Sol_75N98026Q01101.pdf

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ADDENDA

ADDENDA

75N98026Q01101

See Schedule See Schedule

National Institutes of Health Div. Simplified Acq. Policy & Services, OALM 6701 Rockledge Drive, RK II, 4th floor Bethesda, MD 20817

09/04/2026 1500 ED

ROXANE BURKETT

+1 000 000 0000

OD/OALM

ADM-NHLBI

ROXANE S. BURKETT

334516

1,000

08/27/2026

ADMINISTERED BY:

National Institutes of Health

National, Heart, Lung and Blood

Institute

Bethesda MD 20892-7511 US

Leica EM GP2 Automatic Plunge Freezer for

Continued...

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ITEM NO.

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SCHEDULE OF SUPPLIES/SERVICES

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32g. EMAIL OF AUTHORIZED GOVERNMENT REPRESENTATIVE

33. SHIP NUMBER 34. VOUCHER NUMBER 35. AMOUNT VERIFIED

CORRECT FOR

PARTIAL FINAL

37. CHECK NUMBER

38. S/R ACCOUNT NUMBER 39. S/R VOUCHER NUMBER

36. PAYMENT

COMPLETE PARTIAL FINAL

ACCEPTED,

Cryo-Electron Tomography (cryo-ET)

PUBLIC NOTICE OF PROPOSED ACQUISITION

Office of Acquisitions, Office of Management

National Heart, Lung, and Blood Institute

(FAR Subparts 5.101(a)(2))

1. Announcement/Number: 75N98026Q01101

2. Post Date: 08/27/2026

3. Closing Response Date: 09/04/2026

4. Proposed Award Date: 09/28/2026 – 09/27/2027

5. Project Title: Leica EM GP2 Automatic Plunge Freezer for Cryo-Electron Tomography (cryo-ET)

6. Contracting Office: R&D and Professional Services - Division B, OALM

Office of the Director, National Institutes of Health, 6701 Rockledge Drive, Rockledge Building 2, Suite 400, Bethesda, Maryland 20892-7902

7. Contact Point/Contracting Officer/Contract Specialist: Roxane Burkett – roxane.burkett@nih.gov

8. Acquisition Authority: This acquisition is being conducted under Federal Acquisition Regulations (FAR) Part 13 – Simplified Acquisition Procedures, and the resultant contract award will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2026-01.

9. North American Classification System (NAICS) Code: 334516

10. Small business size standard: 1,000 employees

11. Classification Code: 6640

12. Set-aside Status: None, this is a single-sole source (including brand-name) non-competitive action.

mailto:roxane.burkett@nih.gov

13. Description:

The Laboratory of Molecular and Cellular Imaging requires an automated plunge-freezing system to support cryo-electron tomography (cryo-ET) studies of isolated plasma membranes. The required system must provide automated single-sided blotting, a temperature- and humidity-controlled sample chamber, controlled secondary cryogen temperature, and reproducible control of blotting and plunge-freezing parameters. These capabilities are required to prepare high-quality vitrified specimens while minimizing mechanical disturbance, sample damage, ice contamination, and experimental variability.

14. Statutory Authority:

This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Subpart 8.4—Federal Supply Schedules, specifically FAR 8.405-6(b), Items Peculiar to One Manufacturer. The Government has determined, based upon market research conducted in accordance with FAR Part 10, that the Leica EM GP2 is essential to the Government’s requirements and that other commercially available products do not meet the Government’s complete minimum requirements.

Pursuant to FAR 8.405-6, orders placed under the Federal Supply Schedule program are exempt from the competition requirements of FAR Part 6.

Accordingly, the Government may restrict consideration to the Leica EM GP2 as a brand-name item when the particular brand-name product or features are essential to the Government’s requirements and the market research supports the restriction.

15. Single-sole Source (Including brand-name) Determination:

The determination by the Government to restrict this acquisition to a brand-name item is based upon the market research conducted as prescribed in FAR Part 10—Market Research. Specifically, the results of the market research concluded that the Leica EM GP2 is the only product identified as capable of fulfilling the Government’s complete minimum requirements for this acquisition.

The Laboratory of Molecular and Cellular Imaging requires an automated plunge-freezing system to prepare delicate isolated plasma membrane samples for cryo-electron tomography (cryo-ET). The laboratory’s established vitrification methodology requires automated single-sided blotting to remove excess liquid without applying simultaneous blotting pressure to both sides of the grid, thereby minimizing mechanical disturbance or damage to the sample-bearing grid. The system must also provide precise control of sample-chamber temperature and humidity, controlled secondary cryogen temperature, sensor-controlled blotting, and reproducible control of blotting and plunge-freezing parameters.

Market research determined that commercially available cryo-EM vitrification technologies provide overlapping sample-preparation capabilities; however, no other product identified through the research was demonstrated to provide the complete combination of automated single-sided blotting, controlled environmental-chamber temperature and humidity, controlled secondary cryogen temperature, and programmable blotting and plunge parameters required by the Government. The Leica EM GP2 provides this complete combination of capabilities and supports the laboratory’s established isolated plasma membrane vitrification methodology without requiring a material change to the existing sample-preparation workflow.

Accordingly, the Leica EM GP2 is the only product identified through market research as capable of satisfying the Government’s complete minimum requirement while maintaining the laboratory’s established cryo-ET sample-preparation methodology and minimizing the risk of sample damage and experimental variability. For these reasons, the Government will restrict the requirement to the Leica EM GP2 as a brand-name item under FAR 8.405-6(b)..

16. Closing Statement:

This notice is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice.

Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include:

unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.”

A determination by the Government not to compete this proposed action based upon responses to this notice is solely within the discretion of the Government.

The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

http://www.sam.gov/

All responses must be received by September 4, 2026 at 3:00PM EST.

Responses must be submitted via email to the Contracting Officer identified above.

“All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.”