A-2 SON_Mass Spec-051321.docx

Statement of Need / Required Specifications VOCUS 2R PTR TOF Positive Ion Mass Spectrometer System

Background The Indoor Air Quality and Ventilation Group in the Building Energy & Environment Division under the Engineering Laboratory at the National Institute of Standards and Technology (NIST) develops computer simulation programs and measurement procedures and applies them to better understand the phenomena of air and contaminant transport in buildings. These efforts support industry to improve environmental conditions in buildings in a cost-effective manner.

The Gas Sensing Metrology Group in the Chemical Science Division under the Material and Measurement Laboratory at NIST applies high-quality, traceable gas measurements to create certified gas standards in support of industries responding to U.S. and state regulations, environmental concerns, fairness in trade issues, and global climate change.

The Indoor Air Quality and Ventilation Group and the Gas Sensing Metrology Group has a current requirement to purchase one (1) VOCUS 2R Proton Transfer Reaction (PTR) Time-Of-Flight (TOF) Positive Ion (PI) Mass Spectrometer (MS) System with inlet systems appropriate to atmospheric chemistry applications that is produced by Aerodyne Research, Inc. (ARI), located at 45 Manning Rd, Billerica, MA, 01821-3934. The Original Equipment Manufacturer (OEM) of the subject mass spectrometer is Tofwerk USA, Inc., located at 2760 29th St, Boulder, CO, 80301. ARI is the exclusive partner of Tofwerk for atmospheric chemistry applications of the OEM mass spectrometer. ARI develops Tofwerk TOF technology for atmospheric research products and chemistry applications.

Indoor environments are dynamic environments that are constantly changing. Occupant actions (e.g. breathing, cooking, cleaning and more) are constantly changing the indoor air chemistry. To date, most sampling methods for indoor air require time averaged (often hours) sampling techniques. These methods do not allow quantification of process that happen on second to minute time scales. However, to better understand the indoor environment and the risk associated with spending 90% of our lives indoors, NIST needs to be able to measure chemical concentrations in real time.

Proton Transfer Reaction – Time of Flight Positive Ion Mass Spectrometer Systems (PTR-TOF-PI-MS) allow the identification of chemical ion fragments in real time. Real time chemical speciation with high mass resolution of ambient pressure indoor air enables a wide range of questions to be addressed.

Current NIST research objectives to which this instrument will be directly applicable include:

1) Analysis of chemical breath composition, factors that impact that composition, and stability of those chemicals to allow development of clinical standards by the Gas Sensing Group.

2) Analysis of changes in chemical composition of indoor air in a test house when oxidants such as ozone are introduced in the presence of various volatile organic chemicals (VOCs).

3) Analysis of changes in chemical composition in rooms being treated with chemistry-based air cleaning devices.

Purpose The purpose of this acquisition is to procure a Proton Transfer Reaction – Time of Flight Positive Ion Mass Spectrometer System to enable NIST to perform real-time quantification of airborne compounds as identified in this Statement of Need.

Description of Required Products The contractor shall provide one (1) VOCUS 2R PTR TOF Positive Ion Mass Spectrometer System produced by Aerodyne Research, Inc. in accordance with the following salient characteristics. Specifically, the vendor shall provide (1) analytical instrument system that meets the following technical specification requirements. The Contractor shall deliver the instrument within 150 days of award to the NIST Gaithersburg Campus and provide warranty and training as described below.

Hardware

1. PTR-TOF-PI-MS:

a. Must use less than 1100 watts peak power

b. Must have a glass ion molecular reactor (IMR) cell capable of:

i. Temperature control between ambient and 175 °C

ii. RF focusing and pressure regulation

iii. Service without venting

iv. IMR temperature-controlled water vapor source

v. Real-time automated switching between reagent ions

c. Must have quadrupole ion guide and focusing lenses between the IMR and time-of-flight (TOF) analyzer.

d. Must have a TOF mass analyzer with:

i. A mass resolving power: up to 15,000 Th/Th

ii. Humidity independent sensitivity: 30,000 cps/ppb at mass resolving power 10000 Th/Th

iii. Capable of a mass range: up to 4000 Th

iv. A time response: < 100 ms

e. Must be capable to be upgraded to high pressure ionization sources and use negative ionization

f. Must have integrated automatic calibration of external gas standard at 1:500 ratios

g. Instrument must produce its own clean and humidified air for baseline measurements

h. All pumps and pressure measurement systems must be included and controlled with supplied software

2. Reagent Ion Switching component for NH4+

a. Must have hardware and software capability to automatically switch between H3O+ and NH4+ ionization sources

3. Breath Gas Sampling Inlet

a. Must include disposable mouth pieces

b. Must include a check valve on sampling inlet for safety purposes

c. Must include a temperature regulated heated transfer line

d. Must be capable of providing baseline air measurements between breath samples

e. Must have instrument control switching software

4. Single-Channel Gas Chromatograph (GC) attachment

a. Must use less than 300 watts peak power

b. Must be able to heat at a rate of 120 °C/min and cool at a rate of 250 °C/min

c. Must have a maximum oven temperature of 260 °C and an accuracy of at least ±0.5°C

d. Must include a 30 m column

e. Must include pressure and mass flow controllers

f. Must be connected to the TOF-PI-MS with a heated transfer line with automated makeup gas

5. Two stage thermal desorption preconcentration system

a. Must use less than 600 watts peak power

b. Must be connected to GC

c. Must be able to analyze a single sorption tube with a focusing trap

d. Tube heating rate must be at least 40 °C/s

e. Maximum trap temperature must be at least 375 °C with an accuracy of ±1 °C

f. Must be compatible with major sorbent tube manufacturers (1/4 inch out diameter x 3.5 inch long, Produced by Markes International, Suppelco, Gerstel).

6. Liquid calibration system

a. Evaporator calibrator integrated into the inlet

b. Liquid flow accuracy of <5%

c. Thermal nebulizer capable of reaching 250 ° C

Software

1. Software for the PTR-TOF-PI-MS must provide ability to control instrument and perform data acquisition for 4-dimensional data, and provide ability to post-process data

2. Software must have the ability to auto-tune PTR-TOF-PI-MS instrument

3. Software for the GC attachment must include data acquisition and analysis software

4. All software must include relevant licenses that are effective for at least five years

Other

1. The system must include an operations and maintenance manual covering proper operation, routine maintenance, and troubleshooting for the instrument, peripherals, and controlling software

a. The manual must be supplied in both hard-copy and electronic formats

2. Manufacturer must provide a rack enclosure and instrument shipping case

3. All Hardware and Software components described above shall be delivered within 150 days after receipt of an order in accordance with the delivery section described in this Statement of Need.

Additional Contractor Responsibilities Initial Design and Configuration Review The Contractor shall be responsible for submitting the instrument design and configuration drawings to the NIST Technical Point of Contact (TPOC) and Contracting Officer’s Representative (COR) within thirty [30] days after contract award. The TPOC and COR will evaluate the design and configuration submitted by the Contractor and provide acceptance or questions, if applicable, to the Contractor within 14 days. If questions or revisions to the design or configuration are requested, the Contractor shall have an additional 7 days to submit a revised version of the design and configuration. The TPOC and COR will evaluate the resubmission of the design and configuration, if necessary, and respond to the Contractor within 7 days. The Contractor shall submit a final instrument design and configuration to the NIST TPOC and COR within 7 days following the TPOC and COR’s response to the resubmission, if applicable. The NIST TPOC and COR will provide final acceptance, or additional questions if applicable, within 14 days of receipt. Contractor may not proceed without NIST’s final acceptance of instrument design and configuration. Contractor shall adhere to the following delivery schedule:

Deliverable Schedule

[1] electronic Within 150 days after award

Government-Furnished Property, Material, Equipment, or Information (GFP, GFM, GFE, or GFI) Not Applicable as no government furnished properties will be used to fulfill this contract.

Security The Contractor shall be responsible for safely accessing the NIST campus if the Contractor is required to come to the NIST campus for any warranty-related repairs. NIST is a restricted campus. A visitor identification badge is required for access for entry into buildings and also is shown to the armed Security Police when entering the campus. Contractor employees shall comply with NIST identification and access requirements. The Contractor shall provide the name and citizenship information of employees for on-site visits to the NIST TPOC prior to arrival. The TPOC will submit the names and citizenship information to the NIST Office of Security in order for a given Contractor employee to enter the NIST campus. The Contractor employee is responsible for absences due to missing or expired identification and access documents. Each Contractor employee shall wear a visible identification badge provided by the NIST Security Office. All Contractor employees must register their vehicles with the NIST Security Office to gain access to the campus. A valid driver’s license, Government-furnished civilian ID (which in most cases can be a valid driver’s license), proof of insurance and current registration must be presented to the NIST Security Office.

COVID 19 Precautions:

Contractor personnel shall follow NIST Visitor and Contractor Protocols for Mitigating COVID-19 Exposure on NIST Campuses as identified at this link: https://www.nist.gov/about-nist/visit/nist-visitor-and-contractor-protocols-mitigating-covid-19-exposure-nist-campuses

It is the Contractor’s responsibility to be familiar with this site and any updates made to it during the course of the requirement. If Contractor personnel are unable to meet all requirements for campus access identified at the link, services will need to be rescheduled and shall be rescheduled at the Contractor’s expense with consideration to the Government for any delays suffered.

Travel No travel costs will be reimbursed. All costs associated with travel time must be included within the fixed price quotation. The Contractor is responsible for any warranty-required travel costs.

Special Material Requirements Not Applicable.

Other Unique Requirements Not Applicable.

Place of Performance The instrument shall be delivered to Building 226, Room A310 on the NIST Gaithersburg, MD Campus.

Warranty Requirements

The Contractor shall include a one-year, standard warranty for the purchased equipment. The warranty shall cover all parts, labor and travel. The standard warranty shall commence upon acceptance of the instrument, which will be consequent to the successful completion of delivery, training and demonstration of all required specifications.

Standard warranty shall include providing technical support. The Contractor shall provide one year of technical instrument and application support for both the PTR-TOF-PI-MS and GC. This support shall commence upon acceptance of the instrument. Technical Support shall include technical telephone or web conferencing response for service support of NIST TPOC inquires and shall include software and hardware technical telephone consulting support by factory trained engineers available during normal business hours. Technical requests shall be resolved within one (1) week and inquiry responses shall be submitted within two (2) business days.

An extended warranty for the PTR-TOF-PI-MS and GC shall be included for an additional two years following the one-year standard warranty. This 2-year extended warranty will be identical to the standard warranty covering all parts, labor and travel. The extended warranty shall commence upon the conclusion of the standard warranty and shall be included in the overall firm fixed price for this requirement.

Delivery Requirements

The Contractor shall deliver the instrument to the NIST Gaithersburg, MD campus. NIST assembly shall be limited to removal from the shipping crate, attaching the monitor, connecting sample lines and mounting the GC to the PTR-TOF-PI-MS. Delivery shall be coordinated with the NIST TPOC.

Delivery of the instrument and peripherals shall be made F.O.B. Destination within 150 days after Contractor receipt of order to the National Institute of Standards and Technology at the address identified below.

National Institute of Standards and Technology (NIST) 100 Bureau Drive Building 301 Shipping & Receiving Gaithersburg, MD 20899-0001

FOB Destination means: The contractor shall pack and mark the shipment in conformance with carrier requirements, deliver the shipment in good order and condition to the point of delivery specified in the purchase order, be responsible for any loss of and/or damage to the goods occurring before receipt and acceptance of the shipment by the consignee at the delivery point specified in the purchase order; and pay all charges to the specified point of delivery.

Note: The NIST Gaithersburg, MD campus is a controlled-access facility and is also under limited access restrictions due to COVID-19. Deliveries are only accepted when arranged in advance. The Contractor shall request approval of delivery time with the NIST Technical Point of Contact (TPOC) in advance of shipment. The Contractor shall comply with the NIST Visitor and Contractor Protocols for Mitigating COVID-19 Exposure on NIST Campuses identified above for any delivery related requirements occurring on the NIST campus.

Contractor failure to confirm delivery method and procedures and to receive TPOC approval prior to shipment shall release the Government of any liability and may result in payment being withheld until the campus access restrictions have been lifted and the item can be received and physically inspected.

Installation Requirements

Installation and assembly of the subject instrument and peripherals will be performed by the Government. The contractor shall provide online support during the assembly process. The instrument shall operate to manufacturer’s specifications upon installation and in accordance with the Inspection and Acceptance criteria described below.

Inspection & Acceptance

The NIST TPOC or COR will inspect delivered products within ten (10) business days after delivery to ensure that they conform to the requirements identified in this Statement of Need. If all requirements are met in accordance with the technical specifications identified above and the Performance Standards listed in the following table, and the equipment is operational, the product shall be accepted.

The Contractor has the right, at its expense, to be present during the inspection. The place of inspection and acceptance shall be: NIST, 100 Bureau Drive, Building 226, Room A310, at Gaithersburg, MD 20899.

PTR-TOF-PI-MS

Detection limit

Training The Contractor shall provide a three-day training session for two NIST personnel. The training shall be conducted at the Contractor’s location, unless health restrictions prevent travel in which case online training may be performed instead. The Contractor is not responsible for any of NIST personnel travel costs. Training shall be provided before instrument delivery.

Payment Schedule The contractor shall be paid for milestone deliveries, in accordance with Net 30-day payment terms, upon receipt and acceptance of a proper invoice. The Government proposes milestone payment in accordance with the following terms:

Firm Fixed Price Payment Schedule

The Contractor may propose an alternative contract milestone payment schedule that will be evaluated by NIST. An alternative payment schedule, including any changes to the table specified above, if proposed, must include a breakdown of payment, deliverable and date, or days after receipt of award, for time to complete.