Attachment 1 -Purchase Description.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

Currently, the Magnetoencephalography (MEG) Core Facility of the National Institute of Mental Health (NIMH) has two magnetoencephalography systems for measuring brain activity. We have a fixed gantry CTF-275 device, using cryogenically cooled SQUID sensors, housed within a large Vacuumschmelze magnetically shielded room (MSR) and a device utilizing optically pumped magnetometers (OPMs) currently under active development.

The OPM system possesses some strengths compared to the CTF device. It does not have a fixed gantry and can be moved. It has much higher signal to noise due to the fact that the sensors can be placed much closer to the scalp.

This system requires more development, however, before it can be widely utilized for research or clinical uses. Currently, the development of the system is hampered by the fact that it shares space with the (Superconducting Quantum Interference Device) SQUID MEG system. This system is heavily utilized, leaving very little time for OPM development. This acquisition is for a second magnetically shielded room or MSR, optimized for the OPM device, which would allow significantly accelerated development of the technology.

One further issue is that the OPM sensors require a much lower field than the CTF system, which required us to purchase additional compensation coils which sit inside the current NIMH MSR. These coils are bulky and require extensive set-up time, further deducting from available development time.

2. Background Information and Objective:

Optically pumped magnetometers have been in development since the 1970's, although they have only attained sufficient sensitivity for brain imaging in the last 10-15 years. Several laboratories, most prominently one at the University of Nottingham, have led the development of the technique. While most laboratories have focused on whole brain devices, the NIH device is designed to image a portion of the cortex, but at higher resolution, Currently, this development occurs when other NIH intramural scientists are not using the magnetically shielded room housing our CTF-275 system. This effectively reduces our development time to one day a week. With the addition of a second magnetically shielded room, we would be able to have unlimited access to the room for development of the technology. While the existing NIMH MSR is quite large, a requirement to hold the large CTF gantry, the requested MSR is quite compact, less than 6 feet in length and width, In addition, this room is equipped with active shielding coils embedded in the walls of the MSR, allowing for further field compensation.

3. Generic Name of Product: Magnetically Shielded Room (MSR)

4. Purchase Description:

Generic Name: Magnetically Shielded Room (MSR) Trade name: Magnetic Shields Limited

Brand name: MuRoom Manufacturer: Cerca Magnetics (previously Magnetic Shields Limited) Model: MuRoom OPM Optimised Compact Catalog: MR0003

5. Salient characteristics:

The magnetically shielded room (MSR) should:

• Have a field of < 15nT inside without active shielded (assuming a 50nT background field).

• Ideally possess a shielding factor of 3500 for DC; 100 for 0.01Hz; 300 for

0.1Hz; 2,000 for 1Hz; 5,000 for 10Hz; and 5,000 for 100 Hz.

• Size: 1.3 x 1.3 x 2.0 meters

• Wall thickness: 180 mm

• Allow for customization of MSR (e.g. configuration of door and/or exterior ports) in order to fit the intended lab space).

• Construction: Modular

• Door type: mechanical closure, swing door

• Have degaussing coils which:

o Should be integrated into the MSR.

o Will enable the end user to decrease any remaining magnetic field that will affect OPM measurement.

o Includes a degaussing software.

• Have active field compensation coils which:

o Should be integrated into the MSR o With active field compensation, the room should have an internal field of <2nT.

o Reduces the residual magnetic field and first order gradients within the MSR.

o Includes a software license.

6. Quantity:

• 1x MuRoom OPM Optimised Compact, including the following:

o 1x Installation OPM Optimised Compact o 1x MuRoom degaussing coils (integrated) and supporting equipment (electronics cabinet, National Instruments digital acquisition unit (DAC), oscilloscope, software and license, etc.)

o 1x cCoil: Active shielding for OPM Compact (integrated) and supporting equipment (electronics cabinet, National Instruments digital acquisition unit (DAC), voltage stabilization drivers, cabling, control computer, reference sensor assembly, software and license, etc.)

7. Delivery Date: Including lead time, room should be installed within 10 months of the award. Target installation will be Spring 2024, in Building 10 Rm. B1 D65A.

Access to the NMR Center is restricted outside of normal business hours, but MEG Core staff will be onsite to facilitate installation.

8. Period of Performance:

The MuRoom carries a one-year warranty for all parts and labor, and the operating software is licensed for a period of one year.

9. Option(s): There are no options on this contract.