Sam_Posting_Doc.pdf

COMBINED SYNOPSIS / SOLICITATION (COMPETITIVE)

1. Title: Multi-Probe Micromanipulator Mounting System for Multi-Region Neuropixels Recordings.

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested, and a separate written solicitation will not be issued.

(ii) The solicitation number is 75N98026Q01102 . This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition.

This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition.

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a firm fixed-price to the responsible offeror whose proposal represents the best value to the Government.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular March 2026.

(iv) The associated NAICS code is 334516 and the small business size standard 1000 Employees. This requirement is unrestricted.

(v) Description of Requirement: Brand NameNew Scale Technologies.

The purpose of this acquisition is to procure a Multi-Probe Micromanipulator Mounting System to enable precise, simultaneous positioning and control of multiple Neuropixels probes for in vivo electrophysiological recordings in behaving animals.

New Scale Technologies, Inc. is the only vendor that manufactures the Multi- Probe Micromanipulator (MPM) system capable of automated positioning of multiple neural probes with the required precision, density, and software integration. The system uses patented SQUIGGLE motor technology and compact motorized stages enabling high-density probe placement. It includes proprietary Pathfinder software integrating with the Allen CCF Brain Atlas and trajectory planning tools.

See Attached SOW below.

Delivery Location: Dr. Soohyun Lee

Building 35A 2E-623

35 Convent Dr.

Bethesda, MD 20892

USA (viii) FAR 52.204-7, System for Award Management, applies to this acquisition.

(ix) The provision at FAR 52.212-1, Instructions to Offerors—Commercial Items, applies to this acquisition. Add any agency-specific instructions as required.

(x) The provision at FAR 52.212-2, Evaluation—Commercial Items, applies to this acquisition.

(a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation represents the best value to the Government, price and other factors considered.

(b) Evaluation Factors:

• Price

• Technical capability

• Past performance

• Delivery schedule

(c) A written notice of award or acceptance of an offer, issued within the time specified in the offer, shall result in a binding contract without further action by either party. The Government reserves the right to accept any offer before the expiration date.

(xi) FAR 52.212-4, Contract Terms and Conditions—Commercial Items, applies to this acquisition.

(xii) Additional contract requirements or terms and conditions, as determined necessary by the Contracting Officer and consistent with customary commercial practices: None

(xiii) The Defense Priorities and Allocations System (DPAS) is not applicable.

(xiv) Submission Requirements:

Responses must include sufficient information to demonstrate the offeror’s capability to provide the required product or service. Quotes shall include, at a minimum:

• Unit and total price

• Shipping and handling costs

• Delivery timeframe after award

• Delivery terms

• F.O.B. point (destination)

• Product or catalog numbers (if applicable)

• Product/service description

Additional evaluation considerations may include past performance, warranty, lifecycle cost, maintenance availability, and environmental or energy efficiency.

Responses must include the Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification. All offerors must be actively registered in the System for Award Management (SAM) at www.sam.gov.

All responses must be received by 9/10/26 at 9:00 am ED and must reference solicitation number 75N98026Q01102 . Responses may be submitted electronically to calvin.robinson@nih.gov

Point of Contact:

Calvin Robinson Contract Specialist Office of Logistics and Acquisition Operations (OLAO) NIH Office of Acquisition and Logistics Management (OALM) National Institutes of Health 903 south 4th street Hamilton, MT 59840

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose: The purpose of this acquisition is to procure a Multi-Probe Micromanipulator Mounting System to enable precise, simultaneous positioning and control of multiple Neuropixels probes for in vivo electrophysiological recordings in behaving animals. This system is required to support ongoing NIH research focused on understanding how distributed cortical and subcortical circuits coordinate activity to guide behavior. Current experimental approaches are limited by the inability to reliably position multiple probes within a constrained cranial space with sufficient precision and stability.

The requested system will enable high-density, multi-region recordings with micron-scale accuracy, thereby allowing simultaneous measurement of neuronal population dynamics across distributed brain regions. This capability is essential to restore and expand experimental capacity, improve reproducibility, and enable experiments that are currently infeasible using existing equipment.

2. Background Information and Objective: NIMH conducts research aimed at understanding the neural mechanisms underlying behavior by measuring neuronal activity in vivo. The laboratory has established expertise in Neuropixels-based electrophysiology and routinely performs high-quality recordings with single-cell resolution. However, current instrumentation limits experiments to single-region recordings or imprecise multi-probe configurations. These constraints prevent direct investigation of inter-areal communication, coordinated activity, and long-range circuit dynamics. The objective of this acquisition is to implement a system capable of independently positioning multiple probes with high precision and stability, enabling simultaneous recordings across cortical and subcortical regions.

3. Generic Name of Product: Multi-Probe Micromanipulator Mounting System for Multi-Region Neuropixels Recordings

4. Purchase Description: Multi-Probe Micromanipulator Mounting System compatible with Neuropixels probes, including motorized XYZ micromanipulator stages, multi-degree-of-freedom probe mounting arms, alignment fixtures, platform components, and associated control software for stereotactic positioning and trajectory planning, quantity 1 system with 2 micromanipulators.

5. Salient characteristics

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

• Designed for simultaneous positioning and insertion of multiple neural probes for in vivo electrophysiology

• Capability to support high-density multi-probe placement within constrained experimental space

• Motorized XYZ positioning with micron-scale resolution (~0.5 µm or better)

• Travel range of approximately 15 mm per axis

• Controlled probe insertion speeds, including slow insertion modes for neural recording stability

• Compact motorized stages using piezoelectric or equivalent technology to ensure mechanical stability and minimal drift

• Multi-degree-of-freedom (DOF) probe mounting arms allowing flexible probe alignment and targeting

• Compatibility with Neuropixels probes and similar silicon-based neural probes

• Integrated or compatible software for stereotactic positioning using a 3D brain atlas (e.g., Allen CCF)

• Capability to define and execute probe trajectories (angles, entry points, depth coordinates)

• Integration with third-party trajectory planning tools (e.g., Neuropixels Trajectory

Explorer, Pinpoint)

• Simulation capability to visualize probe trajectories prior to insertion

• Compatibility with common neural data acquisition systems (e.g., Open Ephys, SpikeGLX, Allego)

• Flexible system configuration (e.g., upright or inverted setups)

• Capability to support additional modalities (e.g., optical fibers or waveguides)

6. Quantity: 1 system (with 2 manipulators)

7. Delivery Date: Estimated lead time is approximately four (4) weeks.

8. Period of Performance: Not applicable for equipment purchase. Standard manufacturer warranty shall apply upon delivery and acceptance.

9. Option(s): N/A