75N98026Q00275.pdf

Synopsis No. 75N98026Q00275

Hospital and Laboratory Support Division Office of Logistics and Operations (OLAO) Office of Acquisition and Logistics Management (OALM)

Title: Two-photon Mesoscale Imaging System with Holographic Stimulation Capability

Presolicitation

SYNOPSIS

General Information

Document Type: Presolicitation Synopsis Number: 75N98026Q00275 Posted Date: April 28, 2026 Original Response Date: May 8, 2026 Current Response Date: May 8, 2026 Set Aside: N/A NAICS Code: 334516

Contracting Office Address

National Institutes of Health (NIH), Office of the Director (OD) Office of Logistics and Operations (OLAO) Office of Acquisition and Logistics Management (OALM) Hospital and Laboratory Support Division 6701 Rockledge Drive Bethesda, MD 20817

Description

INTRODUCTION

THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS

TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL

OR OPEN COMPETITION (INCLUDING BRAND-NAME).

The National Institutes of Health (NIH) intends to negotiate and award a contract without providing for full and open competition (Including brand-name) to:

Pacific Optica 3448 Elings Hall, Bldg. 266 University of California Santa Barbara, CA 93106

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE

The intended procurement is classified under NAICS code 334516 with a Size Standard 1,000.

REGULATORY AUTHORITY

The resultant contract will include all applicable provisions and clauses in effect through the

Federal Acquisition Circular (FAC) 2005-99-1, July 16, 2018. This acquisition is conducted under the procedures as prescribed in FAR subpart 13-Simplified Acquisition Procedures at an amount not exceeding the simplified acquisition threshold ($350,000).

STATUTORY AUTHORITY

This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source and is not expected to exceed the simplified acquisition threshold. Contracts awarded using FAR Part 13-Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6- Competition Requirements.

GENERAL INFORMATION

1. Title: Two-photon Mesoscale Imaging System with Holographic Stimulation Capability

2. Background Information: A limiting factor to building computational models of brain systems are the small numbers of cells that can be simultaneously monitored in awake and behaving animals. A recently developed Mesoscale imaging platform, the Dual Independent Enhanced Scan Engine for Large field-of-view Two-Photon imaging (Diesel2p), by Spencer Smith (UCSB), substantially improves imaging access (greater cell numbers) by providing subcellular resolution over a large field-of-view (FOV) of ~25 mm2 (vs. 0.25 mm2 for our current imaging system).

The key advantage of the Diesel2p platform over other systems is holographic 2P stimulation, a technology that the Histed lab employs heavily, which permits the targeting of cells for optogenetic stimulation in awake and behaving mice. Our work is currently conducted with standard 2P imaging systems, those with limited FOVs.

CLOSING STATEMENT

This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include a technical proposal, a cost-price proposal, the period of performance, the Unique Entity ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

All responses must be received by May 8, 2026 at 9:00 AM Eastern time and must reference solicitation number 75N98026Q00275. Responses may be submitted electronically to Mr.

Michael Falzone, Contracting Officer at Michael.falzone@nih.gov. Fax responses will not be http://www.sam.gov/ accepted.

"All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency.”