ministries and agencies to evaluate resources and capabilities

Increased support for animal health ministries to identify vaccination program gaps

Intermediate Outcomes

Rapid acquisition and exchange of surveillance and monitoring information and data by public health and veterinary authorities

Improved animal and veterinary public health infrastructure which is integrated with human health disease surveillance and control

Zoonotic diseases and TADs are prioritized using a One Health approach, mapped and risks identified

iii. Strategies and Activities

1. Surveillance:

Develop, implement, and evaluate evidence-based strategies to enhance national, regional, and global capacity for rapid and effective surveillance and risk mapping of zoonotic diseases and transboundary animal diseases (TADs) to inform and improve early warning, risk analysis, and prevention and response activities at the animal-human-environment interface.

Support development and enhancement of Integrated Animal and Human Health Surveillance.

Support development of real time and community-based syndromic and case-based surveillance for zoonotic diseases and TADs.

Strengthen national and regional capacity for integrated surveillance for antimicrobial resistance (AMR) in animal food production systems.

Support development of timely identification and reporting to local, regional and national animal health, human health and other relevant authorities.

Support the development and improvement of notification to appropriate authorities (i.e.

country, regional networks, international networks, OIE, etc.) of outbreaks of suspected zoonotic origin in the early stage of emergence (prior to efficient human-to-human transmission).

Build or expand upon existing international networks (e.g. of collaborating laboratories) for the rapid acquisition and exchange of surveillance and monitoring information.

Enhance, link, and increase analytic capability within disease reporting systems to ensure that WHO, FAO, OIE and CDC rapidly receive pertinent information.

Improve surveillance and diagnostic capabilities of potential zoonotic disease animal reservoirs in livestock and wildlife populations.

Support the implementation of targeted surveillance, spanning animal and human populations to support disease monitoring, reporting and analysis via bio-surveillance of high-risk wildlife groups.

2. Workforce Development:

Support development and implementation of veterinary applied field epidemiology training to improve capacity of regional and national veterinary services for disease surveillance, recognition, investigation and response, and improve capacity to detect and respond to potential threats from zoonotic diseases and TADs.

Support development of protocols, mechanisms and tools for disease identification, reporting and diagnostic sample submission at the animal-human-environment interface for use by regional and national veterinary services.

Support development and implementation of training for paraveterinary professionals and livestock workers on zoonotic disease prevention and control, vaccination, and biosafety and biosecurity practices.

Support achievement of the Global Health Security Agenda (GHSA) target of a workforce including physicians, veterinarians, biostatisticians, laboratory scientists, and farming/livestock professionals, who can systematically cooperate to meet relevant International Health Regulations (IHR) and OIE’s Performance of Veterinary Services (PVS) core competencies.

3. Laboratory Capacity Building:

Strengthen human and animal health diagnostic and reference laboratory systems and capacity at national and regional levels to improve detection and identification of zoonotic diseases and TADs.

Strengthen and support laboratory biosafety and biosecurity protocols and standards, and promote appropriate disease diagnostic testing techniques to reduce risks to human and animal health from laboratory activities.

Increase the compatibility of existing animal and human diagnostics and surveillance data laboratory information systems at national and regional levels.

4. Facilitate Development of One Health Platforms:

Assist and support activities to operationalize One Health across sectors in collaboration with global One Health partners (WHO, FAO, OIE, CDC, etc.), linking together: public health and animal health; environmental health, including wildlife; epidemiology and laboratory.

Assist and support activities to identify priority zoonotic diseases of concern for human, animal and environmental health sectors.

Support coordination and collaboration across sectors on community based integrated One Health surveillance, disease prevention and control for endemic, emerging and re-emerging zoonotic diseases and TADs.

Evaluate and make recommendations on the implementation of appropriate One Health policies in national operational frameworks to minimize the risk of zoonotic disease emergence and spread.

Develop manuals and tools to promote information exchange and cooperation between sectors.

5. Organizational Capacity Building:

Assist national ministries or agencies tasked with animal health, public health, agriculture, livestock, wildlife or environment to analyze their resources devoted to diagnosis, surveillance, response, prevention, and control for zoonotic diseases and other public health threats. Identify critical shortfalls in human, technical, and equipment resources. Work with the national ministries to develop and implement plans to resolve recognized deficiencies.

6. Special One Health/Public Health Projects:

Develop and implement specific activities and projects consistent with the stated purpose of this cooperative agreement. These may include focused surveillance and response projects, capacity-building activities with specific national governments or institutions, implementation and evaluation of evidence-based prevention programs, applied epidemiology activities, and development of guidance documents related to control and prevention of zoonotic diseases and TADs.

7. Develop capacity and implement response activities for rapidly emerging zoonotic and transboundary animal diseases (TADs):

Conduct rapid response activities to address gaps in and strengthen active surveillance, laboratory confirmation capacity, surveillance and monitoring in animal production animal systems and markets, to reduce or eliminate spread of outbreaks of newly emerging or re-emerging zoonotic diseases and TADs and prevent efficient transmission from animal to human populations. This may be in urgent situations with rapidly changing needs and unique situations in each affected country, with the need for rapid and flexible support.

Assist national ministries of health, agriculture and animal health agencies to develop capacity to control and rapidly respond to outbreaks of zoonotic diseases and TADs, and other CDC priority public health threats as identified.

Support development and implementation of guidance and models on behaviors, policies and practices that can minimize the spillover, spread, and full emergence of zoonotic disease at the animal-human-environment interface, prior to the development of efficient human-to-human transmission.

Support community and professional education and engagement to enhance awareness and strengthen suspect disease recognition and reporting at key points along the production and market chains and at points of human-animal interaction.

Support development and implementation of disease prevention and control practices for emerging or re-emerging zoonotic diseases and TADs.

Support development of guidelines for risk-based disease control within and across countries for enhanced prevention, detection, response and containment activities for emerging zoonotic diseases.

Promote development and implementation and training on best practices for national and regional level preparation and response to zoonotic disease outbreaks.

8. Enhance animal vaccination activities

• Support development or revision of guidelines and resources for animal vaccination activities.

• Develop and disseminate assessment tools for animal vaccination programs.

9. Collaborations

a. With other CDC programs and CDC-funded organizations:

The recipient will be expected to work with other CDC programs including subject matter experts in the National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) and National Center for Immunization and Respiratory Diseases (NCIRD) for specific pathogens being addressed and with the Center for Global Health (CGH) relating to capacity building activities.

b. With organizations not funded by CDC:

The recipient will be expected to collaborate closely with the World Health Organization (WHO), the Food and Agriculture Organization of the United Nations (FAO) and with other global organizations that play an active role in One Health work such as the United Nations Environment Programme (UNEP) or other development agencies. The recipient may also be asked to collaborate with joint CDC and Department of Defense capacity building or research projects were appropriate.

2. Target Populations The recipient's work will provide guidance to help improve social determinants of health for animals and people rural and underserved communities, including non-English speaking populations, by reducing the economic burden of zoonotic diseases and outbreaks. Rural and underserved populations whose primary income is tied to livestock often face economic losses, food insecurity and other challenges if their livestock are affected by an infectious or zoonotic disease infection or outbreak. Activities within this cooperative agreement will provide data and guidance to increase prevention and control measures for zoonotic infectious diseases including those with an impact on animal and human health. Protecting the livelihoods of rural and underserved populations will improve their ability to secure nutritious food, appropriate shelter and seek medical care when need. Preventing and controlling zoonotic infectious diseases may also strengthen the economies of developing countries by improving livestock and food trade opportunities.

a. Health Disparities The recipient's work will provide data and guidance to help improve social determinants of health for animals and people in rural and underserved communities, including non-English speaking populations, by reducing the economic burden of zoonotic diseases and outbreaks.

Rural and underserved populations whose primary income is tied to livestock often face economic losses, food insecurity and other challenges if their livestock are affected by an infectious or zoonotic disease infection or outbreak. Activities within this cooperative agreement will provide data and guidance to increase prevention and control measures for zoonotic infectious diseases including those with an impact on animal and human health. Protecting the livelihoods of rural and underserved populations will improve their ability to secure nutritious food, appropriate shelter and seek medical care when needed. Preventing and controlling zoonotic infectious diseases may also strengthen the economies of developing countries by improving livestock and food trade opportunities.

iv. Funding Strategy The average award in year 1 will be $1,000,000. The average awards in years 2-5 will be between $250,000 and $500,000.

b. Evaluation and Performance Measurement

i. CDC Evaluation and Performance Measurement Strategy

ii. Applicant Evaluation and Performance Measurement Plan Applicants must provide an evaluation and performance measurement plan that demonstrates how the recipient will fulfill the requirements described in the CDC Evaluation and Performance Measurement and Project Description sections of this NOFO. At a minimum, the plan must describe:

How the applicant will collect the performance measures, respond to the evaluation questions, and use evaluation findings for continuous program quality improvement.

How key program partners will participate in the evaluation and performance measurement planning processes.

Available data sources, feasibility of collecting appropriate evaluation and performance data, and other relevant data information (e.g., performance measures proposed by the applicant)

Plans for updating the Data Management Plan (DMP) as new pertinent information becomes available. If applicable, throughout the lifecycle of the project. Updates to DMP should be provided in annual progress reports. The DMP should provide a description of the data that will be produced using these NOFO funds; access to data;

data standards ensuring released data have documentation describing methods of collection, what the data represent, and data limitations; and archival and long-term data preservation plans. For more information about CDC’s policy on the DMP, see https://www.cdc.gov/grants/additionalrequirements/ar-25.html.

https://www.cdc.gov/grants/additionalrequirements/ar-25.html

Where the applicant chooses to, or is expected to, take on specific evaluation studies, the applicant should be directed to:

Describe the type of evaluations (i.e., process, outcome, or both).

Describe key evaluation questions to be addressed by these evaluations.

Describe other information (e.g., measures, data sources).

Recipients will be required to submit a more detailed Evaluation and Performance Measurement plan, including a DMP, if applicable, within the first 6 months of award, as described in the Reporting Section of this NOFO.

A data management plan is not required.

c. Organizational Capacity of Recipients to Implement the Approach The recipient is expected to be a public international organization that has operational presence in all regions of the world, direct access to the governments, agricultural ministries and animal health agencies of countries around the world representing the majority of United Nations member states, and a record of providing technical support in food and agriculture to those countries.

The recipient is expected to identify key personnel with expertise in zoonoses control; addressing animal diseases of local and international impact; animal production systems and impact on associated human communities. The recipient will also be expected to provide a project management structure that is sufficient to achieve project outcomes and clearly defines staff roles.

The recipient is expected to have relevant experience and capacity (management, administrative, and technical) to implement the activities and achieve project outcomes. Key areas of relevant experience include:

zoonotic disease surveillance and surveillance training development;

workforce development and training;

development of agricultural ministry capacity for outbreak response and disease control;

development of laboratory capacity enhancement;

The recipient is expected to have successfully managed a budget for projects in the past 5 years, demonstrating financial responsibility.

The recipient is expected to include a narrative as part of their application that describes their qualifications and experience based on each of the criteria above. The recipient will provide examples of key personnel expertise, past experience in program planning and successful budget management that support their statements of qualifications. The recipient will identify key personnel including qualifications and experience for performing the work outlined in the work plan.

d. Work Plan The work plan allows the project officer to monitor implementation of activities and progress on period of performance outcomes. A detailed workplan is required for activities proposed in the first year and a high-level work plan for years 2-5. There is no specific format for the work plan but it will need to address each outcome proposed for the period and the activities/strategies and associated process measures to reach the outcome. Ensure that outcomes and strategies/activities are closely aligned with those presented in the logic model presented earlier in this announcement. An example work plan format is provided below:

Period of Performance Outcome:

[from Outcomes section and/or logic model]

Outcome Measure:

[from Evaluation and Performance Measurement section]

Strategies and Activities Process Measure [from Evaluation and Performance Measurement section]

Responsible Position /Party

Completion Date

1.

2.

3.

4.

5.

6.

e. CDC Monitoring and Accountability Approach Monitoring activities include routine and ongoing communication between CDC and recipients, site visits, and recipient reporting (including work plans, performance, and financial reporting).

Consistent with applicable grants regulations and policies, CDC expects the following to be included in post-award monitoring for grants and cooperative agreements:

Tracking recipient progress in achieving the desired outcomes.

Ensuring the adequacy of recipient systems that underlie and generate data reports.

Creating an environment that fosters integrity in program performance and results.

Monitoring may also include the following activities deemed necessary to monitor the award:

Ensuring that work plans are feasible based on the budget and consistent with the intent of the award.

Ensuring that recipients are performing at a sufficient level to achieve outcomes within stated timeframes.

Working with recipients on adjusting the work plan based on achievement of outcomes, evaluation results and changing budgets.

Monitoring performance measures (both programmatic and financial) to assure satisfactory performance levels.

Monitoring and reporting activities that assist grants management staff (e.g., grants management officers and specialists, and project officers) in the identification, notification, and management of high-risk recipients.

Priority measures include what resources were developed and provided to partner countries and how activities assisted countries and regions to strengthen One Health activities. Examples of CDC oversight and monitoring activities are listed below:

1. Review and approve recipient's annual work plan and detailed budget.

2. Review and approve the recipient's monitoring and evaluation plan.

3. Provide introductions to CDC funded partners and review coordination and collaboration with those partners on a semi-annual basis.

4. Meet on a regular basis with the recipient to assess expenditures in relation to approved work plan and modify plans as necessary.

5. Meet on a quarterly basis with the recipient to assess quarterly technical and financial progress reports and modify plans as necessary.

6. Meet on an annual basis with the recipient to review annual progress report for each U.S.

Government Fiscal Year, and to review annual work plans and budgets for the subsequent year.

7. Provide technical oversight for all activities under this award.

8. Conduct site visits to monitor and evaluate capacity to implement high-quality activities, by assessing key program area elements of performance and collaborating strategically with the recipient on identified gaps and continuous quality improvement.

B. Award Information

1. Funding Instrument Type:

CA (Cooperative Agreement) CDC's substantial involvement in this program appears in the CDC Program Support to Recipients Section.

2. Award Mechanism:

E11: Grants for Public Health Special Projects

3. Fiscal Year:

4. Approximate Total Fiscal Year Funding:

$ 1,000,000

5. Total Period of Performance Funding:

$ 3,000,000 This amount is subject to the availability of funds.

Estimated Total Funding:

$ 3,000,000

6. Total Period of Performance Length:

year(s)

7. Expected Number of Awards:

8. Approximate Average Award:

$ 1,000,000 Per Project Period

The average award in year 1 will be $1,000,000.

9. Award Ceiling:

$ 1,200,000 Per Budget Period

This amount is subject to the availability of funds.

10. Award Floor:

$ 50,000 Per Budget Period

11. Estimated Award Date:

July 01, 2021

12. Budget Period Length:

12 month(s)

Throughout the project period, CDC will continue the award based on the availability of funds, the evidence of satisfactory progress by the recipient (as documented in required reports), and the determination that continued funding is in the best interest of the federal government. The total number of years for which federal support has been approved (project period) will be shown in the “Notice of Award.” This information does not constitute a commitment by the federal government to fund the entire period. The total period of performance comprises the initial competitive segment and any subsequent non-competitive continuation award(s).

13. Direct Assistance Direct Assistance (DA) is not available through this NOFO.

If you are successful and receive a Notice of Award, in accepting the award, you agree that the award and any activities thereunder are subject to all provisions of 45 CFR part 75, currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions.

C. Eligibility Information

1. Eligible Applicants Eligibility Category:

25 (Others (see text field entitled "Additional Information on Eligibility" for clarification))

2. Additional Information on Eligibility This is a single source award to support the World Organisation for Animal Health (OIE).

3. Justification for Less than Maximum Competition The World Organisation for Animal Health (OIE) is the only international organization responsible for improving animal health worldwide and is recognized as a reference organization by the World Trade Organization. Therefore, OIE is the only organization that can partner with CDC to work across multiple countries and with other international organizations on emerging infectious diseases to prevent and respond to outbreaks at the animal-human-environmental interface while setting standards and guidance to address emerging infectious diseases for the animal health sector in support of public health needs. OIE has 182 member countries and maintains relationships with approximately 75 other international and regional organizations.

OIE has regional and sub-regional offices on every continent which will enhance CDC’s ability to collaborate and strengthen activities worldwide. OIE also has a network of 246 collaborating centers and reference laboratories, of which CDC/NCEZID manages an OIE collaborating center for Emerging and Re-emerging Zoonotic Diseases. Establishing this cooperative agreement will strengthen CDC’s activities as an OIE collaborating center. OIE has several objectives that align with CDC’s One Health, emerging infections, and zoonotic disease objectives. These include, collecting, analyzing and disseminating scientific information on animal disease prevention and control efforts and providing technical support to member countries requesting assistance to control animal diseases, especially those that present a risk to public health. Over 60% of all diseases known to infect humans are zoonotic, or transmissible between animals and humans.

Approximately 75% of emerging or re-emerging infectious diseases and 80% of those with bioterrorism potential are zoonotic, and an estimated 20% of human illness and death in the least developed countries are due to endemic zoonotic disease. The majority of these diseases also have negative effects on animal health and livestock production, and thereby impact food safety and security, environmental health, and threaten trade and travel. These impacts make human and animal health sector collaboration and a “One Health” approach integrating public health, agriculture, wildlife and environmental agency activities essential for zoonotic disease control and prevention. In order to take a "One Health" approach it is necessary to have a strong partner with recognized international responsibility for animal health to work with CDC to strengthen One Health activities and approaches in countries worldwide. OIE offers unique opportunities to CDC to further One Health coordination and collaboration between animal health and public health programs through OIE’s organizational attributes and programs, global infrastructure, extensive partnerships with UN and other international partner organizations and expertise in zoonotic and transboundary animal diseases (TADs). The overall intent of this NOFO is to support OIE to develop and build capacities of national governments and regional authorities to address emerging and re-emerging zoonotic diseases, TADs, and other public health threats at the animal-human-environmental interface. This intent would not be attainable by supporting multiple individual organizations that are not strategically linked and do not have formal government-to-government and membership relationships.

4. Cost Sharing or Matching Cost Sharing / Matching Requirement:

No

Cost sharing or matching funds are not required for this program. Although no statutory matching requirement for this NOFO exists, leveraging other resources and related ongoing efforts to promote sustainability is strongly encouraged.

5. Maintenance of Effort Is not required for this program.

D. Application and Submission Information

1. Required Registrations An organization must be registered at the three following locations before it can submit an application for funding at www.grants.gov.

a. Data Universal Numbering System:

All applicant organizations must obtain a Data Universal Numbering System (DUNS) number. A DUNS number is a unique nine-digit identification number provided by Dun & Bradstreet (D&B). It will be used as the Universal Identifier when applying for federal awards or cooperative agreements.

The applicant organization may request a DUNS number by telephone at 1-866-705-5711 (toll free) or internet at http:// fedgov.dnb. com/ webform/ displayHomePage.do. The DUNS number will be provided at no charge.

If funds are awarded to an applicant organization that includes sub-recipients, those sub-recipients must provide their DUNS numbers before accepting any funds.

b. System for Award Management (SAM):

The SAM is the primary registrant database for the federal government and the repository into which an entity must submit information required to conduct business as a recipient. All applicant organizations must register with SAM, and will be assigned a SAM number. All information relevant to the SAM number must be current at all times during which the applicant has an application under consideration for funding by CDC. If an award is made, the SAM information must be maintained until a final financial report is submitted or the final payment is received, whichever is later. The SAM registration process can require 10 or more business days, and registration must be renewed annually. Additional information about registration procedures may be found at https://www.sam.gov/SAM/.

c. Grants.gov:

The first step in submitting an application online is registering your organization at www.grants.gov, the official HHS E-grant Web site. Registration information is located at the "Applicant Registration" option at www.grants.gov.

All applicant organizations must register at www.grants.gov. The one-time registration process usually takes not more than five days to complete. Applicants should start the registration process as early as possible.

StepSystem Requirements Duration Follow Up https://www.grants.gov/ http://fedgov.dnb.com/webform/displayHomePage.do https://www.sam.gov/SAM/ https://grants.gov/ https://www.grants.gov/ http://www.grants.gov/

Data Universal Number System

(DUNS)

1. Click on http:// fedgov.dnb.com/ webform

2. Select Begin DUNS search/request process

3. Select your country or territory and follow the instructions to obtain your DUNS 9-digit #

4. Request appropriate staff member(s) to obtain DUNS number, verify & update information under DUNS number

1-2 Business Days

To confirm that you have been issued a new DUNS number check online at (http:// fedgov.dnb.com/ webform) or call 1-866-705-

System for Award Management

(SAM)

formerly Central Contractor Registration

(CCR)

1. Retrieve organizations DUNS number

2. Go to https://www.sam.gov/SAM/ and designate an E-Biz POC (note CCR username will not work in SAM and you will need to have an active SAM account before you can register on grants.gov)

3-5 Business Days but up to 2 weeks and must be renewed once a year

For SAM Customer Service Contact https://fs d.gov/ fsd-gov/ home.do Calls: 86 6-606-8220

3 Grants.gov

1. Set up an individual account in Grants.gov using organization new DUNS number to become an authorized organization representative

(AOR)

2. Once the account is set up the E-BIZ POC will be notified via email

3. Log into grants.gov using the password the E-BIZ POC received and create new password

4. This authorizes the AOR to submit applications on behalf of the organization

Same day but can take 8 weeks to be fully registered and approved in the system (note, applicants MUST obtain a DUNS number and SAM account before applying on grants.gov)

Register early!

Log into grants.gov and check AOR status until it shows you have been approved

2. Request Application Package Applicants may access the application package at www.grants.gov.

3. Application Package Applicants must download the SF-424, Application for Federal Assistance, package associated with this notice of funding opportunity at www.grants.gov.

4. Submission Dates and Times If the application is not submitted by the deadline published in the NOFO, it will not be processed. Office of Grants Services (OGS) personnel will notify the applicant that their http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform http://fedgov.dnb.com/webform https://www.sam.gov/SAM/ https://fsd.gov/fsd-gov/home.do https://fsd.gov/fsd-gov/home.do https://fsd.gov/fsd-gov/home.do application did not meet the deadline. The applicant must receive pre-approval to submit a paper application (see Other Submission Requirements section for additional details). If the applicant is authorized to submit a paper application, it must be received by the deadline provided by OGS.

a. Letter of Intent Deadline (must be emailed or postmarked by)

The LOI date will generate once the Synopsis is published if Days or a Date are entered.

b. Application Deadline

Due Date for Applications 05/28/2021

Application Due Date will be submitted as: date based on the value specified for Due Date for Applications 11:59 pm U.S. Eastern Standard Time, at www.grants.gov. If Grants.gov is inoperable and cannot receive applications, and circumstances preclude advance notification of an extension, then applications must be submitted by the first business day on which grants.gov operations resume.

Due Date for Information Conference Call N/A

5. Pre-Award Assessments Risk Assessment Questionnaire Requirement

CDC is required to conduct pre-award risk assessments to determine the risk an applicant poses to meeting federal programmatic and administrative requirements by taking into account issues such as financial instability, insufficient management systems, non-compliance with award conditions, the charging of unallowable costs, and inexperience. The risk assessment will include an evaluation of the applicant’s CDC Risk Questionnaire, located at https://www.cdc.gov/grants/documents/PPMR-G-CDC-Risk-Questionnaire.pdf, as well as a review of the applicant’s history in all available systems; including OMB-designated repositories of government-wide eligibility and financial integrity systems (see 45 CFR 75.205(a)), and other sources of historical information. These systems include, but are not limited to: FAPIIS (https://www.fapiis.gov/), including past performance on federal contracts as per Duncan Hunter National Defense Authorization Act of 2009; Do Not Pay list; and System for Award Management (SAM) exclusions.

CDC requires all applicants to complete the Risk Questionnaire, OMB Control Number 0920- 1132 annually. This questionnaire, which is located at https://www.cdc.gov/grants/documents/PPMR-G-CDC-Risk-Questionnaire.pdf, along with supporting documentation must be submitted with your application by the closing date of the Notice of Funding Opportunity Announcement. If your organization has completed CDC’s Risk Questionnaire within the past 12 months of the closing date of this NOFO, then you must submit a copy of that questionnaire, or submit a letter signed by the authorized organization representative to include the original submission date, organization’s EIN and DUNS.

When uploading supporting documentation for the Risk Questionnaire into this application package, clearly label the documents for easy identification of the type of documentation. For example, a copy of Procurement policy submitted in response to the questionnaire may be labeled using the following format: Risk Questionnaire Supporting Documents _ Procurement https://www.grants.gov/ https://www.cdc.gov/grants/documents/PPMR-G-CDC-Risk-Questionnaire.pdf https://www.cdc.gov/grants/documents/PPMR-G-CDC-Risk-Questionnaire.pdf

Policy.

Duplication of Efforts

Applicants are responsible for reporting if this application will result in programmatic, budgetary, or commitment overlap with another application or award (i.e. grant, cooperative agreement, or contract) submitted to another funding source in the same fiscal year. Programmatic overlap occurs when (1) substantially the same project is proposed in more than one application or is submitted to two or more funding sources for review and funding consideration or (2) a specific objective and the project design for accomplishing the objective are the same or closely related in two or more applications or awards, regardless of the funding source. Budgetary overlap occurs when duplicate or equivalent budgetary items (e.g., equipment, salaries) are requested in an application but already are provided by another source. Commitment overlap occurs when an individual’s time commitment exceeds 100 percent, whether or not salary support is requested in the application. Overlap, whether programmatic, budgetary, or commitment of an individual’s effort greater than 100 percent, is not permitted. Any overlap will be resolved by the CDC with the applicant and the PD/PI prior to award.

Report Submission: The applicant must upload the report in Grants.gov under “Other Attachment Forms.” The document should be labeled: "Report on Programmatic, Budgetary, and Commitment Overlap.”

6. Content and Form of Application Submission Applicants are required to include all of the following documents with their application package at www.grants.gov.

7. Letter of Intent LOI is not requested or required as part of the application for this NOFO.

8. Table of Contents (There is no page limit. The table of contents is not included in the project narrative page limit.): The applicant must provide, as a separate attachment, the “Table of Contents” for the entire submission package.

Provide a detailed table of contents for the entire submission package that includes all of the documents in the application and headings in the "Project Narrative" section. Name the file "Table of Contents" and upload it as a PDF file under "Other Attachment Forms" at www.grants.gov.

9. Project Abstract Summary A project abstract is included on the mandatory documents list and must be submitted at www.grants.gov. The project abstract must be a self-contained, brief summary of the proposed project including the purpose and outcomes. This summary must not include any proprietary or confidential information. Applicants must enter the summary in the "Project Abstract Summary" text box at www.grants.gov.

https://www.grants.gov/ https://www.grants.gov/

10. Project Narrative (Unless specified in the "H. Other Information" section, maximum of 20 pages, single spaced, 12 point font, 1-inch margins, number all pages. This includes the work plan. Content beyond the specified page number will not be reviewed.)

Applicants must submit a Project Narrative with the application forms. Applicants must name this file “Project Narrative” and upload it at www.grants.gov. The Project Narrative must include all of the following headings (including subheadings): Background, Approach, Applicant Evaluation and Performance…