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This document outlines a federal solicitation from the Proactive Health Office at ARPA-H seeking innovative solutions. Specifically, PHO is interested in proposals that improve population health outcomes through increased access to and uptake of disease prevention, early detection methods, prophylactic interventions, and system-level delivery innovations. Interested parties must submit solution summaries, questions, or proposals through the appropriate links on the ARPA-H website by the unspecified deadlines. Proposers requesting a Cooperative Agreement are encouraged but not required to use the ARPA-H proposal submission link. The soliciting agency is the Department of Health and Human Services National Institutes of Health.